JPH11178843A - Antibacterial denture stabilizer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prevent the adhesion and growth of bacteria in the oral cavity stably over a long term by applying a constitution that a denture stabilizer is made to contain an inorganic antibacterial agent by a specific weight percentage for a total amount. SOLUTION: A denture stabilizer preferably uses a phosphate compound, particularly calcium phosphate compound as a carrier. In particular, one type of antibacterial metal selected from silver, copper, zinc or the like is carried as an inorganic antibacterial agent. This inorganic antibacterial agent is carried by an amount within the range of 0.05 to 10.0 wt.% for the carrier. The antibacterial function drops when the amount is equal to or less than a value in the range, and the application volume of the agent itself increase. On the other hand, the antibacterial metal is liable to be desorbed and the denture is liable to be colored, when the amount exceeds the range. For example, a denture stabilizer containing a phosphoric acid 3 calcium-silver antibacterial agent with an approximately 2.0 wt.% in terms of silver carried, shows the maintenance of the antibacterial function over a long term within the content range when subjected to an antibacterial test using coli bacilli.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a denture stabilizer.

[0002]

2. Description of the Related Art A person who has used a denture (for example, a resin denture base) for a long period of time not only causes pain during mastication due to absorption of alveolar bone, contact with a sharp bone margin, and the like. The compatibility of the denture is deteriorated due to absorption of the alveolar ridge, and the denture may be shaken or fall off, and the chewing ability may not be sufficiently exhibited.

[0003] As a method of solving these problems, a denture stabilizer is used for the purpose of restoring the oral mucosa to a healthy state and restoring the function as a denture base (especially improving the mastication ability). Is applied to the mucous membrane surface (lining surface of the denture base). The denture stabilizer temporarily fixes the denture base and the oral mucosa, and its releasability and wearability (adhesion) are incompatible with each other so that the denture base user can appropriately wear and release the denture 2. It has two properties. Such denture stabilizers are usually sold in tubes as viscous pastes and are commercially available.

As the denture stabilizer, an adhesive type containing a water-soluble polymer such as sodium carboxymethylcellulose or karaya gum as a main component, or an adhesive type containing vinyl acetate or the like as a main component (main base) has been used. I have.

[0005] A soft backing agent may be adhered to the back surface of the denture base for the purpose of reducing the pressure applied to the mucous membrane under the denture base during mastication. This soft lining material is a material that has a low fluidity and is firmly fixed to the back surface of the denture base so as not to be easily peeled off, and is applied by a dentist (dentist) according to the case of the user. Thus, unlike denture stabilizers, the user cannot obtain and apply it to the denture base by himself.

[0006]

Since the denture stabilizer is relatively soft, plaque and the like may infiltrate into the contact surface between the denture stabilizer and the oral mucosa. As a result, it has been pointed out that various bacteria adhere and propagate on the mucous membrane in the oral cavity, causing a mucous membrane disease and bad breath.

A denture base is disclosed in which an inorganic antibacterial agent is blended with a raw material such as plastic and molded, but the denture base is usually indirectly fixed to the oral mucosa via a denture stabilizer ( Therefore, the denture stabilizer which comes into direct contact with the oral mucosa must have antibacterial properties.

Further, the bactericide or antibacterial agent used in the conventional denture stabilizer is mainly an organic compound, and easily leaks out by contact with saliva at the time of adhesion and easily volatilizes. When the germicide (or the antibacterial agent) flows out, the germicidal action is reduced with time and the bactericidal effect is not maintained, but also harmful to the user.

The present invention has been made in view of the above-mentioned circumstances, and has an object to have sufficient antibacterial properties and to have a long lasting antibacterial activity even if oral bacteria try to grow by adhering thereto. An object of the present invention is to provide an antibacterial denture stabilizer capable of stably preventing the adhesion and propagation of oral bacteria over a long period of time.

[0010]

Means for Solving the Problems The inventors of the present invention have made intensive studies to solve the above-mentioned problems, and as a result, by adding a predetermined amount of an inorganic antibacterial agent to a denture stabilizer,
It has been found that an antibacterial denture stabilizer which exhibits a high antibacterial effect and has excellent durability can be obtained.

