JPS5640634A - Cyclohexane derivative, its preparation, and pharmaceutical containing the same - Google Patents
Cyclohexane derivative, its preparation, and pharmaceutical containing the sameInfo
- Publication number
- JPS5640634A JPS5640634A JP11524079A JP11524079A JPS5640634A JP S5640634 A JPS5640634 A JP S5640634A JP 11524079 A JP11524079 A JP 11524079A JP 11524079 A JP11524079 A JP 11524079A JP S5640634 A JPS5640634 A JP S5640634A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- halogen
- phenyl
- cyclohexane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A cyclohexane derivative of formula I (R is phenyl or furyl; A is (CH2)n or NH; n is 0W4; X, Y and Z are H, lower alkyl, lower alkoxy, lower alkylcarbonyloxy, hydroxy, lower alkylsulfonyl, nitro, cyano or halogen) or its salt.
EXAMPLE: 2-(3-Phenylpropionyl)-5-phenyl-cyclohexane-1,3-dione.
USE: A low-toxic and long-acting agent for remedy and prophylaxis of various hypertensions such as renal, endocrine, cardiovascular, nervous or essential hypertension. It is also useful as an antimicrobial agent effective to Grampositive bacteria, Gram- negative bacteria and fungi.
PROCESS: The compound of formula I is prepared by heating a mixture of a compound of formula II and a compound of formula III (B is halogen) pref. in the presence of a catalyst such as triethylamine at the boiling point of the solvent such as benzene.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11524079A JPS5640634A (en) | 1979-09-10 | 1979-09-10 | Cyclohexane derivative, its preparation, and pharmaceutical containing the same |
US06/133,694 US4350705A (en) | 1979-03-31 | 1980-03-25 | Cyclohexane derivatives, process for preparation thereof and medicines containing these cyclohexane derivatives |
DE8080101685T DE3068412D1 (en) | 1979-03-31 | 1980-03-28 | Derivatives of 2,5-disubstituted-cyclohexane-1,3-diones, process for preparation thereof and pharmaceutical composition containing them |
EP80101685A EP0017195B1 (en) | 1979-03-31 | 1980-03-28 | Derivatives of 2,5-disubstituted-cyclohexane-1,3-diones, process for preparation thereof and pharmaceutical composition containing them |
US06/362,358 US4421763A (en) | 1979-03-31 | 1982-03-26 | Cyclohexane derivatives, process for preparation thereof and medicines containing these cyclohexane derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11524079A JPS5640634A (en) | 1979-09-10 | 1979-09-10 | Cyclohexane derivative, its preparation, and pharmaceutical containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5640634A true JPS5640634A (en) | 1981-04-16 |
JPH0210133B2 JPH0210133B2 (en) | 1990-03-06 |
Family
ID=14657807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11524079A Granted JPS5640634A (en) | 1979-03-31 | 1979-09-10 | Cyclohexane derivative, its preparation, and pharmaceutical containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5640634A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2219646A2 (en) * | 2007-12-21 | 2010-08-25 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4832850A (en) * | 1971-09-02 | 1973-05-02 | ||
JPS4943951A (en) * | 1972-09-01 | 1974-04-25 | ||
JPS511633A (en) * | 1974-06-25 | 1976-01-08 | Toray Industries | NOENGEI YOSATSUKINZAI |
-
1979
- 1979-09-10 JP JP11524079A patent/JPS5640634A/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4832850A (en) * | 1971-09-02 | 1973-05-02 | ||
JPS4943951A (en) * | 1972-09-01 | 1974-04-25 | ||
JPS511633A (en) * | 1974-06-25 | 1976-01-08 | Toray Industries | NOENGEI YOSATSUKINZAI |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2219646A2 (en) * | 2007-12-21 | 2010-08-25 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
EP2219646A4 (en) * | 2007-12-21 | 2010-12-22 | Univ Rochester | Method for altering the lifespan of eukaryotic organisms |
Also Published As
Publication number | Publication date |
---|---|
JPH0210133B2 (en) | 1990-03-06 |
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