JPS55122780A - Preparation of theobromine derivative - Google Patents
Preparation of theobromine derivativeInfo
- Publication number
- JPS55122780A JPS55122780A JP2893479A JP2893479A JPS55122780A JP S55122780 A JPS55122780 A JP S55122780A JP 2893479 A JP2893479 A JP 2893479A JP 2893479 A JP2893479 A JP 2893479A JP S55122780 A JPS55122780 A JP S55122780A
- Authority
- JP
- Japan
- Prior art keywords
- theobromine
- alkali
- dibromopropane
- acetylacetone
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title compound in two steps, by reacting theobromine with 1,3-dibromopropane in a specific solvent in the presence of an alkali, and then reacting the product with acetylacetone in ethanol in the presence of an alkali carbonate and optionally KI.
CONSTITUTION: Theobromine is reacted with 1,3-dibromopropane in the presence of an alkali carbonate or an alkali hydroxide, in an organic solvent which is a poor solvent of alkali metal salts of theobromine, and the resulting 1-(3-bromopropyl)theobromine of formula II is made to react with acetylacetone in ethanol, in the presence of an alkali carbonate, and if necessary, potassium iodide (reaction accerelator), to obtain the objective compound I.
EFFECT: The objective compound can be prepared with simple operation and treatment, in high yield, without using hazardous substance and special apparatus and tool.
USE: Remedy for cerebral thrombosis, having excellent vasodilating effect.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2893479A JPS55122780A (en) | 1979-03-13 | 1979-03-13 | Preparation of theobromine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2893479A JPS55122780A (en) | 1979-03-13 | 1979-03-13 | Preparation of theobromine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55122780A true JPS55122780A (en) | 1980-09-20 |
Family
ID=12262220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2893479A Pending JPS55122780A (en) | 1979-03-13 | 1979-03-13 | Preparation of theobromine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55122780A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS567785A (en) * | 1979-07-02 | 1981-01-27 | Maruko Seiyaku Kk | Preparation of theobromine derivative |
-
1979
- 1979-03-13 JP JP2893479A patent/JPS55122780A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS567785A (en) * | 1979-07-02 | 1981-01-27 | Maruko Seiyaku Kk | Preparation of theobromine derivative |
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