That is, the present invention relates to an antibacterial denture stabilizer (hereinafter referred to as "the present invention") containing an inorganic antibacterial agent in an amount of 0.05 to 10.0% by weight based on the total amount of the denture stabilizer. Of denture stabilizers.).

According to the denture stabilizer of the present invention, the content of the inorganic antibacterial agent is 0.05% by weight to 10.0% by weight based on the total amount of the denture stabilizer. It has sufficient antibacterial activity and can exhibit high antibacterial effect at the same time, so it can prevent various bacteria from adhering and proliferating on the mucous membrane in the oral cavity and causing mucosal diseases and bad breath, The state in the oral cavity can be maintained.

Since the denture stabilizer of the present invention contains an appropriate amount of an antibacterial agent, the denture is removed during use, washed with water, and when worn again, is retained without spilling because it is inorganic. Therefore, various bacteria can be sufficiently removed at the time of washing, and the number of bacteria can be reduced even when reused.

When the amount is less than 0.05% by weight, it is difficult to exhibit a sufficient antibacterial effect over a long period of time, and even if the amount exceeds 10% by weight, the antibacterial effect is not improved. In addition, the usability and operability at the time of wearing the denture stabilizer may deteriorate, and at the same time, the antibacterial agent may be detached. Further, the amount is preferably 1.0% by weight to 5.0% by weight, more preferably 1.0% by weight to 3.0% by weight.

[0015]

DETAILED DESCRIPTION OF THE INVENTION In general, denture stabilizers can be classified into two types: adhesive type and close contact type. As the former,
Examples thereof include those based on a water-soluble polymer such as sodium carboxymethylcellulose, polyacrylic acid, and gum karaya, and the latter based on vinyl acetate or the like. As the main base constituting the denture stabilizer of the present invention, any of the aforementioned bases can be used. In addition, the said "main base" is a main component which comprises a denture stabilizer, and may be called a matrix agent.

In addition to the above-mentioned main base, a mono- or binary homopolymer or copolymer obtained by polymerizing an acrylate such as methyl acrylate and / or a methacrylate such as ethyl methacrylate may be used. It can also be used as the main base of the denture stabilizer of the present invention.

As the main base, one of the above-mentioned components may be used, but if necessary, two or more of the above-mentioned components may be selected and used as the main base.

That is, the denture stabilizer of the present invention has an appropriate fluidity when worn, adheres well to the denture base, adheres well to the oral mucosa, and has long-lasting elasticity in the oral cavity. It is desirable to use a main base that can be retained and thereafter uniformly and easily exfoliated from the oral mucosa and the denture base (that is, compatible with exfoliation and adhesion). Examples thereof include an adhesive-type main base composed of liquid paraffin, sodium carboxymethylcellulose, and karaya gum, and a cohesive-type main base composed of polyvinyl acetate, ethanol, and propylene glycol. The main base used in the denture stabilizer of the present invention has a viscosity (viscosity) of 10 ² to 10 ⁶ poise, and preferably has relatively high fluidity.

The denture stabilizer of the present invention may optionally contain other optional components in addition to the above-mentioned components. As optional components, non-toxic waxes, plasticizers, water-insoluble powders, preservatives, emulsifiers, wetting agents, pigments, pigments, fragrances, pH adjusters, water, ethanol, etc. are added as required by known methods. be able to.

For example, non-toxic waxes such as beeswax, wood wax, microcrystalline wax, and carnauba wax; glycerin fatty acid esters such as triacetin as plasticizers; sucrose fatty acid esters such as sucrose acetate isobutyrate (SAIB); Water-insoluble powders such as calcium carbonate, calcium hydrogen phosphate, tricalcium phosphate, hydroxyapatite, silicon dioxide, plastic powder, cellulose powder, etc .; triclosan, ethyl paraben, etc. as preservatives; monoglyceride stearate, oleic acid as an emulsifier Monoglycerides, acetylated glyceryl fatty acid esters such as acetylated glyceryl monostearate, etc., polyethylene glycol, propylene glycol, glyceryl as wetting agents It can be used sorbit.

