JPS5780328A - Preparation of stable pharmaceutical preparation - Google Patents

Preparation of stable pharmaceutical preparation

Info

Publication number
JPS5780328A
JPS5780328A JP15679580A JP15679580A JPS5780328A JP S5780328 A JPS5780328 A JP S5780328A JP 15679580 A JP15679580 A JP 15679580A JP 15679580 A JP15679580 A JP 15679580A JP S5780328 A JPS5780328 A JP S5780328A
Authority
JP
Japan
Prior art keywords
preparation
hso
imidazolium
carbamoyl
oleate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15679580A
Other languages
Japanese (ja)
Inventor
Yoshinari Yamahira
Takaharu Fujioka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP15679580A priority Critical patent/JPS5780328A/en
Priority to DE8181305148T priority patent/DE3176849D1/en
Priority to EP81305148A priority patent/EP0051962B1/en
Priority to CA000389484A priority patent/CA1186999A/en
Publication of JPS5780328A publication Critical patent/JPS5780328A/en
Priority to CA000442797A priority patent/CA1186227A/en
Priority to US06/667,385 priority patent/US4582845A/en
Pending legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

PURPOSE: To obtain a stable carcinostatic preparation resistance to the discoloration with oxygen, heat, light, etc., by adding a sulfur compound generating HSO3 -, SO3 2-, and S2O5 2- to 4-carbamoyl-imidazolium-5-oleate.
CONSTITUTION: A compound generating the ions selected from HSO3 -, SO3 2- and S2O5 2-, e.g. sodium bisulfite, sodium sulfite, sodium pyrosulfite, etc., is added to 4-carbamoyl-imidazolium-5-oleate of formula, its salt, or their hydrate, which are carcino-static agents having antimetabolic activity to purine, and remarkable effect against esp. hard cancer. The amount of the sulfur compound to be added is pref. 0.01W0.50pts.wt. per 1pt. of the compound of formula in view of the stabilizing effect and the safety.
COPYRIGHT: (C)1982,JPO&Japio
JP15679580A 1980-11-05 1980-11-06 Preparation of stable pharmaceutical preparation Pending JPS5780328A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP15679580A JPS5780328A (en) 1980-11-06 1980-11-06 Preparation of stable pharmaceutical preparation
DE8181305148T DE3176849D1 (en) 1980-11-05 1981-10-29 Pharmaceutical composition comprising 4-carbamoyl-imidazolium-5-olate
EP81305148A EP0051962B1 (en) 1980-11-05 1981-10-29 Pharmaceutical composition comprising 4-carbamoyl-imidazolium-5-olate
CA000389484A CA1186999A (en) 1980-11-05 1981-11-05 Pharmaceutical composition for injection
CA000442797A CA1186227A (en) 1980-11-05 1983-12-07 Pharmaceutical composition for injection
US06/667,385 US4582845A (en) 1980-11-05 1984-11-02 Pharmaceutical composition for injection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15679580A JPS5780328A (en) 1980-11-06 1980-11-06 Preparation of stable pharmaceutical preparation

Publications (1)

Publication Number Publication Date
JPS5780328A true JPS5780328A (en) 1982-05-19

Family

ID=15635468

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15679580A Pending JPS5780328A (en) 1980-11-05 1980-11-06 Preparation of stable pharmaceutical preparation

Country Status (1)

Country Link
JP (1) JPS5780328A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994020143A1 (en) * 1993-03-03 1994-09-15 Fujisawa Pharmaceutical Co., Ltd. Optical isomerization inhibitor
KR100399483B1 (en) * 2000-12-12 2003-09-29 대화제약 주식회사 New antispasmodic solution containing phloroglucinol as active ingredient
WO2014112529A1 (en) * 2013-01-15 2014-07-24 富士フイルム株式会社 5-hydroxy-1h-imidazole-4-carboxamide sulfate
WO2014112531A1 (en) 2013-01-15 2014-07-24 富士フイルム株式会社 Package for solid preparation including 5-hydroxy-1h-imidazole-4-carboxamide or salt or hydrate thereof

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994020143A1 (en) * 1993-03-03 1994-09-15 Fujisawa Pharmaceutical Co., Ltd. Optical isomerization inhibitor
KR100399483B1 (en) * 2000-12-12 2003-09-29 대화제약 주식회사 New antispasmodic solution containing phloroglucinol as active ingredient
WO2014112529A1 (en) * 2013-01-15 2014-07-24 富士フイルム株式会社 5-hydroxy-1h-imidazole-4-carboxamide sulfate
WO2014112531A1 (en) 2013-01-15 2014-07-24 富士フイルム株式会社 Package for solid preparation including 5-hydroxy-1h-imidazole-4-carboxamide or salt or hydrate thereof
US9089558B2 (en) 2013-01-15 2015-07-28 Fujifilm Corporation Packaged product of solid preparation containing 5-hydroxy-1H-imidazole-4-carboxamide or salt thereof, or hydrate thereof
JP6001684B2 (en) * 2013-01-15 2016-10-05 富士フイルム株式会社 5-hydroxy-1H-imidazole-4-carboxamide sulfate
US9475778B2 (en) 2013-01-15 2016-10-25 Fujifilm Corporation Sulfate of 5-hydroxy-1H-imidazole-4-carboxamide
US9481652B2 (en) 2013-01-15 2016-11-01 Fujifilm Corporation Packaged product of solid preparation containing 5-hydroxy-1H-imidazole-4-carboxamide or salt thereof, or hydrate thereof

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