JPH11199447A - Liquid composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition excellent in low-temperature stability and feeling of use and useful for agents for hair of the head, cosmetics, medicines, nail agents, industrial chemicals, etc., by formulating a specific crystalline compound with a solvent and a specific amine oxide. SOLUTION: This liquid composition is obtained by formulating (A) a crystalline compound selected from fatty acids having a 7-30C alkyl group, an aliphatic alcohol having an 8-30C alkyl group, salts thereof and derivatives thereof with (B) a solvent and (C) an amine oxide represented by formula I or II [R<1> is a 1-24C alkyl or a 2-24C alkenyl; R<2> and R<3> are each a 1-10C alkylene or a 2-10C alkenylene; A<1> and A<2> are each H or OH; (n) is 0-3]. Furthermore, (D) a nonionic surfactant having <=10 value of hydrophile-lipophile balance(HLB) or (E) a glucide-based surfactant represented by formula III (R<4> to R<11> are each OH or an 8-22C carboxyl), formula IV (R<12> to R<15> are each OH, an 8-22C carboxyl or the like; R<16> is an aglycone residue) or the like or both are preferably formulated with the composition.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a crystalline compound such as a fatty acid having an alkyl group having 7 to 30 carbon atoms, an aliphatic alcohol having an alkyl group having 8 to 30 carbon atoms, salts thereof and derivatives thereof, and a solvent. And a liquid composition comprising an amine oxide, and more specifically, a liquid composition which is excellent in low-temperature stability, prevents crystallization of the crystalline compound at low temperatures as much as possible, and is excellent in usability. About things.

[0002]

2. Description of the Related Art It has been known that fatty acids having an alkyl group having an even carbon chain length, aliphatic alcohols having an odd carbon chain length, and salts and derivatives thereof have hair growth and hair growth effects. A hair tonic containing these as an active ingredient has been proposed in JP-A-59-27809 and the like. However, the active ingredients such as the fatty acids described above,
In general, the solubility decreases as the number of carbon atoms increases.
For this reason, the hair-growing / hair-growing agent containing the above-mentioned active ingredient may cause inconvenience such as clouding or precipitation of crystals at a low temperature, and there is a concern that the hair-growing / hair-growing effect may be reduced. Therefore, there is a demand for the development of a hair-growing / hair-growing agent that has excellent hair-growing / hair-growing effects and good low-temperature stability.

Accordingly, a nonionic surfactant having an HLB value of 10 or less is used together with the above-mentioned crystalline compound as a low-temperature stabilizer (described in JP-A-61-15815). Adding an amphoteric polymer in addition to the surfactant (Japanese Patent Application No. 63-163594)
No.) or using a carboxylic acid type amphoteric surfactant (Japanese Patent Application No. 63-320074) and using a certain saccharide-based surfactant (Japanese Patent Application No. 7-354296).
It has been proposed to improve the low-temperature stability of the liquid compositions described above. However, in general, as the amount of these stabilizers increases, stickiness occurs in the product composition, causing a problem that the feeling of use is significantly deteriorated. In addition, if a small amount of the stabilizer is used in order to obtain a composition which is non-greasy and has excellent usability, low-temperature stabilization becomes insufficient. Therefore, in the conventional composition, it is inevitable that a large amount of these stabilizers are blended, and it is difficult to obtain a product having a good feeling in use. Therefore, there is a strong demand for drastically improving low-temperature stability and obtaining a composition excellent in usability that can ensure stability with a small amount of a stabilizer.

[0004]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and the low-temperature stability is remarkably superior to that of the prior art. It is an object of the present invention to provide a liquid composition which hardly precipitates and is excellent in use feeling.

