JPS562989A - Manufacture of 4*44disubstitutedd3*88 dioxabicyclo*3*2*1*octanee11acetic acid - Google Patents

Manufacture of 4*44disubstitutedd3*88 dioxabicyclo*3*2*1*octanee11acetic acid

Info

Publication number
JPS562989A
JPS562989A JP6346280A JP6346280A JPS562989A JP S562989 A JPS562989 A JP S562989A JP 6346280 A JP6346280 A JP 6346280A JP 6346280 A JP6346280 A JP 6346280A JP S562989 A JPS562989 A JP S562989A
Authority
JP
Japan
Prior art keywords
dioxabicyclo
manufacture
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6346280A
Other languages
English (en)
Inventor
Chien Robaato
Hayosu Zorutan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of JPS562989A publication Critical patent/JPS562989A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP6346280A 1979-05-18 1980-05-15 Manufacture of 4*44disubstitutedd3*88 dioxabicyclo*3*2*1*octanee11acetic acid Pending JPS562989A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/040,345 US4215048A (en) 1979-05-18 1979-05-18 Total synthesis of (1RS, 4SR, 5RS)-4-(4,8-dimethyl-5-hydroxy-7-nonenyl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid

Publications (1)

Publication Number Publication Date
JPS562989A true JPS562989A (en) 1981-01-13

Family

ID=21910501

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6346280A Pending JPS562989A (en) 1979-05-18 1980-05-15 Manufacture of 4*44disubstitutedd3*88 dioxabicyclo*3*2*1*octanee11acetic acid

Country Status (5)

Country Link
US (1) US4215048A (ja)
EP (1) EP0024095B1 (ja)
JP (1) JPS562989A (ja)
CA (1) CA1149402A (ja)
DE (1) DE3069265D1 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322353A (en) * 1980-04-18 1982-03-30 Ortho Pharmaceutical Corporation Synthesis of dioxabicyclo(3.2.1)octanes and oxepanes
KR850000218B1 (ko) * 1980-07-31 1985-03-06 오오소오 화아마슈이티갈 코오포레이숀 디옥사비시클로[3.2.1]옥탄 유도체의 합성방법
US4307019A (en) * 1980-08-25 1981-12-22 Ortho Pharmaceutical Corporation Total synthesis of 1RS,4SR,5RS,-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid
US4277401A (en) * 1980-08-25 1981-07-07 Ortho Pharmaceutical Corporation Total synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl)-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid
JPS6287590A (ja) * 1985-10-14 1987-04-22 Teijin Ltd イソカルバサイクリン誘導体及びその製造方法
US5959130A (en) * 1996-07-02 1999-09-28 Finetex, Inc. Castor based benzoate esters
ES2328213B1 (es) * 2008-05-06 2010-07-23 Consejo Superior De Investigaciones Cientificas Procedimiento de obtencion del acido zaragocico y derivados del mismo.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2957009A (en) * 1955-11-25 1960-10-18 Du Pont Metal salts of open-chain dihydroxydioic acids and esters, their monolactone acids, salts, esters, and amides and their preparation
GB1514931A (en) * 1974-06-05 1978-06-21 Bush Boake Allen Ltd Citronellene lactones and their use in perfumery
US4102895A (en) * 1976-11-18 1978-07-25 Ortho Pharmaceutical Corporation Oxepanes
US4176188A (en) * 1976-11-18 1979-11-27 Ortho Pharmaceutical Corp. Utero-evacuants

Also Published As

Publication number Publication date
EP0024095A1 (en) 1981-02-25
US4215048A (en) 1980-07-29
EP0024095B1 (en) 1984-09-26
DE3069265D1 (en) 1984-10-31
CA1149402A (en) 1983-07-05

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