JPH10330247A - Plaster for nail - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a plaster matrix for nails capable of promoting the health through the nails and maintaining or improving the nails in healthy conditions by formulating a specific pharmacodynamically effective ingredient together with a tacky agent therein. SOLUTION: This plaster matrix for nails contains a tacky agent and a pharmacodynamically effective ingredient. For example, a cooling ingredient, a thermesthesic ingredient, an antimicrobial ingredient, a humectant ingredient and a keratin proliferation promoting ingredient can be cited as the pharmacodynamically effective ingredient. As for the pharmacodynamically effective ingredient, menthol, thymol, camphor, etc., are concretely preferred as the cooling ingredient. Glycerol, an extract from Guinea pepper and capsaicin, etc., are preferred as the thermestesic ingredient. Clotrimazole, miconazole nitrate, etc., are preferred as the antimicrobial ingredient and sodium hyaluronate, etc., are preferred as the humectant ingredient. An ecdysteroid, etc., are preferred as the keratin proliferation promoting ingredient. The amount of the pharmacodynamically effective ingredient is 0.01-10 wt.% based on the total amount of the matrix. An acrylic tacky agent is preferred as the tacky agent and preferably formulated in an amount of 0.1-99 pts.wt.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a patch and a patch matrix, and more particularly to a patch and a patch matrix for nails.

[0002]

2. Description of the Related Art Nails are formed from hard keratin and are said to have no physiological activity. However, it has been suggested that nail conditions are deeply related to human health, as it is said that the condition of the nail in natural conditions is a barometer of health. However, no attempt has been made to stimulate the nails to contribute to the health of the whole organism.

[0003] The nail is located on the uppermost surface of the most prominent finger and has an important aesthetic meaning. For this reason, keeping the condition of the nails beautiful is important in terms of forming a beautiful image of the person himself. For this reason, attempts have been made to increase the moisturizing properties by applying wax or to improve and maintain the condition of nails by applying cosmetics such as cream. However, it was hoped that such an attempt was effective. Further, when a nail color or the like is applied to decorate the nail, a phenomenon called yellowing of the nail sometimes appears, but the means for preventing and treating such yellowing has been insufficient in some cases.

[0004] Nail lesions include tinea unguium, a disease in which nails are degenerated by Trichophyton, and treatment by administration of an antifungal agent or treatment by excision of the nail is performed. It is difficult to restore the degenerated nails, and in reality, it is impossible to expect beautiful nails from such diseases.

[0005] In other words, there has been a demand for means for improving health through the nails, and means for maintaining or improving the health of the nails.

[0006] On the other hand, the application of a patch to the nail, and thus the promotion of health through the nail, and the maintenance or improvement of the health of the nail, have not been performed at all.

[0007]

SUMMARY OF THE INVENTION The present invention has been made under such circumstances, and provides means for improving health through nails and means for maintaining or improving the health of nails. That is the task.

[0008]

In view of such circumstances, the present inventors have conducted intensive research on means for improving health through nails and for maintaining or improving the health of nails. Create a patch matrix for nails containing an adhesive and a medicinal component, and apply this to a support to form a patch,
By affixing this to a nail, it has been found that it is possible to promote health through the nail, to maintain and improve the health of the nail, and to complete the invention. Hereinafter, the present invention will be described in detail focusing on embodiments.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION

(1) Patch matrix for nails of the present invention The patch matrix for nails of the present invention is characterized by containing an adhesive and a pharmaceutically active ingredient. As the medicinal component, for example, a cooling component, a warming sensation component, an antibacterial component, a moisturizing component, a keratin growth promoting component can be preferably exemplified, and these may contain only one medicinal effect or two or more medicinal effects. May be contained. Preferred medicinal ingredients include
Specifically, the cooling component may be one or more selected from menthol, thymol, camphor, methyl salicylate and cyclodextrin clathrates thereof, and the warming component may be glycerin, capsicum extract, capsaicin And one or more selected from these cyclodextrin clathrates, wherein the antibacterial component is clotrimazole, miconazole nitrate, econazole nitrate,
One or two or more selected from bifonazole, butenafine, and terbinafine can be exemplified, and one or two or more moisturizing components selected from sodium hyaluronate, trehalose sodium, and sodium sulfated trehalose can be exemplified, and keratin growth promotion can be exemplified. The component is selected from borei extract, hawthorn extract, ecdysteroid, polyporsterone and 9,10-dihydroxystearic acid1
The species or two or more species can be exemplified. The preferable content of these medicinal ingredients is 0.01 to 10% by weight, more preferably 0.05 to 5% by weight, based on the total amount of the matrix when the matrix is applied and dried.

The matrix of the present invention can contain a pressure-sensitive adhesive. Examples of the pressure-sensitive adhesive include an acrylic pressure-sensitive adhesive and a rubber-based pressure-sensitive adhesive. Among these, in terms of percutaneous absorbability, methyl acrylate-2-ethylhexyl acrylate, methacrylic acid / acrylic acid copolymer or Acrylic acid
Acrylic pressure-sensitive adhesives such as 2-ethylhexyl / ethyl acrylate / vinyl acetate copolymer are preferred. The preferred content of the pressure-sensitive adhesive in the matrix of the present invention is 0.1 to 99 parts by weight, more preferably 5 to 97 parts by weight, and still more preferably 10 to 95 parts by weight in the matrix after coating and drying. Parts by weight.