These optional components are used as adjuvants for adjusting the hardness and feeling of use of the denture stabilizer. For example, microcrystalline wax is one of non-toxic waxes, It can serve as a plasticizer for adjusting the hardness. In addition, for example, water-insoluble powders such as calcium carbonate reduce the stickiness of the denture stabilizer, and serve as a plasticizer for adjusting the hardness, and increase the moisture retention power of the denture stabilizer. It can be maintained for a long time without deteriorating the adhesive force, and can also provide excellent releasability.

Next, the antibacterial component (antibacterial agent) used in the denture stabilizer of the present invention will be described.

The inorganic antibacterial agent according to the present invention comprises an inorganic antibacterial agent in which a metal element and / or metal ion having antibacterial properties (hereinafter sometimes referred to as antibacterial metal) is supported on an inorganic carrier. There is no particular limitation as long as it is safe for the human body.

The antibacterial metal carried by the inorganic antibacterial agent may be silver, copper, zinc, or the like in consideration of human safety.
At least one selected from the group consisting of gold, platinum and nickel is mentioned, but ensuring high antibacterial properties,
In consideration of productivity, production cost, and the like, use of silver, copper, or zinc is most preferable among the above-mentioned antibacterial metals. These antibacterial metals may be used alone or in combination of two or more.

On the other hand, carriers for supporting antibacterial metal elements and metal ions include activated carbon, alumina, silica gel, zeolite, phosphate compounds such as calcium phosphate and zirconium phosphate, calcium carbonate, calcium silicate, bentonite, and the like. At least one selected from the group consisting of titanium oxide can be used.

The aforementioned compounds, ie, activated carbon, alumina,
Silica gel, zeolite, phosphate compounds, calcium carbonate, calcium silicate, bentonite, and titanium oxide are safe for the human body and have excellent ability to fix metal elements and / or metal ions. Among these carriers, a single compound can be selected and used as a carrier, but a plurality of compounds can be selected and used as a carrier.

Of these, a phosphate compound is preferably selected and used as a carrier because it is a substance having a high ion exchange capacity and a low elution amount of the supported antibacterial metal. In addition, the supporting form of the antibacterial metal and the carrier is not all ion-exchanged as metal ions, and it is considered that some metals are adsorbed and held. Preferably, there is.

Specific examples of the phosphate compound include:
Tricalcium phosphate [Ca ₃ (PO ₄ ) ₂ ], calcium hydrogen phosphate [CaHPO ₄ ], hydroxyapatite [Ca ₁₀ (PO ₄ ) ₆ (OH) ₂ ], calcium hydrogen pyrophosphate [CaH ₂ P ₂ O _7] A calcium phosphate compound such as calcium pyrophosphate [Ca ₂ P ₂ O ₇ ];
Titanium phosphate compounds such as Ti (HPO ₄ ) ₂ , Zr
(HPO ₄ ) _{2 and} other zirconium phosphate compounds, Mg
₃ (PO ₄ ) ₂ etc. magnesium phosphate compound, Al
Aluminum phosphate compounds such as PO ₄ , Mn ₃ (PO
₄ ) Manganese phosphate compound such as ₂ and Fe ₃ (P
At least one selected from the group consisting of iron phosphate compounds such as O ₄ ) ₂ can be used. Antibacterial agents using these phosphate compounds as carriers have particularly low metal ion elution amounts (desorption) and high sustainability of the antibacterial effect.

These carriers may be natural products or synthetic products, but synthetic products are preferred because uniform quality particles can be obtained. When a phosphate is synthesized by a wet method based on a solution reaction, an amorphous product can be produced, and a product having a high crystallinity can be obtained by performing a calcination process. Although any crystalline material can be obtained, any material may be used. The phosphate may contain water of crystallization.