[0005]

Means for Solving the Problems As a result of intensive studies to achieve the above object, the present inventors have found that at least one specific amine oxide has an alkyl group having 7 to 30 carbon atoms. When compounded in a solvent dissolution / dispersion of a crystalline compound such as a fatty acid, an aliphatic alcohol having an alkyl group having 8 to 30 carbon atoms, a salt thereof, and a derivative thereof, these amine oxides can be obtained under the low temperature of the crystalline compound. And exhibits excellent solubility and low temperature stability effects. For example, even when stored at a low temperature of about −5 ° C. for a long time, there is almost no cloudiness of the solution and no precipitation of crystals, and the low temperature A liquid composition having excellent stability is obtained, and the composition has at least one of (A) at least one nonionic surfactant having an HLB value of 10 or less and / or (B) at least one of a saccharide-based surfactant. One kind By combining the above, the above effects are more effectively exhibited, and it has been found that even more excellent effects can be obtained by adding a more specific amphoteric polymer to the above composition, which led to the present invention. It is.

That is, according to the present invention, first, a fatty acid having an alkyl group having 7 to 30 carbon atoms, and a fatty acid having 8 to 3 carbon atoms.
At least one crystalline compound selected from aliphatic alcohols having an alkyl group of 0, salts thereof and derivatives thereof, a solvent and the following general formula (I) or general formula (II)
And a liquid composition comprising at least one of the amine oxides represented by the formula:

Embedded image (In the formula, R ¹ is an alkyl group having 1 to 24 carbon atoms or an alkenyl group having 2 to 24 carbon atoms. R ² and R ³ are an alkylene group having 1 to 10 carbon atoms or an alkylene group having 2 to 10 carbon atoms. Alkenylene group, A ¹ and A ² are hydrogen or hydroxyl group, and n is an integer of 0 to ^3. )

According to the present invention, secondly, the first liquid composition further comprises (A) at least one nonionic surfactant having an HLB value of 10 or less and / or (B) A liquid composition comprising at least one of the saccharide-based surfactants represented by Formula (III), Formula (IV) and Formula (V) is provided.

Embedded image (In the formula, R ^{4 to} R ¹¹ are each a hydroxyl group or a carboxyl group having 8 to 22 carbon atoms.)

Embedded image (Wherein, R ^{12 to} R ¹⁵ are a hydroxyl group, a carboxyl group having 8 to 22 carbon atoms, or the following groups.

Embedded image m is an integer of 1 to 120 and y is an integer of 8 to 22. R ¹⁶ is an aglycone residue. )

Embedded image (However, in the formula, R ^{12 to} R ¹⁶ are the same as those in the formula (IV).)

Further, according to the present invention, thirdly, at least one amphoteric polymer containing a unit structure represented by the following general formula (VI) is further added to the first or second liquid composition. Liquid compositions are provided.

Embedded image (Wherein, R ¹⁷ is a hydrogen atom or a methyl group, R ¹⁸ is an alkylene group having 1 to 4 carbon atoms, and R ¹⁹ and R ²⁰ are a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, respectively. A ³ is an oxygen atom or an NH group.)

