JPS5640634A - Cyclohexane derivative, its preparation, and pharmaceutical containing the same - Google Patents

Cyclohexane derivative, its preparation, and pharmaceutical containing the same

Info

Publication number
JPS5640634A
JPS5640634A JP11524079A JP11524079A JPS5640634A JP S5640634 A JPS5640634 A JP S5640634A JP 11524079 A JP11524079 A JP 11524079A JP 11524079 A JP11524079 A JP 11524079A JP S5640634 A JPS5640634 A JP S5640634A
Authority
JP
Japan
Prior art keywords
formula
compound
halogen
phenyl
cyclohexane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11524079A
Other languages
Japanese (ja)
Other versions
JPH0210133B2 (en
Inventor
Sukeyuki Hamano
Shinichi Kitamura
Shunji Igarashi
Yoshiaki Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP11524079A priority Critical patent/JPS5640634A/en
Priority to US06/133,694 priority patent/US4350705A/en
Priority to DE8080101685T priority patent/DE3068412D1/en
Priority to EP80101685A priority patent/EP0017195B1/en
Publication of JPS5640634A publication Critical patent/JPS5640634A/en
Priority to US06/362,358 priority patent/US4421763A/en
Publication of JPH0210133B2 publication Critical patent/JPH0210133B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A cyclohexane derivative of formula I (R is phenyl or furyl; A is (CH2)n or NH; n is 0W4; X, Y and Z are H, lower alkyl, lower alkoxy, lower alkylcarbonyloxy, hydroxy, lower alkylsulfonyl, nitro, cyano or halogen) or its salt.
EXAMPLE: 2-(3-Phenylpropionyl)-5-phenyl-cyclohexane-1,3-dione.
USE: A low-toxic and long-acting agent for remedy and prophylaxis of various hypertensions such as renal, endocrine, cardiovascular, nervous or essential hypertension. It is also useful as an antimicrobial agent effective to Grampositive bacteria, Gram- negative bacteria and fungi.
PROCESS: The compound of formula I is prepared by heating a mixture of a compound of formula II and a compound of formula III (B is halogen) pref. in the presence of a catalyst such as triethylamine at the boiling point of the solvent such as benzene.
COPYRIGHT: (C)1981,JPO&Japio
JP11524079A 1979-03-31 1979-09-10 Cyclohexane derivative, its preparation, and pharmaceutical containing the same Granted JPS5640634A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP11524079A JPS5640634A (en) 1979-09-10 1979-09-10 Cyclohexane derivative, its preparation, and pharmaceutical containing the same
US06/133,694 US4350705A (en) 1979-03-31 1980-03-25 Cyclohexane derivatives, process for preparation thereof and medicines containing these cyclohexane derivatives
DE8080101685T DE3068412D1 (en) 1979-03-31 1980-03-28 Derivatives of 2,5-disubstituted-cyclohexane-1,3-diones, process for preparation thereof and pharmaceutical composition containing them
EP80101685A EP0017195B1 (en) 1979-03-31 1980-03-28 Derivatives of 2,5-disubstituted-cyclohexane-1,3-diones, process for preparation thereof and pharmaceutical composition containing them
US06/362,358 US4421763A (en) 1979-03-31 1982-03-26 Cyclohexane derivatives, process for preparation thereof and medicines containing these cyclohexane derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11524079A JPS5640634A (en) 1979-09-10 1979-09-10 Cyclohexane derivative, its preparation, and pharmaceutical containing the same

Publications (2)

Publication Number Publication Date
JPS5640634A true JPS5640634A (en) 1981-04-16
JPH0210133B2 JPH0210133B2 (en) 1990-03-06

Family

ID=14657807

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11524079A Granted JPS5640634A (en) 1979-03-31 1979-09-10 Cyclohexane derivative, its preparation, and pharmaceutical containing the same

Country Status (1)

Country Link
JP (1) JPS5640634A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2219646A2 (en) * 2007-12-21 2010-08-25 University Of Rochester Method for altering the lifespan of eukaryotic organisms

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4832850A (en) * 1971-09-02 1973-05-02
JPS4943951A (en) * 1972-09-01 1974-04-25
JPS511633A (en) * 1974-06-25 1976-01-08 Toray Industries NOENGEI YOSATSUKINZAI

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4832850A (en) * 1971-09-02 1973-05-02
JPS4943951A (en) * 1972-09-01 1974-04-25
JPS511633A (en) * 1974-06-25 1976-01-08 Toray Industries NOENGEI YOSATSUKINZAI

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2219646A2 (en) * 2007-12-21 2010-08-25 University Of Rochester Method for altering the lifespan of eukaryotic organisms
EP2219646A4 (en) * 2007-12-21 2010-12-22 Univ Rochester Method for altering the lifespan of eukaryotic organisms

Also Published As

Publication number Publication date
JPH0210133B2 (en) 1990-03-06

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