JPS56133259A - Azetidine derivative and its preparation - Google Patents

Azetidine derivative and its preparation

Info

Publication number
JPS56133259A
JPS56133259A JP3636580A JP3636580A JPS56133259A JP S56133259 A JPS56133259 A JP S56133259A JP 3636580 A JP3636580 A JP 3636580A JP 3636580 A JP3636580 A JP 3636580A JP S56133259 A JPS56133259 A JP S56133259A
Authority
JP
Japan
Prior art keywords
compound
formula
affords
oxoazetidine
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3636580A
Other languages
Japanese (ja)
Inventor
Taisuke Matsuo
Toru Sugawara
Hironaga Masuya
Yasuhiko Kawano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP3636580A priority Critical patent/JPS56133259A/en
Priority to EP80301898A priority patent/EP0021676B1/en
Priority to AT80301898T priority patent/ATE4641T1/en
Priority to DE8080301898T priority patent/DE3064810D1/en
Priority to CA000353510A priority patent/CA1242188A/en
Publication of JPS56133259A publication Critical patent/JPS56133259A/en
Priority to US06/322,661 priority patent/US4416817A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 2-oxoazetidine derivative of formula I (R1 is amino which may be acylated or protected.)
EXAMPLE: 3-Phenylacetamido-3-methoxy-2-oxoazetidine.
USE: A synthetic intermediate of pharmaceutical. For example, N-sulfonation of the compound affords a remedy of bacteriosis.
PROCESS: A compound of formula III (R4 is ester residue) is made to react with a disulfidizing agent (e.g. a thiol compound) to obtain a compound of formula IV (R5 is thiol residue). By appropriate selection of the reaction solvent, time, temperature, etc., a compound of formula V can also be obtained. Treatment of the compound of formula IV with a base such as pyridine also gives the compound of formula V. The reductive desulfurization of the compound of formula V with Raney nickel, etc. affords the compound of formula VI, which is converted to the compound of formula I by oxidation.
COPYRIGHT: (C)1981,JPO&Japio
JP3636580A 1979-06-08 1980-03-22 Azetidine derivative and its preparation Pending JPS56133259A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP3636580A JPS56133259A (en) 1980-03-22 1980-03-22 Azetidine derivative and its preparation
EP80301898A EP0021676B1 (en) 1979-06-08 1980-06-06 3-methoxy-2-oxoazetidine derivatives and their production
AT80301898T ATE4641T1 (en) 1979-06-08 1980-06-06 3-METHOXY-2-AZETIDINONE DERIVATIVES AND THEIR PREPARATION.
DE8080301898T DE3064810D1 (en) 1979-06-08 1980-06-06 3-methoxy-2-oxoazetidine derivatives and their production
CA000353510A CA1242188A (en) 1979-06-08 1980-06-06 3-methoxy-2-oxoazetidine derivatives and their production
US06/322,661 US4416817A (en) 1979-06-08 1981-11-18 3-Methoxy-2-oxoazetidine derivatives and their production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3636580A JPS56133259A (en) 1980-03-22 1980-03-22 Azetidine derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS56133259A true JPS56133259A (en) 1981-10-19

Family

ID=12467801

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3636580A Pending JPS56133259A (en) 1979-06-08 1980-03-22 Azetidine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS56133259A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55164671A (en) * 1979-06-08 1980-12-22 Takeda Chem Ind Ltd Azetidine derivative and its preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55164671A (en) * 1979-06-08 1980-12-22 Takeda Chem Ind Ltd Azetidine derivative and its preparation

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