JPS54145627A - Preparation of 2-(2,6-dichloroanilino)phenyl acetic acid - Google Patents

Preparation of 2-(2,6-dichloroanilino)phenyl acetic acid

Info

Publication number
JPS54145627A
JPS54145627A JP5373078A JP5373078A JPS54145627A JP S54145627 A JPS54145627 A JP S54145627A JP 5373078 A JP5373078 A JP 5373078A JP 5373078 A JP5373078 A JP 5373078A JP S54145627 A JPS54145627 A JP S54145627A
Authority
JP
Japan
Prior art keywords
dichloroanilino
acetic acid
benzyl
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5373078A
Other languages
Japanese (ja)
Inventor
Ryoji Sakota
Isao Hashiba
Shuichi Fukushima
Kazuo Endo
Genichi Dobashi
Katsuyuki Ogura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Sagami Chemical Research Institute
Original Assignee
Nissan Chemical Corp
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp, Sagami Chemical Research Institute filed Critical Nissan Chemical Corp
Priority to JP5373078A priority Critical patent/JPS54145627A/en
Publication of JPS54145627A publication Critical patent/JPS54145627A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the title compound nearly quantitatively with an extremely simple operation by the hydrogenolysis of a novel 2-(N-benzyl-2,6-dichloroanilino) phenyl acetic acid in the presence of a precious metal catalyst under specific reaction conditions and in a specific ratio of the material to the catalyst.
CONSTITUTION: 1-[N-Benzyl-o-(2,6-dichloroanilino)phenyl]-2-methylsulphinyl- 2-methylthioethylene is dissolved in 1,2-dimethoxyethane. To this solution are added concentrated hydrochloric acid, and then methylene chloride and water. The separationn of the organic solution gives novel 2-(N-benzyl-2,6-dichloroanilino)phenyl acetic acid of formula II, which is subjected to hydrogenolysis with H2 in a solvent in an amount of 2W30 times that of the compound of formula II, at normal or higher pressure at 30W170°C in the presence of 0.1W100wt% based on the compound of formula II of a precious metal cvatalyst.
USE: A sodium salt of the objective compound is an antiphlogistic and analgesic.
COPYRIGHT: (C)1979,JPO&Japio
JP5373078A 1978-05-08 1978-05-08 Preparation of 2-(2,6-dichloroanilino)phenyl acetic acid Pending JPS54145627A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5373078A JPS54145627A (en) 1978-05-08 1978-05-08 Preparation of 2-(2,6-dichloroanilino)phenyl acetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5373078A JPS54145627A (en) 1978-05-08 1978-05-08 Preparation of 2-(2,6-dichloroanilino)phenyl acetic acid

Publications (1)

Publication Number Publication Date
JPS54145627A true JPS54145627A (en) 1979-11-14

Family

ID=12950936

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5373078A Pending JPS54145627A (en) 1978-05-08 1978-05-08 Preparation of 2-(2,6-dichloroanilino)phenyl acetic acid

Country Status (1)

Country Link
JP (1) JPS54145627A (en)

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