JPH11243871A - Feed additive composition for ruminant and its production - Google Patents

Abstract

PROBLEM TO BE SOLVED: To produce a feed additive composition for ruminants capable of protecting physiological substances in the rumen and excellent in handleability and preservation stability and eluting the physiological substances from the abomasum by including lysine magnesium phosphate, etc., and having the moisture content within a prescribed range. SOLUTION: This feed additive composition for a ruminants contains (A) lysine magnesium phosphate, (B) magnesium oxide, (C) a binder such as starch and (D) water and has 5-15 wt.% moisture content. A coating layer is preferably formed on the periphery of a core comprising the composition, which is preferably produced by mixing the components A with B and C, feeding water or steam to the resultant mixture and extruding and granulating the prepared hydrous mixture.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a feed additive composition for ruminants and a method for producing the same. In particular, the present invention relates to a ruminant animal feed additive composition containing amino acids as a physiologically active substance in the feed additive and containing water to such an extent that it can be easily granulated, and a method for producing the same.

[0002]

2. Description of the Related Art When a physiologically active substance such as amino acids and vitamins is directly orally administered to ruminants such as cows and sheep,
Most of the physiologically active substances are decomposed by microorganisms in the rumen of animals, and are not effectively used. Accordingly, there is a need for a ruminant feed additive that protects such physiologically active substances from degradation by microorganisms in the rumen and is sufficiently digested and absorbed in the digestive organs of the abomasum and beyond. . As a method of obtaining a ruminant feed additive for solving such a problem, for example, Japanese Patent Publication No. Sho 5
JP-A-9-10780 and JP-A-60-168351 disclose in a matrix containing a protective substance such as oil and fat.
A method for dispersing and granulating a biologically active substance is disclosed. However, since the biologically active substance existing near the surface of the granulated substance is easily decomposed, especially the first active substance is used.
The effect is weak when the residence time in the stomach is long. Also, JP-A-54-46823, JP-A-63-31705
No. 3 discloses a method of coating a core containing a biologically active substance with an acid-sensitive substance such as a hydrophobic substance such as oil or fat or a basic polymer substance. However, especially in the case of a compound feed, the coating may be destroyed due to the influence of other compounds and the like, and therefore, it cannot be said to be a versatile method. Further, Japanese Patent Application Laid-Open No. 9-17297
No. 9 discloses an animal feed additive composition comprising a phosphate amino acid complex salt insoluble in a neutral or alkaline aqueous solution and soluble in an acidic aqueous solution, and an antacid. However, it has been difficult to granulate the additive composition so that the additive composition can be easily handled and the additive composition can be easily added to animal feed. On the other hand, with regard to a method for producing active element granules by extrusion, JP-A-25508023 discloses that an active element in an amount of more than 75% by weight consists of extruding a mass of the active element in the presence of a fusible binder. A method of granulating a nutritionally or therapeutically active ingredient comprising the same is disclosed.
However, this method is an alternative to extruding a wet mixture by adding water, and does not provide an extrusion granulation method of a mixture containing a certain amount of water. Therefore, a ruminant feed additive composition for ruminants which does not decompose physiologically active substances in the rumen, is effectively used in the digestive organs after the abomasum, and can be easily granulated has not been obtained. It was the current situation.

[0003]

SUMMARY OF THE INVENTION Accordingly, the present invention is directed to the present invention, when the feed additive contains a bioactive substance, that the bioactive substance is sufficiently protected in the rumen of the ruminant animal, It is an object of the present invention to provide a ruminant feed additive composition for ruminants that can be easily granulated by an extrusion granulation method or the like, which is rapidly eluted in, and a method for producing the same.

[0004]

Means for Solving the Problems The present inventors have made intensive studies to achieve the above object, and as a result, have used lysine magnesium phosphate and magnesium oxide in combination as feed additives, and furthermore, have a certain water content. By including it,
The inventor has found that the above object can be achieved, and has completed the present invention. That is, the present invention provides (A) lysine magnesium phosphate, (B) magnesium oxide, (C)
A ruminant feed additive composition comprising a binder and (D) water, wherein the composition has a water content of 5 to 15% by weight. The present invention further provides (1) a step of mixing lysine magnesium phosphate, magnesium oxide, and a binder, (2) a step of supplying water or steam to the mixture, and (3) an extrusion molding of the obtained water-containing mixture. A method for producing a ruminant animal feed additive composition, comprising the step of granulating.

