JPS57112325A - Aggregation inhibitor of blood platelet - Google Patents

Aggregation inhibitor of blood platelet

Info

Publication number
JPS57112325A
JPS57112325A JP55179169A JP17916980A JPS57112325A JP S57112325 A JPS57112325 A JP S57112325A JP 55179169 A JP55179169 A JP 55179169A JP 17916980 A JP17916980 A JP 17916980A JP S57112325 A JPS57112325 A JP S57112325A
Authority
JP
Japan
Prior art keywords
aggregation
blood platelets
protopine
inhibitor
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55179169A
Other languages
Japanese (ja)
Other versions
JPS634804B2 (en
Inventor
Michitoku Kubo
Kazumi Ogata
Takashi Noma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SENJIYU SEIYAKU KK
Senju Pharmaceutical Co Ltd
Original Assignee
SENJIYU SEIYAKU KK
Senju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SENJIYU SEIYAKU KK, Senju Pharmaceutical Co Ltd filed Critical SENJIYU SEIYAKU KK
Priority to JP55179169A priority Critical patent/JPS57112325A/en
Publication of JPS57112325A publication Critical patent/JPS57112325A/en
Publication of JPS634804B2 publication Critical patent/JPS634804B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: An aggregation inhibitor of blood platelets, containing protopine or a salt thereof, useful as a preventing agent and remedy for cerebromalacia, cardiac infarction, etc., and having powerful aggregation inhibitory action on the blood platelets.
CONSTITUTION: An aggregation inhibitor of blood platelets containing protopine or a salt thereof extracted and purified from a constituent of a plant belonging to the family Papaveraceae. The protopine has aggregation inhibitory action on blood platelets about 10 times that of the aspirin, and inhibits the aggregation in an amount of 250W500μg/ml remarkably and dissociates the aggregation almost completely. The improvement in local circulation of blood by the action renders the inhibitor useful as a preventing agent and remedy for subconjunctival hemorrhage and remits the tension of ciliary muscles and congestion in a nipple. Another effect, e.g. prevention or treatment of short sight, is expectable. The oral dose is generally 1W500mg/day usually divided in several fractions. As for an injection, the dose is 0.1W100mg/day in one W divided fractions, and as for an external agent such as an eye drop, the concentration of 50W1,000μg/ml is applicable.
COPYRIGHT: (C)1982,JPO&Japio
JP55179169A 1980-12-17 1980-12-17 Aggregation inhibitor of blood platelet Granted JPS57112325A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55179169A JPS57112325A (en) 1980-12-17 1980-12-17 Aggregation inhibitor of blood platelet

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55179169A JPS57112325A (en) 1980-12-17 1980-12-17 Aggregation inhibitor of blood platelet

Publications (2)

Publication Number Publication Date
JPS57112325A true JPS57112325A (en) 1982-07-13
JPS634804B2 JPS634804B2 (en) 1988-02-01

Family

ID=16061139

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55179169A Granted JPS57112325A (en) 1980-12-17 1980-12-17 Aggregation inhibitor of blood platelet

Country Status (1)

Country Link
JP (1) JPS57112325A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0218703U (en) * 1988-07-22 1990-02-07
US10711238B2 (en) 2012-10-02 2020-07-14 Repligen Corporation Method for proliferation of cells within a bioreactor using a disposable pumphead and filter assembly

Also Published As

Publication number Publication date
JPS634804B2 (en) 1988-02-01

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