JPS5681517A - Drug having inhibiting action of thromboxane a2 - Google Patents

Drug having inhibiting action of thromboxane a2

Info

Publication number
JPS5681517A
JPS5681517A JP15876879A JP15876879A JPS5681517A JP S5681517 A JPS5681517 A JP S5681517A JP 15876879 A JP15876879 A JP 15876879A JP 15876879 A JP15876879 A JP 15876879A JP S5681517 A JPS5681517 A JP S5681517A
Authority
JP
Japan
Prior art keywords
action
txa
thromboxane
formula
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15876879A
Other languages
Japanese (ja)
Other versions
JPS6232721B2 (en
Inventor
Haruo Onishi
Koji Kojiyaku
Yasuo Suzuki
Suguru Mochida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Priority to JP15876879A priority Critical patent/JPS5681517A/en
Publication of JPS5681517A publication Critical patent/JPS5681517A/en
Publication of JPS6232721B2 publication Critical patent/JPS6232721B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: A drug useful for remedying and preventing a circulatory organ disease, e.g., myocardial infarction, cerebtal apoplexy, etc., having an inhibiting action of thromboxane A2, comprising trapidil as an active ingredient.
CONSTITUTION: A drug comprising 5-methyl-7-diethylamino-S-triazolo[1,5-a]-pyrimidine (common name: trapidil) shown by the formula as an active ingredient. The compound shown by the formula is a well-known compound which is apt to be dissolved in water and an organic solvent, white to slightly yellow crystalline powder of a bitter taste, has a dilation action of corona blood, and it is found not only to inhibit an action of blood platelet aggregation and a vasoconstriction action of thromboxane A2(TXA2) but also to inhibit the formation of TXA2. TXA2 causes not only hemostasis action as a normal action but also an abnormal vasoconstriction and thrombus formation, and it is a substance causing a disease, e.g., cerebral apoplexy, myocardial infarction, angina pectoris, etc. Consequently, the compound shown by the formula I is useful for remodying and preventing these diseases basically.
COPYRIGHT: (C)1981,JPO&Japio
JP15876879A 1979-12-07 1979-12-07 Drug having inhibiting action of thromboxane a2 Granted JPS5681517A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15876879A JPS5681517A (en) 1979-12-07 1979-12-07 Drug having inhibiting action of thromboxane a2

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15876879A JPS5681517A (en) 1979-12-07 1979-12-07 Drug having inhibiting action of thromboxane a2

Publications (2)

Publication Number Publication Date
JPS5681517A true JPS5681517A (en) 1981-07-03
JPS6232721B2 JPS6232721B2 (en) 1987-07-16

Family

ID=15678909

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15876879A Granted JPS5681517A (en) 1979-12-07 1979-12-07 Drug having inhibiting action of thromboxane a2

Country Status (1)

Country Link
JP (1) JPS5681517A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0419719U (en) * 1990-06-11 1992-02-19

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54160745A (en) * 1978-06-06 1979-12-19 Mochida Pharm Co Ltd Circulatory disease treating agent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54160745A (en) * 1978-06-06 1979-12-19 Mochida Pharm Co Ltd Circulatory disease treating agent

Also Published As

Publication number Publication date
JPS6232721B2 (en) 1987-07-16

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