Among the above-mentioned phosphate compounds, calcium phosphate is particularly preferred because of its good affinity with the human body (biocompatibility), high antimicrobial durability and excellent safety. The use of a system compound is most preferred. As the calcium phosphate compound, in addition to those described above,
Halogenated apatite and non-stoichiometric apatite Ca _10-z (HPO ₄ ) of ₁₀ (PO ₄ ) ₆ X ₂ (X = F, Cl)
_y (PO ₄ ) _6-y X _2-y · _z H ₂ O (X = OH, F, C
l; y and z may be non-stoichiometric).

In the denture stabilizer of the present invention, the above-mentioned compound as a carrier, preferably a phosphate compound, particularly a calcium phosphate compound, is selected as a carrier. It is preferable that at least one antibacterial metal selected from silver, copper, and zinc is supported, and this is used as the inorganic antibacterial agent.

Examples of the method of supporting the antibacterial metal on the simple substance include a method of supporting a metal element and / or a metal ion by adsorption, a method of supporting a metal element and / or a metal ion by an ion exchange reaction, and a method of supporting a metal element and / or a metal ion by a mechanochemical reaction. These methods can be used to prepare an inorganic antibacterial agent in which an antibacterial metal is supported on a carrier made of an inorganic compound.

The mechanochemical reaction is a method for producing a slurry of an antibacterial agent having a uniform particle size while performing adsorption and / or ion exchange from a starting material by using a mixing device such as a ball mill. For example, a starting material (a calcium compound such as calcium carbonate, phosphoric acid, etc.) and an antibacterial metal aqueous solution for producing a carrier are charged into a ball mill, and the ball mill is operated for a certain period of time. Can stir the slurry of the starting material and simultaneously grind the reaction product. As described above, by performing the mechanochemical reaction for a certain period of time, the reaction of the starting material and the pulverization of the reaction product are simultaneously performed, so that an antibacterial agent having a uniform and uniform particle size can be obtained, particularly for mass production. It is suitable.

As the inorganic antibacterial agent, the aforementioned antibacterial metal is used in an amount of 0.05 to 10.0% by weight based on the carrier.
It is preferable to carry it within the range of weight%. If the amount of the antibacterial metal is less than 0.05% by weight, the antibacterial performance is low, and it may be necessary to use a large amount of the antibacterial agent itself. On the other hand, when the antibacterial metal is supported at a supporting amount exceeding 10.0% by weight, the bonding between the antibacterial metal and the carrier is weak, so that the antibacterial metal is easily detached,
The denture stabilizer tends to be easily colored.

In addition, the inorganic antibacterial agent used in the present invention may contain, in addition to the inorganic compound as the carrier and the antibacterial metal, other than the inorganic compound as long as the object of the present invention is not hindered. For example, it may contain another inorganic compound such as silicon dioxide or zinc oxide. For example, silicon dioxide has the effect of improving the whiteness of the antibacterial agent, and zinc oxide has the effect of improving the antibacterial spectrum of the antibacterial agent (the number of target bacteria that can act on the antibacterial effect increases) Both inorganic compounds are safe for the human body.
In this case, in particular, when silver is used as the antibacterial metal, the target of the antibacterial action is widened, and in the case of copper, there is an antifungal effect.

The inorganic antibacterial agent using a phosphate compound as a carrier is preferably further subjected to a calcination treatment at 500 ° C. to 1200 ° C. The inorganic antibacterial agent that has been subjected to the baking treatment, compared with those that have not been calcined,
Since the rate of dissolution of antibacterial metals is extremely low and the durability (persistence) of antibacterial effect is even more excellent, in particular, denture stabilizers are used for a long time in direct contact with the oral mucosa. More preferred is the use of a phosphate compound.

The particle diameter of the inorganic antibacterial agent is 10
μm or less is preferable, and 5 μm or less is more preferable. When the particle size exceeds 10 μm, the specific surface area becomes small, so that the amount of the inorganic antibacterial agent must be increased in order to exert the antibacterial effect. However, since the particle size is large, the amount is small. If the amount is too large, the denture stabilizer tends to peel off when worn. In addition, if the particle diameter of the inorganic antibacterial agent is 5 μm or less, without impairing the feeling of use when wearing the denture stabilizer,
It can exert antibacterial power more effectively.

