JPH11292126A - Vial container and vial container protector - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a simply structured vial container which can be hermetically sealed only by placing a plug wherein a seal member can be prevented from dropping into the container at the time of sticking through a connection needle and air permeability can be improved while the plug is halfway placed. SOLUTION: A seal member 30 is formed like a cap, a seal member holding portion of a lid member 20 is formed like a cap for friction-holding with this fitted inside, and a position for sticking through a connection needle is structured to be positioned above a seal member holding position. A through hole 24 which is to be a vent path while a plug is halfway placed and to be a receiving means for an elastic piece 23 during transition from the halfway placed state to a fully placed state is formed on a portion of a lid member cylinder to be positioned between a lower end of the seal member and an upper end of a container mouth when the plug is halfway placed.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a vial container capable of being in a half-plugged state in which the inside and the outside of the container communicate with each other, and a fully plugged state in which the inside of the container is sealed. And a protector for the vial container.

[0002]

2. Description of the Related Art Conventionally, a well-known vial container contains a medicine in a container body, freeze-dried,
A rubber stopper is plugged into the opening of the container body, and then an aluminum flip-off cap is wound tightly to seal. For this reason, it is necessary for the pharmaceutical manufacturer to perform a stoppering process in the freeze-drying chamber after the drug is freeze-dried, and then carry out the crimping step from the freeze-drying chamber. In addition, there are various inconveniences, such as deterioration of assembly efficiency due to the increase in the number of processes, the problem of hygiene and safety due to the use of aluminum, and the necessity of separate disposal.

To prevent such inconvenience, Japanese Patent Application Laid-Open No. 9-286453 discloses an apparatus having an opening or a needle window 112a in a top wall 112, as shown in FIGS. A cover member 110 made of a synthetic resin having a ventilation means between the outside and the inside of the bottle container 100 and a locking means for maintaining the stopper in a completely plugged state, on the inner peripheral surface of the shape portion 111; In a vial container fitted with a disc-shaped rubber stopper 120 for sealing between the inner surface of the top plate and the mouth of the bottle container in the fully stoppered state, The upper end is constituted by an elastic piece 113 which can be bent and deformed inward and upward in the radial direction of the lid member cylindrical portion, and the elastic pieces 113 are provided at appropriate intervals in the circumferential direction of the cylindrical portion 111. In addition, the ventilation means is provided between the elastic pieces in the circumferential direction. It has been described that constituted by 116. According to the configuration described in the above publication, the half-plugged state and the fully plugged state of the lid member are firmly maintained by the configuration, and the lid member can be prevented from floating in each state,
Further, various effects such as improvement of work efficiency can be achieved by eliminating the need for a winding step,
There is still room for improvement.

[0004] That is, the one described in the publication is a rubber stopper 12.
As shown in FIG. 10, when the dissolving solution such as distilled water is injected into the bottle container by piercing the communication needle, the rubber stopper is pulled radially inward as shown in FIG. There was a danger that the rubber stopper would fall into the vial container. In particular, when a large diameter needle such as a two-hole needle is used for the communication needle, a radially inward pulling force acting on the rubber stopper when the communication needle is pierced causes the lid member to clamp the rubber stopper. It is easy to be larger than the clamping pressure between the top plate and the surface of the mouth of the bottle container.
The danger of falling inside was likely to occur.

As shown in FIG. 8 which is a longitudinal sectional view passing through the elastic piece 113, the cover described in
The lower portion of the cylindrical portion is a thick portion 114, the elastic piece 113 is formed at the upper end of the thick portion, and further, when the lid member 110 shifts from a half-plugged state to a full-plugged state, A gap portion 115 accommodating the elastic piece 113 which is bent radially outward.
Since the structure of the lid member is complicated, for example, when it is provided above the thick portion, the cost increases due to the mold manufacturing cost and the like.

Further, according to the publication, the elastic pieces 113 are provided at appropriate intervals in the circumferential direction of the cylindrical portion, and the thickness of the thick portion in the circumferential direction of each elastic piece is reduced. An air passage 116 is formed (see FIG. 9), and since the air passage 116 is located below the bottle container opening, the air passage between the inside and the outside of the container has a U-turn shape as indicated by an arrow. Met. Therefore, sufficient air permeability between the inside and the outside of the container at the time of half tapping cannot be ensured, and the freeze-drying efficiency deteriorates.