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in more detail. As described above, the liquid composition of the present invention can be used as a crystallization inhibitor of a crystalline compound, as described in the above general formula (I) or (I).
It contains the amine oxide represented by I). As the amine oxide having such a structure,
Specifically, N-lauryl-N, N-dimethylamine oxide, N-lauryl-N, N-diethylamine oxide, N-lauryl-N, N-dipropylamine oxide, N-oleyl-N, N-dimethyl Amine oxide,
N-oleyl-N, N-diethylamine oxide, N-
Oleyl-N, N-dipropylamine oxide, N-myristyl-N, N-dimethylamine oxide, N-myristyl-N, N-diethylamine oxide, N-myristyl-N, N-dipropylamine oxide, N-palmityl -N, N-dimethylamine oxide, N-palmityl-N, N-diethylamine oxide, N-palmityl-N, N-dipropylamine oxide, N-stearyl-N, N-dimethylamine oxide, N-stearyl-
N, N-diethylamine oxide, N-stearyl-
N, N-dipropylamine oxide, N-lauryl-
N, N-dihydroxymethylamine oxide, N-lauryl-N, N-dihydroxyethylamine oxide, N
-Lauryl-N, N-dihydroxypropylamine oxide, N-oleyl-N, N-dihydroxymethylamine oxide, N-oleyl-N, N-dihydroxyethylamine oxide, N-oleyl-N, N-dihydroxypropylamine oxide, N-myristyl-N, N-
Dihydroxymethylamine oxide, N-myristyl-
N, N-dihydroxyethylamine oxide, N-myristyl-N, N-dihydroxypropylamine oxide, N-palmityl-N, N-dihydroxymethylamine oxide, N-palmityl-N, N-dihydroxyethylamine oxide, N-palmityl- N, N-dihydroxypropylamine oxide, N-stearyl-N,
N-dihydroxymethylamine oxide, N-stearyl-N, N-dihydroxyethylamine oxide, N-
Stearyl-N, N-dihydroxypropylamine oxide, N-lauryl polyoxyethylene-N, N-dimethylamine oxide, N-lauryl polyoxyethylene-N, N-diethylamine oxide, N-lauryl polyoxyethylene-N, N -Dipropylamine oxide,
N-oleylpolyoxyethylene-N, N-dimethylamine oxide, N-oleylpolyoxyethylene-N,
N-diethylamine oxide, N-oleyl polyoxyethylene-N, N-dipropylamine oxide, N-myristyl polyoxyethylene-N, N-dimethylamine oxide, N-myristyl polyoxyethylene-N, N
-Diethylamine oxide, N-myristyl polyoxyethylene-N, N-dipropylamine oxide, N-palmityl polyoxyethylene-N, N-dimethylamine oxide, N-palmityl polyoxyethylene-N, N
-Diethylamine oxide, N-palmityl polyoxyethylene-N, N-dipropylamine oxide, N-stearylpolyoxyethylene-N, N-dimethylamine oxide, N-stearylpolyoxyethylene-N, N
-Diethylamine oxide, N-stearylpolyoxyethylene-N, N-dipropylamine oxide, and the like.

In the present invention, as described above, one of the above amine oxides is added to the solvent solution / dispersion of the crystalline compound.
Seeds or two or more kinds are blended. The compounding amount of the amine oxide can be appropriately adjusted according to the compounding amount of the crystalline compound and the like, but it is 0.001 to 10% (% by weight, hereinafter the same), particularly 0.01% to 5% of the whole liquid composition. It is preferable that

In the present invention, it is preferable that (A) a nonionic surfactant having an HLB value of 10 or less and / or (B) a saccharide-based surfactant are added together with the amine oxide. .

The HLB value of the component (A) used in the present invention is 1
Specific examples of the nonionic surfactant of 0 or less include sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbite fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil fatty acid ester, Polyglycerin fatty acid ester, N-long-chain acyl-L-glutamic acid higher alcohol diester, N-long-chain acyl-L-glutamic acid polyoxyethylene higher alcohol ether diester and the like can be mentioned. The HLB value of these nonionic surfactants can be generally adjusted by the number of moles of ethylene oxide and propylene oxide added and the carbon chain length of the lipophilic group, but a nonionic surfactant having an HLB value of more than 10 is used. Then, the low-temperature stability of the liquid composition may not be improved in some cases. Therefore, it is desirable that the HLB value of the nonionic surfactant is 10 or less. In addition,
One or two or more nonionic surfactants having an HLB of 10 or less can be blended, and the blending amount can be appropriately adjusted according to the blending amount of the crystalline compound. 0.001 to 10% of the whole, especially 0.01% to 5%
It is preferable that