The denture stabilizer having an antibacterial component (antibacterial agent) according to the present invention may be prepared by mixing and dispersing the above-mentioned inorganic antibacterial agent and various components into a paste-like composition.
It can be produced by various methods, and can be used in the same manner as ordinary denture stabilizers.

[0039]

EXAMPLES Hereinafter, the present invention will be described in detail with reference to Examples, but the present invention is not limited to the following Examples.

<Preparation of Antibacterial Agent> First, the following antibacterial agents (antibacterial components) 1 to 5 were prepared in the following manner.

(1) Antibacterial agent 1 (tricalcium phosphate-silver antibacterial agent) 100 g of tricalcium phosphate and 3.3 g of silver nitrate were added to 1000 mL of distilled water, and the mixture was sufficiently stirred and mixed at room temperature. After thoroughly washing the obtained product with distilled water, 12
It was dried at 0 ° C. (wet method: the same applies to the following preparation methods).

Next, the dried product is fired at 700 ° C.
The obtained calcined product was pulverized to obtain a powder of tricalcium phosphate carrying silver (tricalcium phosphate-silver antibacterial agent). The proportion (amount) of silver in this powder was 2.0% by weight.

(2) Antibacterial agent 2 (hydroxyapatite-silver antibacterial agent) Hydroxyapatite 100 was added to 1000 mL of distilled water.
g and 3.3 g of silver nitrate were added, thoroughly stirred and mixed at room temperature, and the resulting product was thoroughly washed with distilled water.
Dry at 120 ° C.

Next, the dried product is fired at 1000 ° C., and the obtained fired product is pulverized to obtain a hydroxyapatite carrying silver (hydroxyapatite-silver antibacterial agent:
Hereinafter, it is referred to as a HAP-silver antibacterial agent. ) Was obtained.
The ratio of silver (support amount) in this powder was 2.0% by weight.
Met.

(3) Antibacterial Agent 3 (Zeolite-Silver Antibacterial Agent) To 1000 mL of distilled water, 100 g of dried sodium type A zeolite and 3.3 g of silver nitrate were added, and thoroughly stirred and mixed at room temperature. The obtained product was thoroughly washed with distilled water and dried at 120 ° C.

Next, the dried product was pulverized to obtain a powder of zeolite carrying silver (zeolite-silver antibacterial agent). The proportion (amount) of silver in this powder was 2.0% by weight.

(4) Antibacterial agent 4 (zirconium phosphate-silver antibacterial agent) Dried zirconium phosphate 1 in 1000 mL of distilled water
After adding 00 g and silver nitrate 3.3 g, and sufficiently stirring and mixing at room temperature, the obtained product was thoroughly washed with distilled water and then dried at 120 ° C.

Next, the dried product was pulverized to obtain powder of zirconium phosphate carrying zirconium (zirconium phosphate-silver antibacterial agent). The proportion (amount) of silver in this powder was 2.0% by weight.

(5) Antibacterial agent 5 (titanium oxide-silver antibacterial agent) 100 g of dried titanium oxide and 3.3 g of silver nitrate were added to 1000 mL of distilled water, and the mixture was sufficiently stirred and mixed at room temperature, and then obtained. After thoroughly washing the product with distilled water,
Dried at 0 ° C.

Next, the dried product was pulverized to obtain a powder of titanium oxide (titanium oxide-silver antibacterial agent) carrying silver. The proportion (amount) of silver in this powder was 2.0% by weight.

<Preparation of Denture Stabilizer> The above-mentioned antibacterial agents 1 to 5
Was used to prepare denture stabilizers of the following Examples and Comparative Examples.

Example 1 A denture stabilizer having the following components and compounding ratio was prepared by the following method.

A predetermined amount of liquid paraffin was weighed to 100 m
In a glass beaker L, stirring was started while heating at a rotation speed of 150 rpm.

