JPS56133259A - Azetidine derivative and its preparation - Google Patents
Azetidine derivative and its preparationInfo
- Publication number
- JPS56133259A JPS56133259A JP3636580A JP3636580A JPS56133259A JP S56133259 A JPS56133259 A JP S56133259A JP 3636580 A JP3636580 A JP 3636580A JP 3636580 A JP3636580 A JP 3636580A JP S56133259 A JPS56133259 A JP S56133259A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- affords
- oxoazetidine
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 2-oxoazetidine derivative of formula I (R1 is amino which may be acylated or protected.)
EXAMPLE: 3-Phenylacetamido-3-methoxy-2-oxoazetidine.
USE: A synthetic intermediate of pharmaceutical. For example, N-sulfonation of the compound affords a remedy of bacteriosis.
PROCESS: A compound of formula III (R4 is ester residue) is made to react with a disulfidizing agent (e.g. a thiol compound) to obtain a compound of formula IV (R5 is thiol residue). By appropriate selection of the reaction solvent, time, temperature, etc., a compound of formula V can also be obtained. Treatment of the compound of formula IV with a base such as pyridine also gives the compound of formula V. The reductive desulfurization of the compound of formula V with Raney nickel, etc. affords the compound of formula VI, which is converted to the compound of formula I by oxidation.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3636580A JPS56133259A (en) | 1980-03-22 | 1980-03-22 | Azetidine derivative and its preparation |
| DE8080301898T DE3064810D1 (en) | 1979-06-08 | 1980-06-06 | 3-methoxy-2-oxoazetidine derivatives and their production |
| AT80301898T ATE4641T1 (en) | 1979-06-08 | 1980-06-06 | 3-METHOXY-2-AZETIDINONE DERIVATIVES AND THEIR PREPARATION. |
| EP80301898A EP0021676B1 (en) | 1979-06-08 | 1980-06-06 | 3-methoxy-2-oxoazetidine derivatives and their production |
| CA000353510A CA1242188A (en) | 1979-06-08 | 1980-06-06 | 3-methoxy-2-oxoazetidine derivatives and their production |
| US06/322,661 US4416817A (en) | 1979-06-08 | 1981-11-18 | 3-Methoxy-2-oxoazetidine derivatives and their production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3636580A JPS56133259A (en) | 1980-03-22 | 1980-03-22 | Azetidine derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56133259A true JPS56133259A (en) | 1981-10-19 |
Family
ID=12467801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3636580A Pending JPS56133259A (en) | 1979-06-08 | 1980-03-22 | Azetidine derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56133259A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55164671A (en) * | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Azetidine derivative and its preparation |
-
1980
- 1980-03-22 JP JP3636580A patent/JPS56133259A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55164671A (en) * | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Azetidine derivative and its preparation |
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