[0005]

DETAILED DESCRIPTION OF THE INVENTION The component (A) used in the ruminant feed additive composition of the present invention is lysine magnesium phosphate. Lysine magnesium phosphate is represented by the general formula (Lys) _a Mg _b H _c PO ₄ .nH ₂ O (where (Lys) means lysine, and a is 0.05 to
1.0 and b are 1.0 to 1.47, c is 0 to 0.3, a + 2 × b + c = 3, and n represents a number of 0 to 20. Lysine magnesium orthophosphate represented by the general formula (Lys) _a Mg _b H _c PO ₄ (PO ₃ ) _m · nH ₂ O (where (Lys) represents lysine Means a is 0.02 ×
(M + 3) to 0.3 × (m + 3), b is 0.35 × (m
+3) to 0.49 × (m + 3), c is 0 to 0.2 × (m
+3), a + 2 × b + c = 3, and m is 1 to
50, n represents the number of 0-20. ) May be used. The solubility characteristics of lysine magnesium phosphate are not particularly limited, but are preferably insoluble in a neutral or alkaline aqueous solution and soluble in an acidic aqueous solution. The amount of lysine magnesium phosphate in the composition of the present invention is from the viewpoint of imparting sufficient protection in the rumen of ruminants while ensuring the effectiveness of lysine as a physiologically active substance. It is preferably from 25 to 80% by weight, particularly preferably from 50 to 70% by weight, based on the total weight of the composition.

The component (B) used in the ruminant feed additive composition of the present invention is magnesium oxide. The magnesium oxide is not particularly limited as long as it is generally available.
About 00 mg / g and an average particle size of 3 to 100 μm
A degree is desirable. The amount of magnesium oxide in the composition of the present invention is such that the molar ratio of component (A) to component (B) is 3 from the viewpoint of facilitating preparation of the composition and obtaining sufficient protection of the physiologically active substance. : 1 to 1: 4, preferably in an amount of 2: 1 to 1: 3.

The component (C) used in the ruminant feed additive composition of the present invention is a binder. The binder is not particularly limited as long as the component (A) and the component (B) can be bound, and any water-soluble binder, hydrophobic binder, or the like can be used. Examples of the water-soluble binder include starch, salts of carboxymethylcellulose, alginate, methylcellulose, ethylcellulose, hydroxypropylcellulose, water-soluble polysaccharides such as salts of starch glycolic acid, sodium caseinate, gelatin, water-soluble proteins such as soy protein And saccharides such as molasses, lactose and dextrin; and synthetic polymers such as polymethacrylate, polyvinyl alcohol and polyvinylpyrrolidone. Examples of hydrophobic binders include shellac resin, rosin, beeswax,
Natural waxes such as paraffin wax, cetanol,
Fatty acids and related substances such as higher fatty acids such as stearic acid and metal salts thereof, animal and vegetable fats such as palm oil, hardened animal and vegetable fats and oils,
Nonionic surfactants such as glycerin monostearate,
And semi-synthetic resins and synthetic polymers such as acetylcellulose, polyvinyl acetate, ester gum, and coumarone resin. Among these binders, it is preferable to use higher fatty acids and fats and oils-related substances from the viewpoint of safety and the like. The above-mentioned binders may be used alone, or two or more binders may be used in combination. The blending amount of the binder can be arbitrarily determined in relation to the blending amounts of the component (A) and the component (B).
It is preferably within the range of 10: 1 to 1: 3, and 5: 1.
It is particularly preferred that it is in the range of ２2: 1.

The component (D) used in the ruminant feed additive composition of the present invention is water. When water is added to the composition, it can be added in any suitable form such as steam. The feed additive composition of the present invention contains 5 to 15% by weight of water, based on the weight of the entire composition, from the viewpoint of easy handling during granulation and storage stability. The water content of the composition is particularly preferably from 8 to 12% by weight.

