JPS5795997A - Removal of admixed protein from albumin-containing solution in presence of water-soluble high polymer - Google Patents
Removal of admixed protein from albumin-containing solution in presence of water-soluble high polymerInfo
- Publication number
- JPS5795997A JPS5795997A JP17207880A JP17207880A JPS5795997A JP S5795997 A JPS5795997 A JP S5795997A JP 17207880 A JP17207880 A JP 17207880A JP 17207880 A JP17207880 A JP 17207880A JP S5795997 A JPS5795997 A JP S5795997A
- Authority
- JP
- Japan
- Prior art keywords
- albumin
- solution
- water
- high polymer
- soluble high
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To remove admixed protein completely from an albumin solution and to purify it in high purity, by adding a specific amount of a stabilizer to the albumin-containing solution in the presence of a water-soluble high polymer, hea t-treating the solution under specified conditions, e.g. pH, temperature, etc., followed by filtration, etc.
CONSTITUTION: For example, preferably 0.1W25wt% water-soluble high polymer, polyethylene glycol, etc. is added to 0.1W25wt% aqueous protein solution containing albumin derived from human plasma, etc. A stabilizer (preferably a mixture of sodium caprate and D,L-acetyltriptophan) in a molar amount of 1W20 times that of albumin is added to the aqueous solution, and heat-treated in a pH of 4W9 in an ionic strength of 0.01W1.0 at 45W70°C for 10minW10hr. The solution is subjected to filtration, centrifugation, gel filtration, etc., preferably further ion exchange chromatography, etc., to remove thermally unstable protein completely.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17207880A JPS5795997A (en) | 1980-12-08 | 1980-12-08 | Removal of admixed protein from albumin-containing solution in presence of water-soluble high polymer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17207880A JPS5795997A (en) | 1980-12-08 | 1980-12-08 | Removal of admixed protein from albumin-containing solution in presence of water-soluble high polymer |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5795997A true JPS5795997A (en) | 1982-06-15 |
Family
ID=15935123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17207880A Pending JPS5795997A (en) | 1980-12-08 | 1980-12-08 | Removal of admixed protein from albumin-containing solution in presence of water-soluble high polymer |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5795997A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015617A1 (en) * | 1989-06-15 | 1990-12-27 | The Green Cross Corporation | Albumin preparation and method of producing the same |
JPH03103188A (en) * | 1989-09-18 | 1991-04-30 | Green Cross Corp:The | Production of human serum albumin |
US6022954A (en) * | 1989-06-08 | 2000-02-08 | Centre Regional De Transfusion Sanguine De Lille | Process for the preparation of purified albumin solutions |
JP2020510068A (en) * | 2017-03-16 | 2020-04-02 | セラピュア バイオファーマ インコーポレーテッド | Method for purifying albumin |
-
1980
- 1980-12-08 JP JP17207880A patent/JPS5795997A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6022954A (en) * | 1989-06-08 | 2000-02-08 | Centre Regional De Transfusion Sanguine De Lille | Process for the preparation of purified albumin solutions |
WO1990015617A1 (en) * | 1989-06-15 | 1990-12-27 | The Green Cross Corporation | Albumin preparation and method of producing the same |
JPH03103188A (en) * | 1989-09-18 | 1991-04-30 | Green Cross Corp:The | Production of human serum albumin |
JP2020510068A (en) * | 2017-03-16 | 2020-04-02 | セラピュア バイオファーマ インコーポレーテッド | Method for purifying albumin |
US11427613B2 (en) | 2017-03-16 | 2022-08-30 | Evolve Biologics Inc. | Method for purification of albumin |
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