JPS5625112A - Preparation of urogastrone - Google Patents

Preparation of urogastrone

Info

Publication number
JPS5625112A
JPS5625112A JP10031379A JP10031379A JPS5625112A JP S5625112 A JPS5625112 A JP S5625112A JP 10031379 A JP10031379 A JP 10031379A JP 10031379 A JP10031379 A JP 10031379A JP S5625112 A JPS5625112 A JP S5625112A
Authority
JP
Japan
Prior art keywords
urine
urogastrone
adsorbent
aluminosilicate powder
pref
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10031379A
Other languages
Japanese (ja)
Other versions
JPS5942650B2 (en
Inventor
Shigemi Sato
Yatsuhiko Hirayama
Shigeto Ichida
Takao Yamada
Yasunobu Enotani
Tsuneko Kimura
Akira Kida
Masako Nakamura
Akihito Kakuiri
Juji Wada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FUJI ZOKI SEIYAKU
Fujirebio Inc
Original Assignee
FUJI ZOKI SEIYAKU
Fujirebio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FUJI ZOKI SEIYAKU, Fujirebio Inc filed Critical FUJI ZOKI SEIYAKU
Priority to JP54100313A priority Critical patent/JPS5942650B2/en
Publication of JPS5625112A publication Critical patent/JPS5625112A/en
Publication of JPS5942650B2 publication Critical patent/JPS5942650B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PURPOSE: To prepare urogastrone useful as an antiulcer agent and gastric juice secretion suppressing agent, in high purity and yield, by adjusting the pH of the urine of a mammal, removing the precipitate from the urine, and adding a specific aluminosilicate powder as an adsorbent thereto.
CONSTITUTION: The pH of the urine of human, a pregnant mammal, etc. is adjusted to 3.3W4.8, and the precipitate is removed by centrifugal separation, etc. The urine is treated with pref. a weak basic anion exchange resin to remove the components other than urogastrone, and then added with aluminosilicate powder of formula Al2O3.9SiO2.xH2O as an adsorbent. The adsorbed urogastrone is eluted with an alkaline buffer solution containing 10% ammonium acetate, etc. The adsorbent is pref. the one prepared by treating the aluminosilicate powder having particle diameters of 150W350μ with e.g. 3N aqueous hydrochloric acid solution, washing with water, drying, and heating at 400°C for 30min for activation.
COPYRIGHT: (C)1981,JPO&Japio
JP54100313A 1979-08-08 1979-08-08 How to make urogastrone Expired JPS5942650B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP54100313A JPS5942650B2 (en) 1979-08-08 1979-08-08 How to make urogastrone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54100313A JPS5942650B2 (en) 1979-08-08 1979-08-08 How to make urogastrone

Publications (2)

Publication Number Publication Date
JPS5625112A true JPS5625112A (en) 1981-03-10
JPS5942650B2 JPS5942650B2 (en) 1984-10-16

Family

ID=14270680

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54100313A Expired JPS5942650B2 (en) 1979-08-08 1979-08-08 How to make urogastrone

Country Status (1)

Country Link
JP (1) JPS5942650B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58134029A (en) * 1982-02-02 1983-08-10 Nippon Chem Res Kk Fractional collection of component suppressing castric juice secretion
JPS59196820A (en) * 1983-04-20 1984-11-08 Nippon Chem Res Kk Method for heat-treating human epithelial cell growth factor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58134029A (en) * 1982-02-02 1983-08-10 Nippon Chem Res Kk Fractional collection of component suppressing castric juice secretion
JPH0354087B2 (en) * 1982-02-02 1991-08-19
JPS59196820A (en) * 1983-04-20 1984-11-08 Nippon Chem Res Kk Method for heat-treating human epithelial cell growth factor

Also Published As

Publication number Publication date
JPS5942650B2 (en) 1984-10-16

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