[0009] The feed additive composition of the present invention may also contain other physiologically active substances in addition to the component (A). Any known physiologically active substance can be used as the physiologically active substance. Specific examples of such a physiologically active substance include amino acids such as methionine, tryptophan and threonine; amino acid derivatives such as N-acyl amino acids and calcium salts of N-hydroxymethylmethionine;
Hydroxy homologues of amino acids such as hydroxy-4-methylmercaptobutyric acid and salts thereof; sources of calories such as starch, fatty acids and metal salts thereof; vitamin A;
Vitamin A acetate, vitamin A palmitate, vitamin B group, thiamine, thiamine hydrochloride, riboflavin, nicotinic acid, nicotinamide, calcium pantothenate,
Choline pantothenate, pyridoxine hydrochloride, choline chloride,
Vitamins such as cyanocobalamin, biotin, folic acid, p-aminobenzoic acid, vitamin D ₂ , vitamin D ₃ , and vitamin E and those having similar functions; tetracyclines, aminoglycosides, macrolides, polyethers, etc. Insecticides such as Negphone; insecticides such as piperazine; hormones such as estrogen, stilbestol, hexestrol, tyloprotein, goitrogen, growth hormone and the like. Although the component (A) of the feed additive composition of the present invention is lysine magnesium phosphate, even basic amino acids other than lysine can form magnesium phosphate, such as ornithine and arginine. For example, as in the case of lysine,
It is believed that it can be added to the feed additive composition in the form of magnesium phosphate.

[0010] The feed additive composition of the present invention further comprises, from the viewpoint of adjusting the specific gravity, enhancing the strength of the feed additive, enhancing the dissolution property in the abomasum, or improving the processability during granulation.
Inorganic substances such as alkaline earth metal carbonates, phosphates, hydroxides, talc, bentonite, clay, and fine silica;
Paraffin wax, polyethylene powder, pulp powder,
It may contain organic substances such as cellulose powder and chitosan.

[0011] The feed additive composition of the present invention can be formed into any shape, but when granulated, the dispersion of the additive composition in the feed is eliminated. From the viewpoint of facilitating the mixing with other components in the feed, it is preferable that the average particle diameter is in the range of 1.0 to 6.5 mm and the length is in the range of 1 to 10 mm.

[0012] In the feed additive composition of the present invention, by further providing a coating layer around a core comprising the above components, it is possible to enhance the protection of a physiologically active substance in the rumen of a ruminant animal. It is. Examples of the coating agent that can be used to form the coating layer include, among those listed above as examples of the binder, from the viewpoint of compatibility between the core and the coating layer, higher fatty acids and metal salts thereof, and hardened animal and vegetable fats and oils. It is desirable to provide a coating layer as a coating agent. The amount of the coating agent is not particularly limited, but is preferably 5 to 50% by weight, and particularly preferably 7.5 to 30% by weight, based on the total weight of the core components. .

[0013] The feed additive composition of the present invention can be produced by any known method. As an example of the production method, after mixing each component, extrusion granulation, tumbling granulation,
Examples of the method include granulation by compression granulation, melt spray granulation, and the like. Among them, the feed additive composition of the present invention,
(1) a step of mixing lysine magnesium phosphate, magnesium oxide, and a binder, (2) a step of supplying water or steam to the mixture, and (3) a step of extruding and granulating the obtained hydrated mixture. It can be suitably manufactured by the method. When each component is mixed in the step (1), any known mixing method can be used. When water or steam is supplied in the step (2), the supply of water is preferably performed by blowing steam from the viewpoint of granulation, and the supply amount of water is 5 to 30 based on the weight of the whole composition. % By weight. In the case where the water-containing mixture is extruded and granulated in the step (3), there is no particular limitation, but any known extruded granulator may be used, and the die temperature of the extruded granulator may be equal to or higher than the melting point of the binder fat. It is desirable to manufacture under. When a coating layer is provided on the feed additive composition of the present invention, first, a granulated material serving as a core is produced by the above method, and after a drying step, if necessary, the coating agent is sprayed on the granulated material. It can be carried out by any known method such as The formation of the coating layer
Desirably, the core is fluidized using a tumbling fluidized granulator,
The method is carried out by dropping the coating agent or by flowing the core in a coating pan and spraying the coating agent.

