JPS5759815A - Drug composition having preventing and remedying action on rotavirus infectious disease - Google Patents
Drug composition having preventing and remedying action on rotavirus infectious diseaseInfo
- Publication number
- JPS5759815A JPS5759815A JP13626880A JP13626880A JPS5759815A JP S5759815 A JPS5759815 A JP S5759815A JP 13626880 A JP13626880 A JP 13626880A JP 13626880 A JP13626880 A JP 13626880A JP S5759815 A JPS5759815 A JP S5759815A
- Authority
- JP
- Japan
- Prior art keywords
- rotavirus
- preventing
- iga
- monomer
- monomer iga
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PURPOSE: A preventive and remedy for a rotavirus infections diesease, having neutralizing activity on rotavirus and high safety, comprising a monomer IgA as a main ingredient.
CONSTITUTION: An immunoglobulin comprising a monomer IgA as a main ingredient is collected from the serum, plasma, and placental blood of humal and mammals as a raw material, and used for preventing and remedying rotavirus. The raw material is purified by salting out method, ion exchange chromatography, gel filtration, affinity chromatography, etc., so that the content of IgG causing allergic reactions like anaphylaxis is ≤10wt%, preferably a mall amount as less as possible. The obtained monomer IgA exhibits strong neutralizing acrivity against rotavirus, and also suppresses the propagation of rotarirus in an animal experiment. In pharmaceutical preparation, after being converted into a common oral drug, it is advantageously subjected to enteric coating. The dosage is 10W5,000mg/day as monomer IgA.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13626880A JPS5759815A (en) | 1980-09-30 | 1980-09-30 | Drug composition having preventing and remedying action on rotavirus infectious disease |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13626880A JPS5759815A (en) | 1980-09-30 | 1980-09-30 | Drug composition having preventing and remedying action on rotavirus infectious disease |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5759815A true JPS5759815A (en) | 1982-04-10 |
JPS6355494B2 JPS6355494B2 (en) | 1988-11-02 |
Family
ID=15171210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13626880A Granted JPS5759815A (en) | 1980-09-30 | 1980-09-30 | Drug composition having preventing and remedying action on rotavirus infectious disease |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5759815A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57185222A (en) * | 1981-05-01 | 1982-11-15 | Cutter Lab | Oral immunogloblin |
WO1995022350A1 (en) * | 1994-02-18 | 1995-08-24 | Immuno Aktiengesellschaft | Composition and method for preventing and treating inflammation with immunoglobulin a |
EP0692491A1 (en) | 1994-07-14 | 1996-01-17 | IMMUNO Aktiengesellschaft | Human virus-free monomeric immunoglobulin A and method for its production |
EP1267928A2 (en) * | 2000-03-27 | 2003-01-02 | Medarex, Inc. | Methods for immunostimulation using bispecific binding agents for the fc receptor of immunoglobulin a and for cancer cells or infectious antigen |
US6646108B1 (en) | 1996-01-12 | 2003-11-11 | Baxter Aktiengesellschaft | Process for isolating IgG and IgA |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51139617A (en) * | 1975-05-29 | 1976-12-02 | Green Cross Corp:The | A process for preparing a remedy for intestinal infectious diseases |
-
1980
- 1980-09-30 JP JP13626880A patent/JPS5759815A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51139617A (en) * | 1975-05-29 | 1976-12-02 | Green Cross Corp:The | A process for preparing a remedy for intestinal infectious diseases |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57185222A (en) * | 1981-05-01 | 1982-11-15 | Cutter Lab | Oral immunogloblin |
WO1995022350A1 (en) * | 1994-02-18 | 1995-08-24 | Immuno Aktiengesellschaft | Composition and method for preventing and treating inflammation with immunoglobulin a |
US5833984A (en) * | 1994-02-18 | 1998-11-10 | Immuno Aktiengesellschaft | Composition and method for preventing and treating inflammation with Immunoglobulin A |
EP0692491A1 (en) | 1994-07-14 | 1996-01-17 | IMMUNO Aktiengesellschaft | Human virus-free monomeric immunoglobulin A and method for its production |
DE4424935C1 (en) * | 1994-07-14 | 1996-03-21 | Immuno Ag | Human virus-safe monomeric immunoglobulin A and process for its preparation |
US5808000A (en) * | 1994-07-14 | 1998-09-15 | Immuno Aktiengesellschaft | Virus-safe monomeric human immunoglobulin A and methods for its production |
US6646108B1 (en) | 1996-01-12 | 2003-11-11 | Baxter Aktiengesellschaft | Process for isolating IgG and IgA |
EP1267928A2 (en) * | 2000-03-27 | 2003-01-02 | Medarex, Inc. | Methods for immunostimulation using bispecific binding agents for the fc receptor of immunoglobulin a and for cancer cells or infectious antigen |
Also Published As
Publication number | Publication date |
---|---|
JPS6355494B2 (en) | 1988-11-02 |
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