JPS57168163A - Carier for immunoserological inspection reagent - Google Patents

Carier for immunoserological inspection reagent

Info

Publication number
JPS57168163A
JPS57168163A JP5292981A JP5292981A JPS57168163A JP S57168163 A JPS57168163 A JP S57168163A JP 5292981 A JP5292981 A JP 5292981A JP 5292981 A JP5292981 A JP 5292981A JP S57168163 A JPS57168163 A JP S57168163A
Authority
JP
Japan
Prior art keywords
ethylenically unsaturated
latex
cooh
beta
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5292981A
Other languages
Japanese (ja)
Other versions
JPH0157687B2 (en
Inventor
Eijiro Tagami
Shiro Yasukawa
Mari Kawakami
Haruhiro Hirai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JSR Corp
Nippon Synthetic Chemical Industry Co Ltd
Original Assignee
Nippon Synthetic Chemical Industry Co Ltd
Japan Synthetic Rubber Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Synthetic Chemical Industry Co Ltd, Japan Synthetic Rubber Co Ltd filed Critical Nippon Synthetic Chemical Industry Co Ltd
Priority to JP5292981A priority Critical patent/JPS57168163A/en
Publication of JPS57168163A publication Critical patent/JPS57168163A/en
Publication of JPH0157687B2 publication Critical patent/JPH0157687B2/ja
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

PURPOSE:To obtain a carrier which is stable and especially highly sensitive to optical measurement from a copolymer containing a specified amount of COOH on the surface thereof, prepared by polymerizing a mixture of an aromatic vinyl compound as a major component and an alpha, beta-ethylenically unsaturated carboxylic acid as a minor component. CONSTITUTION:A monomer mixture of 97-99wt% aromatic vinyl compound, 1- 3wt% of alpha, beta-ethylenically unsaturated caboxylic acid and othe ethylenically unsaturated compounds (e.g., an acrylate ester, acrylonitrile) is emulsion-polymerized using a proper amount of alkyl mercaptan as a polymerization initiator to form a polymer latex with an average particle diameter of about 0.5-0.7mu containing 0.01-0.3meq/g of COOH on the surface of a polymer particle. A sensitized latex is prepared in a PBS buffer solution with a concentration of the latex polymer particles of 0.25% and used for the agglutionation reaction of a rheumatism factor in serum. The sensitized latex remains stable for several months with an excellent sensitivity.
JP5292981A 1981-04-10 1981-04-10 Carier for immunoserological inspection reagent Granted JPS57168163A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5292981A JPS57168163A (en) 1981-04-10 1981-04-10 Carier for immunoserological inspection reagent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5292981A JPS57168163A (en) 1981-04-10 1981-04-10 Carier for immunoserological inspection reagent

Publications (2)

Publication Number Publication Date
JPS57168163A true JPS57168163A (en) 1982-10-16
JPH0157687B2 JPH0157687B2 (en) 1989-12-07

Family

ID=12928523

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5292981A Granted JPS57168163A (en) 1981-04-10 1981-04-10 Carier for immunoserological inspection reagent

Country Status (1)

Country Link
JP (1) JPS57168163A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5897656A (en) * 1981-12-07 1983-06-10 Sekisui Chem Co Ltd Latex for diagnosis reagent
JPS60173008A (en) * 1984-02-20 1985-09-06 Mitsubishi Chem Ind Ltd Carrier latex for diagnostic reagent
JPS62118256A (en) * 1985-11-19 1987-05-29 Japan Synthetic Rubber Co Ltd Carrier particle for diagnosing medicine
EP0286687A1 (en) * 1986-09-09 1988-10-19 Mitsui Petrochemical Industries, Ltd. Carrier latex for diagnostic reagent
EP0447205A2 (en) * 1990-03-13 1991-09-18 Tosoh Corporation Process for producing a carrier for immunoassay

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5428816A (en) * 1977-08-03 1979-03-03 Hoffmann La Roche Immunological diagnostic reagent
JPS5732921A (en) * 1980-08-07 1982-02-22 Badische Yuka Co Ltd Automatic regulation of specific gravity of foamed synthetic resin particle

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5428816A (en) * 1977-08-03 1979-03-03 Hoffmann La Roche Immunological diagnostic reagent
JPS5732921A (en) * 1980-08-07 1982-02-22 Badische Yuka Co Ltd Automatic regulation of specific gravity of foamed synthetic resin particle

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5897656A (en) * 1981-12-07 1983-06-10 Sekisui Chem Co Ltd Latex for diagnosis reagent
JPS60173008A (en) * 1984-02-20 1985-09-06 Mitsubishi Chem Ind Ltd Carrier latex for diagnostic reagent
JPS62118256A (en) * 1985-11-19 1987-05-29 Japan Synthetic Rubber Co Ltd Carrier particle for diagnosing medicine
EP0286687A1 (en) * 1986-09-09 1988-10-19 Mitsui Petrochemical Industries, Ltd. Carrier latex for diagnostic reagent
EP0447205A2 (en) * 1990-03-13 1991-09-18 Tosoh Corporation Process for producing a carrier for immunoassay
US5182329A (en) * 1990-03-13 1993-01-26 Tosoh Corporation Process for producing carriers for immunoassay

Also Published As

Publication number Publication date
JPH0157687B2 (en) 1989-12-07

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