[0014]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples. [Preparation of ruminant feed additive composition] Example 1 (Granulation step) 100 kg of dried lysine / magnesium / phosphate (I-type crystal) and 10 kg of magnesium oxide, 16.2 kg of powdered stearic acid, 28 palm oil 0.4 kg, ethyl cellulose 3.3 kg and DL-methionine 12 kg were mixed with a Nauter mixer for 40 minutes to obtain a uniform powder mixture. this,
The mixture was fed at a rate of 100 kg / Hr to a mixer of a California pellet mill (CPM 1112-2) equipped with a 3 mmφ die. Steam was blown in front of the die to form pellets. L / D was 1.0-3.0. At this time, the temperature in the mixer after the steam injection was adjusted to 60 ° C to 65 ° C. The steam pressure at this time is 0.5
0.6 kg / cm ² , and the amount of steam added is 5 kg / Hr to 7 kg
/ Hr. The temperature of the pellet immediately after molding is 75 to 80
° C, and the water content was 12% as measured by a Kett moisture meter (135 ° C, 20 minutes, sample amount: 6 g). The obtained granulated product weighed 180 kg. (Drying step) The obtained granulated product was dried with a fluidized bed drier, and hot air of 90 ° C was blown therein. When the product temperature reached 70 ° C, drying was completed. The dried granulated product weighed 170 kg and had a water content of 9.4% as measured by a Kett moisture meter. (Coating step) The coating was performed using GRX-300 manufactured by Freund Corporation. That is, the granulated product obtained by the above method was sieved using a 2 mm net and 135 kg was put into a coating machine. Product temperature 53-5
A mixture of 12.5 kg of hardened soybean oil, 0.62 kg of lecithin and 0.38 kg of palm oil, which was previously kept at 5 ° C. and melted and kept at 70 ° C., was added dropwise (9% of the total weight was a coating portion, hereinafter 9%).
% Coating), 143 kg of composition. At this time, the intake air temperature is 52 ° C., the intake air volume is 60 m ³ / min, and the intake static pressure is 12
0mmH was ₂ O. The exhaust air volume of about 65 m ³ / min, exhaust static pressure was -300mmH ₂ O.

Example 2 The amount of palm oil and ethyl cellulose added was 8.8 k each.
The same operation as in Example 1 was performed except that g and 0 kg were changed, to obtain 151 kg and 140 kg of a granulated product and a dried product, respectively. The water content measured with a Kett moisture meter was 12.5% and 9.
6%. Using 135 kg of the dried granulated product, the same coating operation as in Example 1 was performed to obtain 140 kg of the composition. Example 3 The amounts of addition of palm oil and ethyl cellulose were 16.0, respectively.
The same operation as in Example 1 was performed except that the weight was changed to 0 kg and 0 kg, respectively, to obtain 155 kg and 141 kg of a granulated product and a dried product, respectively. The water content measured by the Kett moisture meter was 12.2% and 9.
6%. Using 135 kg of the dried granulated product, the same coating operation as in Example 1 was performed to obtain 140 kg of the composition. Example 4 The same operation as in Example 1 was performed except that the addition amounts of powdered stearic acid, palm oil, and ethyl cellulose were changed to 32 kg, 0 kg, and 0 kg, respectively, to obtain 174 kg and 164 kg of a granulated product and a dried product, respectively. . The water content measured with a Kett moisture meter was 12.0% and 9.1%, respectively. Using 135 kg of the dried granulated product, the same coating operation as in Example 1 was performed to obtain 145 kg of the composition. Example 5 The same operation as in Example 1 was carried out except that the addition amounts of palm oil, powdered stearic acid, and ethyl cellulose were changed to 32 kg, 0 kg, and 0 kg, respectively, to obtain 162 kg and 151 kg of a granulated product and a dried product, respectively. . The water content measured with a Kett moisture meter was 12.2% and 9.3%, respectively. Using 135 kg of the dried granulated product, the same coating operation as in Example 1 was performed to obtain 142 kg of the composition.

[0016]Example 6 Implemented except that the amount of magnesium oxide added was changed to 7 kg
The same operation as in Example 1 was performed.
78 kg and 169 kg were obtained. The moisture measured with a Kett moisture meter is
They were 12.1% and 9.1%, respectively. Dried granulated bag
The same coating as in Example 1 using 135 kg
The operation was performed to obtain 144 kg of the composition.Example 7 Except that the amount of magnesium oxide added was changed to 27 kg.
The same operation as in Example 1 was performed, and the granulated product and the dried product were respectively
188 kg and 176 kg were obtained. The moisture measured with a Kett moisture meter is
They were 11.5% and 8.9%, respectively. Of dried granulated product
The same coating as in Example 1 was performed using 135 kg of these.
Operation to obtain 144 kg of the composition. Example 8 Same as Example 1 except that the drying step is not performed after the granulation step
Was performed to obtain 162 kg of a granulated product. With Kett Moisture Analyzer
The measured water content was 12.0% each. Dry building
Using 135 kg of the granules, the same coat as in Example 1 was used.
By carrying out a taping operation, 142 kg of a composition was obtained.

