JPS57139096A - Heat denaturing deoxyribonucleic acid md-011 having antitumor activity and antitumor agent - Google Patents

Heat denaturing deoxyribonucleic acid md-011 having antitumor activity and antitumor agent

Info

Publication number
JPS57139096A
JPS57139096A JP2366981A JP2366981A JPS57139096A JP S57139096 A JPS57139096 A JP S57139096A JP 2366981 A JP2366981 A JP 2366981A JP 2366981 A JP2366981 A JP 2366981A JP S57139096 A JPS57139096 A JP S57139096A
Authority
JP
Japan
Prior art keywords
antitumor
deoxyribonucleic acid
heat
heat denaturing
antitumor activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2366981A
Other languages
Japanese (ja)
Other versions
JPH0366316B2 (en
Inventor
Yoshio Furuya
Hiroshi Yamamoto
Tamotsu Fukuda
Shizuo Shimada
Osamu Yano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP2366981A priority Critical patent/JPS57139096A/en
Publication of JPS57139096A publication Critical patent/JPS57139096A/en
Publication of JPH0366316B2 publication Critical patent/JPH0366316B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

NEW MATERIAL:A heat denaturing deoxyribonucleic acid MD-011. Elementary analysis %: C, 25.57-29.75; H, 3.80-4.75; N, 12.67-13.47; P, 7.30-7.91; Na, 8.12-11.59. Molecular weight: 30,000-1,000,000. Soluble in water and insoluble in ethanol, ether, acetone, etc. Negative to the orcinol, ninhydrin and anthrone reactions, and positive to the diphenylamine reaction. pH of the aqueous solution: 6.5-7.5. While powder. Base composition %: Guanine, 30.4; adenine, 16.9; cytosine, 30.8; thymine, 21.9. Loses the antitumor activity with deoxyribonuclease I, and no change with ribonuclease T2. Melting point and transition temperature: Indefinite. USE:An antitumor agent. PROCESS:A bacterium, e.g. bovine tubercle bacillus (ATCC19015), of the genus Mycobacterium is crushed and centrifuged to give an extract. A nucleic acid fraction of the resultant extract is then heat-treated.
JP2366981A 1981-02-21 1981-02-21 Heat denaturing deoxyribonucleic acid md-011 having antitumor activity and antitumor agent Granted JPS57139096A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2366981A JPS57139096A (en) 1981-02-21 1981-02-21 Heat denaturing deoxyribonucleic acid md-011 having antitumor activity and antitumor agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2366981A JPS57139096A (en) 1981-02-21 1981-02-21 Heat denaturing deoxyribonucleic acid md-011 having antitumor activity and antitumor agent

Publications (2)

Publication Number Publication Date
JPS57139096A true JPS57139096A (en) 1982-08-27
JPH0366316B2 JPH0366316B2 (en) 1991-10-16

Family

ID=12116890

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2366981A Granted JPS57139096A (en) 1981-02-21 1981-02-21 Heat denaturing deoxyribonucleic acid md-011 having antitumor activity and antitumor agent

Country Status (1)

Country Link
JP (1) JPS57139096A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5855499A (en) * 1981-09-28 1983-04-01 Sanraku Inc Preparation of modified deoxyribonucleic acid having antitumor action
FR2547500A1 (en) * 1983-05-30 1984-12-21 Mitsui Toatsu Chemicals PHARMACEUTICAL PREPARATION FOR DIGESTIVE TUBE ULCER

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5855499A (en) * 1981-09-28 1983-04-01 Sanraku Inc Preparation of modified deoxyribonucleic acid having antitumor action
FR2547500A1 (en) * 1983-05-30 1984-12-21 Mitsui Toatsu Chemicals PHARMACEUTICAL PREPARATION FOR DIGESTIVE TUBE ULCER

Also Published As

Publication number Publication date
JPH0366316B2 (en) 1991-10-16

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