JPS55111481A - Ester type hypotensive agent - Google Patents

Ester type hypotensive agent

Info

Publication number
JPS55111481A
JPS55111481A JP1881279A JP1881279A JPS55111481A JP S55111481 A JPS55111481 A JP S55111481A JP 1881279 A JP1881279 A JP 1881279A JP 1881279 A JP1881279 A JP 1881279A JP S55111481 A JPS55111481 A JP S55111481A
Authority
JP
Japan
Prior art keywords
formula
compound shown
lower alkyl
hypotensive agent
ester type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1881279A
Other languages
Japanese (ja)
Other versions
JPS6141512B2 (en
Inventor
Junichi Iwao
Masayuki Ooya
Tadashi Iso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Priority to JP1881279A priority Critical patent/JPS55111481A/en
Priority to US06/086,996 priority patent/US4483861A/en
Priority to GB7936988A priority patent/GB2038800B/en
Priority to SE7908994A priority patent/SE448541B/en
Priority to IT26923/79A priority patent/IT1124841B/en
Priority to CH977979A priority patent/CH642351A5/en
Priority to FR7926983A priority patent/FR2440365A1/en
Priority to DE19792944037 priority patent/DE2944037A1/en
Publication of JPS55111481A publication Critical patent/JPS55111481A/en
Priority to US06/395,128 priority patent/US4496578A/en
Publication of JPS6141512B2 publication Critical patent/JPS6141512B2/ja
Granted legal-status Critical Current

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  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by the formula I (Q is CH2 or S; R<1> is H, alkyl, cycloalkyl; R<2> is H, lower alkyl, aralkyl; R<3> is acryloxy lower alkyl or lower alkyl bonded to imide; A is 1-3C alkylene) or its salt. EXAMPLE:(4R)-[(2s)-S-benzoyl-3-mercapto-2-methylpropanoyl]-4-thiazolid inecarboxylic acid (1,3-dihydro-1,3-dioxo-2H-isoindole-2-yl) methyl ester. USE:A hypotensive agent having improved absorption characteristics and prolonged action. PROCESS:A compound shown by the formula II is reacted with a compound shown by the formula R<3>-X (X is halogen) to give the desired compound shown by the formula I. When the compound is prescribed to a human or an animal, it is hydrolyzed enzymically and chemically to release an enzyme inhibritor of angiotensin conversion.
JP1881279A 1978-10-31 1979-02-19 Ester type hypotensive agent Granted JPS55111481A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP1881279A JPS55111481A (en) 1979-02-19 1979-02-19 Ester type hypotensive agent
US06/086,996 US4483861A (en) 1978-10-31 1979-10-22 Antihypertensive sulfur-containing compounds
GB7936988A GB2038800B (en) 1978-10-31 1979-10-25 Antihypertensive sulphurcontaining compounds
SE7908994A SE448541B (en) 1978-10-31 1979-10-30 NEW TIAZOLIDINE AND PYRROLIDINE DERIVATIVES AND A PHARMACEUTICAL PREPARATION THEREOF
IT26923/79A IT1124841B (en) 1978-10-31 1979-10-30 COMPOUNDS CONTAINING SULFUR ANTI-HYPERTENSION
CH977979A CH642351A5 (en) 1978-10-31 1979-10-31 Antihypertensive, SULPHUR CONTAINING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND CONTAINING THEM Pharmaceutical Compositions.
FR7926983A FR2440365A1 (en) 1978-10-31 1979-10-31 NOVEL MERCAPTO-AZOLIDINE-CARBOXYLIC ACID DERIVATIVES USEFUL AS HYPERTENSORS
DE19792944037 DE2944037A1 (en) 1978-10-31 1979-10-31 ANTI-HYPERTENSIVE SULFURING COMPOUNDS
US06/395,128 US4496578A (en) 1978-10-31 1982-07-06 Antihypertensive sulfur-containing compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1881279A JPS55111481A (en) 1979-02-19 1979-02-19 Ester type hypotensive agent

Publications (2)

Publication Number Publication Date
JPS55111481A true JPS55111481A (en) 1980-08-28
JPS6141512B2 JPS6141512B2 (en) 1986-09-16

Family

ID=11981987

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1881279A Granted JPS55111481A (en) 1978-10-31 1979-02-19 Ester type hypotensive agent

Country Status (1)

Country Link
JP (1) JPS55111481A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0331214U (en) * 1989-08-07 1991-03-27
JP7236642B2 (en) 2019-02-05 2023-03-10 パナソニックＩｐマネジメント株式会社 Light source device and projection type image display device

Also Published As

Publication number Publication date
JPS6141512B2 (en) 1986-09-16

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