Example 9 135 kg of the dried granulated product of Example 1 was used, and the coating agent was 12.5 kg of hardened beef tallow and lecithin 0.2%.
The same operation as in Example 1 was performed except that the mixture was changed to a mixture of 62 kg and 0.38 kg of palm oil (9% coating) to obtain 143 kg of a composition. Example 10 The same operation as in Example 1 was performed except that 135 kg of the dried granulated product of Example 1 was used and the coating agent was changed to only 13.5 kg of hardened soybean oil (9% coating). 140 kg of the composition were obtained. Example 11 135 kg of the dried granulated product of Example 1 was used, and the coating agent was 12.8 kg of hardened soybean oil and lecithin 0.2%.
The same operation as in Example 1 was carried out except that the mixture was changed to 7 kg of the mixture (9% coating) to obtain 143 kg of the composition. Example 12 Of the dried granulated product of Example 1, 135 kg was used, and the coating agent was changed to 10.1 kg of hardened soybean oil, lecithin.
The same operation as in Example 1 was carried out, except that the mixture was changed to a mixture of 0.5 kg and 0.3 kg of palm oil (7.5% coating).
142 kg of the composition were obtained. Example 13 135 kg of the dried granulated product of Example 1 was used to coat 22 kg of hardened soybean oil and lecithin 1.0.
The same operation as in Example 1 was performed, except that the mixture was changed to a mixture of 9 kg and palm oil (0.67 kg, 15% coating).
145 kg of the composition were obtained. Example 14 Of the dried granulated product of Example 1, 5 kg was put into a concrete mixer, and the mixer was rotated. Hot air was blown into this, and the product temperature was set to 45 to 47 ° C. To this, 0.5 kg (9% coating) of hardened beef tallow melted at 70 ° C. was sprayed using a spray nozzle to carry out coating to obtain 5.1 kg of a composition.

[Evaluation of Performance of Ruminant Animal Feed Additive Composition] The compositions obtained in Examples 1 to 14 were evaluated by the following methods. That is, 1.5 g of the composition was placed in a 300 ml Erlenmeyer flask, and 200 ml of a 0.2 M phosphate buffer was added as a rumen model solution. This is carried out at 39 ° C. and 100 rpm for 20 minutes.
After shaking for a time, amino acid analysis was performed by HPLC to determine the rumen protection rate. Then, as the abomasum model liquid,
After adding 8 ml of acetic acid and shaking for 4 hours under the same conditions, amino acid analysis was performed to determine the elution rate of the abomasum. Table 1 shows the evaluation results.

[0019]

Table 1 Table 1 Pediazine Lysine Lysine Methionine Methionion Rumen Protection Rate Rumen dissolution rate Rumen protection rate Rumen dissolution rate Example 1 85% 45% 80% 40% Example 2 80% 50% 75% 45% Example 3 85% 55% 78% 49% Example 4 90% 41% 85% 35% Example 5 88% 43% 80% 36% Example 6 78% 40% 71% 32% Example 7 86% 46% 82% 41% Example 8 85% 50% 81% 42% Example 9 90% 48% 86% 42% Example 10 77% 41% 69% 39% Example 11 74% 43% 70% 40% Example 12 75% 51% 72% 46% Example 13 95% 35% 90% 31% Example 14 81% 46% 75% 38%

From Table 1, it can be seen that both lysine and methionine, which are physiologically active substances, are effectively protected from degradation in the rumen and are sufficiently eluted in the abomasum.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Nobuyoshi Kitamura 1-1, Suzukicho, Kawasaki-ku, Kawasaki, Kanagawa Prefecture Ajinomoto Co., Inc. (72) Inventor Tadashi Takemoto 1-Suzukicho, Kawasaki-ku, Kawasaki-ku, Kanagawa Prefecture 1 Ajinomoto Co., Inc. Central Research Laboratory

Claims (3)

[Claims] (1) (A) lysine magnesium phosphate,
A ruminant feed additive composition comprising (B) magnesium oxide, (C) a binder, and (D) water, wherein the water content is 5 to 15% by weight. 2. The ruminant feed additive composition according to claim 1, further comprising a coating layer provided around a core made of the composition according to claim 1. 3. (1) a step of mixing lysine magnesium phosphate, magnesium oxide, and a binder,
(2) a step of supplying water or steam to the mixture, and (3) a step of extruding and granulating the obtained hydrated mixture.
A method for producing a ruminant feed additive composition.