JPH11171752A - Dentifrice composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a dentifrice composition with excellent Streptococcus mutans inhibitory effect as well as dentin strengthening ability, therefore high in dental caries preventive effect. SOLUTION: This dentifrice composition is obtained by formulating fluoride(s), a chlorhexidine salt, and xylitol; wherein the fluoride(s) is at least one kind among sodium monofluorophosphate, odium fluoride, stannous fluoride, or a combination thereof, the concentration in terms of fluorine being <=1,000 ppm; the chlorhexidine salt is chlorhexidine gluconate or chlorhexidine hydrochloride, its concentration being 0.01-1.0 wt.%; and the xylitol is <=15 wt.% in concentration, pref. accounting for >=50 wt.% of the total sweeteners formulated.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dentifrice composition which is excellent in strengthening teeth and suppressing mutans bacteria and having a high caries prevention effect.

[0002]

BACKGROUND OF THE INVENTION Fluoride ions not only improve the structure of enamel crystals and increase their resistance to the acids produced by cariogenic bacteria, but also desorb more than healthy tooth enamel. It is widely known that a large amount is taken into the ash portion and has an effect of promoting remineralization.

Chlorhexidine gluconate is a cationic fungicide having a broad antibacterial activity known as Hibiten, and a 0.02% solution thereof is also used as a mouthwash.

[0004] Xylitol is a food additive having the same level of sweetness as sucrose. Since it is not metabolized by mutans bacteria in the oral cavity, it cannot not only produce bacteria but also produce large amounts of xylitol. It is also attracting attention as a caries preventive agent characterized by the fact that the process of consuming energy is repeated, resulting in fatigue and reduction.

[0005] Dentifrice compositions using these components alone are disclosed in JP-A-4-275213 and JP-A-6-2397.
No. 23, Japanese Patent Application Laid-Open No. 51-106741 and the like, and a dentifrice composition used in combination of two types has already been disclosed, but it is disclosed in Japanese Patent Application Laid-Open No. 3-48613. In the case of a mixture of only a fluoride ion supply and xylitol, which has no fungicide, the effect on cariogenic bacteria is weak.
A compound containing only chlorhexidine and xylitol as disclosed in, for example, JP-A-224613, has a temporary bactericidal effect, but is inferior in strengthening of the tooth substance, and is still not effective as a long-term caries preventive effect. It was not enough.

[0006]

The object of the present invention is to provide a dentifrice composition which solves the above-mentioned drawbacks of the prior art, is excellent in strengthening teeth and suppresses mutans bacteria, and is more effective in preventing dental caries. Make it an issue.

[0007]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to solve the above-mentioned problems, and as a result, by combining three types of fluoride, chlorhexidine salts, and xylitol, the tooth strengthening has been achieved. The present inventors have found that a dentifrice composition having an excellent mutans-inhibiting effect and a higher caries-preventing effect can be obtained, and the present invention has been accomplished.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the dentifrice composition according to the present invention will be described in detail. The fluoride used in the present invention is not particularly limited as long as it is dentally acceptable. For example, one or more of sodium monofluorophosphate, sodium fluoride and stannous fluoride may be used. It is optimal to use them in combination. It is desirable that the concentration as fluorine be kept at 1000 ppm or less from the viewpoint of safety.

As the chlorhexidine salts, chlorhexidine gluconate or chlorhexidine hydrochloride, which has a solubility in water which does not cause any practical problems, is most preferable.
The chlorhexidine concentration is 0.01 to 1.0%.
(% By weight, the same applies hereinafter), and preferably 0.02 to 0.5%. If it is less than 0.01%, sufficient sterilizing ability may not be obtained, and if it exceeds 1.0%, side effects such as shock symptoms may be caused.

[0010] In addition to the sweetener, xylitol also plays a role as a caries suppressant, and its compounding amount is 15% or less of the whole living tissue, particularly 50% of the total compounding sweetener.
It is most desirable that this is the case. If it exceeds 15%, the dentifrice is too sweet and lacks a refreshing feeling.
If it is less than 0%, the effect as a caries inhibitor is inferior.

The dentifrice composition according to the present invention containing such constituents can be prepared in the form of toothpaste, toothpaste, liquid dentifrice and the like. Known components such as abrasives, wetting agents, foaming agents, adhesives, flavoring agents, coloring agents, preservatives, anti-inflammatory agents, enzymes, and the like can be blended as long as the effects of the present invention are not impaired.

[0012]

EXAMPLES The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In addition,% in each example is weight%.
Toothpaste and liquid dentifrice were prepared in the usual manner according to the formulation shown in Table 1, and the number of mutans bacteria as a result of three subjects brushing twice a day for three minutes twice a day for three months using each toothpaste composition The table below shows the inhibition rate and the plaque inhibition rate based on the Plaque Control Record.

Using the Dentocult SM (manufactured by Orion), the amount of mutans bacteria in the oral cavity of each test subject before and after using each dentifrice braid for three months was measured using Dentocult SM (Orion). Calculate the bacterial suppression rate by the formula,
The average of three persons was shown.

Plaque control rate For each subject, the Plaque Control Record was obtained by the O 'Leary method before using each dentifrice composition and after using it for 3 months.
(Hereinafter abbreviated as PCR) (The Plaque Control Reco
rd. J. Periodontol 43:38, 1972. ) Was measured, and the plaque inhibition rate was calculated by the following equation, and the average of the three persons was shown.

As is clear from Table 1, it was confirmed that the combination of fluoride, chlorhexidine salt and xylitol in the dentifrice composition increased the caries prevention effect.

[0016]

[Table 1]

[0017]

Industrial Applicability As described in detail above, the present invention, by blending three kinds of fluoride, chlorhexidine salts and xylitol, is excellent in the effect of suppressing mutans bacteria at the same time as strengthening teeth and preventing caries. It is a highly effective dentifrice composition.

Claims (5)

[Claims] 1. A fluoride, chlorhexidine salts,
A dentifrice composition comprising three types of xylitol. 2. The method according to claim 1, wherein the fluoride is one or a combination of sodium monofluorophosphate, sodium fluoride and stannous fluoride, and the concentration as fluorine is 1000 ppm or less. 2. The dentifrice composition according to 1. 3. The dentifrice composition according to claim 1, wherein the chlorhexidine salt is chlorhexidine gluconate or chlorhexidine hydrochloride, and the chlorhexidine concentration is 0.01 to 1.0% by weight. 4. The dentifrice composition according to any one of claims 1 to 3, wherein the concentration of xylitol is 15% by weight or less. 5. The dentifrice composition according to any one of claims 1 to 4, wherein the concentration of xylitol is 50% or more of the total sweetener.