JPS54151988A - 55fluorouracil derivative*its manufacture and antiitumor drug containing it - Google Patents

55fluorouracil derivative*its manufacture and antiitumor drug containing it

Info

Publication number
JPS54151988A
JPS54151988A JP5847078A JP5847078A JPS54151988A JP S54151988 A JPS54151988 A JP S54151988A JP 5847078 A JP5847078 A JP 5847078A JP 5847078 A JP5847078 A JP 5847078A JP S54151988 A JPS54151988 A JP S54151988A
Authority
JP
Japan
Prior art keywords
antiitumor
derivative
manufacture
drug containing
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5847078A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6134428B2 (enrdf_load_stackoverflow
Inventor
Takeshi Tomiyama
Itaru Tomiyama
Kouichi Kubota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kotobuki Seiyaku Co Ltd
Original Assignee
Kotobuki Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kotobuki Seiyaku Co Ltd filed Critical Kotobuki Seiyaku Co Ltd
Priority to JP5847078A priority Critical patent/JPS54151988A/ja
Priority to BE78190883A priority patent/BE870982A/xx
Publication of JPS54151988A publication Critical patent/JPS54151988A/ja
Publication of JPS6134428B2 publication Critical patent/JPS6134428B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP5847078A 1978-05-17 1978-05-17 55fluorouracil derivative*its manufacture and antiitumor drug containing it Granted JPS54151988A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP5847078A JPS54151988A (en) 1978-05-17 1978-05-17 55fluorouracil derivative*its manufacture and antiitumor drug containing it
BE78190883A BE870982A (fr) 1978-05-17 1978-10-03 Derives de 5-fluorouracile, leur preparation et leur utilisation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5847078A JPS54151988A (en) 1978-05-17 1978-05-17 55fluorouracil derivative*its manufacture and antiitumor drug containing it

Publications (2)

Publication Number Publication Date
JPS54151988A true JPS54151988A (en) 1979-11-29
JPS6134428B2 JPS6134428B2 (enrdf_load_stackoverflow) 1986-08-07

Family

ID=13085309

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5847078A Granted JPS54151988A (en) 1978-05-17 1978-05-17 55fluorouracil derivative*its manufacture and antiitumor drug containing it

Country Status (2)

Country Link
JP (1) JPS54151988A (enrdf_load_stackoverflow)
BE (1) BE870982A (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil

Also Published As

Publication number Publication date
BE870982A (fr) 1979-02-01
JPS6134428B2 (enrdf_load_stackoverflow) 1986-08-07

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