JPS57179114A - Acetylsalicylic acid liposome preparation - Google Patents

Acetylsalicylic acid liposome preparation

Info

Publication number
JPS57179114A
JPS57179114A JP6284981A JP6284981A JPS57179114A JP S57179114 A JPS57179114 A JP S57179114A JP 6284981 A JP6284981 A JP 6284981A JP 6284981 A JP6284981 A JP 6284981A JP S57179114 A JPS57179114 A JP S57179114A
Authority
JP
Japan
Prior art keywords
acetylsalicylic acid
acid salt
film
liposomes
chloroform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6284981A
Other languages
Japanese (ja)
Inventor
Takashi Imagawa
Takashi Shoji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Priority to JP6284981A priority Critical patent/JPS57179114A/en
Publication of JPS57179114A publication Critical patent/JPS57179114A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

PURPOSE:To provide the titled preparation free of irritation and adhesion to the digestive tracts, having mild activity, and high absorption efficiency in blood, and exhibiting long effect by the administration of a small dose, by filling the gap between liposomes with an easily water-soluble acetylsalicylic acid salt. CONSTITUTION:Yolk lecithin is mixed with cholesterol and dipalmityl glycerophosphate, and the mixture is dissolved in chloroform, etc. and cast. Chloroform is evaporated from the cast film to obtain lipid film. The film is mixed with a phosphate buffer solution containing an easily water-soluble acetylsalicylic acid salt (e.g. acetylsalicylic acid DL-lysine salt of formula), and the dispersion is subjected to ultrasonic treatment to fill the gaps between the liposomes with the acetylsalicylic acid salt and to obtain the objective preparation.
JP6284981A 1981-04-25 1981-04-25 Acetylsalicylic acid liposome preparation Pending JPS57179114A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6284981A JPS57179114A (en) 1981-04-25 1981-04-25 Acetylsalicylic acid liposome preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6284981A JPS57179114A (en) 1981-04-25 1981-04-25 Acetylsalicylic acid liposome preparation

Publications (1)

Publication Number Publication Date
JPS57179114A true JPS57179114A (en) 1982-11-04

Family

ID=13212162

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6284981A Pending JPS57179114A (en) 1981-04-25 1981-04-25 Acetylsalicylic acid liposome preparation

Country Status (1)

Country Link
JP (1) JPS57179114A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6295134A (en) * 1985-10-21 1987-05-01 Nippon Saafuakutanto Kogyo Kk Production of liposome
EP0249561A2 (en) * 1986-06-12 1987-12-16 The Liposome Company, Inc. Compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
US4923854A (en) * 1986-01-22 1990-05-08 The Liposome Company, Inc. Solubilization of hydrophobic materials using lysophospholipid

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6295134A (en) * 1985-10-21 1987-05-01 Nippon Saafuakutanto Kogyo Kk Production of liposome
US4923854A (en) * 1986-01-22 1990-05-08 The Liposome Company, Inc. Solubilization of hydrophobic materials using lysophospholipid
EP0249561A2 (en) * 1986-06-12 1987-12-16 The Liposome Company, Inc. Compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs

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