JPS55164630A - Freeze-dried preparation of anti-hbs globulin - Google Patents
Freeze-dried preparation of anti-hbs globulinInfo
- Publication number
- JPS55164630A JPS55164630A JP7319979A JP7319979A JPS55164630A JP S55164630 A JPS55164630 A JP S55164630A JP 7319979 A JP7319979 A JP 7319979A JP 7319979 A JP7319979 A JP 7319979A JP S55164630 A JPS55164630 A JP S55164630A
- Authority
- JP
- Japan
- Prior art keywords
- hbs
- globulin
- freeze
- drying
- purified anti
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PURPOSE: To obtain the titled preparation useful for the prevention of viral hepatitis type B, and having improved storage stability, by adding a stabilizing agent to an aqueous solution of purified anti-HBs globulin, and freeze-drying the mixture.
CONSTITUTION: The titled preparation is obtained by (1) adjusting the protein concentration of an aqueous solution of purified anti-HBs globulin below 10% (W/V), (2) dissolving (a) 1W5% (W/V) of a neutral amino acid (e.g. aminoacetic acid), (b) 0W2% (W/V) of a vehicle, (c) 0.1W2% (W/V) of a neutral salt (e.g. sodium chloride), and (d) 0.01W0.05% (W/V) of a polymeric nonionic surface active agent having a molecular weight of 2,000W20,000 (e.g. polyoxyethylene polyoxypropylene copolymer) in the above solution, (3) adjusting the pH of the mixture between 5 and 7.5, and (4) freeze-drying the product. The purified anti- HBs globulin can be obtained by the conventional fractionation of anti-HBs positive blood-plasma. The preparation thus obtained is free from lowering of the isotonicity and antibody titer by drying, and can be stored for ≥5 years at ≤10°C without lowering the antibody titer.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7319979A JPS55164630A (en) | 1979-06-11 | 1979-06-11 | Freeze-dried preparation of anti-hbs globulin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7319979A JPS55164630A (en) | 1979-06-11 | 1979-06-11 | Freeze-dried preparation of anti-hbs globulin |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55164630A true JPS55164630A (en) | 1980-12-22 |
Family
ID=13511229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7319979A Pending JPS55164630A (en) | 1979-06-11 | 1979-06-11 | Freeze-dried preparation of anti-hbs globulin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55164630A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995003826A1 (en) * | 1993-07-30 | 1995-02-09 | Pasteur Merieux Sérums Et Vaccins | Stabilised immunoglobulin preparations and method for preparing same |
US5945098A (en) * | 1990-02-01 | 1999-08-31 | Baxter International Inc. | Stable intravenously-administrable immune globulin preparation |
WO2007074880A1 (en) * | 2005-12-28 | 2007-07-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing stabilizing preparation |
US8511916B2 (en) | 2010-02-22 | 2013-08-20 | Seiko Precision Inc. | Blade driving device and optical instrument |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5347515A (en) * | 1976-10-13 | 1978-04-28 | Green Cross Corp:The | Gamma-globulin pharmaceutical preparation for intravenous injection |
JPS5423115A (en) * | 1977-07-19 | 1979-02-21 | Green Cross Corp:The | Gamma-globulin for intravenous injection and its preparation |
-
1979
- 1979-06-11 JP JP7319979A patent/JPS55164630A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5347515A (en) * | 1976-10-13 | 1978-04-28 | Green Cross Corp:The | Gamma-globulin pharmaceutical preparation for intravenous injection |
JPS5423115A (en) * | 1977-07-19 | 1979-02-21 | Green Cross Corp:The | Gamma-globulin for intravenous injection and its preparation |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5945098A (en) * | 1990-02-01 | 1999-08-31 | Baxter International Inc. | Stable intravenously-administrable immune globulin preparation |
WO1995003826A1 (en) * | 1993-07-30 | 1995-02-09 | Pasteur Merieux Sérums Et Vaccins | Stabilised immunoglobulin preparations and method for preparing same |
FR2708467A1 (en) * | 1993-07-30 | 1995-02-10 | Pasteur Merieux Serums Vacc | Stabilized immunoglobulin preparations and process for their preparation. |
WO2007074880A1 (en) * | 2005-12-28 | 2007-07-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing stabilizing preparation |
JP5231810B2 (en) * | 2005-12-28 | 2013-07-10 | 中外製薬株式会社 | Antibody-containing stabilized preparation |
US9084777B2 (en) | 2005-12-28 | 2015-07-21 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing formulations |
US10316096B2 (en) | 2005-12-28 | 2019-06-11 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing formulations |
US8511916B2 (en) | 2010-02-22 | 2013-08-20 | Seiko Precision Inc. | Blade driving device and optical instrument |
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