JPS5756498A - Production of crude ursodeoxycholic acid - Google Patents

Production of crude ursodeoxycholic acid

Info

Publication number
JPS5756498A
JPS5756498A JP13009580A JP13009580A JPS5756498A JP S5756498 A JPS5756498 A JP S5756498A JP 13009580 A JP13009580 A JP 13009580A JP 13009580 A JP13009580 A JP 13009580A JP S5756498 A JPS5756498 A JP S5756498A
Authority
JP
Japan
Prior art keywords
alkali
organic solvent
earth metal
alkaline earth
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13009580A
Other languages
Japanese (ja)
Other versions
JPS6354720B2 (en
Inventor
Haruki Takeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokyo Tanabe Co Ltd
Original Assignee
Tokyo Tanabe Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Tanabe Co Ltd filed Critical Tokyo Tanabe Co Ltd
Priority to JP13009580A priority Critical patent/JPS5756498A/en
Publication of JPS5756498A publication Critical patent/JPS5756498A/en
Publication of JPS6354720B2 publication Critical patent/JPS6354720B2/ja
Granted legal-status Critical Current

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Abstract

PURPOSE: 3d-Hydroxy-7-ketocholanic acid is hydrogenated in a specific organic solvent using an alkali or alkaline earth metal to produce the titled product of relatively high purity readily in an industrial scale.
CONSTITUTION: The hydrogenation of 3d-hydroxy-7-ketocholanic acid is conducted in an organic solvent dissolving an alkali or alkaline earth metal such as hexamethyl phosphoric triamide in the presence or absence of a proton source using an alkali alkaline earth metal to produce ursodeoxycholic acid. When an organic solvent is used as the proteon source, the amount of the proton source or is 5W100% based on the mixture thereof with the above organic solvent. The amount of the alkali or alkaline earth metal added is more than 5 times the molar amount of the ketocholanic acid.
COPYRIGHT: (C)1982,JPO&Japio
JP13009580A 1980-09-20 1980-09-20 Production of crude ursodeoxycholic acid Granted JPS5756498A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13009580A JPS5756498A (en) 1980-09-20 1980-09-20 Production of crude ursodeoxycholic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13009580A JPS5756498A (en) 1980-09-20 1980-09-20 Production of crude ursodeoxycholic acid

Publications (2)

Publication Number Publication Date
JPS5756498A true JPS5756498A (en) 1982-04-05
JPS6354720B2 JPS6354720B2 (en) 1988-10-28

Family

ID=15025832

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13009580A Granted JPS5756498A (en) 1980-09-20 1980-09-20 Production of crude ursodeoxycholic acid

Country Status (1)

Country Link
JP (1) JPS5756498A (en)

Also Published As

Publication number Publication date
JPS6354720B2 (en) 1988-10-28

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