JPS5814436B2 - Pyrazolopyridine - Google Patents
PyrazolopyridineInfo
- Publication number
- JPS5814436B2 JPS5814436B2 JP15415675A JP15415675A JPS5814436B2 JP S5814436 B2 JPS5814436 B2 JP S5814436B2 JP 15415675 A JP15415675 A JP 15415675A JP 15415675 A JP15415675 A JP 15415675A JP S5814436 B2 JPS5814436 B2 JP S5814436B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- reaction
- general formula
- same
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
【発明の詳細な説明】
本発明は新規ピラゾロピリジン誘導体の製造法に関する
。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for producing novel pyrazolopyridine derivatives.
本発明で得られるピラゾロピリジン誘導体は一般式
〔式中Ｒ１、Ｒ２及びＲ３は、それぞれ同一又は異なっ
て、低級アルキル基を示す。The pyrazolopyridine derivative obtained in the present invention has the general formula: [In the formula, R1, R2 and R3 are each the same or different and represent a lower alkyl group.
またＲ３は低級アルキル基を示す。Moreover, R3 represents a lower alkyl group.
〕で表わされる化合物である。] is a compound represented by
本発明の上記化合物は新規化合物であって、抗炎症作用
、抗菌作用を有し、医薬として有用なものである。The above compound of the present invention is a new compound, has anti-inflammatory and antibacterial effects, and is useful as a medicine.
本発明に係るピラゾロピリジン誘導体は一般式〔式中Ｒ
１、Ｒ２及びＲ３は上記に同じ。The pyrazolopyridine derivative according to the present invention has the general formula [wherein R
1, R2 and R3 are the same as above.
〕で表わされる化合物を閉環縮合することによって得る
ことができる。] can be obtained by ring-closing condensation of the compound represented by
本発明を詳細に説明すると本発明原料として用いられる
化合物（Ｉ）は新規化合物であり、該化合物は例えば公
知の一般式
〔式中Ｒ１及びＲ２は上記に同じ〕
で表わされる化合物と一般式
Ｃ ２ Ｈ５ ０ＣＨ ＝Ｃ （ Ｃｏ Ｏ Ｒａ ）
２〔式中Ｒ３は上記に同じ。To explain the present invention in detail, the compound (I) used as a raw material of the present invention is a new compound, and the compound is, for example, a compound represented by the known general formula [wherein R1 and R2 are the same as above] and a general formula C 2 H5 0CH = C (Co O Ra)
2 [In the formula, R3 is the same as above.
〕で表わされる化合物とを反応させることによって得る
ことができる。] can be obtained by reacting with a compound represented by:
上記化合物（■）と化合物（■）とから化合物（Ｉ）を
得る反応は単に両者を混合して約１００〜１５０℃に加
熱するだけで行ない得る。The reaction to obtain compound (I) from the above compound (■) and compound (■) can be carried out by simply mixing the two and heating the mixture to about 100-150°C.
上記反応は一般に円滑に進行し、ほぼ定量的収率で目的
とする化合物（Ｉ）が得られる。The above reaction generally proceeds smoothly, and the target compound (I) is obtained in a nearly quantitative yield.
上記反応に於ける化合物（ＩＩ）と化合物（■）との使
用割合は適宜選択すれば良いが、一般に前者に対し後者
を等モル〜２倍モル程度用いるのがよい。The ratio of Compound (II) and Compound (■) to be used in the above reaction may be selected as appropriate, but it is generally preferable to use about 1 to 2 times the mole of the latter to the former.
尚上記反応ではエタノールが生成するが、エタノールを
反応系外に除去しつつ反応を行なうことにより短時間で
反応を完結せしめることができると共に生成する化合物
（Ｉ）を特に精製することなく純品として得ることが可
能である。Although ethanol is produced in the above reaction, by carrying out the reaction while removing ethanol from the reaction system, the reaction can be completed in a short time and the produced compound (I) can be produced as a pure product without any particular purification. It is possible to obtain.
このようにして得られる化合物（Ｉ）を閉環縮合させる
と本発明の目的化合物であるピラゾロピリジン誘導体が
得られる。When compound (I) thus obtained is subjected to ring-closing condensation, a pyrazolopyridine derivative, which is the target compound of the present invention, is obtained.
上記反応は一般に縮合剤の存在下に行なわれる。The above reaction is generally carried out in the presence of a condensing agent.
この際使用される縮合剤としては広く公知の縮合剤が有
効に使用され得るが、通常ポリリン酸、ポリリン酸エス
テル、五酸化リン、硫酸等が好適に用いられる。As the condensing agent used in this case, widely known condensing agents can be effectively used, and usually polyphosphoric acid, polyphosphoric acid ester, phosphorus pentoxide, sulfuric acid, etc. are preferably used.
縮合剤の使用量は化合物■）に対し数倍モル程度の通常
の使用割合で用いればよい。The amount of the condensing agent to be used may be several times the molar ratio of the compound (1).
