JPS57130998A - Human interferon-beta-gene - Google Patents
Human interferon-beta-geneInfo
- Publication number
- JPS57130998A JPS57130998A JP1437381A JP1437381A JPS57130998A JP S57130998 A JPS57130998 A JP S57130998A JP 1437381 A JP1437381 A JP 1437381A JP 1437381 A JP1437381 A JP 1437381A JP S57130998 A JPS57130998 A JP S57130998A
- Authority
- JP
- Japan
- Prior art keywords
- dna
- human
- beta
- gene
- human interferon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE:To collect the recombinant DNA containing the chromosome gene of human interferon-beta from recombinant DNAs obtained by fragmentizing the whole DNA of human chromosome with restriction enzyme to a proper length, concentrating the fragments, and inserting into vector DNA. CONSTITUTION:The whole DNA of human chromosome is fragmentized to a proper length by the partial digestion with a restriction enzyme such as HaeIII, AluI, etc., and concentrated by electrophoresis, etc. as it is or after collecting the fraction having a proper length. The fraction is inserted in the DNA such as E. coli phage to obtain recombinant DNA or a human gene library which is a collection of the recombinants including the whole human genes. A recombinant DNA having a DNA exhibiting complementarity to the human interferon-beta messenger RNA is labeled with radioactive isotope, and used as an explorer to select and separate the recombinant DNA having the DNA fragment containing human interferon-beta gene, from the above library.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1437381A JPS57130998A (en) | 1981-02-04 | 1981-02-04 | Human interferon-beta-gene |
DE1982900385 DE70906T1 (en) | 1981-02-04 | 1982-02-04 | HUMAN GENE FOR INTERFERON BETA. |
DE8282900385T DE3273787D1 (en) | 1981-02-04 | 1982-02-04 | Human interferon-beta gene |
EP82900385A EP0070906B1 (en) | 1981-02-04 | 1982-02-04 | Human interferon-beta gene |
PCT/JP1982/000034 WO1982002715A1 (en) | 1981-02-04 | 1982-02-04 | Human interferon-beta gene |
US07/070,120 US4738931A (en) | 1981-02-04 | 1987-07-06 | Human interferon-β gene |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1437381A JPS57130998A (en) | 1981-02-04 | 1981-02-04 | Human interferon-beta-gene |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57130998A true JPS57130998A (en) | 1982-08-13 |
JPH0255035B2 JPH0255035B2 (en) | 1990-11-26 |
Family
ID=11859239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1437381A Granted JPS57130998A (en) | 1981-02-04 | 1981-02-04 | Human interferon-beta-gene |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57130998A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5810599A (en) * | 1981-07-11 | 1983-01-21 | Japan Found Cancer | Human interferon-beta gene |
JPS61158791A (en) * | 1984-07-31 | 1986-07-18 | アメリカ合衆国 | Perfect gene and its shearing and cloning method |
JPH083791B2 (en) * | 1985-11-27 | 1996-01-17 | モトロ−ラ・インコ−ポレ−テッド | Data processor controller |
KR100511749B1 (en) * | 2001-11-06 | 2005-09-02 | 선바이오(주) | Modified interferon-beta, and chemically modified conjugates thereof |
US7256181B2 (en) | 1997-08-29 | 2007-08-14 | Biogen Idec Ma Inc. | Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta |
-
1981
- 1981-02-04 JP JP1437381A patent/JPS57130998A/en active Granted
Non-Patent Citations (2)
Title |
---|
PROC JAPAN ACAD=1979 * |
PROC NATL.ACAD SUI USA=1980 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5810599A (en) * | 1981-07-11 | 1983-01-21 | Japan Found Cancer | Human interferon-beta gene |
JPS61158791A (en) * | 1984-07-31 | 1986-07-18 | アメリカ合衆国 | Perfect gene and its shearing and cloning method |
JPH0773496B2 (en) * | 1984-07-31 | 1995-08-09 | アメリカ合衆国 | Complete gene isolation method |
JPH083791B2 (en) * | 1985-11-27 | 1996-01-17 | モトロ−ラ・インコ−ポレ−テッド | Data processor controller |
US7256181B2 (en) | 1997-08-29 | 2007-08-14 | Biogen Idec Ma Inc. | Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta |
KR100511749B1 (en) * | 2001-11-06 | 2005-09-02 | 선바이오(주) | Modified interferon-beta, and chemically modified conjugates thereof |
Also Published As
Publication number | Publication date |
---|---|
JPH0255035B2 (en) | 1990-11-26 |
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