Next, the saccharide-based surfactant of the component (B) used in the present invention has a sugar or a derivative thereof in the hydrophilic part, and has the above-mentioned general formula (III), (IV) or (V). Can be mentioned. Specific examples of such a saccharide-based surfactant include sucrose stearate, sucrose palmitate, sucrose myristate, sucrose oleate, sucrose laurate, and sucrose behenate. Sucrose erucic acid ester, sucrose coconut oil fatty acid ester, sucrose hardened tallow fatty acid ester, polyoxyethylene methyl glucoside, polyoxypropylene methyl glucoside, distearate polyoxyethylene methyl glucoside, distearate polyoxypropylene methyl glucoside, poly Methyl oxyethylene dioleate glucoside, polyoxyethylene methyl glucoside sesquistearate, methyl glucoside sesquistearate, methyl glucoside caprylate, methyl glucoside caprate, laurin Methyl glucoside, methyl myristate glucoside, methyl stearate glucoside, methyl oleate glucoside, ethyl caprylate glucoside, ethyl caprate glucoside, ethyl laurate glucoside, ethyl myristate glucoside, ethyl stearate glucoside,
Ethyl oleate glucoside, methyl mannoside caprylate, methyl mannoside laurate, methyl mannoside myristate, methyl mannoside stearate, methyl mannoside oleate, ethyl mannoside caprylate,
Examples thereof include ethyl mannoside caprate, ethyl mannoside laurate, ethyl mannoside myristate, ethyl mannoside stearate, and ethyl mannoside oleate. The sugar-based surfactant is 1
Seed or two or more kinds can be blended, and the blending amount of the saccharide-based surfactant can be appropriately adjusted according to the blending amount of the crystalline compound, etc., but 0.001 to 10% of the whole liquid composition,
In particular, the content is preferably 0.01% to 5%.

In the composition of the present invention, an amphoteric polymer is used together with the above-mentioned amine oxide or the amine oxide and (A) a nonionic surfactant having an HLB value of 10 or less and / or (B) a saccharide-based surfactant. Is preferably blended. Here, the amphoteric polymer used in the present invention has the following general formula (VI)

Embedded image (Wherein, R ¹⁷ is a hydrogen atom or a methyl group, R ¹⁸ is an alkylene group having 1 to 4 carbon atoms, and R ¹⁹ and R ²⁰ are a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, respectively. A ³ is an oxygen atom or an NH group.) A betaine-containing dialkylaminoalkyl acrylate, a betaine-containing dialkylaminoalkyl methacrylate, a betaine-containing dialkylaminoalkyl acrylylamide and a betaine-containing dialkylaminoalkyl methacryl having a unit structure represented by the following formula: It is at least one amphoteric polymer selected from amides.

In this case, the unit structure of the above formula (VI) is, for example, dimethylaminoethyl acrylate and methacrylate, diethylaminoethyl acrylate and methacrylate, dimethylaminopropyl acrylate and methacrylate, dimethylaminoethyl acrylamide and methacrylamide, diethylaminopropyl acrylamide and methacryl It can be obtained by modifying a homopolymer of a polymerizable monomer such as an amide or a polymer of the monomer and a monomer capable of polymerizing with the monomer shown below with a halogenated acetic acid or the like. The proportion of the unit structure represented by the above formula (VI) in the amphoteric polymer is not particularly limited, but may be 2% of the entire polymer.
Preferably it is 0 to 100%.

Further, the amphoteric polymer according to the present invention has the following structure (VII) together with the unit structure (VI):

Embedded image (Wherein, R ¹⁷ is the same as the above formula (VI), and R ²¹
Is an alkyl group, alkenyl group or cycloalkyl group having 1 to 30 carbon atoms. ) Is preferably present in the molecule. Examples of the monomer constituting the unit structure of the formula (VII) include acrylic acid and methacryl such as 2-ethylhexyl acrylate and methacrylate, stearyl acrylate and methacrylate, lauryl acrylate and methacrylate, isobutyl acrylate and methacrylate, cyclohexyl acrylate and methacrylate, and the like. Examples thereof include acid esters and the like.

