JPS5598185A - Novel maytansinoid compound and its preparation - Google Patents
Novel maytansinoid compound and its preparationInfo
- Publication number
- JPS5598185A JPS5598185A JP630779A JP630779A JPS5598185A JP S5598185 A JPS5598185 A JP S5598185A JP 630779 A JP630779 A JP 630779A JP 630779 A JP630779 A JP 630779A JP S5598185 A JPS5598185 A JP S5598185A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- compound
- maytansinoid compound
- maytansinol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A maytansinoid compound of formula I (X is H or Cl; R is hydrocarbon residue which may have a substituent).
EXAMPLE: Maytansinol 3-isopropyl carbonate.
USE: Medicines having mitosis inhibitory and antitumor actions, and antifungals and antiprotozoan agents.
PROCESS: Maytansinol of formula II or dechloromaytansinol is reacted with a halogenocarbonate, e.g. isopropyl chloroformate, of formula III (Y is halogen) in the presence of a base, e.g. an alkali metal (hydride), to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP630779A JPS5598185A (en) | 1979-01-22 | 1979-01-22 | Novel maytansinoid compound and its preparation |
US06/093,742 US4263294A (en) | 1978-11-20 | 1979-11-13 | Maytansinoids, pharmaceutical compositions thereof and method of use thereof |
EP79104537A EP0011302A1 (en) | 1978-11-20 | 1979-11-16 | Maytansinoids, their production and use |
CA340,192A CA1132981A (en) | 1978-11-20 | 1979-11-20 | Maytansinoids, their production and use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP630779A JPS5598185A (en) | 1979-01-22 | 1979-01-22 | Novel maytansinoid compound and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5598185A true JPS5598185A (en) | 1980-07-25 |
Family
ID=11634707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP630779A Pending JPS5598185A (en) | 1978-11-20 | 1979-01-22 | Novel maytansinoid compound and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5598185A (en) |
-
1979
- 1979-01-22 JP JP630779A patent/JPS5598185A/en active Pending
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