JPS565435A - Trans-2,2-dimethyl-3- p-substituted phenyl -cyclopropane- carboxylic acid and its preparation - Google Patents
Trans-2,2-dimethyl-3- p-substituted phenyl -cyclopropane- carboxylic acid and its preparationInfo
- Publication number
- JPS565435A JPS565435A JP8059779A JP8059779A JPS565435A JP S565435 A JPS565435 A JP S565435A JP 8059779 A JP8059779 A JP 8059779A JP 8059779 A JP8059779 A JP 8059779A JP S565435 A JPS565435 A JP S565435A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- trans
- dimethyl
- substituted phenyl
- cyclopropane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
NEW MATERIAL:trans-2, 2-Dimethyl-3-( p-substituted phenyl )cyclopropanecarboxylic acid of formula I (X is Br, alkyl except CH3, cycloalkyl, CF3, trialkylsilyl, dialkylamino, CN, or SCH3). EXAMPLE:trans-2,2-Dimethyl-3-(p-t-butylphenyl)cyclopropanecarboxylic acid. USE:Intermediate of a substituted phenylcyclopropanecarboxylic ester which is an insecticidal and miticidal agent effective to control house vermin and agricultural and horticultural vermin. PROCESS:Carboxylic ester of formula IV is obtained by the reaction of p-substituted cinnamic ester of formula II (R is lower alkyl) with isopropyltriphenylphosphonium iodide of formula III in the pesence of a base, e.g. n-butyl lithium. The compound of formula IV thus obtained is then hydrolyzed to give the objective compound of formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8059779A JPS565435A (en) | 1979-06-26 | 1979-06-26 | Trans-2,2-dimethyl-3- p-substituted phenyl -cyclopropane- carboxylic acid and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8059779A JPS565435A (en) | 1979-06-26 | 1979-06-26 | Trans-2,2-dimethyl-3- p-substituted phenyl -cyclopropane- carboxylic acid and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS565435A true JPS565435A (en) | 1981-01-20 |
JPH0112741B2 JPH0112741B2 (en) | 1989-03-02 |
Family
ID=13722731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8059779A Granted JPS565435A (en) | 1979-06-26 | 1979-06-26 | Trans-2,2-dimethyl-3- p-substituted phenyl -cyclopropane- carboxylic acid and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS565435A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57150635A (en) * | 1981-02-20 | 1982-09-17 | Chinoin Gyogyszer Es Vegyeszet | Manufacture of dihalovinylcyclopropane carboxylic acid |
WO2006097817A1 (en) * | 2005-03-17 | 2006-09-21 | Pfizer Japan Inc. | N- (n-sulfonylaminomethyl) cyclopropanecarboxamide derivatives useful for the treatment of pain |
-
1979
- 1979-06-26 JP JP8059779A patent/JPS565435A/en active Granted
Non-Patent Citations (1)
Title |
---|
CHEMICAL ABSTRACTS * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57150635A (en) * | 1981-02-20 | 1982-09-17 | Chinoin Gyogyszer Es Vegyeszet | Manufacture of dihalovinylcyclopropane carboxylic acid |
JPH0521904B2 (en) * | 1981-02-20 | 1993-03-25 | Kinoin Giogisuzeru Esu Begiesuzechi Terumekeku Giara Ruto | |
WO2006097817A1 (en) * | 2005-03-17 | 2006-09-21 | Pfizer Japan Inc. | N- (n-sulfonylaminomethyl) cyclopropanecarboxamide derivatives useful for the treatment of pain |
JP2008535801A (en) * | 2005-03-17 | 2008-09-04 | ファイザー株式会社 | N- (N-sulfonylaminomethyl) cyclopropanecarboxamide derivatives useful for the treatment of pain |
US7622589B2 (en) | 2005-03-17 | 2009-11-24 | Pfizer Inc. | Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists |
US7915448B2 (en) * | 2005-03-17 | 2011-03-29 | Pfizer Inc. | Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists |
Also Published As
Publication number | Publication date |
---|---|
JPH0112741B2 (en) | 1989-03-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Effective date: 20040512 Free format text: JAPANESE INTERMEDIATE CODE: A621 |
|
A131 | Notification of reasons for refusal |
Effective date: 20070320 Free format text: JAPANESE INTERMEDIATE CODE: A131 |
|
A313 | Final decision of rejection without a dissenting response from the applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A313 Effective date: 20070808 |
|
A02 | Decision of refusal |
Effective date: 20070918 Free format text: JAPANESE INTERMEDIATE CODE: A02 |