Further, the amphoteric polymer of the present invention may be used in the above (VI)
In addition to the units of the formulas (VII) and (VII), a unitary structure of a hydrophilic ethylenic monomer may be present in the molecule. Here, as the hydrophilic ethylenic monomer, for example, N-vinylpyrrolidone, acrylamide, hydroxyethylene acrylate and methacrylate, hydroxypropyl acrylate and methacrylate, polyethylene glycol monoacrylate and monomethacrylate,
Polypropylene glycol monoacrylate and monomethacrylate, and the like, acrylonitrile, styrene, chlorostyrene, vinyl toluene, vinyl acetate, polypropylene glycol monoacrylate or monomethacrylate, vinyl trichlorosilane, methacryloxypropyl trimethoxysilane, and the like can be used.

As described above, the amphoteric polymer according to the present invention has a unit structure of the formula (VI) as an essential structure in the molecule and preferably has a unit structure of the formula (VII) in the molecule,
In addition, it can also contain a unit structure of a hydrophilic ethylenic monomer, and these monomers are variously selected according to the application, and a monopolymer, dipolymer, terpolymer, tetrapolymer, pentapolymer, etc. It can be.
Further, the amphoteric polymer has an average molecular weight of 400 to 2.0.
00,000 and an amphoteric ratio of 20 to 100.
%. In the present invention, (V
An amphoteric polymer containing a unit structure of the formulas (I) and (VII),
Among them, as the unit structures of the formulas (VI) and (VII), each of R ¹⁷ , R ¹⁹ and R ^{20 in} the above formula is a methyl group, R ¹⁸
Is an ethylene group, R ²¹ is an alkyl group having 1 to 30 carbon atoms, A is an oxygen atom, and the average molecular weight is 70,000 to 90,000, for example, N-
Methacrylylethyl, N, N-dimethylammonium
α-N-methylcarboxybetaine / methacrylic acid C ₂
Mixed alkyl copolymer -C ₂₄ and the like are preferably used.

The amphoteric polymer can be produced by the same method as that of a usual polymer. As a solvent, particularly a hydrophilic solvent, for example, a monoalcohol such as methanol, ethanol or isopropanol, ethylene glycol, ethylene glycol ethyl ether or Aliphatic alcohols such as polyalcohols such as butyl ether (preferably those having 1 to 4 carbon atoms), and esters such as methyl acetate, dioxane and dimethylformamide are used. After copolymerization, the polymer formed in a hydrophilic solvent is further represented by the following formula

Embedded image wherein X is a halogen acetate represented by XCH ₂ COOM ¹ (where X is a halogen atom such as chlorine, bromine or iodine, and M ¹ is an alkali metal salt such as sodium or potassium). By reacting, it can be easily obtained. As such an amphoteric polymer, for example, those sold by Mitsubishi Yuka Co., Ltd. as Yuka Homer (R) can be suitably used. In the liquid composition of the present invention, the compounding amount of the amphoteric polymer can be appropriately adjusted according to the compounding amount of the crystalline compound and the like, but is 0.001 to 10% of the whole composition, particularly 0.01 to 10%.
Preferably, it is 1%.

In the liquid composition of the present invention, the above-mentioned amine oxide or a nonionic surfactant having an HLB value of 10 or less and / or B) Carbohydrate-based surfactants, more preferably those in which an amphoteric polymer is blended. As described above, crystallization of a crystalline compound selected from fatty acids, aliphatic alcohols, salts thereof, and derivatives thereof having an alkyl group having 7 to 30 carbon atoms at a low temperature as described above can be prevented as much as possible. It will be.

The above fatty acids include, for example, octanoic acid, nonanoic acid, decanoic acid, undecanoic acid, dodecanoic acid, tetradecanoic acid, pentadecanoic acid, hexadecanoic acid, heptadecanoic acid, octadecanoic acid, nonadecanoic acid,
Examples include eicosanoic acid, heneicosanoic acid, docosanoic acid, tricosanoic acid, tetracosanoic acid, and pentacosanoic acid. Examples of the salts include these alkali metal salts, ammonium salts, and organic amine salts.

