JPS5484086A - Microbial preparation of hydantoinase specimen - Google Patents
Microbial preparation of hydantoinase specimenInfo
- Publication number
- JPS5484086A JPS5484086A JP14855677A JP14855677A JPS5484086A JP S5484086 A JPS5484086 A JP S5484086A JP 14855677 A JP14855677 A JP 14855677A JP 14855677 A JP14855677 A JP 14855677A JP S5484086 A JPS5484086 A JP S5484086A
- Authority
- JP
- Japan
- Prior art keywords
- specimen
- hydantoinase
- microbials
- pref
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Enzymes And Modification Thereof (AREA)
Abstract
PURPOSE: To prepare the title specimen useful for the preparation of D-N-carbamoylamino acid useful as an intermediate of pharmaceuticals, by culturing microbials in a medium containing a pyrimidine nucleic acid base, thereby stereospecifically hydrolyzing the 5-substituted hydantoin of the base.
CONSTITUTION: Hydantionase-producing microbials, pref. Pseudomonas striata IFO 12996, Mycobacterium smegmatis ATCC 607, etc., are inoculated in a medium containing usually 0.05W0.5 wt%, pref. o.1W0.2 wt% of a pyrimidine nucleic acid base or its derivative, such as uracil, cytosine, thymine, etc., and aerobically cultured at 20W 40°C, and pH5-9 for 10W75 hours. The hydantoinase specimen is separated from the microbial cells.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14855677A JPS5484086A (en) | 1977-12-09 | 1977-12-09 | Microbial preparation of hydantoinase specimen |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14855677A JPS5484086A (en) | 1977-12-09 | 1977-12-09 | Microbial preparation of hydantoinase specimen |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5484086A true JPS5484086A (en) | 1979-07-04 |
JPS6154397B2 JPS6154397B2 (en) | 1986-11-21 |
Family
ID=15455388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14855677A Granted JPS5484086A (en) | 1977-12-09 | 1977-12-09 | Microbial preparation of hydantoinase specimen |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5484086A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0219034A2 (en) * | 1985-10-09 | 1987-04-22 | BASF Aktiengesellschaft | Process for the preparation of mesophilic microorganisms containing D-hydantoinase active at a higher temperature |
WO2002072841A1 (en) * | 2001-03-08 | 2002-09-19 | Ajinomoto Co., Inc. | Dna encoding hydantoinase, dna encoding n-carbamyl-l-amino acid hydrolase, recombinant dna, transformed cells, process for producing protein and process for producing optically active amino acid |
-
1977
- 1977-12-09 JP JP14855677A patent/JPS5484086A/en active Granted
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0219034A2 (en) * | 1985-10-09 | 1987-04-22 | BASF Aktiengesellschaft | Process for the preparation of mesophilic microorganisms containing D-hydantoinase active at a higher temperature |
US4912044A (en) * | 1985-10-09 | 1990-03-27 | Basf Aktiengesellschaft | Preparation of mesophilic microorganisms which contain a D-hydantoinase which is active at elevated temperature |
WO2002072841A1 (en) * | 2001-03-08 | 2002-09-19 | Ajinomoto Co., Inc. | Dna encoding hydantoinase, dna encoding n-carbamyl-l-amino acid hydrolase, recombinant dna, transformed cells, process for producing protein and process for producing optically active amino acid |
US7098020B2 (en) | 2001-03-08 | 2006-08-29 | Ajinomoto Co., Inc. | DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein, and method of producing optically active amino acid |
US7361490B2 (en) | 2001-03-08 | 2008-04-22 | Ajinomoto Co., Inc. | DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein and method of producing optically active amino acid |
US8460902B1 (en) | 2001-03-08 | 2013-06-11 | Ajinomoto Co., Inc. | DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein, and method of producing optically active amino acid |
Also Published As
Publication number | Publication date |
---|---|
JPS6154397B2 (en) | 1986-11-21 |
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