JPS5681517A - Drug having inhibiting action of thromboxane a2 - Google Patents
Drug having inhibiting action of thromboxane a2Info
- Publication number
- JPS5681517A JPS5681517A JP15876879A JP15876879A JPS5681517A JP S5681517 A JPS5681517 A JP S5681517A JP 15876879 A JP15876879 A JP 15876879A JP 15876879 A JP15876879 A JP 15876879A JP S5681517 A JPS5681517 A JP S5681517A
- Authority
- JP
- Japan
- Prior art keywords
- action
- txa
- thromboxane
- formula
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: A drug useful for remedying and preventing a circulatory organ disease, e.g., myocardial infarction, cerebtal apoplexy, etc., having an inhibiting action of thromboxane A2, comprising trapidil as an active ingredient.
CONSTITUTION: A drug comprising 5-methyl-7-diethylamino-S-triazolo[1,5-a]-pyrimidine (common name: trapidil) shown by the formula as an active ingredient. The compound shown by the formula is a well-known compound which is apt to be dissolved in water and an organic solvent, white to slightly yellow crystalline powder of a bitter taste, has a dilation action of corona blood, and it is found not only to inhibit an action of blood platelet aggregation and a vasoconstriction action of thromboxane A2(TXA2) but also to inhibit the formation of TXA2. TXA2 causes not only hemostasis action as a normal action but also an abnormal vasoconstriction and thrombus formation, and it is a substance causing a disease, e.g., cerebral apoplexy, myocardial infarction, angina pectoris, etc. Consequently, the compound shown by the formula I is useful for remodying and preventing these diseases basically.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15876879A JPS5681517A (en) | 1979-12-07 | 1979-12-07 | Drug having inhibiting action of thromboxane a2 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15876879A JPS5681517A (en) | 1979-12-07 | 1979-12-07 | Drug having inhibiting action of thromboxane a2 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5681517A true JPS5681517A (en) | 1981-07-03 |
JPS6232721B2 JPS6232721B2 (en) | 1987-07-16 |
Family
ID=15678909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15876879A Granted JPS5681517A (en) | 1979-12-07 | 1979-12-07 | Drug having inhibiting action of thromboxane a2 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5681517A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0419719U (en) * | 1990-06-11 | 1992-02-19 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54160745A (en) * | 1978-06-06 | 1979-12-19 | Mochida Pharm Co Ltd | Circulatory disease treating agent |
-
1979
- 1979-12-07 JP JP15876879A patent/JPS5681517A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54160745A (en) * | 1978-06-06 | 1979-12-19 | Mochida Pharm Co Ltd | Circulatory disease treating agent |
Also Published As
Publication number | Publication date |
---|---|
JPS6232721B2 (en) | 1987-07-16 |
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