JPS5756477A - Spiro compound, its preparation and prophylactic and remedy for circulatory disorders - Google Patents

Spiro compound, its preparation and prophylactic and remedy for circulatory disorders

Info

Publication number
JPS5756477A
JPS5756477A JP1129081A JP1129081A JPS5756477A JP S5756477 A JPS5756477 A JP S5756477A JP 1129081 A JP1129081 A JP 1129081A JP 1129081 A JP1129081 A JP 1129081A JP S5756477 A JPS5756477 A JP S5756477A
Authority
JP
Japan
Prior art keywords
compound
remedy
prophylactic
preparation
circulatory disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1129081A
Other languages
Japanese (ja)
Other versions
JPH0118915B2 (en
Inventor
Isuke Imada
Hirosada Sugihara
Mitsuru Kawada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/188,834 external-priority patent/US4362740A/en
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of JPS5756477A publication Critical patent/JPS5756477A/en
Publication of JPH0118915B2 publication Critical patent/JPH0118915B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A spiro compound of formulaI[n is integer of 1W4; X is halogen, lower alkyl, nitro, acyl, carboxyl, lower alkoxycarbonyl, lower alkylthio, lower alkylsulfonyl, amino, hydroxyl, carbonamide or sulfonamide, which may be substituted, two Xs on the 5 and 6 positions form CH=CHCH=CH].
EXAMPLE: 5-Chlorospiro[benzo(b)thiophene-2(3H),1'-cyclopropane]-3-one.
USE: It is high activity of inhibiting blood platlet coagulation and is used as a prophylactic or remedy for circulatory disorders such as thrombosis, cerebral apoplexy, myocardiac infarction, stenocardia, thrombotic phlebitis or glomerulonephritis or its synthetic intermediate.
PREPARATION: The decarboxylation reaction of a compound of formula II gives the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP1129081A 1980-09-19 1981-01-28 Spiro compound, its preparation and prophylactic and remedy for circulatory disorders Granted JPS5756477A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/188,834 US4362740A (en) 1979-09-25 1980-09-19 Spiro compounds, their production and use

Publications (2)

Publication Number Publication Date
JPS5756477A true JPS5756477A (en) 1982-04-05
JPH0118915B2 JPH0118915B2 (en) 1989-04-07

Family

ID=22694725

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1129081A Granted JPS5756477A (en) 1980-09-19 1981-01-28 Spiro compound, its preparation and prophylactic and remedy for circulatory disorders

Country Status (1)

Country Link
JP (1) JPS5756477A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54130560A (en) * 1978-03-31 1979-10-09 Takeda Chem Ind Ltd Sipro compound and its preparation
JPS5646879A (en) * 1979-09-25 1981-04-28 Takeda Chem Ind Ltd Spiro compound, its preparation, and preventive and remedy for circulatory system disorder

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54130560A (en) * 1978-03-31 1979-10-09 Takeda Chem Ind Ltd Sipro compound and its preparation
JPS5646879A (en) * 1979-09-25 1981-04-28 Takeda Chem Ind Ltd Spiro compound, its preparation, and preventive and remedy for circulatory system disorder

Also Published As

Publication number Publication date
JPH0118915B2 (en) 1989-04-07

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