Next, while maintaining the temperature of the liquid paraffin at 90 ° C., first, a predetermined amount of sodium carboxymethylcellulose was weighed and charged into the glass beaker. After 10 minutes, predetermined amounts of karaya gum and antibacterial agent 1 (tricalcium phosphate-silver-based antibacterial agent: silver carrying amount 2.0% by weight) were weighed, and charged every 5 minutes in this order for 30 minutes. Stirring was continuously performed, and after confirming that all components were uniformly dispersed, the stirring was terminated.

The composition and mixing ratio of the denture stabilizer in this example are as follows. Liquid paraffin 51% by weight Sodium carboxymethylcellulose 24% by weight Karaya gum 23% by weight Antibacterial agent 1 0.05% by weight

Example 2 A denture stabilizer having the following components and compounding ratio was prepared by the following method.

First, a predetermined amount of ethanol was weighed, and 100
In a mL glass beaker, stirring was started at a rotation speed of 150 rpm. Next, a predetermined amount of polyvinyl acetate was weighed and charged into the glass beaker. After 10 minutes, predetermined amounts of propylene glycol, antibacterial agent 1 (tricalcium phosphate-silver antibacterial agent: silver carrying amount 2.0% by weight), and calcium carbonate are weighed, and charged in this order every 5 minutes. Then, stirring was continuously performed for 30 minutes, and it was confirmed that all components were uniformly dispersed.

The composition and mixing ratio of the denture stabilizer in this example are as follows. Polyvinyl acetate 60% by weight Ethanol 25% by weight Propylene glycol 5% by weight Antibacterial agent 1 10% by weight

Example 3 Instead of 0.05% by weight of antibacterial agent 1, 0.05% by weight
Antibacterial agent 3 (zeolite-silver antibacterial agent: silver carrying amount 2.0
% By weight), and a denture stabilizer was prepared in the same manner as in Example 1.

Example 4 Except that 0.05% by weight of antimicrobial agent 1 was replaced by 2.0% by weight of antimicrobial agent 3 (zeolite-silver-based antimicrobial agent: silver carrying amount 2.0% by weight) A denture stabilizer was prepared in the same manner as in Example 1.

Example 5 Instead of 0.05% by weight of antibacterial agent 1, 2.0% by weight of antibacterial agent 4 (zirconium phosphate-silver based antibacterial agent: silver carrying amount 2.0% by weight) was used. Except for the above, a denture stabilizer was prepared in the same manner as in Example 1.

Example 6 Except that 0.05% by weight of antibacterial agent 1 was replaced by 2.0% by weight of antibacterial agent 5 (titanium oxide-silver antibacterial agent: silver carrying amount 2.0% by weight) Produced a denture stabilizer in the same manner as in Example 1.

Example 7 Instead of 0.05% by weight of antibacterial agent 1, 10.0% by weight
Antibacterial agent 5 (titanium oxide-silver antibacterial agent: silver carrying amount 2.0
% By weight), and a denture stabilizer was prepared in the same manner as in Example 1.

Example 8 Except that 0.05% by weight of antibacterial agent 1 was replaced by 2.0% by weight of antibacterial agent 2 (HAP-silver-based antibacterial agent: silver carrying amount 2.0% by weight) A denture stabilizer was prepared in the same manner as in Example 1.

Example 9 Instead of 0.05% by weight of antibacterial agent 1, 2.0% by weight of antibacterial agent 1 (tricalcium phosphate-silver based antibacterial agent: silver carrying amount 2.0% by weight) was used. A denture stabilizer was prepared in the same manner as in Example 1 except for the difference.

Example 10 Instead of 0.05% by weight of antibacterial agent 1, 5.0% by weight of antibacterial agent 1 (tricalcium phosphate-silver antibacterial agent: silver carrying amount 2.0% by weight) was used. A denture stabilizer was prepared in the same manner as in Example 1 except for the difference.

Example 11 Instead of 0.05% by weight of antibacterial agent 1, 1.0% by weight of antibacterial agent 1 (tricalcium phosphate-silver antibacterial agent: silver carrying amount 2.0% by weight) was used. A denture stabilizer was prepared in the same manner as in Example 1 except for the difference.

