JPS55129295A - Amidino derivative of insulin secretion stimulating substance - Google Patents

Amidino derivative of insulin secretion stimulating substance

Info

Publication number
JPS55129295A
JPS55129295A JP3587779A JP3587779A JPS55129295A JP S55129295 A JPS55129295 A JP S55129295A JP 3587779 A JP3587779 A JP 3587779A JP 3587779 A JP3587779 A JP 3587779A JP S55129295 A JPS55129295 A JP S55129295A
Authority
JP
Japan
Prior art keywords
insulin secretion
stimulating substance
secretion stimulating
cultures
isolated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3587779A
Other languages
Japanese (ja)
Other versions
JPS6223759B2 (en
Inventor
Katsumi Nogimori
Kiyoshi Ito
Makoto Tamura
Akio Terajima
Toshi Murai
Chikanori Tomioka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Kakenyaku Kako KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd, Kakenyaku Kako KK filed Critical Kaken Pharmaceutical Co Ltd
Priority to JP3587779A priority Critical patent/JPS55129295A/en
Publication of JPS55129295A publication Critical patent/JPS55129295A/en
Publication of JPS6223759B2 publication Critical patent/JPS6223759B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

NEW MATERIAL:A reaction product of an insulin secretion stimulating substance, isolated from cultures of microorganisms belonging to the genus Bordetella, with an amidination agent of the formula (R1 is H, 1W4C alkyl group, etc.; R2 is 1W4C alkyl group).
USE: Remedies and preventives for diabetes, with little side effects, e.g. leucocytosis actions.
PROCESS: An insulin secretion stimulating substance (1AP), isolated from cultures of microorganisms belonging to the genus Bordetella, and an amidination agent, e.g. ethyl acetimidate hydrochloride, of the formula are dissolved in a 1M carbonic acid buffer containing 1M of urea and reacted at room temperature for 20min. The reaction product is purified by gel filtration to form the objective compound.
COPYRIGHT: (C)1980,JPO&Japio
JP3587779A 1979-03-27 1979-03-27 Amidino derivative of insulin secretion stimulating substance Granted JPS55129295A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3587779A JPS55129295A (en) 1979-03-27 1979-03-27 Amidino derivative of insulin secretion stimulating substance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3587779A JPS55129295A (en) 1979-03-27 1979-03-27 Amidino derivative of insulin secretion stimulating substance

Publications (2)

Publication Number Publication Date
JPS55129295A true JPS55129295A (en) 1980-10-06
JPS6223759B2 JPS6223759B2 (en) 1987-05-25

Family

ID=12454223

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3587779A Granted JPS55129295A (en) 1979-03-27 1979-03-27 Amidino derivative of insulin secretion stimulating substance

Country Status (1)

Country Link
JP (1) JPS55129295A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125892A2 (en) * 1983-05-11 1984-11-21 Kaken Pharmaceutical Co., Ltd. Islets-activating protein derivatives
JPH0788A (en) * 1993-06-15 1995-01-06 Minoru Sangyo Kk Apparatus for spraying chemical liquid for agriculture

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125892A2 (en) * 1983-05-11 1984-11-21 Kaken Pharmaceutical Co., Ltd. Islets-activating protein derivatives
EP0125892B1 (en) * 1983-05-11 1989-11-08 Kaken Pharmaceutical Co., Ltd. Islets-activating protein derivatives
JPH0788A (en) * 1993-06-15 1995-01-06 Minoru Sangyo Kk Apparatus for spraying chemical liquid for agriculture

Also Published As

Publication number Publication date
JPS6223759B2 (en) 1987-05-25

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