JPS5756498A - Production of crude ursodeoxycholic acid - Google Patents
Production of crude ursodeoxycholic acidInfo
- Publication number
- JPS5756498A JPS5756498A JP13009580A JP13009580A JPS5756498A JP S5756498 A JPS5756498 A JP S5756498A JP 13009580 A JP13009580 A JP 13009580A JP 13009580 A JP13009580 A JP 13009580A JP S5756498 A JPS5756498 A JP S5756498A
- Authority
- JP
- Japan
- Prior art keywords
- alkali
- organic solvent
- earth metal
- alkaline earth
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Steroid Compounds (AREA)
Abstract
PURPOSE: 3d-Hydroxy-7-ketocholanic acid is hydrogenated in a specific organic solvent using an alkali or alkaline earth metal to produce the titled product of relatively high purity readily in an industrial scale.
CONSTITUTION: The hydrogenation of 3d-hydroxy-7-ketocholanic acid is conducted in an organic solvent dissolving an alkali or alkaline earth metal such as hexamethyl phosphoric triamide in the presence or absence of a proton source using an alkali alkaline earth metal to produce ursodeoxycholic acid. When an organic solvent is used as the proteon source, the amount of the proton source or is 5W100% based on the mixture thereof with the above organic solvent. The amount of the alkali or alkaline earth metal added is more than 5 times the molar amount of the ketocholanic acid.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13009580A JPS5756498A (en) | 1980-09-20 | 1980-09-20 | Production of crude ursodeoxycholic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13009580A JPS5756498A (en) | 1980-09-20 | 1980-09-20 | Production of crude ursodeoxycholic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5756498A true JPS5756498A (en) | 1982-04-05 |
JPS6354720B2 JPS6354720B2 (en) | 1988-10-28 |
Family
ID=15025832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13009580A Granted JPS5756498A (en) | 1980-09-20 | 1980-09-20 | Production of crude ursodeoxycholic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5756498A (en) |
-
1980
- 1980-09-20 JP JP13009580A patent/JPS5756498A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6354720B2 (en) | 1988-10-28 |
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