また上記反応は溶媒の不存在下に行なってもよく、反応
をより円滑にするためにエーテル、ハロゲン化炭化水素
、石油系溶媒等反応に関与しない溶媒を用いて溶媒中で
行なってもよい。Further, the above reaction may be carried out in the absence of a solvent, or in order to make the reaction smoother, it may be carried out in a solvent using a solvent that does not participate in the reaction, such as ether, halogenated hydrocarbon, or petroleum solvent.
上記反応に於ける反応温度は適宜選択すれば良いが、一
般に約０〜２００℃（好ましくは１００℃附近）の広い
範囲で進行し、特に低温で行ない得る利点がある。The reaction temperature in the above reaction may be selected as appropriate, but it generally proceeds over a wide range of about 0 to 200°C (preferably around 100°C), and has the advantage of being able to be carried out particularly at low temperatures.
尚上記反応を約２００〜２５０℃程度の高温下に行なえ
ば縮合剤の不存在下でも反応は進行する。Incidentally, if the above reaction is carried out at a high temperature of about 200 to 250 DEG C., the reaction will proceed even in the absence of a condensing agent.
この場合反応は溶媒中で有利に進行し、溶媒としては一
般にジフエニルエーテル又はジフエニルエーテルとジフ
エニルとの混合物等の如き反応に関与しない高沸点の溶
媒を用いるのが好ましい。In this case, the reaction proceeds advantageously in a solvent, and it is generally preferable to use a high boiling point solvent that does not participate in the reaction, such as diphenyl ether or a mixture of diphenyl ether and diphenyl.
上記反応により本発明の目的化合物であるピラゾロピリ
ジン誘導体が得られ、之は通常の分離手段により単離可
能である。The above reaction yields a pyrazolopyridine derivative, which is the target compound of the present invention, and can be isolated by conventional separation means.
本発明を具体的に説明するために実施例を掲げる。Examples will be given to specifically explain the present invention.
実施例 ｌ
ｌ・３−ジメチル−４−アミノピラゾール４２グ及びエ
トキシメチレンマロン酸ジエチル８．４ｇを１２０℃に
２時間加熱しながら、生成するエタノールを連続的に除
去すると（ｌ・３−ジメチル−５−ピラゾリル）アミノ
メチレンマロン酸ジエチルが油状物として得られる。Example 1 When 42 g of l.3-dimethyl-4-aminopyrazole and 8.4 g of diethyl ethoxymethylene malonate were heated to 120°C for 2 hours, the produced ethanol was continuously removed. Diethyl 5-pyrazolyl) aminomethylenemalonate is obtained as an oil.
収率は定量的である。Yield is quantitative.
このままで純品であり次の反応に使用することができる
が酢酸エチルを展開溶媒としシリカゲルを吸着剤とする
カラムクロマトグラフイーにより精製してもよい。Although it is a pure product and can be used in the next reaction as it is, it may be purified by column chromatography using ethyl acetate as a developing solvent and silica gel as an adsorbent.
元素分析値（ Ｃ１３ Ｈ１９ Ｎ３ ｏ４として）Ｈ
Ｃ Ｎ
計算値（％） ６．８１ ５５．５９ １４．９
４実測値（％） ６．８６ ５５．４５ １４．
８５次に上記で得られる（ｌ・３−ジメチル−５一ピラ
ゾリル）アミノメチレンマロン酸ジエチル１０ｇ及びジ
フエニルエーテル１５ｇを２５０℃に１時間加熱攪拌し
たのちジフエニルエーテルを減圧留去する。Elemental analysis value (as C13 H19 N3 o4) H
C N Calculated value (%) 6.81 55.59 14.9
4 Actual value (%) 6.86 55.45 14.
85 Next, 10 g of diethyl (1.3-dimethyl-5-pyrazolyl)aminomethylenemalonate obtained above and 15 g of diphenyl ether were heated and stirred at 250° C. for 1 hour, and then the diphenyl ether was distilled off under reduced pressure.
残清をＯ．１Ｎ−ＮａＯＨ 水溶液に溶解しクロロホル
ムで洗ったのち塩酸を加えてｐＨ６とする。The remaining liquid was washed with O. After dissolving in 1N-NaOH aqueous solution and washing with chloroform, hydrochloric acid is added to adjust the pH to 6.
析出物を沢取し、水洗後乾燥すると融点２６８〜２７０
℃の１・３−ジメチル−７−ヒドロキシピラゾロ〔４・
３−ｂ）ピリジンー６−カルボン酸エチル５．６ｇが得
られる。When the precipitate is collected, washed with water and dried, the melting point is 268-270.
1,3-dimethyl-7-hydroxypyrazolo[4.
3-b) 5.6 g of ethyl pyridine-6-carboxylate are obtained.