[0007]

SUMMARY OF THE INVENTION The present invention has been made in order to solve the above-mentioned problems, and it is an object of the present invention to provide a vial container and a vial container protector which can form a sealed state only by a stoppering process. It is an object of the present invention to provide a vial container and a vial container protector that can effectively prevent the sealing member from falling into the container body when the communication needle is inserted into the sealing member.

[0008] Further, the present invention achieves the above object,
An object of the present invention is to provide a vial container having a simple structure capable of improving the air permeability between the inside and the outside of the container in a half stoppered state, and a protector for the vial container.

A further object of the present invention is to provide a protector for a vial container which can meet various outer diameters of the mouth while achieving the above object.

[0010]

In order to achieve the above object, the present invention has a container body having a body, an opening forming an opening above the body, and a central hole along the axial direction. A synthetic resin lid member having a cylindrical shape and a lower portion attached around the mouth of the container main body, and held by the lid member so as to face the container main body opening in a central hole of the lid member. An elastic seal member, wherein the lid member comprises:
In the vial container, the sealing member may be in a completely stoppered state in which the container member opening is closed by the seal member, and in a semi-plugged state in which the sealing member is separated from the container body opening. The member has a cap shape having a flange portion extending radially outward at a lower end,
At the time of the entire stopper state, the flange portion comes into contact with the upper end surface of the container main body mouth portion to close the container main body opening,
The lid member includes a cap-shaped holding portion that frictionally holds the seal member in an fitted state on an axially substantially central inner peripheral surface of the cylindrical portion, and the holding portion is provided for a needle communicating with a top wall. The cover member has an insertion hole, and the lid member further includes an air passage communicating the container body opening to the outside in a half-plugged state, a top end of the container body opening in a half-plugged state of the cylindrical portion, and a sealing member. A portion located between the lower ends of the flange portions is provided with a resilient piece that can be bent and deformed and has an inclined upper end facing radially inward and upward. During the transition to the stoppering state, the container body is bent radially outward by the mouth of the container to allow the lid member to transition, and after the lid member transitions to the entire stoppering state, the lid member enters the inclined state. Restoring, maintaining the entire stoppered state where the upper end abuts on the lower end face of the container body opening and maintains the entire stoppered state There is provided a vial container constituting the stage.

Preferably, the ventilation path is formed as a through-hole formed in the cylindrical portion of the lid member and communicating the center hole and the outside, and the through-hole changes from a half-plugged state of the lid member to a fully-plugged state. During the transition, the elastic piece bent radially outward by the container body opening can be accommodated.

Further, it is preferable that the lid member is provided with an easily removable closing member for closing an upper end opening of the cylindrical portion.

According to another aspect of the present invention, there is provided a synthetic resin tube having a central hole, wherein a lower portion has a body and an opening forming an opening above the body. A lid member attached to surround the mouth of the vial container body, and a seal member held by the lid member so as to face the container body opening in a central hole of the lid member, In a vial container protector adapted to be able to take a full stopper state in which the container body opening is closed by the seal member and a half stopper state in which the seal member is separated from the container body opening, the seal member has a lower end. Is a cap type having a flange portion extending radially outward, and in the fully stoppered state, the flange portion is in contact with the upper end surface of the container main body opening to close the container main body opening. The lid member includes a cap-shaped holding portion that frictionally holds the seal member in an fitted state on an axially substantially central inner peripheral surface of the cylindrical portion, and the holding portion is provided for a needle communicating with a top wall. Further, the lid member has an insertion hole, and the lid member is located between the upper end of the container body opening and the lower end of the seal member flange portion in the half-plugged state of the cylindrical portion, and the upper end is radially inward and An elastic piece capable of bending and deforming in an inclined state facing upward, and a vent hole communicating with the center hole and the outside are provided, and the elastic piece is changed from a half-plugged state of the lid member to a fully-plugged state. During the transition, while being bent in the radial direction outward by the container body opening and accommodated in the vent hole, after the transition of the entire stoppering state of the lid member, the lid member is restored to the inclined state, The upper end is in contact with the lower end surface of the mouth of the container body, and constitutes a whole stoppered state maintaining means for maintaining the stoppered state. There is provided a vial container for protector.

Preferably, a rib protruding radially inward can be formed on the inner peripheral surface of the cylindrical portion of the lid member facing the outer peripheral surface of the container main body after the transition to the completely plugged state.

