JPH1176910A - Applicator and coating utensil using the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prevent a chemical from leaking before using an applicator even when pressurized by laminating a chemical sealing material for sealing a chemical and having notches, a covering material for covering the notches, and a coating material for applying the chemical in order. SOLUTION: An applicator is constituted of a chemical sealing material which has e.g. linear or, V-shaped notches forming openings by pressure on use, a covering material for wholly and partially covering the notches in which films, fabrics, or the like for preventing the covering material from being drawn when removed are laminated, and a coating material of a chemical. As the coating material, that which can apply the chemical to a material to be coated, such as water flow slip non-woven fabric is used, and that which is excellent in diffusibility, such as non-woven fabric is interposed between the coating material and a chemical sealing material. In the applicator, the chemical sealing material, the covering material, and the coating material are laminated in order, or moreover, a diffusing material and/or a holding material is laminated between the covering material and the coating material and a defoaming material that is not mixed with the chemical is stuck to any of the coating material, the holding material or the diffusing material for the chemical. The chemical is prevented from leaking during manufacture, transport, custody, or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a drug application material and an applicator using the same.

[0002]

2. Description of the Related Art Conventionally, a coating material in which a coating material such as a medicine is sealed in a film bag which can be opened by applying pressure is disclosed in Japanese Patent Laid-Open Publication No.
No. 3971 discloses this. However, these coating materials have a problem that the coating material is opened due to unexpected pressure during manufacturing, transportation, or storage, and the coating material leaks.

[0003]

[Problems to be solved by the invention]
As a result of various studies, the inventors have succeeded in developing a coating material that does not leak medicine even when pressurized before using the coating material. An object of the present invention is to provide an application material that does not leak a medicine even when pressed, and an application tool using the same.

[0004]

Means for Solving the Problems The present invention is directed to a coating method in which a drug enclosure having a cut in which a drug is sealed, a coating material for coating the cut, and a coating material for coating the drug are sequentially laminated. About materials.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The coating material according to the present invention has a cutout for forming an opening by a pressure during use, a drug-filled material in which a drug is sealed, a coating material for covering the cutout, And a substance coated with a drug. Since the cuts are covered with the coating material in this manner and the openings are not formed unless a certain amount of pressure is applied, the drug does not leak during manufacturing, transportation, or storage. It is preferable that the drug inclusion is a plastic film bag that has excellent airtightness and does not easily break under pressure. This is a preferred embodiment when the drug enclosure is divided into a plurality of spaces, since the amount of drug release can be adjusted.

In the case of a straight cut, the cut is S-shaped, V-shaped, W-shaped, L-shaped, J-shaped, N-shaped, U-shaped, Z-shaped, semicircular, U-shaped. In the case where a predetermined shape can be formed by connecting notches and the ends of the notches, or like a Y-shape, an X-shape, a T-shape, a K-shape, an H-shape,
In some cases, a predetermined shape can be formed by connecting the ends of the cuts to the ends of the cuts. Among these, it is preferable that a predetermined shape can be formed by tying the notches and the ends of the notches, and that a predetermined shape can be formed by connecting the notches and the ends of the notches. In the case of a linear shape, the length is preferably about 2 to 10 mm, more preferably about 4 to 8 mm.
On the other hand, in the case where a predetermined shape can be formed by connecting notches and the ends of the notches, or in the case where a predetermined shape can be formed by connecting the ends of the notches and the ends of the notches, the area per one of these predetermined shapes Is 0.2 ~
It is preferably ² mm ² , more preferably 0.4 to ¹ mm ² . In addition, when a predetermined shape can be formed by connecting notches to the ends of the notches, or when a predetermined shape can be formed by connecting the ends of the notches to the ends of the notches, the total area of these predetermined shapes is a drug. It is preferably 0.01 to 0.1%, more preferably 0.02 to 0.08% of the area of one side of the inclusion. The cuts are preferably arranged so that the cuts do not become larger than the cuts when removing the covering material. For example, in the case of a V-shaped cut, it is preferable to arrange the cut material so that a straight line connecting the cut ends to the longitudinal direction of the coating material (see FIG. 1).
Preferably, the cuts are formed in two or more rows so that the entire medicine can be used up. Further, it is preferable that the size of the cut at both ends is made larger than the size of the cut other than both ends so that the medicine can be applied uniformly.

