JPS5795997A - Removal of admixed protein from albumin-containing solution in presence of water-soluble high polymer - Google Patents

Removal of admixed protein from albumin-containing solution in presence of water-soluble high polymer

Info

Publication number
JPS5795997A
JPS5795997A JP17207880A JP17207880A JPS5795997A JP S5795997 A JPS5795997 A JP S5795997A JP 17207880 A JP17207880 A JP 17207880A JP 17207880 A JP17207880 A JP 17207880A JP S5795997 A JPS5795997 A JP S5795997A
Authority
JP
Japan
Prior art keywords
albumin
solution
water
high polymer
soluble high
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP17207880A
Other languages
Japanese (ja)
Inventor
Sukekazu Tomono
Nobuo Watanabe
Keiji Ishida
Eiichi Tokunaga
Hirokimi Itou
Tsugio Takeuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIHON SEKIJIYUUJISHIYA
NIPPON SEKIJIYUUJISHIYA
Original Assignee
NIHON SEKIJIYUUJISHIYA
NIPPON SEKIJIYUUJISHIYA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIHON SEKIJIYUUJISHIYA, NIPPON SEKIJIYUUJISHIYA filed Critical NIHON SEKIJIYUUJISHIYA
Priority to JP17207880A priority Critical patent/JPS5795997A/en
Publication of JPS5795997A publication Critical patent/JPS5795997A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To remove admixed protein completely from an albumin solution and to purify it in high purity, by adding a specific amount of a stabilizer to the albumin-containing solution in the presence of a water-soluble high polymer, hea t-treating the solution under specified conditions, e.g. pH, temperature, etc., followed by filtration, etc.
CONSTITUTION: For example, preferably 0.1W25wt% water-soluble high polymer, polyethylene glycol, etc. is added to 0.1W25wt% aqueous protein solution containing albumin derived from human plasma, etc. A stabilizer (preferably a mixture of sodium caprate and D,L-acetyltriptophan) in a molar amount of 1W20 times that of albumin is added to the aqueous solution, and heat-treated in a pH of 4W9 in an ionic strength of 0.01W1.0 at 45W70°C for 10minW10hr. The solution is subjected to filtration, centrifugation, gel filtration, etc., preferably further ion exchange chromatography, etc., to remove thermally unstable protein completely.
COPYRIGHT: (C)1982,JPO&Japio
JP17207880A 1980-12-08 1980-12-08 Removal of admixed protein from albumin-containing solution in presence of water-soluble high polymer Pending JPS5795997A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17207880A JPS5795997A (en) 1980-12-08 1980-12-08 Removal of admixed protein from albumin-containing solution in presence of water-soluble high polymer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17207880A JPS5795997A (en) 1980-12-08 1980-12-08 Removal of admixed protein from albumin-containing solution in presence of water-soluble high polymer

Publications (1)

Publication Number Publication Date
JPS5795997A true JPS5795997A (en) 1982-06-15

Family

ID=15935123

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17207880A Pending JPS5795997A (en) 1980-12-08 1980-12-08 Removal of admixed protein from albumin-containing solution in presence of water-soluble high polymer

Country Status (1)

Country Link
JP (1) JPS5795997A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015617A1 (en) * 1989-06-15 1990-12-27 The Green Cross Corporation Albumin preparation and method of producing the same
JPH03103188A (en) * 1989-09-18 1991-04-30 Green Cross Corp:The Production of human serum albumin
US6022954A (en) * 1989-06-08 2000-02-08 Centre Regional De Transfusion Sanguine De Lille Process for the preparation of purified albumin solutions
JP2020510068A (en) * 2017-03-16 2020-04-02 セラピュア バイオファーマ インコーポレーテッド Method for purifying albumin

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022954A (en) * 1989-06-08 2000-02-08 Centre Regional De Transfusion Sanguine De Lille Process for the preparation of purified albumin solutions
WO1990015617A1 (en) * 1989-06-15 1990-12-27 The Green Cross Corporation Albumin preparation and method of producing the same
JPH03103188A (en) * 1989-09-18 1991-04-30 Green Cross Corp:The Production of human serum albumin
JP2020510068A (en) * 2017-03-16 2020-04-02 セラピュア バイオファーマ インコーポレーテッド Method for purifying albumin
US11427613B2 (en) 2017-03-16 2022-08-30 Evolve Biologics Inc. Method for purification of albumin

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