Examples of the aliphatic alcohol include decanol, undecanol, dodecanol, tridecanol, tetradecanol, pentadecanol, hexadecanol, heptadecanol, octadecanol, nonadecanol, eicosanol, heineicosanol, docosanol , Tricosanol, tetracosanol, pentacosanol and the like.

As the fatty acid derivative, the above-mentioned fatty acid or aliphatic alcohol derivatives are preferable, and examples thereof include the following crystalline compounds (a) to (nu).

(A) Glycerin ester represented by the following formula

Embedded image (Wherein, R ²² is a fatty acid residue having an alkyl group of 7 to 30 carbon atoms.)

(B) an ester represented by the following formula:

Embedded image R ²² COOR ²³ (where R ²² is the same as above. R ²³ is a monovalent or divalent alcohol residue such as methanol or ethanol, or a polyoxyethylene residue.)

(C) an amide represented by the following formula:

Embedded image (However, R ²² is the same as above. R ²⁴ and R ²⁵ are each a hydrogen atom or an organic group.)

(D) Dibasic acids and salts thereof represented by the following formula:

Embedded image M ² OOCR ²² COOM ² (where R ²² is the same as above; M ² is an alkali metal atom;
Alkaline earth metal atoms, ammonium or organic amines. )

(E) sterol ester represented by the following formula:

Embedded image (Wherein, R ²² is as defined above.)

(F) Phospholipid represented by the following formula

Embedded image (However, R ²² is the same as described above. A ⁴ represents a choline residue, a serine residue, or an inositol residue. When A ⁴ is a choline residue, it is phosphatidylcholine; (Fatidylethanolamine, serine is phosphatidylserine, and inositol is phosphatidylinositol.)

(G) Phospholipid represented by the following formula

Embedded image (Wherein, R ²² is as defined above.)

(H) Sphingolipid represented by the following formula

Embedded image (Wherein, R ²² is the same .A ⁵ above represent sugar residues, phosphate residues, or an amine base residue such as choline or ethanolamine.)

(I) an ester represented by the following formula:

Embedded image R ²⁶ —O—R ²⁷ (where R ²⁶ is an aliphatic alcohol residue having an alkyl group having 8 to 30 carbon atoms, and R ²⁷ is a fatty acid residue, preferably having 2 to 24 carbon atoms) Having a chain length; a residue of an organic acid such as succinic acid, citric acid, fumaric acid, lactic acid, malic acid, or oxaloacetic acid or a residue of an inorganic acid such as phosphoric acid;

(Nu) an ester represented by the following formula:

Embedded image R ²⁶ —O—R ²⁸ (where R ²⁶ is the same as above; R ²⁸ is a monohydric alcohol residue, preferably having a chain length of 2 to 24 carbon atoms;
Glycerin, polyglycerin, ethylene glycol, propylene glycol, polyhydric alcohol residues such as butanediol or glucose, ribose, galactose,
Indicates sugar residues such as arabinose, mannose, xylose, sorbitol, mannitol. )

In the present invention, in addition to the above compounds, the crystalline compounds include vitamins such as biotin, riboflavin, ascorbic acid and cyanocobalamin, amino acids such as glutamic acid, lysine and cysteine, glutathione, quinones and perchlorine. An electrolyte such as tetrabutylammonium acid may also be used. As the crystalline compound, one or more of the above compounds can be used. Among them, polyhydric alcohol derivatives of fatty acids or aliphatic alcohols, particularly, glycerin fatty acid esters and sorbite fatty acid esters are preferable. Furthermore,
The amount of the crystalline compound is not particularly limited, but is preferably 0.001 to 50%, particularly preferably 1 to 5% of the whole liquid composition.

