JPS54109990A - Crystals of cyclophosphamide - Google Patents

Crystals of cyclophosphamide

Info

Publication number
JPS54109990A
JPS54109990A JP1630478A JP1630478A JPS54109990A JP S54109990 A JPS54109990 A JP S54109990A JP 1630478 A JP1630478 A JP 1630478A JP 1630478 A JP1630478 A JP 1630478A JP S54109990 A JPS54109990 A JP S54109990A
Authority
JP
Japan
Prior art keywords
cyclophosphamide
formula
preparation
room temperature
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1630478A
Other languages
Japanese (ja)
Inventor
Tadao Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP1630478A priority Critical patent/JPS54109990A/en
Publication of JPS54109990A publication Critical patent/JPS54109990A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:Water-free crystals of cyclophosphamide given as the formula.
USE: Remedy for giant follicular lymphoma, Hodgkin's disease, lymphatic leukaemia and reticulo sarcoma. The anhydrous crystal form improves the shelf stability and processability on preparation.
PREPARATION: An anhydrous oil of cyclophosphamide of the formula is dissolved in an ether solvent at room temperature to 100°C and crystal seeds of cyclophosphamide are added to the solution. Then the solution is stood at 0°C to room temperature to crystallize out the objective compound.
COPYRIGHT: (C)1979,JPO&Japio
JP1630478A 1978-02-14 1978-02-14 Crystals of cyclophosphamide Pending JPS54109990A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1630478A JPS54109990A (en) 1978-02-14 1978-02-14 Crystals of cyclophosphamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1630478A JPS54109990A (en) 1978-02-14 1978-02-14 Crystals of cyclophosphamide

Publications (1)

Publication Number Publication Date
JPS54109990A true JPS54109990A (en) 1979-08-29

Family

ID=11912791

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1630478A Pending JPS54109990A (en) 1978-02-14 1978-02-14 Crystals of cyclophosphamide

Country Status (1)

Country Link
JP (1) JPS54109990A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114437130A (en) * 2022-02-18 2022-05-06 安徽普利药业有限公司 Method for refining cyclophosphamide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF THE AMERICAN SOCIETY=1977 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114437130A (en) * 2022-02-18 2022-05-06 安徽普利药业有限公司 Method for refining cyclophosphamide
CN114437130B (en) * 2022-02-18 2024-05-17 安徽普利药业有限公司 Process for purifying cyclophosphamide

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