JPS57139096A - Heat denaturing deoxyribonucleic acid md-011 having antitumor activity and antitumor agent - Google Patents
Heat denaturing deoxyribonucleic acid md-011 having antitumor activity and antitumor agentInfo
- Publication number
- JPS57139096A JPS57139096A JP2366981A JP2366981A JPS57139096A JP S57139096 A JPS57139096 A JP S57139096A JP 2366981 A JP2366981 A JP 2366981A JP 2366981 A JP2366981 A JP 2366981A JP S57139096 A JPS57139096 A JP S57139096A
- Authority
- JP
- Japan
- Prior art keywords
- antitumor
- deoxyribonucleic acid
- heat
- heat denaturing
- antitumor activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
NEW MATERIAL:A heat denaturing deoxyribonucleic acid MD-011. Elementary analysis %: C, 25.57-29.75; H, 3.80-4.75; N, 12.67-13.47; P, 7.30-7.91; Na, 8.12-11.59. Molecular weight: 30,000-1,000,000. Soluble in water and insoluble in ethanol, ether, acetone, etc. Negative to the orcinol, ninhydrin and anthrone reactions, and positive to the diphenylamine reaction. pH of the aqueous solution: 6.5-7.5. While powder. Base composition %: Guanine, 30.4; adenine, 16.9; cytosine, 30.8; thymine, 21.9. Loses the antitumor activity with deoxyribonuclease I, and no change with ribonuclease T2. Melting point and transition temperature: Indefinite. USE:An antitumor agent. PROCESS:A bacterium, e.g. bovine tubercle bacillus (ATCC19015), of the genus Mycobacterium is crushed and centrifuged to give an extract. A nucleic acid fraction of the resultant extract is then heat-treated.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2366981A JPS57139096A (en) | 1981-02-21 | 1981-02-21 | Heat denaturing deoxyribonucleic acid md-011 having antitumor activity and antitumor agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2366981A JPS57139096A (en) | 1981-02-21 | 1981-02-21 | Heat denaturing deoxyribonucleic acid md-011 having antitumor activity and antitumor agent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57139096A true JPS57139096A (en) | 1982-08-27 |
JPH0366316B2 JPH0366316B2 (en) | 1991-10-16 |
Family
ID=12116890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2366981A Granted JPS57139096A (en) | 1981-02-21 | 1981-02-21 | Heat denaturing deoxyribonucleic acid md-011 having antitumor activity and antitumor agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57139096A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5855499A (en) * | 1981-09-28 | 1983-04-01 | Sanraku Inc | Preparation of modified deoxyribonucleic acid having antitumor action |
FR2547500A1 (en) * | 1983-05-30 | 1984-12-21 | Mitsui Toatsu Chemicals | PHARMACEUTICAL PREPARATION FOR DIGESTIVE TUBE ULCER |
-
1981
- 1981-02-21 JP JP2366981A patent/JPS57139096A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5855499A (en) * | 1981-09-28 | 1983-04-01 | Sanraku Inc | Preparation of modified deoxyribonucleic acid having antitumor action |
FR2547500A1 (en) * | 1983-05-30 | 1984-12-21 | Mitsui Toatsu Chemicals | PHARMACEUTICAL PREPARATION FOR DIGESTIVE TUBE ULCER |
Also Published As
Publication number | Publication date |
---|---|
JPH0366316B2 (en) | 1991-10-16 |
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