The solvent used in the liquid composition of the present invention includes:
The amine oxide is not particularly limited, and the above-mentioned amine oxide, H of component A
Any of water and organic solvents can be used as long as the solvent can dissolve a nonionic surfactant having an LB value of 10 or less, a saccharide-based surfactant of the B component, an amphoteric polymer and a crystalline compound. . The organic solvent may be a hydrophilic solvent or a lipophilic solvent. In particular, a non-aqueous solvent having a water content of 5% or less can be suitably used. Such non-aqueous solvents include methyl alcohol,
Examples thereof include propyl alcohol, isopropyl alcohol, n-paraffin, benzene, hexane, chloroform, and the like. When the liquid composition of the present invention is used as cosmetics, among them, use highly safe ethyl alcohol. Is preferred.

The liquid composition of the present invention may contain optional components in addition to the above components depending on the purpose of use. For example, hair growth by combining polyhydric alcohol, other surfactants, oils and fats and vitamins, hormones, vasodilators, amino acids, anti-inflammatory agents, skin function enhancers, keratin enhancers, and other medicinal ingredients Agent, hair tonic, hair liquid, hair lotion, hair spray, etc., as well as external preparations for skin such as various medicines, cosmetics, nail preparations, etc., as well as coloring materials, paraffin, petroleum, lime, etc. Therefore, it can be widely applied as industrial products such as paints and fuel oils.

[0037]

Next, the present invention will be described more specifically with reference to examples.

Experimental Example 1 [Evaluation of low-temperature stability] Samples having the component compositions shown in Tables 1 to 6 were prepared, and the number of stabilization days and low-temperature stability were determined by the following methods.
The low-temperature stability (crystallization suppression effect) of the sample was evaluated. The results are shown in Tables 1 to 6.

(Evaluation method of stabilization days and low-temperature stability)
About 50 g of the test sample was placed in a transparent glass bottle and stored in a constant temperature room at -5 ° C, and the number of days obtained by subtracting one day from the day of crystal precipitation was defined as the number of stabilization days. In addition, the result was represented by the number of days obtained by rounding the average number of days of the three measurement results. The low-temperature stability was evaluated as ◎ when the number of stabilization days was 46 days or more, 35 days or more.
The case of 45 days was evaluated as ○, the case of 20 days to 34 days as Δ, and the case of 19 days or less as X.

Experimental Example 2 [Evaluation of usability] Using the samples shown in Table 5, the usability (stickiness) was evaluated by the following method. Table 5 shows the results.

(Evaluation Method for Feeling of Use) The feeling of use (stickiness) of each sample was evaluated by a panelists of 10 persons by actually applying each sample to the skin and performing a sensory test, according to the following criteria. Code Percentage of panelists judged to be good ━━━━━━━━━ ◎ ◎: fairly good 80% or more ○: good 60% or more and less than 80% △: Normal 40% or more and less than 60% ×: Poor 40% or less

[0042]

[Table 1]

[0043]

[Table 2]

[0044]

[Table 3]

[0045]

[Table 4]

[0046]

[Table 5]

[0047]

[Table 6]

From the results shown in Tables 1 to 6, the liquid composition according to the present invention comprising the crystalline compound and the specific amine oxide is excellent in low-temperature stability and stable with a small amount of a stabilizer. And (B) a sugar-based surfactant having a HLB value of 10 or less and / or (B) a saccharide-based surfactant.
Further, it was confirmed that the effect was effectively exhibited. In addition, it was confirmed that the liquid composition in which the specific amphoteric polymer was blended together with the above composition had better low-temperature stability. Subsequently, examples will be described, but the present invention is not limited to these examples.

<Example 1> (Hair restorer) Glyceride pentadecanoate 3.0% dl-α-tocopherol acetate 0.1% Sorbitan monolaurate 1.0% Pyridoxine dicaprylate 0.1% Safflower oil 0.2 % Succinic acid 0.2% Assembly extract paste 0.1% Biotin 0.001% Sucrose myristate 0.1% N-lauryl-N, N-dimethylamine oxide 0.3% Hinokitiol 0.05% Fragrance 0 0.3% 99.5% ethanol balance total 100.0%

