JPS55164630A - Freeze-dried preparation of anti-hbs globulin - Google Patents

Freeze-dried preparation of anti-hbs globulin

Info

Publication number
JPS55164630A
JPS55164630A JP7319979A JP7319979A JPS55164630A JP S55164630 A JPS55164630 A JP S55164630A JP 7319979 A JP7319979 A JP 7319979A JP 7319979 A JP7319979 A JP 7319979A JP S55164630 A JPS55164630 A JP S55164630A
Authority
JP
Japan
Prior art keywords
hbs
globulin
freeze
drying
purified anti
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7319979A
Other languages
Japanese (ja)
Inventor
Satoru Funakoshi
Yatsuhiro Kamimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Priority to JP7319979A priority Critical patent/JPS55164630A/en
Publication of JPS55164630A publication Critical patent/JPS55164630A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PURPOSE: To obtain the titled preparation useful for the prevention of viral hepatitis type B, and having improved storage stability, by adding a stabilizing agent to an aqueous solution of purified anti-HBs globulin, and freeze-drying the mixture.
CONSTITUTION: The titled preparation is obtained by (1) adjusting the protein concentration of an aqueous solution of purified anti-HBs globulin below 10% (W/V), (2) dissolving (a) 1W5% (W/V) of a neutral amino acid (e.g. aminoacetic acid), (b) 0W2% (W/V) of a vehicle, (c) 0.1W2% (W/V) of a neutral salt (e.g. sodium chloride), and (d) 0.01W0.05% (W/V) of a polymeric nonionic surface active agent having a molecular weight of 2,000W20,000 (e.g. polyoxyethylene polyoxypropylene copolymer) in the above solution, (3) adjusting the pH of the mixture between 5 and 7.5, and (4) freeze-drying the product. The purified anti- HBs globulin can be obtained by the conventional fractionation of anti-HBs positive blood-plasma. The preparation thus obtained is free from lowering of the isotonicity and antibody titer by drying, and can be stored for ≥5 years at ≤10°C without lowering the antibody titer.
COPYRIGHT: (C)1980,JPO&Japio
JP7319979A 1979-06-11 1979-06-11 Freeze-dried preparation of anti-hbs globulin Pending JPS55164630A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7319979A JPS55164630A (en) 1979-06-11 1979-06-11 Freeze-dried preparation of anti-hbs globulin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7319979A JPS55164630A (en) 1979-06-11 1979-06-11 Freeze-dried preparation of anti-hbs globulin

Publications (1)

Publication Number Publication Date
JPS55164630A true JPS55164630A (en) 1980-12-22

Family

ID=13511229

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7319979A Pending JPS55164630A (en) 1979-06-11 1979-06-11 Freeze-dried preparation of anti-hbs globulin

Country Status (1)

Country Link
JP (1) JPS55164630A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003826A1 (en) * 1993-07-30 1995-02-09 Pasteur Merieux Sérums Et Vaccins Stabilised immunoglobulin preparations and method for preparing same
US5945098A (en) * 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
WO2007074880A1 (en) * 2005-12-28 2007-07-05 Chugai Seiyaku Kabushiki Kaisha Antibody-containing stabilizing preparation
US8511916B2 (en) 2010-02-22 2013-08-20 Seiko Precision Inc. Blade driving device and optical instrument

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5347515A (en) * 1976-10-13 1978-04-28 Green Cross Corp:The Gamma-globulin pharmaceutical preparation for intravenous injection
JPS5423115A (en) * 1977-07-19 1979-02-21 Green Cross Corp:The Gamma-globulin for intravenous injection and its preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5347515A (en) * 1976-10-13 1978-04-28 Green Cross Corp:The Gamma-globulin pharmaceutical preparation for intravenous injection
JPS5423115A (en) * 1977-07-19 1979-02-21 Green Cross Corp:The Gamma-globulin for intravenous injection and its preparation

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945098A (en) * 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
WO1995003826A1 (en) * 1993-07-30 1995-02-09 Pasteur Merieux Sérums Et Vaccins Stabilised immunoglobulin preparations and method for preparing same
FR2708467A1 (en) * 1993-07-30 1995-02-10 Pasteur Merieux Serums Vacc Stabilized immunoglobulin preparations and process for their preparation.
WO2007074880A1 (en) * 2005-12-28 2007-07-05 Chugai Seiyaku Kabushiki Kaisha Antibody-containing stabilizing preparation
JP5231810B2 (en) * 2005-12-28 2013-07-10 中外製薬株式会社 Antibody-containing stabilized preparation
US9084777B2 (en) 2005-12-28 2015-07-21 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing formulations
US10316096B2 (en) 2005-12-28 2019-06-11 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing formulations
US8511916B2 (en) 2010-02-22 2013-08-20 Seiko Precision Inc. Blade driving device and optical instrument

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