JPS57212194A - Hepatic basic protein and its preparation - Google Patents
Hepatic basic protein and its preparationInfo
- Publication number
- JPS57212194A JPS57212194A JP56098717A JP9871781A JPS57212194A JP S57212194 A JPS57212194 A JP S57212194A JP 56098717 A JP56098717 A JP 56098717A JP 9871781 A JP9871781 A JP 9871781A JP S57212194 A JPS57212194 A JP S57212194A
- Authority
- JP
- Japan
- Prior art keywords
- blp
- liver
- hepatic
- precipitated
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
NEW MATERIAL:A hepatic basic protein (BLP), present in the liver, capable of exhibiting a molecular weight of about 35,000 by the SDS polyacrylamide gel electrophoresis and a molecular weight of about 100,000 by the thin layer gel filtration with "Sephadex G200 Superfine ") and a weakly basic isoelectric point by the isoelectric point electrophoresis.
USE: A protein specifically present in the liver effective for the diagnosis and the judgment of the recuperation of various diseases by sensing the amount of BLP in blood.
PROCESS: An extract from the liver of a rat is precipitated by ammonium sulfate having a saturation degree of 35W60%, and the BLP is then precipitated from the resultant fraction. Thus, the extract is salted out by the ammonium sulfate having a saturation degree of 50W60%, equilibrated by a weakly basic buffer solution and chromatographed by "DEAE-Sepharose ", and the unadsorbed substance is then recovered. The recovered substance is further purified by the affinity chromatography to give the aimed BLP of high purity.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56098717A JPS57212194A (en) | 1981-06-25 | 1981-06-25 | Hepatic basic protein and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56098717A JPS57212194A (en) | 1981-06-25 | 1981-06-25 | Hepatic basic protein and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57212194A true JPS57212194A (en) | 1982-12-27 |
Family
ID=14227268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56098717A Pending JPS57212194A (en) | 1981-06-25 | 1981-06-25 | Hepatic basic protein and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57212194A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0605219A1 (en) * | 1992-12-25 | 1994-07-06 | JCR PHARMACEUTICALS Co., LTD. | Products containing active milk protein components and process for producing the same |
-
1981
- 1981-06-25 JP JP56098717A patent/JPS57212194A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0605219A1 (en) * | 1992-12-25 | 1994-07-06 | JCR PHARMACEUTICALS Co., LTD. | Products containing active milk protein components and process for producing the same |
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