JPS5788185A - Maytansinoid compound and its preparation - Google Patents

Maytansinoid compound and its preparation

Info

Publication number
JPS5788185A
JPS5788185A JP55164835A JP16483580A JPS5788185A JP S5788185 A JPS5788185 A JP S5788185A JP 55164835 A JP55164835 A JP 55164835A JP 16483580 A JP16483580 A JP 16483580A JP S5788185 A JPS5788185 A JP S5788185A
Authority
JP
Japan
Prior art keywords
compound
formula
maytansinoid
maytansinoid compound
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55164835A
Other languages
Japanese (ja)
Inventor
Toru Hasegawa
Mikio Izawa
Seiichi Tanida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP55164835A priority Critical patent/JPS5788185A/en
Publication of JPS5788185A publication Critical patent/JPS5788185A/en
Pending legal-status Critical Current

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Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The maytansinoid compound of formulaI(one of R<1> and R<2> is OH or lower acyloxy, and the other is H; Y is H or methyl). USE:An antiprotozoal and antitumor agent having low toxicity. PROCESS:Bacterial belonging to Nocardia genus and capable of producing a maytansinoid compound of formula II (one of R1' and R2' is OH and the other is H),[e.g. Nocardia sp. No.N-1231 strain, IFO 13963,]etc. are cultured, and the produced and accumulated compound of formula II is separated from the cultured product. To obtain a large amount of the objective compound, the cultivation is pref. carried out in a liquid medium by submerged technique under aeration and agitation.
JP55164835A 1980-11-21 1980-11-21 Maytansinoid compound and its preparation Pending JPS5788185A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55164835A JPS5788185A (en) 1980-11-21 1980-11-21 Maytansinoid compound and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55164835A JPS5788185A (en) 1980-11-21 1980-11-21 Maytansinoid compound and its preparation

Publications (1)

Publication Number Publication Date
JPS5788185A true JPS5788185A (en) 1982-06-01

Family

ID=15800827

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55164835A Pending JPS5788185A (en) 1980-11-21 1980-11-21 Maytansinoid compound and its preparation

Country Status (1)

Country Link
JP (1) JPS5788185A (en)

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