JPS56127400A - Preparation of saponin by acid hydrolysis - Google Patents

Preparation of saponin by acid hydrolysis

Info

Publication number
JPS56127400A
JPS56127400A JP6150880A JP6150880A JPS56127400A JP S56127400 A JPS56127400 A JP S56127400A JP 6150880 A JP6150880 A JP 6150880A JP 6150880 A JP6150880 A JP 6150880A JP S56127400 A JPS56127400 A JP S56127400A
Authority
JP
Japan
Prior art keywords
saponin
glucopyranosyl
substitutent
saccharide
eluted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6150880A
Other languages
Japanese (ja)
Other versions
JPS6352634B2 (en
Inventor
Tsunematsu Takemoto
Shigenobu Arihara
Tadashi Nakajima
Megumi Okudaira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shoji Co Ltd
Original Assignee
Nippon Shoji Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shoji Co Ltd filed Critical Nippon Shoji Co Ltd
Priority to JP6150880A priority Critical patent/JPS56127400A/en
Priority to US06/205,377 priority patent/US4339442A/en
Priority to DE19803042117 priority patent/DE3042117A1/en
Publication of JPS56127400A publication Critical patent/JPS56127400A/en
Publication of JPS6352634B2 publication Critical patent/JPS6352634B2/ja
Granted legal-status Critical Current

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  • Steroid Compounds (AREA)

Abstract

PURPOSE: To obtain gynosaponin having the same composition as the saponin of Panax ginseng, and useful as a drug, etc., by hydrolyzing a specific novel saponin with a weak acid, thereby eliminating the saccharide from the substitutent at the 20-position while keeping the substitutent at the 3-position unchanged.
CONSTITUTION: A saponin of formula [R1 is [β-D-glucopyranosyl(1→2)-α-L- rhamopyranosyl(1→6)]-β-D-glucopyranosyl group, etc.; R2 is β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl group, etc.] which is a constituent of "Amacha-zuru" (Gynostemapentaphyllum Makino, a plant belonging to Cucurbitaceae family), is hydrolyzed with a weak acid (e.g. acetic acid) to eliminate the saccharide from the substituent group of the 20-position. The hydrolyzed product is if necessary adsorbed with a polystyrene-based adsorbent resin and silica gel, and eluted. The eluate is evaporated to dryness, and developed and eluted by thin layer chromatography using a solvent to obtain the objective compound.
COPYRIGHT: (C)1981,JPO&Japio
JP6150880A 1980-03-11 1980-05-08 Preparation of saponin by acid hydrolysis Granted JPS56127400A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP6150880A JPS56127400A (en) 1980-05-08 1980-05-08 Preparation of saponin by acid hydrolysis
US06/205,377 US4339442A (en) 1980-03-11 1980-11-07 Gynosaponins, their use and a process for preparing the same
DE19803042117 DE3042117A1 (en) 1980-03-11 1980-11-07 GYNOSAPONINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAL PREPARATIONS CONTAINING THESE COMPOUNDS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6150880A JPS56127400A (en) 1980-05-08 1980-05-08 Preparation of saponin by acid hydrolysis

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP55030636A Division JPS6043359B2 (en) 1980-03-11 1980-03-11 Gynosaponins and their production method

Publications (2)

Publication Number Publication Date
JPS56127400A true JPS56127400A (en) 1981-10-06
JPS6352634B2 JPS6352634B2 (en) 1988-10-19

Family

ID=13173098

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6150880A Granted JPS56127400A (en) 1980-03-11 1980-05-08 Preparation of saponin by acid hydrolysis

Country Status (1)

Country Link
JP (1) JPS56127400A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102759597A (en) * 2011-04-29 2012-10-31 天津药物研究院 Rapid detection method of aescin component
CN112588318A (en) * 2020-12-15 2021-04-02 江南大学 Green and efficient preparation method of short-sugar-chain C21 steroid glycoside of radix cynanchi bungei

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102759597A (en) * 2011-04-29 2012-10-31 天津药物研究院 Rapid detection method of aescin component
CN112588318A (en) * 2020-12-15 2021-04-02 江南大学 Green and efficient preparation method of short-sugar-chain C21 steroid glycoside of radix cynanchi bungei
CN112588318B (en) * 2020-12-15 2022-02-15 江南大学 Green and efficient preparation method of short-sugar-chain C21 steroid glycoside of radix cynanchi bungei

Also Published As

Publication number Publication date
JPS6352634B2 (en) 1988-10-19

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