JPS5572163A - Preparation of 1-(2,6-dichlorophenyl)-indolinone - Google Patents

Preparation of 1-(2,6-dichlorophenyl)-indolinone

Info

Publication number
JPS5572163A
JPS5572163A JP14573178A JP14573178A JPS5572163A JP S5572163 A JPS5572163 A JP S5572163A JP 14573178 A JP14573178 A JP 14573178A JP 14573178 A JP14573178 A JP 14573178A JP S5572163 A JPS5572163 A JP S5572163A
Authority
JP
Japan
Prior art keywords
dichlorophenyl
dione
reacting
dichloroanilino
indoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14573178A
Other languages
Japanese (ja)
Other versions
JPS5919538B2 (en
Inventor
Muneaki Takase
Masao Okuyama
Naoki Fukuda
Toshihiko Komatsu
Takashi Iwaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zenyaku Kogyo KK
Original Assignee
Zenyaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo KK filed Critical Zenyaku Kogyo KK
Priority to JP14573178A priority Critical patent/JPS5919538B2/en
Publication of JPS5572163A publication Critical patent/JPS5572163A/en
Publication of JPS5919538B2 publication Critical patent/JPS5919538B2/en
Expired legal-status Critical Current

Links

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  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound useful as an intermediate of 0-(2,6-dichloroanilino)-phenylacetic acid, in high yield, by reducing 1-(2,6-dichlorophenyl)- indoline-2,3-dione with HI and red phosphorus.
CONSTITUTION: The objective compound III is prepared by (1) reacting 2,6-dichloroaniline with 2-iodobenzoic acid methyl ester in a solvent in the presence of potassium carbonate, at 170W240°C, (2) reacting the resulting product with sodium dimsyl to obtain O-(2,6-dichloroanilino)-ω-(methylsulfinyl)acetophenone I, (3) reacting the compound I with cupric halide to afford 1-(2,6-dichlorophenyl)-indoline-2,3-dione II, and (4) reducing the dione II with hydrogen iodide and red phosphorus. Each step can be carried out in high yield and in a short time, and the yield of the whole reaction is also high.
COPYRIGHT: (C)1980,JPO&Japio
JP14573178A 1978-11-25 1978-11-25 Method for producing 1-(2,6-dichlorophenyl)-2-indolinone Expired JPS5919538B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14573178A JPS5919538B2 (en) 1978-11-25 1978-11-25 Method for producing 1-(2,6-dichlorophenyl)-2-indolinone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14573178A JPS5919538B2 (en) 1978-11-25 1978-11-25 Method for producing 1-(2,6-dichlorophenyl)-2-indolinone

Publications (2)

Publication Number Publication Date
JPS5572163A true JPS5572163A (en) 1980-05-30
JPS5919538B2 JPS5919538B2 (en) 1984-05-07

Family

ID=15391829

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14573178A Expired JPS5919538B2 (en) 1978-11-25 1978-11-25 Method for producing 1-(2,6-dichlorophenyl)-2-indolinone

Country Status (1)

Country Link
JP (1) JPS5919538B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103145574A (en) * 2013-04-02 2013-06-12 中国人民解放军防化学院 Method for preparing diclofenac sodium

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0219752U (en) * 1988-07-26 1990-02-08

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103145574A (en) * 2013-04-02 2013-06-12 中国人民解放军防化学院 Method for preparing diclofenac sodium

Also Published As

Publication number Publication date
JPS5919538B2 (en) 1984-05-07

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