In the patch matrix for nails of the present invention,
In addition to the pressure-sensitive adhesive and the medicinal component, it can contain optional components usually used in patches. Examples of such optional components include, as bases, hydrocarbons such as squalane, petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, higher alcohols such as cetanol and oleyl alcohol, and stearin. Acids, fatty acids such as oleic acid, thickeners such as carbopol, preservatives, ultraviolet absorbers, antioxidants, dyes, powders, nonionic surfactants, anionic surfactants, cationic surfactants, etc. Is mentioned. The preferable content of the base is 0.1 to 60% by weight, more preferably 0.5 to 50% by weight, further preferably 1 to 50% by weight in the matrix after coating and drying.
４０40% by weight. As an optional ingredient other than the base,
Examples include polyhydric alcohols such as 1,3-butanediol and polyethylene oxide, and plasticizers such as triethyl citrate.

The matrix of the present invention can be produced by a conventional method such as kneading these components with a kneader. The thus-obtained patch matrix can be used as a patch by coating and drying on a support.

(2) Patch of the Present Invention The patch of the present invention is characterized by having the above-mentioned matrix mounted thereon. The mounting amount of the matrix is 1 to 50 per 1 cm 2 with respect to the support in a state after coating and drying.
It is preferred to spread mg. The support can be used without any particular limitation as long as it is usually used in a patch. Examples of such a support include polyester,
Preferable examples include polyvinyl chloride, lint cloth, nylon, non-woven fabric and composite materials thereof. Among these materials, a particularly preferable one is a nonwoven fabric. The shape of the support is preferably a shape that can be fixed to the fingertip, for example,
As shown in FIGS. 1 and 2, it is preferable to have a portion for covering and fixing the fingertip. In the patch for nails of the present invention, the above-mentioned patch matrix may be applied to the entire surface or may be obtained only at the portion where the nail is applied. However, in the case where the coating is applied only to the area where the nail hits, the other area must be coated with an adhesive. It is also possible to mount a reservoir made of a matrix such as an address cloth or gauze. The method of applying the matrix to the support may be performed according to a usual method, and it can be obtained by spreading with a coating bar and drying by blowing air. Here, when a patch coated with a patch matrix containing a cooling component as a medicinal component is applied to nails, effects such as recovery from fatigue and improvement in shoulder stiffness can be obtained, and a coating containing a warming component is applied. In the case of applying, the effects such as relaxation of tension, improvement of cold, improvement of cold feeling of fingertips can be obtained by applying, and those containing antibacterial components, especially antifungal agents are excellent for treating onychomycosis such as tinea unguium Those that contain moisturizing ingredients are excellent in improving nail roughness due to the use of nail color, and those that contain keratin growth-promoting ingredients quickly restore damaged nails to healthy nails Excellent action to make.

[0014]

EXAMPLES The present invention will be described in detail below with reference to Examples, but it goes without saying that the present invention is not limited to only these Examples.

Example 1 Production Example An emulsion was prepared in accordance with the following emulsion formulation. That is, A and B were each heated to 80 ° C., and B was gradually added to A while stirring to prepare an emulsion. Using this emulsion, a patch matrix liquid was prepared according to the matrix liquid formulation. That is, the prescription components were mixed well to obtain a patch matrix liquid. This solution was coated on a PET sheet having a thickness of 25 μm and having a shape shown in FIG. 1 at a wet film thickness of 150 μm, and dried at 60 ° C. for 1 hour to fix the matrix of the present invention on PET.
The liner was pressed to obtain a patch. The composition of this product after coating and drying is also shown. The effect of improving shoulder stiffness of a person with severe shoulder stiffness was examined by use tests. That is, ten people with severe shoulder stiffness were allowed to apply this patch for one week before going to bed, and the improvement of shoulder stiffness was examined. Ten control groups were asked to use one prepared by replacing thymol with water. As a result, five persons in the group administered with the example showed a clear improvement, and three persons showed a slight improvement, while only one person in the control group answered a slight improvement. (Emulsion formulation) Polyglyceryl (13) Polyoxybutylene (14) Stearyl ether 4 parts by weight Soybean oil 40.0 parts by weight b Glycerin 2.2 parts by weight Water 53.8 parts by weight (Matrix liquid) Acrylic acid methyl acrylate / acrylic acid 2-Ethylhexyl copolymer 10.6 parts by weight Polyethylene glycol 300 0.5 parts by weight Emulsion 0.8 parts by weight 0.5 N aqueous potassium hydroxide solution 0.8 parts by weight Water 0.2 parts by weight Thymol 0.8 parts by weight Parts (component composition after coating and drying) 78.9 parts by weight of methyl acrylate / -2-ethylhexyl acrylate copolymer 6.4 parts by weight of polyethylene glycol 300 0.3 parts by weight of potassium hydroxide 10 parts by weight of thymol Soybean oil 3.8 parts by weight Glycerin 0.2 parts by weight Polyglyceryl (13) Polyoxybutylene (14) 0.4% by weight of tearyl ether