Example 12 Instead of 0.05% by weight of antibacterial agent 1, 0.5% by weight of antibacterial agent 1 (tricalcium phosphate-silver based antibacterial agent: silver carrying amount 2.0% by weight) was used. A denture stabilizer was prepared in the same manner as in Example 1 except for the difference.

Comparative Example 1 Instead of 0.05% by weight of antibacterial agent 1, 0.04% by weight
A denture stabilizer was prepared in the same manner as in Example 1, except that Antibacterial Agent 1 (tricalcium phosphate-silver-based antibacterial agent: silver carrying amount 2.0% by weight) was used.

Comparative Example 2 Instead of 0.05% by weight of antibacterial agent 1, 11.0% by weight
A denture stabilizer was prepared in the same manner as in Example 1, except that Antibacterial Agent 1 (tricalcium phosphate-silver-based antibacterial agent: silver carrying amount 2.0% by weight) was used.

Comparative Example 3 A denture stabilizer was prepared in the same manner as in Example 1 except that no antibacterial agent was added.

<Antibacterial test (evaluation method)> Escherichia coli was used as a test bacterium, and these bacterial solutions were prepared by the following method.

First, the strain was cultured in a normal broth medium with shaking at 37 ° C. for 18 hours, and then the culture was inoculated into the medium and cultured with shaking at 37 ° C. for 8 hours. Then, this was appropriately diluted, and the viable cell count before the test was about 1.5 × 10 ⁵
The solution was adjusted to give a number of cells / mL, and 5 mL thereof was added to 70 mL of sterile phosphate buffer to prepare a test bacterial solution.

As the test pieces, the denture stabilizers of the above Examples and Comparative Examples were each formed into a flat plate having a thickness of 1.0 mm. Then, 2.0 g of the molded denture stabilizer of Example or Comparative Example was placed in an Erlenmeyer flask containing the test bacterial solution, and shaken at 25 ° C. for 6 hours. After shaking for 6 hours, a part of the test bacterial solution was taken out, and the viable cell count was measured using a pour culture solution (35 ° C., 48 hours) using an agar medium. This is defined as the viable cell count at the beginning of use. The antimicrobial count after immersing each test piece in water at 37 ° C. for 14 days was 1
The number of viable bacteria after 4 days has passed.

<Antibacterial Test (Evaluation Results)> Examples 1-1
Table 1 below shows the antibacterial activity test results of Comparative Example 2, Comparative Examples 1, 2 and Comparative Example 3.

[0076]

[0077]

According to the test results, antibacterial effects were observed at the beginning of use in each of Examples 1 to 12 and Comparative Examples 1 and 2 using the antibacterial agent. In Comparative Example 3 (blank sample) in which no antibacterial agent was used, the number of bacteria was decreased at the beginning of use, and antibacterial properties were observed. This is considered to be due to the bactericidal effect of ethanol.

However, the results of the antibacterial test after immersing each test piece in water at 37 ° C. for 14 days show that the sample containing the antibacterial agent was compared with Comparative Example 3 (blank sample) not containing the antibacterial agent. It can be seen that the antibacterial effect is persistent.

In Example 8 having antibacterial agent 2 (HAP-silver antibacterial agent) or Example 9 having antibacterial agent 1 (tricalcium phosphate-silver antibacterial agent), the antibacterial activity was sufficient even after 14 days. It is maintained and has little or no reduction. As described above, these are phosphate-based compounds, have high biocompatibility, have a strong silver holding power as compared with zeolite, and have been subjected to a calcination treatment, so that silver It is considered that silver was hardly eluted and the antibacterial activity was maintained because the retention was further strengthened.

In Example 5 having antibacterial agent 4 (zirconium phosphate-silver-based antibacterial agent), Example 4 having antibacterial agent 3 (zeolite-silver-based antibacterial agent) showed an antibacterial activity after 14 days.
Example 6 having antibacterial agent 5 (titanium oxide-silver-based antibacterial agent)
Although the antibacterial performance was almost the same as that of Example 8, it can be seen that the ability to retain the antibacterial activity was lower than that of Example 8 having the antibacterial agent 2 or Example 9 having the antibacterial agent 1.

