JPS5756477A - Spiro compound, its preparation and prophylactic and remedy for circulatory disorders - Google Patents
Spiro compound, its preparation and prophylactic and remedy for circulatory disordersInfo
- Publication number
- JPS5756477A JPS5756477A JP1129081A JP1129081A JPS5756477A JP S5756477 A JPS5756477 A JP S5756477A JP 1129081 A JP1129081 A JP 1129081A JP 1129081 A JP1129081 A JP 1129081A JP S5756477 A JPS5756477 A JP S5756477A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- remedy
- prophylactic
- preparation
- circulatory disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A spiro compound of formulaI[n is integer of 1W4; X is halogen, lower alkyl, nitro, acyl, carboxyl, lower alkoxycarbonyl, lower alkylthio, lower alkylsulfonyl, amino, hydroxyl, carbonamide or sulfonamide, which may be substituted, two Xs on the 5 and 6 positions form CH=CHCH=CH].
EXAMPLE: 5-Chlorospiro[benzo(b)thiophene-2(3H),1'-cyclopropane]-3-one.
USE: It is high activity of inhibiting blood platlet coagulation and is used as a prophylactic or remedy for circulatory disorders such as thrombosis, cerebral apoplexy, myocardiac infarction, stenocardia, thrombotic phlebitis or glomerulonephritis or its synthetic intermediate.
PREPARATION: The decarboxylation reaction of a compound of formula II gives the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/188,834 US4362740A (en) | 1979-09-25 | 1980-09-19 | Spiro compounds, their production and use |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5756477A true JPS5756477A (en) | 1982-04-05 |
JPH0118915B2 JPH0118915B2 (en) | 1989-04-07 |
Family
ID=22694725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1129081A Granted JPS5756477A (en) | 1980-09-19 | 1981-01-28 | Spiro compound, its preparation and prophylactic and remedy for circulatory disorders |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5756477A (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54130560A (en) * | 1978-03-31 | 1979-10-09 | Takeda Chem Ind Ltd | Sipro compound and its preparation |
JPS5646879A (en) * | 1979-09-25 | 1981-04-28 | Takeda Chem Ind Ltd | Spiro compound, its preparation, and preventive and remedy for circulatory system disorder |
-
1981
- 1981-01-28 JP JP1129081A patent/JPS5756477A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54130560A (en) * | 1978-03-31 | 1979-10-09 | Takeda Chem Ind Ltd | Sipro compound and its preparation |
JPS5646879A (en) * | 1979-09-25 | 1981-04-28 | Takeda Chem Ind Ltd | Spiro compound, its preparation, and preventive and remedy for circulatory system disorder |
Also Published As
Publication number | Publication date |
---|---|
JPH0118915B2 (en) | 1989-04-07 |
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