JPS54145627A - Preparation of 2-(2,6-dichloroanilino)phenyl acetic acid - Google Patents
Preparation of 2-(2,6-dichloroanilino)phenyl acetic acidInfo
- Publication number
- JPS54145627A JPS54145627A JP5373078A JP5373078A JPS54145627A JP S54145627 A JPS54145627 A JP S54145627A JP 5373078 A JP5373078 A JP 5373078A JP 5373078 A JP5373078 A JP 5373078A JP S54145627 A JPS54145627 A JP S54145627A
- Authority
- JP
- Japan
- Prior art keywords
- dichloroanilino
- acetic acid
- benzyl
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound nearly quantitatively with an extremely simple operation by the hydrogenolysis of a novel 2-(N-benzyl-2,6-dichloroanilino) phenyl acetic acid in the presence of a precious metal catalyst under specific reaction conditions and in a specific ratio of the material to the catalyst.
CONSTITUTION: 1-[N-Benzyl-o-(2,6-dichloroanilino)phenyl]-2-methylsulphinyl- 2-methylthioethylene is dissolved in 1,2-dimethoxyethane. To this solution are added concentrated hydrochloric acid, and then methylene chloride and water. The separationn of the organic solution gives novel 2-(N-benzyl-2,6-dichloroanilino)phenyl acetic acid of formula II, which is subjected to hydrogenolysis with H2 in a solvent in an amount of 2W30 times that of the compound of formula II, at normal or higher pressure at 30W170°C in the presence of 0.1W100wt% based on the compound of formula II of a precious metal cvatalyst.
USE: A sodium salt of the objective compound is an antiphlogistic and analgesic.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5373078A JPS54145627A (en) | 1978-05-08 | 1978-05-08 | Preparation of 2-(2,6-dichloroanilino)phenyl acetic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5373078A JPS54145627A (en) | 1978-05-08 | 1978-05-08 | Preparation of 2-(2,6-dichloroanilino)phenyl acetic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54145627A true JPS54145627A (en) | 1979-11-14 |
Family
ID=12950936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5373078A Pending JPS54145627A (en) | 1978-05-08 | 1978-05-08 | Preparation of 2-(2,6-dichloroanilino)phenyl acetic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54145627A (en) |
-
1978
- 1978-05-08 JP JP5373078A patent/JPS54145627A/en active Pending
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