[0015]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of a vial container according to the present invention will be described below with reference to the accompanying drawings. FIG. 1 is a longitudinal sectional view of a vial container according to the present embodiment, and shows a case where a lid member is in a half-plugged state. FIG. 2 is an enlarged view of a lid member portion in FIG.
FIGS. 3 and 4 are enlarged views of the lid member at the time of transition from the half-plugged state to the full-plugged state and after the transition to the fully-plugged state, respectively.

As shown in the figure, a vial container 1 according to the present embodiment has a container body 10 having a body 11 and a mouth 12 forming an opening above the body, and a central hole along the axial direction. A synthetic resin lid member 20 having a lower portion attached around the mouth portion 12 of the container body.
And a cap-shaped elastic seal member 30 held by the lid member 20 so as to face the container main body opening in the center hole of the lid member 20. In the drawing, reference numeral 40 denotes a protective cap for preventing impurities from adhering to the cover member 20 at the time of transfer or the like, and is removed when the solution is injected into the vial container using the communication needle.

The lid member 20 is fully plugged so that the opening of the container body is closed by the seal member 30 (see FIG. 3).
And a half-plugged state (see FIG. 1) in which the seal member 30 is separated from the opening of the container main body.

As shown in FIG. 2, the sealing member 30 held in the center hole of the lid member 20 has a cylindrical body 31b.
An upper wall portion 31c for closing the upper opening of the body portion; and a flange portion 31 extending radially outward from the outer peripheral surface below the body portion.
and a form a hat that is integrally formed. The upper wall 3
1c is a site through which the communication needle for dissolving solution injection is pierced,
In order to facilitate the penetration of the communication needle, it is preferable to make the communication needle thinner than other parts. Preferably, a rib 32 protruding radially outward can be formed on the outer peripheral surface of the body portion 31b, whereby the seal member 30 can be held by a lid member holding portion described later in a holding property. Can be improved.

The lid member 20 includes a first flange portion 21a extending radially inward from an inner circumferential surface substantially at the center in the axial direction of the cylindrical portion,
A cap-shaped holding portion 21 having a peripheral wall portion 21b extending upward from an inner end of the first flange portion and a second flange portion 21c extending radially inward from an upper end of the peripheral wall portion is integrally provided. . In the holding portion 21, the first flange portion 21a, the peripheral wall portion 21b, and the second flange portion 21c abut against the flange portion 31a, the body portion 31b, and the upper wall portion 31c of the seal member 30, respectively. 30 is frictionally held in an internally fitted state. In addition,
In the present embodiment, as shown in FIG.
Although b is substantially vertical, the peripheral wall portion 21b may be tapered so that the inner diameter decreases from above to below in order to improve the retention of the seal member 30.

As shown in FIG. 1 and FIG.
In the inner peripheral surface of the cylindrical portion 0, a portion located between the upper end of the container main body mouth portion 12 and the lower end of the seal member 30 in the half-plugged state has a slanting posture in which the upper end takes a radially inward and upward direction. An elastic piece 23 that can be flexibly deformed is integrally formed. Further, a vent hole 24 for communicating the center hole with the outside is formed in the portion of the cylindrical portion of the lid member 20. The ventilation hole 24
Is an air passage between the inside and the outside of the container when the lid member 20 is freeze-dried in a half stoppered state. Further, as shown in the figure, a rib 25 protruding radially inward may be formed on a portion of the inner peripheral surface of the lid member tubular portion that comes into contact with the outer peripheral surface of the container body opening portion in the fully stoppered state. it can.
By providing the rib 25, the lid member 20 can be applied to container bodies having various diameters.

Here, the operation of the elastic piece 23 when the lid member 20 is in the half-plugged state, in the transition from the half-plugged state to the full-plugged state, and in the full-plugged state will be described. I do.

First, in the half-plugged state, as shown in FIGS. 1 and 2, the elastic piece 23 is in the inclined position, and the lower surface thereof is in contact with the upper end of the container main body opening 12, and This contributes to maintaining the lid member 20 in a half-plugged state.

Next, at the time of transition from the half-plugged state to the fully-plugged state, as shown in FIG. It is bent to bend from the inclined position to a bent position in which the upper end faces substantially vertically upward. At this time, the air holes 24 are
The outwardly bent elastic piece is accommodated. Therefore, the elastic piece 2
3 does not hinder the transition of the lid member 20 from the half-plugged state to the full-plugged state.

Further, after the entire stopper is shifted, the elastic member 23 is restored from the bent position to the original inclined position by the elastic force of the elastic member 23 as shown in FIG. And
The upper end abuts on the lower end surface of the container main body mouth portion 12, thereby contributing to the holding of the lid member in the entire stoppered state.

