JPS54132587A - Preparation of 5-fluorouracil - Google Patents
Preparation of 5-fluorouracilInfo
- Publication number
- JPS54132587A JPS54132587A JP4100678A JP4100678A JPS54132587A JP S54132587 A JPS54132587 A JP S54132587A JP 4100678 A JP4100678 A JP 4100678A JP 4100678 A JP4100678 A JP 4100678A JP S54132587 A JPS54132587 A JP S54132587A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouracil
- dihydrocytosine
- fluoro
- hydroxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare 5-fluorouracil useful as a carcinostatic agent, in a simple process, by the deamination of 5-fluoro-6-hydroxy-5,6-dihydrocytosine at proper temperature and acid concentration, followed by the dehydration at an elevated temperature.
CONSTITUTION: 5-Fluorouracil of formula II is prepared by (1) deaminating 5-fluoro-6-hydroxy-5,6-dihydrocytosine of formula I in an aqueous solution containing 0.1W6 M/l of an acid (e.g. HC1) at 20W70°C, and (2) dehydrating the product by heating at 70W100°C, pref. 90W100°C.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4100678A JPS54132587A (en) | 1978-04-07 | 1978-04-07 | Preparation of 5-fluorouracil |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4100678A JPS54132587A (en) | 1978-04-07 | 1978-04-07 | Preparation of 5-fluorouracil |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54132587A true JPS54132587A (en) | 1979-10-15 |
JPS6111225B2 JPS6111225B2 (en) | 1986-04-01 |
Family
ID=12596298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4100678A Granted JPS54132587A (en) | 1978-04-07 | 1978-04-07 | Preparation of 5-fluorouracil |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54132587A (en) |
-
1978
- 1978-04-07 JP JP4100678A patent/JPS54132587A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6111225B2 (en) | 1986-04-01 |
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