[0007] Since the invention of this application has a covering material for covering these cuts, it is possible to reliably prevent leakage of the drug before using the coating material. This covering material may be in the form of a sheet for covering the whole of the drug enclosure, or may be in the form of a tape for partially covering the same. Among them, a tape-shaped partly covered tape is a preferred embodiment because a cut can be partially exposed and the amount of drug release can be adjusted. Note that a film, a woven fabric, a nonwoven fabric, a gauze, a knit, or a laminate of fibers or the like is particularly preferable in order to prevent the coating material from stretching when the coating material is peeled off. This coating material can cover the cuts in the drug enclosure by, for example, adhering to the drug enclosure with an adhesive or fusing with the drug enclosure. When the latter coating material is fused with the drug encapsulation, as the coating material, a surface layer made of a resin having a high affinity with the resin constituting the surface of the drug encapsulation, and a resin having an affinity with the resin constituting the surface layer It is preferable to use a film made of a low resin and made of at least two layers of a release layer adjacent to the surface layer. When the surface layer of the coating material composed of the two or more films is fused to a portion other than the cut of the drug enclosure so that the surface layer of the coating material is in contact with the drug enclosure,
At the fused portion, the affinity between the surface layer of the coating material and the drug inclusion is higher than the affinity between the surface layer of the coating material and the release layer. It is possible to peel off the coating material while leaving it at the notched portion where it is not fused, and to peel off the entire coating material without leaving a surface layer of the coating material on the surface of the drug encapsulation to expose the cut. it can. In this case, the coating material can be peeled off without applying force to the cut, and the cut is not enlarged, which is preferable.

[0008] As the coating substance, any substance can be used as long as it can apply a chemical to a substance to be coated, and nonwoven fabric, woven fabric, knitted fabric, paper and the like are used, and nonwoven fabric is preferable. A hydroentangled nonwoven is preferred.

[0009] It is preferable that a diffusion material for a drug is provided between the drug inclusion and the coating substance. As the diffusing material, a non-woven fabric is preferable so as to be excellent in diffusing properties of the drug, and a non-woven fabric having an apparent density of 0.01 to 0.1 g / cm ³ is particularly preferable. As such a nonwoven fabric, for example, there is a nonwoven fabric obtained by fusing a fiber web containing a core-sheath type composite fiber, and a nonwoven fabric obtained by fusing a fiber web containing a composite fiber containing polyethylene having a sheath component having excellent chemical resistance is particularly preferable. . By doing so, the drug is diffused throughout the applied substance, so that it can be applied uniformly.

It is preferable that a medicine holding material is provided between the medicine filling material and the applied substance. As a holding material,
It is preferable that the porous material is a porous material so as to have excellent drug retention, and the apparent density of the porous material is 0.05 to 0.6.
g / cm ³ . Examples of the porous substance include, for example, a needle punch method, an entanglement method such as a water entanglement method, a nonwoven fabric obtained by partial or full fusion with a fusion fiber, a foam, and the like. A nonwoven fabric obtained by an entanglement method such as a needle punch method and a water entanglement method, which is more excellent in drug retention, can be suitably used. In addition, as a preferable constituent material of the nonwoven fabric, although it differs depending on the drug, when the drug is an aqueous emulsion, it is composed of a hydrolyzate of acrylic fiber, a crosslinked polyacrylate, and a crosslinked carboxymethylcellulose. Highly water-absorbent fiber, rayon fiber, polynosic fiber, cupra fiber, acetate fiber, cellulose fiber such as tencel fiber, water-absorbent fiber such as vegetable fiber such as cotton fiber, hemp fiber, and the same composition as these fibers It is preferable to use a water-absorbing substance such as a powder alone or in an appropriate combination. Among these, the superabsorbent fiber is particularly excellent in the retention of the aqueous emulsion drug,
It is a suitable combination. In this way, the medicine can be held, so that the medicine can be uniformly applied and the service life can be extended.

Further, it is preferable that the drug is impregnated into a porous body such as a sponge or a nonwoven fabric and is held in the drug enclosure. As this nonwoven fabric, the same material as the holding material can be used. By doing so, the medicine can be released little by little, so that the service life is further extended.

[0012] The coating material is formed by laminating a medicine filling material, a coating material, and a coating material in this order, or a diffusion material and / or a holding material between the coating material and the coating material. When laminating a diffusion material and a holding material, a drug enclosure, a coating material, a diffusion material, a holding material,
It is preferable to laminate in the order of the application substances. These materials may be joined by an adhesive or by fusion.

In the case where a diffusion material and / or a holding material are provided, the medicine encapsulating material and the coating substance may be joined, and the diffusion material and / or the holding material may be inserted between the materials to be laminated. . By doing so, the diffusing material and / or
Alternatively, the holding material can be replaced as needed.

Further, in the present invention, it is preferable that the coating material is laminated so that the cutout of the drug encapsulant is exposed to the surface covered with the coating material. Since the coating material can be peeled off after the cutout of the drug inclusion is exposed on the surface covered with the coating material, the workability is excellent. As a method of laminating so that the notched surface of the drug encapsulant can be exposed on the surface, for example, lamination is performed in a state where a part of the drug encapsulation is fixed to the coating substance, or the drug encapsulation is Are stacked in a state where they are not fixed to. When only a part of the drug inclusion is fixed, it may be fixed in a linear or dot shape. For example, in the case of a rectangular drug enclosure, it is preferable to fix only one side.