In the vial container having such a configuration, the following effects can be obtained. That is, according to the conventional vial container in which the sealing member has a simple disk shape,
As shown in FIG. 10, the piercing position of the communication needle 60 is located below the holding position of the seal member sandwiched between the lid member and the container main body mouth portion. A radially inward force acts on the member, and there is a risk that the seal member may fall into the container body. In contrast, the vial container 1 according to the present embodiment
According to this, the seal member 30 is formed in a cap shape, and as shown in FIG. 5, the penetrating position of the communication needle 60 is located above the seal member holding position. A radially outward force acts on 31a. Therefore, the seal member 30 does not fall into the container body. Further, since the sealing member 30 is formed in a cap shape and the holding portion 21 of the lid member 20 is formed in a cap shape engaging with the cap member, the contact area between the sealing member 30 and the lid member 20 can be increased, This also prevents the sealing member 30 from falling into the container body.
Further, the sealing member is formed by forming a rib 32 protruding radially outward on the outer peripheral surface of the body portion 31b of the sealing member, or by forming the peripheral wall portion 21b into a tapered shape in which the inner diameter decreases from above to below. 30 can be more effectively prevented from falling off.

Further, since the air passage 24 between the inside and the outside of the container when the lid member 20 is half-plugged is located above the opening of the container body, the conventional vial container shown in FIG. As compared with the above, the air permeability between the inside and the outside of the container in the half-plugged state can be improved, and thereby the efficiency of the freeze-drying step performed in the half-plugged state can be improved.

Further, when the vent hole 24 is configured to function as a storage portion for the elastic piece 23 when shifting from the half-plugged state to the fully-plugged state, the ventilation means and the elastic piece housing are accommodated. The structure of the cover member 20 can be simplified as compared with a conventional vial container in which the means and the means are separately formed (see FIGS. 8 and 9). Can be reduced.

In the present embodiment, the protective cap 40 is provided. Alternatively, as shown in FIG. 6, a closing member 50 such as a seal or a film is provided on the second flange of the holding portion. May be adhered, or the portion may be formed as a thin film that is easy to penetrate and is integrally formed with the second flange portion.

[0029]

According to the vial container of the present invention, the cap member is formed as the sealing member, and the cap-shaped holding portion is formed on the inner peripheral surface of the lid cylindrical portion so as to frictionally hold the sealing member in the fitted state. When piercing the communication needle for dissolving solution injection into the seal member, the piercing position can be positioned above the seal member sandwiching position, thereby preventing the seal member from falling into the container body. It can be effectively prevented.

In the cylindrical portion of the lid member, a through hole communicating between the central hole and the outside is formed in a portion located between the lower end of the sealing member and the upper end of the opening of the container body in the half-plugged state, The through hole serves as an air passage between the inside of the container and the outside of the vial container in the half-plugged state, and serves as a storage means for an elastic piece that is bent when the half-plugged state is shifted to the full-plugged state. With this configuration, the structure of the lid member can be simplified, and thus the cost can be reduced. In addition, according to such a configuration, in the half-plugged state, the ventilation path is formed above the container body opening, thereby improving the air permeability between the inside and the outside of the container in the half-plugged state. And the efficiency of the freeze-drying step performed in the half-plugged state can be improved.

Further, if the cover member is provided with a removable closing member for closing the upper opening, it is possible to prevent impurities such as dust from adhering to the communicating needle piercing portion.

Further, in the vial protector, a rib protruding radially inward is provided on a portion of the inner peripheral surface of the cylindrical portion of the lid member which faces the outer peripheral surface of the opening of the container main body after the entire stopper is shifted. Is applicable to container bodies having various diameters.

[Brief description of the drawings]

FIG. 1 is a longitudinal sectional view of a vial container according to an embodiment of the present invention in a half-plugged state.

FIG. 2 is an enlarged view of a lid member in FIG. 1;

FIG. 3 is an enlarged cross-sectional view of a lid member when the vial container shown in FIG. 1 shifts from a half-plugged state to a fully-plugged state.

FIG. 4 is an enlarged cross-sectional view of a lid member after the vial container shown in FIG. 1 has transitioned to a completely stoppered state.

FIG. 5 is a vertical cross-sectional view of the vial container shown in FIG. 1 when the communication needle is pierced.

