JPS5583776A - 4,5,6,7-dehydro pgi1 derivative - Google Patents

4,5,6,7-dehydro pgi1 derivative

Info

Publication number
JPS5583776A
JPS5583776A JP15688578A JP15688578A JPS5583776A JP S5583776 A JPS5583776 A JP S5583776A JP 15688578 A JP15688578 A JP 15688578A JP 15688578 A JP15688578 A JP 15688578A JP S5583776 A JPS5583776 A JP S5583776A
Authority
JP
Japan
Prior art keywords
pgi
dehydro
derivative
alkyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15688578A
Other languages
Japanese (ja)
Other versions
JPS6215550B2 (en
Inventor
Hisao Nishiyama
Kiyotaka Ono
Shintaro Nishio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP15688578A priority Critical patent/JPS5583776A/en
Publication of JPS5583776A publication Critical patent/JPS5583776A/en
Publication of JPS6215550B2 publication Critical patent/JPS6215550B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:4,5,6,7-Dehydro PGI1 derivative of formula VI: (R1 is H, 1W12C alkyl, 3W10C cycloalkyl, 7W12C aralkyl, phenyl group, etc.; R2 is 1W12C alkyl, or alkyl, 3W10C cycloalkyl, or 7W12C aralkyl group which may have 0W5 oxygen atoms linked to any positions).
EXAMPLE: 4,5,6,7-Dehydro PGI1-methyl ester.
USE: Medicines similar to PGI2 having blood platelet antiagglutinative, gastric acid secretion inhibitory, and peripheral vasodilator actions. The structural instability is eliminated while retaining the 6,9α-epoxy structure which is important to PGI2.
PROCESS: A compound obtained from a PGF2α derivative by the singlet oxygen is oxidized, cyclized, and deacetylated to give the compound of formula VI.
COPYRIGHT: (C)1980,JPO&Japio
JP15688578A 1978-12-21 1978-12-21 4,5,6,7-dehydro pgi1 derivative Granted JPS5583776A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15688578A JPS5583776A (en) 1978-12-21 1978-12-21 4,5,6,7-dehydro pgi1 derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15688578A JPS5583776A (en) 1978-12-21 1978-12-21 4,5,6,7-dehydro pgi1 derivative

Publications (2)

Publication Number Publication Date
JPS5583776A true JPS5583776A (en) 1980-06-24
JPS6215550B2 JPS6215550B2 (en) 1987-04-08

Family

ID=15637511

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15688578A Granted JPS5583776A (en) 1978-12-21 1978-12-21 4,5,6,7-dehydro pgi1 derivative

Country Status (1)

Country Link
JP (1) JPS5583776A (en)

Also Published As

Publication number Publication date
JPS6215550B2 (en) 1987-04-08

Similar Documents

Publication Publication Date Title
US4108901A (en) Composition and process 2-decarboxy-2-hydroxy-methyl-5-oxa-ω-phenyl-PGE1 compounds
US4061666A (en) 5,6-Didehydro-ω-aryl-11-deoxy-PGE2 analogs
US4097529A (en) 2-Decarboxy-2-hydroxymethyl-11-deoxy-PGE1 analogs
US4088691A (en) 2-Decarboxy-2-hydroxymethyl-cis-4,5-didehydro-11-deoxy-PGE1, compounds
JPS5251020A (en) Compositions for combatting pests and mehod of making the same
US4203924A (en) 2-Decarboxy-2-hydroxymethyl-deoxy-9,10-didehydro-PGD2 analogs
JPS5583776A (en) 4,5,6,7-dehydro pgi1 derivative
JPS523046A (en) Prepration of 4-homotwistane-3-carboxylic acid esters
JPS5315317A (en) 5-acetoamino-2-hydroxyvaleric acid, its lower esters, and modifier of smoking taste of tobacco containing said compounds
US4321370A (en) 2,5-Inter-o-phenylene-3,4-dinor-6,9α-epoxy-6β-PGF1 compounds
JPS5583775A (en) 13,14-epoxyprostaglandin
US4171460A (en) 2-Decarboxy-2-hydroxymethyl-PGF1 α analogs
US4209645A (en) 2-Decarboxy-2-hydroxymethyl PGF2 αanalogs
JPS5233627A (en) Preparation of novel o,o-dialkyl-o-(n-alkoxy-halogeno-acycimidoyl) pho sphates or thionophosphates
US4176236A (en) Composition and process
JPS5283457A (en) Preparation of gamma-lactone derivative
JPS5283436A (en) Preparation of intermediates for synthesis of prostaglandin
JPS5262295A (en) Preparation of n1-oxy-2-thioadenosines
JPS5253838A (en) Preparation of novel 16-alkyl-20-alkoxyprostadienoic acid alkyl ester derivtives
DE2960160D1 (en) Thiol-phosphoric-acid-s-4-nitro-2-trichloromethylphenyl esters, their preparation and their application
JPS5444638A (en) Production of cyclopentanecarboxylic ester derivative
JPS5242884A (en) Preparation of 2,3,6-trimethyl hydroquinone-1-nicotinic acid esters
JPS52236A (en) Process for preparation of alpha-substituted benzylphenylether derivatives
JPS523031A (en) Novel tyrosinol derivatives
JPS5363382A (en) Nicotinic acid esters and their preparation