In the present invention, it is preferable that an antifoaming agent not mixed with a drug adheres to at least one of a coating substance, a drug holding material, and a drug diffusing material. By using an antifoaming agent in this way, it is possible to prevent the occurrence of spots due to the breakage of bubbles generated when the agent is applied.

The defoaming agent may be any as long as it can destroy generated bubbles, and examples thereof include lower alcohols, higher alcohols, oils and fats, fatty acids, fatty acid esters, phosphate esters, metal soaps, mineral oils, and silicones. Of these, silicone is particularly preferred.

The silicone is preferably dimethyl silicone oil, organically modified silicone oil, fluorosilicone oil, or silica / silicone compound. Further, as lower alcohols, methanol and butanol, as higher alcohols, octyl alcohol and hexadecyl alcohol, as fats and oils, as fats and oils and surfactants, as fatty acids, as oleic acid and stearic acid, as fatty acid esters, as fatty acid esters And glycerin monolaurate; phosphate esters as tributyl phosphate; metal soaps as calcium stearate and aluminum stearate; and mineral oils as mineral oil and a surfactant, respectively. In the present invention, it is preferable that an antifoaming agent which is not mixed with a drug is attached to the attached matter by 0.1 to 1 mass%.

The coating material is preferably fixed with a fixture having a handle, a rod, or the like so that the workability is excellent. By doing so, the application material can be more easily used. To this end, it is preferable that at least one of the drug enclosure, the applied substance, the holding material, and the diffusing material is larger than the fixing portion of the fixing device so that the coating material can be fixed to the fixing device. By increasing the size, the portion protruding from the fixing portion of the fixing device can be used as a fixing portion for fixing the fixing device to the fixing device. When the coating material is used as it is, a material having a shape that can be easily held by hand may be laminated on the medicine enclosure.

Each material may be made of a material having a plurality of properties, such as a material in which a diffusion material and a holding material are integrated.

The chemicals vary depending on the use of the coating material. Examples thereof include waxes, resins, surfactants, oils, antibacterial agents, fungicides, moisture absorbents, water repellents, antistatic agents, ultraviolet absorbers, and infrared rays. Absorbent, flame retardant, fragrance, water absorbing agent, etc. alone,
Alternatively, these can be used by appropriately mixing.

[0021]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. Example 1 A V-shaped notch 3 shown in FIG. 1 (a notch 3A having an area of 0.625 mm ^{2 and} a notch 3B having an area of 0.5 mm ² ) having a total area of one side of the drug inclusion as shown in FIG. 0.043% of the area of a three-layer polyethylene / nylon / polypropylene film having a length of 11 cm × width 21 cm and a thickness of 95 μm (length 10 c).
mx 20 cm) containing an aqueous emulsion wax. Next, the cut 3 on the side having the cut 3 was covered by sticking a synthetic paper coating material 4 coated with an acrylic adhesive having a width of 3 cm and a length of 21 cm. Next, a drug encapsulant is placed at the center of a hydroentangled nonwoven fabric (application substance 5) made of polyester fiber having a width of 14 cm × a length of 30 cm and an apparent density of 0.12 g / cm ³ so that the coating material 4 is sandwiched therebetween, and the drug is enclosed. One long side of the object was fused. And, between the coating material 4 and the application substance 5, a width 10
A holding material 7 made of a needle-punched nonwoven fabric obtained by mixing a polyester fiber having an apparent density of 0.1 g / cm ³ and a rayon fiber with a length of cm × 20 cm and an apparent density of 0.1 g / cm ³ was laminated to prepare a coating material 1 having a sectional shape shown in FIG. . The coating material 1 did not leak the drug before use, and when used, the coating material was peeled off, and the notch 3 was opened by pressure to apply the drug. In addition, the portion of the coating substance 5 where the drug inclusion 2 does not exist can be fixed to the handle with a handle and used, and the workability is excellent. Further, the coating material was able to expose the coating material to the surface by inverting the drug inclusion, and was easily peeled off.

Example 2 The four cuts at the end were made into a semicircle having a diameter of 1.4 mm (area per piece: 0.77 mm ² ), and the other twelve cuts were made into a semicircle having a diameter of 1.2 mm (one piece) 0.57 mm ² per area (total area is 0.05% of the area of one side of the drug inclusion)
A coating material was produced in the same manner as in Example 1.

Example 3 The procedure of Example 1 was repeated, except that the end four cuts were used as a straight line having a length of 6 mm, and the other twelve cuts were used as a straight line having a length of 5 mm. A coating material was produced in the same manner.

Example 4 S-shaped notch as shown in FIG. 2 (area 0.51 mm
² notches 3B and area 0.70mm ² notches 3A,
A coating material was prepared in the same manner as in Example 1, except that a drug enclosure containing a total area of 0.045% of the area of one side of the drug enclosure was used.

