JPS57130998A - Human interferon-beta-gene - Google Patents

Human interferon-beta-gene

Info

Publication number
JPS57130998A
JPS57130998A JP1437381A JP1437381A JPS57130998A JP S57130998 A JPS57130998 A JP S57130998A JP 1437381 A JP1437381 A JP 1437381A JP 1437381 A JP1437381 A JP 1437381A JP S57130998 A JPS57130998 A JP S57130998A
Authority
JP
Japan
Prior art keywords
dna
human
beta
gene
human interferon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1437381A
Other languages
Japanese (ja)
Other versions
JPH0255035B2 (en
Inventor
Haruo Sugano
Koretsugu Taniguchi
Shigeo Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GAN KENKIYUUKAI
Japanese Foundation for Cancer Research
Original Assignee
GAN KENKIYUUKAI
Japanese Foundation for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GAN KENKIYUUKAI, Japanese Foundation for Cancer Research filed Critical GAN KENKIYUUKAI
Priority to JP1437381A priority Critical patent/JPS57130998A/en
Priority to DE1982900385 priority patent/DE70906T1/en
Priority to DE8282900385T priority patent/DE3273787D1/en
Priority to EP82900385A priority patent/EP0070906B1/en
Priority to PCT/JP1982/000034 priority patent/WO1982002715A1/en
Publication of JPS57130998A publication Critical patent/JPS57130998A/en
Priority to US07/070,120 priority patent/US4738931A/en
Publication of JPH0255035B2 publication Critical patent/JPH0255035B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE:To collect the recombinant DNA containing the chromosome gene of human interferon-beta from recombinant DNAs obtained by fragmentizing the whole DNA of human chromosome with restriction enzyme to a proper length, concentrating the fragments, and inserting into vector DNA. CONSTITUTION:The whole DNA of human chromosome is fragmentized to a proper length by the partial digestion with a restriction enzyme such as HaeIII, AluI, etc., and concentrated by electrophoresis, etc. as it is or after collecting the fraction having a proper length. The fraction is inserted in the DNA such as E. coli phage to obtain recombinant DNA or a human gene library which is a collection of the recombinants including the whole human genes. A recombinant DNA having a DNA exhibiting complementarity to the human interferon-beta messenger RNA is labeled with radioactive isotope, and used as an explorer to select and separate the recombinant DNA having the DNA fragment containing human interferon-beta gene, from the above library.
JP1437381A 1981-02-04 1981-02-04 Human interferon-beta-gene Granted JPS57130998A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP1437381A JPS57130998A (en) 1981-02-04 1981-02-04 Human interferon-beta-gene
DE1982900385 DE70906T1 (en) 1981-02-04 1982-02-04 HUMAN GENE FOR INTERFERON BETA.
DE8282900385T DE3273787D1 (en) 1981-02-04 1982-02-04 Human interferon-beta gene
EP82900385A EP0070906B1 (en) 1981-02-04 1982-02-04 Human interferon-beta gene
PCT/JP1982/000034 WO1982002715A1 (en) 1981-02-04 1982-02-04 Human interferon-beta gene
US07/070,120 US4738931A (en) 1981-02-04 1987-07-06 Human interferon-β gene

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1437381A JPS57130998A (en) 1981-02-04 1981-02-04 Human interferon-beta-gene

Publications (2)

Publication Number Publication Date
JPS57130998A true JPS57130998A (en) 1982-08-13
JPH0255035B2 JPH0255035B2 (en) 1990-11-26

Family

ID=11859239

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1437381A Granted JPS57130998A (en) 1981-02-04 1981-02-04 Human interferon-beta-gene

Country Status (1)

Country Link
JP (1) JPS57130998A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5810599A (en) * 1981-07-11 1983-01-21 Japan Found Cancer Human interferon-beta gene
JPS61158791A (en) * 1984-07-31 1986-07-18 アメリカ合衆国 Perfect gene and its shearing and cloning method
JPH083791B2 (en) * 1985-11-27 1996-01-17 モトロ−ラ・インコ−ポレ−テッド Data processor controller
KR100511749B1 (en) * 2001-11-06 2005-09-02 선바이오(주) Modified interferon-beta, and chemically modified conjugates thereof
US7256181B2 (en) 1997-08-29 2007-08-14 Biogen Idec Ma Inc. Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PROC JAPAN ACAD=1979 *
PROC NATL.ACAD SUI USA=1980 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5810599A (en) * 1981-07-11 1983-01-21 Japan Found Cancer Human interferon-beta gene
JPS61158791A (en) * 1984-07-31 1986-07-18 アメリカ合衆国 Perfect gene and its shearing and cloning method
JPH0773496B2 (en) * 1984-07-31 1995-08-09 アメリカ合衆国 Complete gene isolation method
JPH083791B2 (en) * 1985-11-27 1996-01-17 モトロ−ラ・インコ−ポレ−テッド Data processor controller
US7256181B2 (en) 1997-08-29 2007-08-14 Biogen Idec Ma Inc. Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta
KR100511749B1 (en) * 2001-11-06 2005-09-02 선바이오(주) Modified interferon-beta, and chemically modified conjugates thereof

Also Published As

Publication number Publication date
JPH0255035B2 (en) 1990-11-26

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