JPS57149281A - Novel piperazine derivative and its preparation - Google Patents

Novel piperazine derivative and its preparation

Info

Publication number
JPS57149281A
JPS57149281A JP56034611A JP3461181A JPS57149281A JP S57149281 A JPS57149281 A JP S57149281A JP 56034611 A JP56034611 A JP 56034611A JP 3461181 A JP3461181 A JP 3461181A JP S57149281 A JPS57149281 A JP S57149281A
Authority
JP
Japan
Prior art keywords
compound
piperazine derivative
formula
preparation
diphenylmethylpiperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56034611A
Other languages
Japanese (ja)
Other versions
JPH0254349B2 (en
Inventor
Mitsuo Mazaki
Hiromitsu Takeda
Koichiro Nishioka
Rokuro Sudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP56034611A priority Critical patent/JPS57149281A/en
Publication of JPS57149281A publication Critical patent/JPS57149281A/en
Publication of JPH0254349B2 publication Critical patent/JPH0254349B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A piperazine derivative of formulaI(R is lower alkyl).
EXAMPLE: 1-[3-{ 2-[2-( N,N-Dimenthylamino )ethoxy]phenyl }-2-hydroxy] propyl-4-diphenylmethylpiperazine.
USE: Useful as an ameliorant for peripheral circulation having peripheral vasodilator and inhibotory action on blood platelet aggregation.
PROCESS: A compound of formula II is reacted with a compound of formula III (X is halogen, acryloxy, tosyloxy or mesyloxy) in a solvent, e.g. benzen, preferably at 60W150°C to give the compound of formulaI. The compound of formula II is synthesized by reacting 1-diphenylmethylpiperazine with 2-(2,3-epoxypropyl)phenol obtained by reacting 2-allylphenol with m-chloroperbenzoic acid.
COPYRIGHT: (C)1982,JPO&Japio
JP56034611A 1981-03-12 1981-03-12 Novel piperazine derivative and its preparation Granted JPS57149281A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56034611A JPS57149281A (en) 1981-03-12 1981-03-12 Novel piperazine derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56034611A JPS57149281A (en) 1981-03-12 1981-03-12 Novel piperazine derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS57149281A true JPS57149281A (en) 1982-09-14
JPH0254349B2 JPH0254349B2 (en) 1990-11-21

Family

ID=12419159

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56034611A Granted JPS57149281A (en) 1981-03-12 1981-03-12 Novel piperazine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57149281A (en)

Also Published As

Publication number Publication date
JPH0254349B2 (en) 1990-11-21

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