？素分析値（Ｃ１Ｈｌ ３ Ｎ３ ０ ３として）ＨＣ
Ｎ
計算値（％） ５．５７ ５６．１６ １７．８
６実測値（％） ５．６２ ５６．０８ １７．
８３実施例 ２
上記実施例ｌと同様にして中間体である（ｌ・３−ジメ
チル−５−ピラゾリル）アミノメチレンマロン酸ジエチ
ルを得る。? Elementary analysis value (as C1Hl 3 N3 0 3) HC
N Calculated value (%) 5.57 56.16 17.8
6 Actual value (%) 5.62 56.08 17.
83 Example 2 The intermediate diethyl (1.3-dimethyl-5-pyrazolyl)aminomethylenemalonate is obtained in the same manner as in Example 1 above.
この（１・３−ジメチル−５−ピラゾリル）アミノメチ
レンマロン酸ジエチル１０ｆ及びポリリン酸３０ｙを９
０〜１００℃で１時間加熱攪拌し冷後氷水中に注加する
。This diethyl (1,3-dimethyl-5-pyrazolyl)aminomethylenemalonate 10f and polyphosphoric acid 30y were added to 9
The mixture was heated and stirred at 0 to 100°C for 1 hour, cooled, and then poured into ice water.
析出物を沢取し０．１Ｎ−ＮａＯＨ 水溶液に溶解し、
塩酸を加えてｐＨ ６とする。A lot of the precipitate was collected and dissolved in 0.1N-NaOH aqueous solution.
Add hydrochloric acid to pH 6.
析出物を濾取し水洗後乾燥すると融点２６８〜２７０℃
の１・３−ジメチル−７−ヒドロキシピラゾロ〔４・３
−ｂ〕ピリジン−６−カルボン酸エチル５．８７が得ら
れる。When the precipitate is collected by filtration, washed with water and dried, the melting point is 268-270℃.
1,3-dimethyl-7-hydroxypyrazolo[4,3
-b] 5.87 ethyl pyridine-6-carboxylate is obtained.
元素分析値（Ｃ１Ｈ１３Ｎ３０３として）ＨＣ
ＮElemental analysis value (as C1H13N303) HC
N
Claims (1)
て、低級アルキル基を示す。 〕で表わされる化合物を閉環縮合することを特徴とする
一般式 〔式中Ｒ１、Ｒ２及びＲ３は上記に同じ。 〕で表わされるピラゾロピリジン誘導体の製造法。 ２ 一般式 〔式中Ｒ１及びＲ２は、それぞれ同一又は異なって、低
級アルキル基を示す。 〕で表わされる化合物と一般式 Ｃ２ Ｈ５０ＣＨ ＝ Ｃ （ ＣＯＯＲｓ ） ２〔
式中Ｒ３は低級アルキル基を示す。 〕で表わされる化合物とを反応させて一般式〔式中Ｒ１
、Ｒ２及びＲ３は上記に同じ。 〕で表わされる化合物を得、次いで之を閉環縮合するこ
とを特徴とする一般式 〔式中Ｒ１、Ｒ２及びＲ３は上記に同じ。 〕で表わされるビラゾロピリジン誘導体の製造法。[Claims] 1. General formula [In the formula, R, , R2 and R3 are each the same or different and represent a lower alkyl group. ] [wherein R1, R2 and R3 are the same as above]. ] A method for producing a pyrazolopyridine derivative represented by 2 General Formula [In the formula, R1 and R2 are each the same or different and represent a lower alkyl group. ] and the general formula C2 H50CH = C (COORs) 2 [
In the formula, R3 represents a lower alkyl group. ] is reacted with a compound represented by the general formula [in the formula R1
, R2 and R3 are the same as above. A compound represented by the general formula [wherein R1, R2 and R3 are the same as above] is obtained by subjecting the compound to ring-closing condensation. ] A method for producing a birazolopyridine derivative represented by
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15415675A JPS5814436B2 (en) | 1975-12-22 | 1975-12-22 | Pyrazolopyridine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15415675A JPS5814436B2 (en) | 1975-12-22 | 1975-12-22 | Pyrazolopyridine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5277086A JPS5277086A (en) | 1977-06-29 |
| JPS5814436B2 true JPS5814436B2 (en) | 1983-03-18 |
Family
ID=15578055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15415675A Expired JPS5814436B2 (en) | 1975-12-22 | 1975-12-22 | Pyrazolopyridine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5814436B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58195038U (en) * | 1982-06-23 | 1983-12-24 | ト−ハツ株式会社 | Pump engine governor device |
| JPH0339180B2 (en) * | 1984-01-06 | 1991-06-13 | Morita Honpu Kk |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8404586D0 (en) * | 1984-02-22 | 1984-03-28 | Beecham Group Plc | Compounds |
| EP0239191A3 (en) * | 1986-01-30 | 1988-07-20 | Beecham Group Plc | Pyrazolo[4,3-b]pyridine derivatives, process for their preparation and pharmaceutical compositions containing them |
-
1975
- 1975-12-22 JP JP15415675A patent/JPS5814436B2/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58195038U (en) * | 1982-06-23 | 1983-12-24 | ト−ハツ株式会社 | Pump engine governor device |
| JPH0339180B2 (en) * | 1984-01-06 | 1991-06-13 | Morita Honpu Kk |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5277086A (en) | 1977-06-29 |
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