JPS5729294A - Preparation of human insulin - Google Patents

Preparation of human insulin

Info

Publication number
JPS5729294A
JPS5729294A JP10472680A JP10472680A JPS5729294A JP S5729294 A JPS5729294 A JP S5729294A JP 10472680 A JP10472680 A JP 10472680A JP 10472680 A JP10472680 A JP 10472680A JP S5729294 A JPS5729294 A JP S5729294A
Authority
JP
Japan
Prior art keywords
cell
insulin
produce
ability
blooded animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10472680A
Other languages
Japanese (ja)
Other versions
JPS5756878B2 (en
Inventor
Kaname Sugimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hayashibara Seibutsu Kagaku Kenkyujo KK
Original Assignee
Hayashibara Biochemical Laboratories Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hayashibara Biochemical Laboratories Co Ltd filed Critical Hayashibara Biochemical Laboratories Co Ltd
Priority to JP10472680A priority Critical patent/JPS5729294A/en
Priority to IT48915/81A priority patent/IT1196534B/en
Priority to KR1019810002634A priority patent/KR860000894B1/en
Priority to GB8122892A priority patent/GB2083826B/en
Priority to FR8114523A priority patent/FR2487851A1/en
Priority to CH4886/81A priority patent/CH649782A5/en
Publication of JPS5729294A publication Critical patent/JPS5729294A/en
Publication of JPS5756878B2 publication Critical patent/JPS5756878B2/ja
Priority to US06/584,017 priority patent/US4621053A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

PURPOSE: To prepare the titled substance in high yield, by subjecting a cell obtained by transplanting and multiplying a cell, derived from a man, and having the ability to produce the titled substance in a nonhuman warm-blooded animal to the action of an insulin inducer.
CONSTITUTION: A human pancreatic Langerhans island β cell, the cell in which a tumor is formed, a cell originally having the ability to produce human insulin, e.g. a human insuloma cell, or a cell in which the productivity of a gene having the ability to produce the insulin is enhanced by the genetic recombining means, etc. is transplanted to a nonhuman warm-blooded animal, e.g. a domestic fowl, pigeon, rabbit, rat or nude mouse. Alternatively, the cell is multiplied while being supplied with the body fluid of the warm-blooded animal. The resultant cell is then reacted with an insulin inducer, e.g. glucose or arginine, to produce the insulin, which is then collected by the well-known purifying and separating method.
COPYRIGHT: (C)1982,JPO&Japio
JP10472680A 1980-07-30 1980-07-30 Preparation of human insulin Granted JPS5729294A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP10472680A JPS5729294A (en) 1980-07-30 1980-07-30 Preparation of human insulin
IT48915/81A IT1196534B (en) 1980-07-30 1981-07-16 PROCEDURE FOR THE PRODUCTION OF HUMAN INSULIN
KR1019810002634A KR860000894B1 (en) 1980-07-30 1981-07-21 Producing method of human insulin
GB8122892A GB2083826B (en) 1980-07-30 1981-07-24 Process for the production of human insulin
FR8114523A FR2487851A1 (en) 1980-07-30 1981-07-27 PROCESS FOR THE PRODUCTION OF HUMAN INSULIN
CH4886/81A CH649782A5 (en) 1980-07-30 1981-07-28 PROCESS FOR THE PRODUCTION OF HUMAN INSULIN.
US06/584,017 US4621053A (en) 1980-07-30 1984-02-27 Process for the production of human peptide hormones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10472680A JPS5729294A (en) 1980-07-30 1980-07-30 Preparation of human insulin

Publications (2)

Publication Number Publication Date
JPS5729294A true JPS5729294A (en) 1982-02-17
JPS5756878B2 JPS5756878B2 (en) 1982-12-01

Family

ID=14388494

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10472680A Granted JPS5729294A (en) 1980-07-30 1980-07-30 Preparation of human insulin

Country Status (6)

Country Link
JP (1) JPS5729294A (en)
KR (1) KR860000894B1 (en)
CH (1) CH649782A5 (en)
FR (1) FR2487851A1 (en)
GB (1) GB2083826B (en)
IT (1) IT1196534B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103168747A (en) * 2013-04-02 2013-06-26 陈景河 Breeding method for improving disease prevention ability of doves
CN104782569A (en) * 2015-04-16 2015-07-22 柳州市大金农业科技有限公司 Total-artificial young pigeon feeding method
CN108513951A (en) * 2018-04-03 2018-09-11 英德市德丰农牧发展有限公司 A kind of pigeon for meat prevalent variety cultivation method
CN111838071A (en) * 2020-08-07 2020-10-30 江苏省家禽科学研究所 Method for breeding pigeon with black tail and/or phoenix head character

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58138395A (en) * 1982-02-12 1983-08-17 Hayashibara Biochem Lab Inc Production of human immune response suppression (hirs) factor
JPS5927286U (en) * 1982-08-16 1984-02-20 前沢化成工業株式会社 oil separation tank
DK402984D0 (en) * 1984-08-23 1984-08-23 Nordisk Insulinlab PROCEDURE FOR PROMOTING INSULIN-PRODUCING CELLS
ES2038602T3 (en) * 1986-10-15 1993-08-01 Battelle Memorial Institute METHOD FOR THE PRODUCTION OF PROTEINS THROUGH INDUCIBLE EXPRESSION SYSTEMS IN GUEST-CELLS IN GENETICALLY MODIFIED CARIOTICS MULTIPLIED IN-VIVO.
FR2637613B1 (en) * 1987-06-19 1991-09-27 Transgene Sa PROCESS FOR THE PREPARATION OF STABLE CELL LINES FOR THE PRODUCTION OF DETERMINED PROTEINS FROM TRANSGENIC ANIMALS; TUMOR CELL LINES AND PROTEINS OBTAINED
ZA892518B (en) * 1988-04-08 1989-12-27 Intracel Corp Method for the in-vivo production and testing of proteins by recombinant gene expression in selected host-cells
GB9015327D0 (en) * 1990-07-12 1990-08-29 Tan Kim S Hybridomas
CN107667981A (en) * 2017-11-24 2018-02-09 广西博白县圣德种养专业合作社 It is a kind of to hatch the high method of pigeon eggs rate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2757169A1 (en) * 1977-12-22 1979-07-05 Hoechst Ag METHOD OF OBTAINING INSULIN-PRODUCING ANIMAL CELLS
GB2016015B (en) * 1978-01-22 1982-05-06 Hayashibara Co Method of preparing interferon and preparations containing interferon

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103168747A (en) * 2013-04-02 2013-06-26 陈景河 Breeding method for improving disease prevention ability of doves
CN104782569A (en) * 2015-04-16 2015-07-22 柳州市大金农业科技有限公司 Total-artificial young pigeon feeding method
CN108513951A (en) * 2018-04-03 2018-09-11 英德市德丰农牧发展有限公司 A kind of pigeon for meat prevalent variety cultivation method
CN111838071A (en) * 2020-08-07 2020-10-30 江苏省家禽科学研究所 Method for breeding pigeon with black tail and/or phoenix head character

Also Published As

Publication number Publication date
FR2487851A1 (en) 1982-02-05
IT1196534B (en) 1988-11-16
CH649782A5 (en) 1985-06-14
IT8148915A0 (en) 1981-07-16
JPS5756878B2 (en) 1982-12-01
GB2083826B (en) 1983-11-30
FR2487851B1 (en) 1984-12-14
GB2083826A (en) 1982-03-31
KR860000894B1 (en) 1986-07-16
KR830005866A (en) 1983-09-14

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