JPS54132587A - Preparation of 5-fluorouracil - Google Patents

Preparation of 5-fluorouracil

Info

Publication number
JPS54132587A
JPS54132587A JP4100678A JP4100678A JPS54132587A JP S54132587 A JPS54132587 A JP S54132587A JP 4100678 A JP4100678 A JP 4100678A JP 4100678 A JP4100678 A JP 4100678A JP S54132587 A JPS54132587 A JP S54132587A
Authority
JP
Japan
Prior art keywords
fluorouracil
dihydrocytosine
fluoro
hydroxy
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4100678A
Other languages
Japanese (ja)
Other versions
JPS6111225B2 (en
Inventor
Kazuo Sakuma
Yasushi Fukai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanto Denka Kogyo Co Ltd
Mitsui Toatsu Chemicals Inc
Original Assignee
Kanto Denka Kogyo Co Ltd
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanto Denka Kogyo Co Ltd, Mitsui Toatsu Chemicals Inc filed Critical Kanto Denka Kogyo Co Ltd
Priority to JP4100678A priority Critical patent/JPS54132587A/en
Publication of JPS54132587A publication Critical patent/JPS54132587A/en
Publication of JPS6111225B2 publication Critical patent/JPS6111225B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To prepare 5-fluorouracil useful as a carcinostatic agent, in a simple process, by the deamination of 5-fluoro-6-hydroxy-5,6-dihydrocytosine at proper temperature and acid concentration, followed by the dehydration at an elevated temperature.
CONSTITUTION: 5-Fluorouracil of formula II is prepared by (1) deaminating 5-fluoro-6-hydroxy-5,6-dihydrocytosine of formula I in an aqueous solution containing 0.1W6 M/l of an acid (e.g. HC1) at 20W70°C, and (2) dehydrating the product by heating at 70W100°C, pref. 90W100°C.
COPYRIGHT: (C)1979,JPO&Japio
JP4100678A 1978-04-07 1978-04-07 Preparation of 5-fluorouracil Granted JPS54132587A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4100678A JPS54132587A (en) 1978-04-07 1978-04-07 Preparation of 5-fluorouracil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4100678A JPS54132587A (en) 1978-04-07 1978-04-07 Preparation of 5-fluorouracil

Publications (2)

Publication Number Publication Date
JPS54132587A true JPS54132587A (en) 1979-10-15
JPS6111225B2 JPS6111225B2 (en) 1986-04-01

Family

ID=12596298

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4100678A Granted JPS54132587A (en) 1978-04-07 1978-04-07 Preparation of 5-fluorouracil

Country Status (1)

Country Link
JP (1) JPS54132587A (en)

Also Published As

Publication number Publication date
JPS6111225B2 (en) 1986-04-01

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