JPS5788185A - Maytansinoid compound and its preparation - Google Patents
Maytansinoid compound and its preparationInfo
- Publication number
- JPS5788185A JPS5788185A JP55164835A JP16483580A JPS5788185A JP S5788185 A JPS5788185 A JP S5788185A JP 55164835 A JP55164835 A JP 55164835A JP 16483580 A JP16483580 A JP 16483580A JP S5788185 A JPS5788185 A JP S5788185A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- maytansinoid
- maytansinoid compound
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The maytansinoid compound of formulaI(one of R<1> and R<2> is OH or lower acyloxy, and the other is H; Y is H or methyl). USE:An antiprotozoal and antitumor agent having low toxicity. PROCESS:Bacterial belonging to Nocardia genus and capable of producing a maytansinoid compound of formula II (one of R1' and R2' is OH and the other is H),[e.g. Nocardia sp. No.N-1231 strain, IFO 13963,]etc. are cultured, and the produced and accumulated compound of formula II is separated from the cultured product. To obtain a large amount of the objective compound, the cultivation is pref. carried out in a liquid medium by submerged technique under aeration and agitation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55164835A JPS5788185A (en) | 1980-11-21 | 1980-11-21 | Maytansinoid compound and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55164835A JPS5788185A (en) | 1980-11-21 | 1980-11-21 | Maytansinoid compound and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5788185A true JPS5788185A (en) | 1982-06-01 |
Family
ID=15800827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP55164835A Pending JPS5788185A (en) | 1980-11-21 | 1980-11-21 | Maytansinoid compound and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5788185A (en) |
-
1980
- 1980-11-21 JP JP55164835A patent/JPS5788185A/en active Pending
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