Example 5 A Y-shaped notch 3 as shown in FIG.
Notch 3B of m ² and notch 3 of area 0.65mm ²
A, the total area is 0.044% of the area of one side of the drug inclusion)
A coating material 1 was prepared in the same manner as in Example 1 except that a drug-filled material containing the was used.

Example 6 The coating material was 3 cm in width, 21 cm in length, polyethylene /
Same as Example 1 except that a two-layer film of polyester was used, and the polyethylene layer serving as the surface layer of the drug inclusion and the polyethylene layer of the coating material were fused and covered at locations other than the cuts. To prepare a coating material. In this coating material, the cut did not expand at all even when the coating material was peeled off.

Example 7 A three-layer product of polyethylene / nylon / polypropylene having a length of 11 cm × width 21 cm, a thickness of 95 μm, and two spaces (two spaces each of length 5 cm × width 20 cm) were prepared.
A coating material 1 having the cross-sectional shape shown in FIG. 5 was produced in the same manner as in Example 1, except that the drug enclosure 2 containing the aqueous emulsion wax was used. This coating material could control the amount of wax released.

Example 8 10 cm.times. Of a fibrous web composed of a composite fiber having polypropylene as a core component and polyethylene as a sheath component was fused.
The cross-sectional shape of FIG. 6 was changed in the same manner as in Example 1 except that the nonwoven fabric having a density of 20 cm and an apparent density of 0.03 g / cm ³ was laminated between the holding material 7 and the drug enclosure 2 as the diffusing material 6. A coating material 1 was prepared. This coating material could be applied uniformly and could be used for a long time.

Example 9 An application material 1 having the cross-sectional shape of FIG. 7 was produced in the same manner as in Example 1 except that the medicine enclosure 2 and the application substance 5 were simply laminated without being fused. This coating material could also easily peel off the coating material.

Example 10 A coating material was prepared in the same manner as in Example 1 except that dimethyl silicone oil as a defoaming agent was applied to the coating material in an amount of 0.5 mass%. This coating material could be applied with wax without causing spots.

[0031]

According to the coating material of the present invention, the cuts in the drug enclosure are covered with a coating material.
Since no opening is formed unless a certain pressure is applied, the drug does not leak during manufacturing, transportation, or storage. Since the notch that causes an opening by pressurization is on the coating substance side, the other side, for example, the mop side, the hand side, etc., is not contaminated by the chemical. If a drug diffusing material is provided between the drug inclusion and the applied substance, the drug is diffused throughout the applied substance and can be applied uniformly.
If a medicine holding material is provided between the medicine filling material and the applied substance, the medicine can be held and applied uniformly, and the service life can be extended. When the cut surface of the drug inclusion is laminated so as to be exposed on the surface, the coating material can be easily peeled after exposing the cut surface of the drug inclusion to the surface. When an antifoaming agent not mixed with a drug is attached to a coating substance, etc.,
It is possible to prevent spots due to breakage of air bubbles generated when applying.

[Brief description of the drawings]

FIG. 1 is a plan view of a drug inclusion.

FIG. 2 is another plan view of the drug inclusion.

FIG. 3 is another plan view of the drug inclusion.

FIG. 4 is a sectional view of a coating material.

FIG. 5 is a cross-sectional view of another coating material.

FIG. 6 is a sectional view of another coating material.

FIG. 7 is a cross-sectional view of another coating material.

[Explanation of symbols]

 REFERENCE SIGNS LIST 1 coating material 2 drug inclusion 3A cut 3B cut 4 coating material 5 coating material 6 diffusion material 7 holding material

 ──────────────────────────────────────────────────続 き Continuing from the front page (72) Inventor Hisao Nishikawa 1772-8 Yasu, Yasu-cho, Yasu-gun, Shiga Prefecture Inside Pacific Giken Co., Ltd. 8 Pacific Engineering Co., Ltd. (72) Inventor Toshiaki Sayanagi 2-14-5 Sotokanda, Chiyoda-ku, Tokyo Inside Japan Vilene Co., Ltd.

Claims (5)

[Claims] 1. A coating material comprising: a drug encapsulant having a cut in which a drug is sealed; a coating material for covering the cut; and a coating substance for coating the drug, which are sequentially laminated. 2. The coating material according to claim 1, wherein the cut has a linear shape with a length of 2 to 10 mm. 3. The coating material according to claim 1, wherein an area formed by connecting the cut and the end of the cut is a cut of 0.2 to ² mm ² . 4. The coating material according to claim 1, wherein an area formed by connecting the ends of the cuts to the ends of the cuts is 0.2 to ² mm ² . 5. An application tool, wherein the application material according to claim 1 is fixed by a fixing tool.