In Example 4 having the antibacterial agent 3 and Example 6 having the antibacterial agent 5, the antibacterial activity after 14 days has been reduced as compared with the initial use. This is considered to be because the zeolite-silver antibacterial agent and the titanium oxide-silver antibacterial agent had a low ability to retain silver and easily eluted the supported silver, so that the antibacterial activity at the beginning of use could not be maintained.

From the results of Comparative Example 1, although the antibacterial agent 1 (tricalcium phosphate-silver-based antibacterial agent) was used as the antibacterial agent, the antibacterial activity was durable, but the amount of the antibacterial agent was small. Compared to the antibacterial activity result of Example 1, the antibacterial activity is inferior.

A comparison between Comparative Example 2 and Example 2 shows that a sufficient antimicrobial effect and sustained antimicrobial activity can be obtained when the amount of the antimicrobial agent is about 10% by weight. However, in Comparative Example 2, since the compounding amount of the antibacterial agent exceeded 10% by weight, the ratio of the main base was relatively reduced. Dropped.

FIG. 1 shows changes in the number of viable cells (open circles) at the initial stage (black circles) and after 14 days, depending on the amount (% by weight) of the antibacterial agent relative to the total amount of the denture stabilizer. In addition, this graph shows Examples 1, 2, 9, 10, 11 and 12 and Comparative Example 1.
And 2.

That is, when the compounding amount of the antibacterial agent is less than 0.05% by weight, the initial antibacterial performance is inferior, and at the same time, the number of viable bacteria after 14 days has greatly increased, and the antibacterial activity and its persistence are reduced. You can see that Although not shown, as described above, when the amount of the antibacterial agent exceeds 10% by weight, the ratio of the main base is relatively reduced. The operability was reduced, and the release of the antibacterial agent was also confirmed. The amount is preferably 1 to 5% by weight, since the antibacterial action, its long-lasting property, and the feeling of use are further improved.

[0087]

The antibacterial denture stabilizer of the present invention is excellent in that it contains 0.05% to 10.0% by weight of an inorganic antibacterial agent based on the total amount of the denture stabilizer. It has an antibacterial action, and its antibacterial action hardly decreases even when used for a long time. Therefore, invasion of bacteria to the contact surface between the oral mucosa and the denture base can be prevented, and adhesion and growth of bacteria can be suppressed.
Therefore, according to the denture stabilizer of the present invention, the inside of the oral cavity is always kept hygienic, and the occurrence of bad breath due to the growth of bacteria can be prevented.

[Brief description of the drawings]

FIG. 1 is a graph showing a change in the number of viable bacteria depending on the amount of an antibacterial agent.

Claims (6)

[Claims] 1. An antibacterial denture stabilizer containing 0.05 to 10.0% by weight of an inorganic antibacterial agent based on the total amount of the denture stabilizer. 2. The method according to claim 2, wherein the inorganic antimicrobial agent is activated carbon, alumina, silica gel, zeolite, phosphate compound, calcium carbonate, calcium silicate, bentonite, and titanium oxide. The antibacterial denture stabilizer according to claim 1, which is an inorganic antibacterial agent carrying at least one metal selected from the group consisting of copper, zinc, gold, platinum and nickel. 3. The phosphate compound is a calcium phosphate compound, a titanium phosphate compound, a zirconium phosphate compound, a magnesium phosphate compound, an aluminum phosphate compound, a manganese phosphate compound, and iron phosphate. The antibacterial denture stabilizer according to claim 2, which is at least one compound selected from the group consisting of a series of compounds. 4. A carrier comprising at least one calcium phosphate compound selected from the group consisting of tricalcium phosphate, calcium hydrogen phosphate and hydroxyapatite, and at least one member selected from the group consisting of silver, copper and zinc. The antibacterial denture stabilizer according to claim 3, wherein the metal is supported. 5. The antibacterial denture stabilizer according to claim 2, wherein the metal is supported at 0.05% by weight to 10.0% by weight based on the carrier. 6. The antibacterial denture stabilizer according to claim 1, wherein the inorganic antibacterial agent is disposed in a main base material which has both releasability and adhesiveness.