JPS5780328A - Preparation of stable pharmaceutical preparation - Google Patents
Preparation of stable pharmaceutical preparationInfo
- Publication number
- JPS5780328A JPS5780328A JP15679580A JP15679580A JPS5780328A JP S5780328 A JPS5780328 A JP S5780328A JP 15679580 A JP15679580 A JP 15679580A JP 15679580 A JP15679580 A JP 15679580A JP S5780328 A JPS5780328 A JP S5780328A
- Authority
- JP
- Japan
- Prior art keywords
- preparation
- hso
- imidazolium
- carbamoyl
- oleate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To obtain a stable carcinostatic preparation resistance to the discoloration with oxygen, heat, light, etc., by adding a sulfur compound generating HSO3 -, SO3 2-, and S2O5 2- to 4-carbamoyl-imidazolium-5-oleate.
CONSTITUTION: A compound generating the ions selected from HSO3 -, SO3 2- and S2O5 2-, e.g. sodium bisulfite, sodium sulfite, sodium pyrosulfite, etc., is added to 4-carbamoyl-imidazolium-5-oleate of formula, its salt, or their hydrate, which are carcino-static agents having antimetabolic activity to purine, and remarkable effect against esp. hard cancer. The amount of the sulfur compound to be added is pref. 0.01W0.50pts.wt. per 1pt. of the compound of formula in view of the stabilizing effect and the safety.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15679580A JPS5780328A (en) | 1980-11-06 | 1980-11-06 | Preparation of stable pharmaceutical preparation |
DE8181305148T DE3176849D1 (en) | 1980-11-05 | 1981-10-29 | Pharmaceutical composition comprising 4-carbamoyl-imidazolium-5-olate |
EP81305148A EP0051962B1 (en) | 1980-11-05 | 1981-10-29 | Pharmaceutical composition comprising 4-carbamoyl-imidazolium-5-olate |
CA000389484A CA1186999A (en) | 1980-11-05 | 1981-11-05 | Pharmaceutical composition for injection |
CA000442797A CA1186227A (en) | 1980-11-05 | 1983-12-07 | Pharmaceutical composition for injection |
US06/667,385 US4582845A (en) | 1980-11-05 | 1984-11-02 | Pharmaceutical composition for injection |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15679580A JPS5780328A (en) | 1980-11-06 | 1980-11-06 | Preparation of stable pharmaceutical preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5780328A true JPS5780328A (en) | 1982-05-19 |
Family
ID=15635468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15679580A Pending JPS5780328A (en) | 1980-11-05 | 1980-11-06 | Preparation of stable pharmaceutical preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5780328A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994020143A1 (en) * | 1993-03-03 | 1994-09-15 | Fujisawa Pharmaceutical Co., Ltd. | Optical isomerization inhibitor |
KR100399483B1 (en) * | 2000-12-12 | 2003-09-29 | 대화제약 주식회사 | New antispasmodic solution containing phloroglucinol as active ingredient |
WO2014112529A1 (en) * | 2013-01-15 | 2014-07-24 | 富士フイルム株式会社 | 5-hydroxy-1h-imidazole-4-carboxamide sulfate |
WO2014112531A1 (en) | 2013-01-15 | 2014-07-24 | 富士フイルム株式会社 | Package for solid preparation including 5-hydroxy-1h-imidazole-4-carboxamide or salt or hydrate thereof |
-
1980
- 1980-11-06 JP JP15679580A patent/JPS5780328A/en active Pending
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994020143A1 (en) * | 1993-03-03 | 1994-09-15 | Fujisawa Pharmaceutical Co., Ltd. | Optical isomerization inhibitor |
KR100399483B1 (en) * | 2000-12-12 | 2003-09-29 | 대화제약 주식회사 | New antispasmodic solution containing phloroglucinol as active ingredient |
WO2014112529A1 (en) * | 2013-01-15 | 2014-07-24 | 富士フイルム株式会社 | 5-hydroxy-1h-imidazole-4-carboxamide sulfate |
WO2014112531A1 (en) | 2013-01-15 | 2014-07-24 | 富士フイルム株式会社 | Package for solid preparation including 5-hydroxy-1h-imidazole-4-carboxamide or salt or hydrate thereof |
US9089558B2 (en) | 2013-01-15 | 2015-07-28 | Fujifilm Corporation | Packaged product of solid preparation containing 5-hydroxy-1H-imidazole-4-carboxamide or salt thereof, or hydrate thereof |
JP6001684B2 (en) * | 2013-01-15 | 2016-10-05 | 富士フイルム株式会社 | 5-hydroxy-1H-imidazole-4-carboxamide sulfate |
US9475778B2 (en) | 2013-01-15 | 2016-10-25 | Fujifilm Corporation | Sulfate of 5-hydroxy-1H-imidazole-4-carboxamide |
US9481652B2 (en) | 2013-01-15 | 2016-11-01 | Fujifilm Corporation | Packaged product of solid preparation containing 5-hydroxy-1H-imidazole-4-carboxamide or salt thereof, or hydrate thereof |
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