JPS5598185A - Novel maytansinoid compound and its preparation - Google Patents

Novel maytansinoid compound and its preparation

Info

Publication number
JPS5598185A
JPS5598185A JP630779A JP630779A JPS5598185A JP S5598185 A JPS5598185 A JP S5598185A JP 630779 A JP630779 A JP 630779A JP 630779 A JP630779 A JP 630779A JP S5598185 A JPS5598185 A JP S5598185A
Authority
JP
Japan
Prior art keywords
formula
preparation
compound
maytansinoid compound
maytansinol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP630779A
Other languages
Japanese (ja)
Inventor
Osamu Miyashita
Hiroshi Akimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP630779A priority Critical patent/JPS5598185A/en
Priority to US06/093,742 priority patent/US4263294A/en
Priority to EP79104537A priority patent/EP0011302A1/en
Priority to CA340,192A priority patent/CA1132981A/en
Publication of JPS5598185A publication Critical patent/JPS5598185A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A maytansinoid compound of formula I (X is H or Cl; R is hydrocarbon residue which may have a substituent).
EXAMPLE: Maytansinol 3-isopropyl carbonate.
USE: Medicines having mitosis inhibitory and antitumor actions, and antifungals and antiprotozoan agents.
PROCESS: Maytansinol of formula II or dechloromaytansinol is reacted with a halogenocarbonate, e.g. isopropyl chloroformate, of formula III (Y is halogen) in the presence of a base, e.g. an alkali metal (hydride), to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP630779A 1978-11-20 1979-01-22 Novel maytansinoid compound and its preparation Pending JPS5598185A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP630779A JPS5598185A (en) 1979-01-22 1979-01-22 Novel maytansinoid compound and its preparation
US06/093,742 US4263294A (en) 1978-11-20 1979-11-13 Maytansinoids, pharmaceutical compositions thereof and method of use thereof
EP79104537A EP0011302A1 (en) 1978-11-20 1979-11-16 Maytansinoids, their production and use
CA340,192A CA1132981A (en) 1978-11-20 1979-11-20 Maytansinoids, their production and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP630779A JPS5598185A (en) 1979-01-22 1979-01-22 Novel maytansinoid compound and its preparation

Publications (1)

Publication Number Publication Date
JPS5598185A true JPS5598185A (en) 1980-07-25

Family

ID=11634707

Family Applications (1)

Application Number Title Priority Date Filing Date
JP630779A Pending JPS5598185A (en) 1978-11-20 1979-01-22 Novel maytansinoid compound and its preparation

Country Status (1)

Country Link
JP (1) JPS5598185A (en)

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