<Example 2> (Hair spray) (stock solution) 1-hexacocene 1.0% Amphoteric polymer ^* 1.0% Methyl mannoside oleate 0.1% Citric acid 0.3% 1-Menthol 0.1% Sorbitan Monooleate 0.8% N-oleyl-N, N-dihydroxyethylamine oxide 0.2% Fragrance 0.5% 99.5% Ethanol balance ━━━━━━━━━━━━━━━━━ ━━━━━━━━━━━━━━━━━ Total 100.0% * N-methacryloylethyl-N, N-dimethylammonium / α-N-methylcarboxybetaine / alkyl methacrylate Combined (diluent for filling) The above stock solution 35.0% Carbon dioxide 40.0% LPG 15.0% Nitrogen 5.0% ━━━━━━━━━━━━━━━━━━━━ ━━━━━━━━━━━━ ━ a total of 100.0%

Example 3 (Hair lotion) Lead sulfocalcate 1.0% Myristyl stearate 0.5% Aloe ECW 0.5% N-myristyl polyoxyethylene-N, N 1.5% -dimethyl Amine oxide Flavor 0.5% 99.5% Ethanol Residual ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Total 100. 0%

Each of the compositions of Examples 1 to 3 was excellent in low-temperature stability and exhibited an effect of suppressing crystallization.

[0053]

EFFECT OF THE INVENTION The liquid composition of the present invention has an HLB value of 1 or less for the amine oxide or the component A blended therewith.
A nonionic surfactant of 0 or less, a saccharide-based surfactant of component B, and an amphoteric polymer suppress the crystallization of the crystalline compound at a low temperature, thereby exhibiting excellent solubility improving and low temperature stability improving effects. Therefore, even when stored at a low temperature of about −5 ° C. for a long time, the solution has almost no cloudiness or precipitation of crystals, and is excellent in low-temperature stability. Therefore, it can be widely used as an agent for hair, a cosmetic, a pharmaceutical, a nail, and an industrial chemical.

────────────────────────────────────────────────── ─── Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/00 A61K 7/00 J (72) Inventor Masahiro Sato 1-3-7 Honjo, Sumida-ku, Tokyo Lion Corporation Inside

Claims (3)

[Claims] An at least one crystalline compound selected from a fatty acid having an alkyl group having 7 to 30 carbon atoms, an aliphatic alcohol having an alkyl group having 8 to 30 carbon atoms, salts thereof and derivatives thereof, A liquid composition comprising a solvent and at least one of amine oxides represented by the following general formula (I) or (II). Embedded image (In the formula, R ¹ is an alkyl group having 1 to 24 carbon atoms or an alkenyl group having 2 to 24 carbon atoms. R ² and R ³ are an alkylene group having 1 to 10 carbon atoms or an alkylene group having 2 to 10 carbon atoms. Alkenylene group, A ¹ and A ² are hydrogen or hydroxyl group, and n is an integer of 0 to ^3. ) (A) at least one nonionic surfactant having an HLB value of 10 or less and / or (B) represented by the following general formulas (III), (IV) and (V): The liquid composition according to claim 1, further comprising at least one kind of saccharide-based surfactant. Embedded image (Wherein, R ^{4 to} R ¹¹ are each a hydroxyl group or a carboxyl group having 8 to 22 carbon atoms.) (However, in the formula, R ^{12 to} R ¹⁵ represent a hydroxyl group or a carbon number of 8 to 22.
Or the following groups. Embedded image m is an integer of 1 to 120 and y is an integer of 8 to 22. R ¹⁶ is an aglycone residue. ) (However, in the formula, R ^{12 to} R ¹⁶ are the same as those in the formula (IV).) 3. The liquid composition according to claim 1, further comprising at least one amphoteric polymer having a unit structure represented by the following general formula (VI). Embedded image (Wherein, R ¹⁷ is a hydrogen atom or a methyl group, R ¹⁸ is an alkylene group having 1 to 4 carbon atoms, and R ¹⁹ and R ²⁰ are a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, respectively. A ³ is an oxygen atom or an NH group.)