JPS5547653A - Novel vitamin d derivative and its preparation - Google Patents
Novel vitamin d derivative and its preparationInfo
- Publication number
- JPS5547653A JPS5547653A JP11991578A JP11991578A JPS5547653A JP S5547653 A JPS5547653 A JP S5547653A JP 11991578 A JP11991578 A JP 11991578A JP 11991578 A JP11991578 A JP 11991578A JP S5547653 A JPS5547653 A JP S5547653A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- preparation
- vitamin
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:1α-Hydroxyvitamin D3 derivatives of formula I (R is H or hydroxyl).
EXAMPLE: Cholesta-5,7-diene-1α,3β-diol-hemisuccinate.
USE: They have strong vitamin D-like activity and are used as a hapten for preparing the antibody for the determination of vitamin D derivatives by the radioimmunoassay method.
PREPARATION: The reaction between a steroid derivative of formula II and succinic anhydride in the presence of a basic substance as pyridine is effected under an inert atmoshpere as nitrogen. The excess reactants are distilled off and the residue is passed over a column chromatography to form a derivative of formula III in which the 3-position is substituted. The compound of formula III is dissolved in a solvent as hydrocarbon and irradiated with ultraviolet rays at room temperature under an inert atmosphere to be converted into previtamine D3 derivative of formula IV, which is isomerized into title compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11991578A JPS5547653A (en) | 1978-09-30 | 1978-09-30 | Novel vitamin d derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11991578A JPS5547653A (en) | 1978-09-30 | 1978-09-30 | Novel vitamin d derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5547653A true JPS5547653A (en) | 1980-04-04 |
JPS6148497B2 JPS6148497B2 (en) | 1986-10-24 |
Family
ID=14773331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11991578A Granted JPS5547653A (en) | 1978-09-30 | 1978-09-30 | Novel vitamin d derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5547653A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5892656A (en) * | 1981-11-30 | 1983-06-02 | Teijin Ltd | Novel vitamin d3 derivative and its preparation |
JPS59148775A (en) * | 1983-02-14 | 1984-08-25 | Teijin Ltd | 25-hydroxyvitamin d3-26,23-lactone derivative and its preparation |
JPS60130581A (en) * | 1983-12-19 | 1985-07-12 | Teijin Ltd | Production of 1alpha,25-dihydroxyvitamin d3-26,23-lactone |
US5075465A (en) * | 1987-10-14 | 1991-12-24 | Toyo Jozo Kabushiki Kaisha | 25-hydroxy vitamin d3 derivatives, process for their production, and assay method using the same |
US5117018A (en) * | 1988-10-05 | 1992-05-26 | Toyo Jozo Kabushiki Kaisha | 1α (or 24R), 25-dihydroxy vitamin D3 derivatives |
US5202266A (en) * | 1987-10-14 | 1993-04-13 | Asahi Kasei Kogyo Kabushiki Kaisha | 25-hydroxy vitamin D3 derivatives, process for their production, and assay method using the same |
US5214170A (en) * | 1988-10-05 | 1993-05-25 | Toyo Jozo Kabushiki Kaisha | Radioisotope iodine-labeled 1α (or 24R), 25-dihydroxy vitamin D3 |
-
1978
- 1978-09-30 JP JP11991578A patent/JPS5547653A/en active Granted
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5892656A (en) * | 1981-11-30 | 1983-06-02 | Teijin Ltd | Novel vitamin d3 derivative and its preparation |
JPS59148775A (en) * | 1983-02-14 | 1984-08-25 | Teijin Ltd | 25-hydroxyvitamin d3-26,23-lactone derivative and its preparation |
JPS60130581A (en) * | 1983-12-19 | 1985-07-12 | Teijin Ltd | Production of 1alpha,25-dihydroxyvitamin d3-26,23-lactone |
JPH0251551B2 (en) * | 1983-12-19 | 1990-11-07 | Teijin Ltd | |
US5075465A (en) * | 1987-10-14 | 1991-12-24 | Toyo Jozo Kabushiki Kaisha | 25-hydroxy vitamin d3 derivatives, process for their production, and assay method using the same |
US5202266A (en) * | 1987-10-14 | 1993-04-13 | Asahi Kasei Kogyo Kabushiki Kaisha | 25-hydroxy vitamin D3 derivatives, process for their production, and assay method using the same |
US5117018A (en) * | 1988-10-05 | 1992-05-26 | Toyo Jozo Kabushiki Kaisha | 1α (or 24R), 25-dihydroxy vitamin D3 derivatives |
US5214170A (en) * | 1988-10-05 | 1993-05-25 | Toyo Jozo Kabushiki Kaisha | Radioisotope iodine-labeled 1α (or 24R), 25-dihydroxy vitamin D3 |
Also Published As
Publication number | Publication date |
---|---|
JPS6148497B2 (en) | 1986-10-24 |
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