JPS57149281A - Novel piperazine derivative and its preparation - Google Patents
Novel piperazine derivative and its preparationInfo
- Publication number
- JPS57149281A JPS57149281A JP56034611A JP3461181A JPS57149281A JP S57149281 A JPS57149281 A JP S57149281A JP 56034611 A JP56034611 A JP 56034611A JP 3461181 A JP3461181 A JP 3461181A JP S57149281 A JPS57149281 A JP S57149281A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- piperazine derivative
- formula
- preparation
- diphenylmethylpiperazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A piperazine derivative of formulaI(R is lower alkyl).
EXAMPLE: 1-[3-{ 2-[2-( N,N-Dimenthylamino )ethoxy]phenyl }-2-hydroxy] propyl-4-diphenylmethylpiperazine.
USE: Useful as an ameliorant for peripheral circulation having peripheral vasodilator and inhibotory action on blood platelet aggregation.
PROCESS: A compound of formula II is reacted with a compound of formula III (X is halogen, acryloxy, tosyloxy or mesyloxy) in a solvent, e.g. benzen, preferably at 60W150°C to give the compound of formulaI. The compound of formula II is synthesized by reacting 1-diphenylmethylpiperazine with 2-(2,3-epoxypropyl)phenol obtained by reacting 2-allylphenol with m-chloroperbenzoic acid.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56034611A JPS57149281A (en) | 1981-03-12 | 1981-03-12 | Novel piperazine derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56034611A JPS57149281A (en) | 1981-03-12 | 1981-03-12 | Novel piperazine derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57149281A true JPS57149281A (en) | 1982-09-14 |
JPH0254349B2 JPH0254349B2 (en) | 1990-11-21 |
Family
ID=12419159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56034611A Granted JPS57149281A (en) | 1981-03-12 | 1981-03-12 | Novel piperazine derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57149281A (en) |
-
1981
- 1981-03-12 JP JP56034611A patent/JPS57149281A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPH0254349B2 (en) | 1990-11-21 |
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