FIG. 6 is a longitudinal sectional view of a modified example of the vial container shown in FIG. 1;

FIG. 7 is a longitudinal sectional view of a conventional vial container.

FIG. 8 is a partial longitudinal sectional view of a section passing through an elastic piece of the vial container shown in FIG. 7;

FIG. 9 is a partial vertical cross-sectional view of a cross section of the vial container shown in FIG. 7 that passes through a ventilation path.

FIG. 10 is a vertical cross-sectional view of the vial container shown in FIG. 7 when the communicating needle is pierced.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Vial container 10 Container main body 20 Lid member 23 Elastic piece 24 Through-hole 30 Seal member

Claims (5)

[Claims] 1. A container body having a body and a mouth forming an opening above the body, and a cylindrical shape having a central hole along an axial direction, and a lower portion surrounding the mouth of the container body. A lid member made of a synthetic resin attached at, and an elastic seal member held by the lid member so as to face the container body opening in the center hole of the lid member, the lid member comprising:
A vial container configured to be able to take a completely stoppered state in which the container body is closed by the seal member with respect to the container body, and a semi-stoppered state in which the seal member is separated from the container body opening; The member is a cap type having a flange portion extending radially outward at the lower end, and in the fully stoppered state, the flange portion comes into contact with the upper end surface of the container main body opening to close the container main body opening. The lid member includes a cap-shaped holding portion that frictionally holds the sealing member in an fitted state on an inner circumferential surface of the cylindrical portion at an approximately central portion in the axial direction, and the holding portion communicates with a top wall. Further, the cover member has an air passage for communicating the container body opening to the outside in the half-plugged state, and the upper end and the seal of the container body mouth part in the half-plugged state of the cylindrical portion. In the part located between the lower ends of the member flanges An elastic piece having an upper end in a radially inwardly and upwardly inclined state that can be bent and deformed, wherein the elastic piece is in the transition from the half-plugged state to the full-plugged state of the lid member, The lid is bent radially outward by the container body opening to allow the lid member to move, and after the lid member has transitioned to the entire stoppered state, the lid member is restored to the inclined state, and the upper end is located below the container body mouth. A vial container comprising an all-plugged state maintaining means for abutting on an end face and maintaining the all-plugged state. 2. The ventilation path is a through-hole formed in a cylindrical portion of the lid member and communicating the center hole and the outside. The through-hole extends from a half-plugged state to a fully-plugged state of the lid member. 2. The vial container according to claim 1, wherein the elastic piece bent radially outward by the container body opening is accommodated during the transition to the vial. 3. 3. The vial container according to claim 1, wherein the lid member further includes an easily removable closing member that closes an upper end opening of the tubular portion. 4. A vial container body having a cylindrical shape having a central hole, and a lower portion attached around a mouth portion of a vial container body having a body portion and a mouth portion forming an opening above the body portion. A lid member, and a seal member held by the lid member so as to face the container main body opening in a central hole of the lid member, and the container main body is closed with respect to the container main body by the seal member. In a vial container protector adapted to be in a stoppered state and a semi-plugged state in which the seal member is separated from the container body opening, the seal member has a flange portion extending radially outward at a lower end portion. It is a cap type, and in the entire stoppered state, the flange portion is hooked on the upper end surface of the container main body mouth portion to close the container main body opening, and the lid member is in the axial direction of the cylindrical portion. Middle A cap-shaped holding portion that frictionally holds the seal member in an inner fitted state is provided on the inner peripheral surface, and the holding portion has an insertion hole for a communication needle in a top wall, and the lid member The upper portion of the cylindrical portion is located between the upper end of the container body opening and the lower end of the sealing member flange in the half-plugged state, and has an upper end in a radially inward and upwardly inclined state. An elastic piece, and a vent hole communicating with the central hole and the outside, wherein the elastic piece is radially moved by the container body opening during the transition from the half-plugged state to the full-plugged state of the lid member. While being bent outward and accommodated in the ventilation hole, after transitioning to the entire stoppered state of the lid member, the lid member is restored to the inclined state,
A vial protector characterized in that an upper end thereof abuts on a lower end surface of a mouth portion of a container main body and constitutes a completely stoppered state maintaining means for maintaining the stoppered state. 5. A radially inwardly projecting rib is formed on a portion of the inner peripheral surface of the cylindrical portion of the lid member that faces the outer peripheral surface of the opening of the container body after transition to the entire stoppered state. The vial container protector according to claim 4, characterized in that: