JPS57158782A - 1,4,5,6,7,8-hexahydro-2-alkyl-4-aryl-5-oxo- 1,7-naphthyridine-3-carboxylic acid esters and use - Google Patents

1,4,5,6,7,8-hexahydro-2-alkyl-4-aryl-5-oxo- 1,7-naphthyridine-3-carboxylic acid esters and use

Info

Publication number
JPS57158782A
JPS57158782A JP57031643A JP3164382A JPS57158782A JP S57158782 A JPS57158782 A JP S57158782A JP 57031643 A JP57031643 A JP 57031643A JP 3164382 A JP3164382 A JP 3164382A JP S57158782 A JPS57158782 A JP S57158782A
Authority
JP
Japan
Prior art keywords
naphthyridine
hexahydro
oxo
aryl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57031643A
Other languages
English (en)
Other versions
JPH0139433B2 (ja
Inventor
Esu Surukousukii Shiadooru
Eru Berugei Jieimusu
Ei Mashiitsutei Arubaato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of JPS57158782A publication Critical patent/JPS57158782A/ja
Publication of JPH0139433B2 publication Critical patent/JPH0139433B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP57031643A 1981-02-27 1982-02-27 1,4,5,6,7,8-hexahydro-2-alkyl-4-aryl-5-oxo- 1,7-naphthyridine-3-carboxylic acid esters and use Granted JPS57158782A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/238,911 US4321384A (en) 1981-02-27 1981-02-27 Antihypertensive agents

Publications (2)

Publication Number Publication Date
JPS57158782A true JPS57158782A (en) 1982-09-30
JPH0139433B2 JPH0139433B2 (ja) 1989-08-21

Family

ID=22899833

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57031643A Granted JPS57158782A (en) 1981-02-27 1982-02-27 1,4,5,6,7,8-hexahydro-2-alkyl-4-aryl-5-oxo- 1,7-naphthyridine-3-carboxylic acid esters and use

Country Status (2)

Country Link
US (1) US4321384A (ja)
JP (1) JPS57158782A (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4365063A (en) * 1981-08-31 1982-12-21 American Home Products Corporation Antihypertensive agents
US4546186A (en) * 1983-12-14 1985-10-08 American Home Products Corporation 1,4,5,6,7,8-Hexahydro-2-methyl-5-oxo-4-(2-thiazolyl)-3-quinoline carboxylic acid 2-methyl(phenylmethyl)amino ethyl ester and pharmaceutically acceptable salts
US4551534A (en) * 1984-03-30 1985-11-05 American Home Products Corporation Aralkyl or aryloxyalkyl 1,7-naphthyridine-3-carboxylic acid esters
US4596805A (en) * 1984-06-13 1986-06-24 Ortho Pharmaceutical Corporation Substituted dioxopyridopyrimidines
US4596873A (en) * 1985-07-29 1986-06-24 American Home Products Corporation 1,4,5,6,7,8-Hexahydro-2-alkyl-4-aryl-5-oxo-1,7-naphthyridine-3-carboxylic acid aromatic esters and pharmaceutically acceptable acid addition salts thereof useful as antihypertensive agents
AU6042686A (en) * 1985-07-29 1987-02-05 American Home Products Corporation 1,4,5,6,7,8-hexahydro-(substituted) phenyl-1,7- napthyridine-3-carboxylic acid derivatives
US6642222B2 (en) 1998-10-28 2003-11-04 Abbott Laboratories Pyrano, piperidino, and thiopyrano compounds and methods of use
US6191140B1 (en) 1998-10-28 2001-02-20 Abbott Laboratories Pyrano, piperidino, and thiopyrano compounds and methods of use

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3429887A (en) * 1965-01-26 1969-02-25 Sterling Drug Inc 1,7-naphthyridine-3-carboxylic acid derivatives and their preparation
US3506668A (en) * 1965-01-26 1970-04-14 Sterling Drug Inc Method of preparing 8-hydroxy-quinolines
US3325505A (en) * 1965-02-24 1967-06-13 Smith Kline French Lab 4-cycloalkyl(or cycloalkenyl)-dihydropyridines
US3441648A (en) * 1967-02-07 1969-04-29 Smithkline Corp Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
US3600394A (en) * 1968-05-17 1971-08-17 Searle & Co 2-aminoalkyl-3-arylisocarbostyrils
US3590036A (en) * 1968-11-18 1971-06-29 George Y Lesher Naphthyridine-3-carboxylic acids,their derivatives and preparation thereof
DE1923990C3 (de) * 1969-05-10 1978-11-23 Bayer Ag Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern
US3963736A (en) * 1970-01-28 1976-06-15 Sumitomo Chemical Company, Limited Preparation of 1-(lower alkyl)-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acids
US3673193A (en) * 1970-05-11 1972-06-27 Sterling Drug Inc 4-oxo-1,8-naphthyridine-3-carboxylates and derivatives thereof
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4022898A (en) * 1972-03-06 1977-05-10 Bayer Aktiengesellschaft 2-Amino-4-pyrimidyl-1,4-dihydropyridine derivatives
US4038399A (en) * 1972-04-18 1977-07-26 Bayer Aktiengesellschaft 1,4-dihydropyridine carboxylic acid esters useful as coronary vessel dilators and anti-hypertensives
US4177278A (en) * 1977-04-05 1979-12-04 Bayer Aktiengesellschaft 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use

Also Published As

Publication number Publication date
JPH0139433B2 (ja) 1989-08-21
US4321384A (en) 1982-03-23

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