JPS5745174A - Preparation of hydroxy-delta-lactone - Google Patents

Preparation of hydroxy-delta-lactone

Info

Publication number
JPS5745174A
JPS5745174A JP55121465A JP12146580A JPS5745174A JP S5745174 A JPS5745174 A JP S5745174A JP 55121465 A JP55121465 A JP 55121465A JP 12146580 A JP12146580 A JP 12146580A JP S5745174 A JPS5745174 A JP S5745174A
Authority
JP
Japan
Prior art keywords
compound
alkyl
hydroxyl group
formula
lactone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55121465A
Other languages
Japanese (ja)
Other versions
JPS6048515B2 (en
Inventor
Mitsuaki Mukoyama
Youji Sakito
Shin Tanaka
Masatoshi Asami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP55121465A priority Critical patent/JPS6048515B2/en
Publication of JPS5745174A publication Critical patent/JPS5745174A/en
Publication of JPS6048515B2 publication Critical patent/JPS6048515B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To obtain the titled substance which is an important compound having the antimicrobial activity industrially and advantageously, by alkylating a lactone containing an optical isomer or a racemate as a raw material, and removing the protecting group of the hydroxyl group.
CONSTITUTION: A lactone of formula I (R1 is alkyl; X is a protecting group of the hydroxyl group) is reacted with a strong base, e.g. lithium amide, to form an anion at the α-position to the carbonyl group. The resultant compound is then alkylated with an alkylating agent, e.g. methyl bromide, and the protecting group of the hydroxyl group is then removed to afford a compound of formula II (R2 is alkyl). The compound of formula I is obtained by reducing a 2-hydroxy-2-alkyl-6-heptenal readily preparable from an aminal of 6-hepten-2-on-1-al as a raw material compound, protecting primary hydroxyl group of the resultant 2-alkyl-6-heptene-1-,2-diol, and cleaving the double bond of the resultant compound oxidatively.
COPYRIGHT: (C)1982,JPO&Japio
JP55121465A 1980-09-01 1980-09-01 Method for producing hydroxy delta lactones Expired JPS6048515B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55121465A JPS6048515B2 (en) 1980-09-01 1980-09-01 Method for producing hydroxy delta lactones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55121465A JPS6048515B2 (en) 1980-09-01 1980-09-01 Method for producing hydroxy delta lactones

Publications (2)

Publication Number Publication Date
JPS5745174A true JPS5745174A (en) 1982-03-13
JPS6048515B2 JPS6048515B2 (en) 1985-10-28

Family

ID=14811805

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55121465A Expired JPS6048515B2 (en) 1980-09-01 1980-09-01 Method for producing hydroxy delta lactones

Country Status (1)

Country Link
JP (1) JPS6048515B2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0469565U (en) * 1990-10-26 1992-06-19
JPH0469564U (en) * 1990-10-26 1992-06-19

Also Published As

Publication number Publication date
JPS6048515B2 (en) 1985-10-28

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