JPS54112847A - Preparation of novel 3alpha, 6alpha-dihydroxy-24-oxo-5beta-cholestane - Google Patents
Preparation of novel 3alpha, 6alpha-dihydroxy-24-oxo-5beta-cholestaneInfo
- Publication number
- JPS54112847A JPS54112847A JP13986877A JP13986877A JPS54112847A JP S54112847 A JPS54112847 A JP S54112847A JP 13986877 A JP13986877 A JP 13986877A JP 13986877 A JP13986877 A JP 13986877A JP S54112847 A JPS54112847 A JP S54112847A
- Authority
- JP
- Japan
- Prior art keywords
- dihydroxy
- formula
- cholestane
- oxo
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- HONQRLPRSAESGO-JOSISPIVSA-N (6r)-6-[(3r,5r,6s,8s,9s,10r,13r,14s,17r)-3,6-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylheptan-3-one Chemical compound C([C@H]1[C@@H](O)C2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCC(=O)C(C)C)[C@@]2(C)CC1 HONQRLPRSAESGO-JOSISPIVSA-N 0.000 title 1
- BJYLYJCXYAMOFT-RRXOBRNQSA-N (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCC(O)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C BJYLYJCXYAMOFT-RRXOBRNQSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 230000000737 periodic effect Effects 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 239000011647 vitamin D3 Substances 0.000 abstract 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Steroid Compounds (AREA)
Abstract
NEW MATERIAL:A 3α, 6α-dihydroxy-24-oxo-5β-cholestane of formula I: (R12 is H or hydroxyl-protecting group; R22 is H or hydroxyl-protecting group).
USE: An intermediate for preparing 1α, 24-dihydroxy-cholecalciferol which is active vitamin D3.
PROCESS: A compound of formula II: (R1 and R2 are hydroxyl-protecting groups; X is halogen), which is a halide derivative of commercially available inexpensive hyodeoxylcholic acid, is reacted with an isopropyl-metal adduct of formula III: (M is metallic atom of Groups IIb or IIIb in the periodic table; ipr is isopropyl group), and, if necessary, hydrolyzed to give the objective compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13986877A JPS54112847A (en) | 1977-11-24 | 1977-11-24 | Preparation of novel 3alpha, 6alpha-dihydroxy-24-oxo-5beta-cholestane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13986877A JPS54112847A (en) | 1977-11-24 | 1977-11-24 | Preparation of novel 3alpha, 6alpha-dihydroxy-24-oxo-5beta-cholestane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS54112847A true JPS54112847A (en) | 1979-09-04 |
Family
ID=15255415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13986877A Pending JPS54112847A (en) | 1977-11-24 | 1977-11-24 | Preparation of novel 3alpha, 6alpha-dihydroxy-24-oxo-5beta-cholestane |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS54112847A (en) |
-
1977
- 1977-11-24 JP JP13986877A patent/JPS54112847A/en active Pending
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