Example 2 Production Example An emulsion was prepared according to the following formulation of the emulsion. That is, A and B were each heated to 80 ° C., and B was gradually added to A while stirring to prepare an emulsion. Using this emulsion, a patch matrix liquid was prepared according to the matrix liquid formulation. That is, the prescription components were mixed well to obtain a patch matrix liquid. This solution was applied to a nonwoven sheet having a thickness of 25 μm and having a shape shown in FIG. 2 at a wet film thickness of 150 μm, and dried at 60 ° C. for 1 hour to fix the matrix of the present invention on the nonwoven fabric.
The liner was pressed to obtain a patch. The composition of this product after coating and drying is also shown. The effect of improving shoulder stiffness of a person with severe shoulder stiffness was examined by use tests. That is, ten people with severe shoulder stiffness were allowed to apply this patch for one week before going to bed, and the improvement of shoulder stiffness was examined. Ten control groups were asked to use those prepared by replacing methyl salicylate and menthol with water. As a result, three persons in the group administered with the example showed a clear improvement, and four persons showed a slight improvement, whereas only one person in the control group showed a slight improvement. (Emulsion formulation) Polyglyceryl (13) Polyoxybutylene (14) Stearyl ether 4 parts by weight Soybean oil 40.0 parts by weight b Glycerin 2.2 parts by weight Water 53.8 parts by weight (Matrix liquid) Acrylic acid methyl acrylate / acrylic acid 2-ethylhexyl copolymer 10.6 parts by weight Polyethylene glycol 300 0.9 parts by weight The above emulsion 0.8 parts by weight 0.5 N aqueous potassium hydroxide solution 0.8 parts by weight Water 0.2 parts by weight Methyl salicylate 0.2 Parts by weight Menthol 0.2 parts by weight (Component composition after coating and drying) Methyl acrylate / -2-ethylhexyl acrylate copolymer 78.9 parts by weight Polyethylene glycol 300 11.4 parts by weight Potassium hydroxide 0.3 parts by weight Part Methyl salicylate 2.5 parts by weight Menthol 2.5 parts by weight Soybean oil 3.8 parts by weight Phosphorus 0.2 part by weight Po Riku Bu Riseriru (13) port Riokishifu Bu styrene (14) stearyl ether 0.4 part by weight

Example 3 Production Example An emulsion was prepared according to the formulation of the emulsion shown below. That is, A and B were each heated to 80 ° C., and B was gradually added to A while stirring to prepare an emulsion. Using this emulsion, a patch matrix liquid was prepared according to the matrix liquid formulation. That is, the prescription components were mixed well to obtain a patch matrix liquid. This solution was coated on a PET sheet having a thickness of 25 μm and having a shape shown in FIG. 2 at a wet film thickness of 150 μm, and dried at 60 ° C. for 1 hour to fix the matrix of the present invention on PET.
The liner was pressed to obtain a patch. The composition of this product after coating and drying is also shown. The effect of improving the cold sensation of the fingertip of a person with severe coldness was examined by a use test. That is, 10 cold-sensitive persons were allowed to apply this patch for one week before going to bed, and the improvement of cold fingertips was examined. Ten control groups were asked to use those prepared by replacing the pepper extract with water. As a result, two persons in the example administration group answered a clear improvement, and six persons answered a slight improvement, while two persons in the control group responded only a slight improvement. In addition, one of the panelists to which the patch for nails of the present invention has been applied.
One reported improvement in insomnia. This was determined to be due to the tension-reducing effect of the patch. (Emulsion formulation) Polyglyceryl (13) Polyoxybutylene (14) Stearyl ether 4 parts by weight Soybean oil 40.0 parts by weight b Glycerin 2.2 parts by weight Water 53.8 parts by weight (Matrix liquid) Acrylic acid methyl acrylate / acrylic acid 2-ethylhexyl copolymer 10.6 parts by weight Polyethylene glycol 300 0.9 parts by weight The above emulsion 0.8 parts by weight 0.5N potassium hydroxide aqueous solution 0.8 parts by weight Water 0.2 parts by weight Pepper extract 0.4 Parts by weight (Component composition after coating and drying) Methyl acrylate / -2-ethylhexyl acrylate copolymer 78.9 parts by weight Polyethylene glycol 300 11.4 parts by weight Potassium hydroxide 0.3 parts by weight Pepper extract 5 parts by weight 3.8 parts by weight of soybean oil 0.2 parts by weight of glycerin Polyglyceryl (13) Bed styrene (14) stearyl ether 0.4 part by weight

Example 4 A patch matrix solution was prepared according to the following formulation. That is, the prescription components were mixed well, and the patch matrix solution was coated on a PET sheet having a thickness of 25 μm and having a wet film thickness of 150 μm as shown in FIG.
m, dried at 60 ° C. for 1 hour to fix the matrix of the present invention on PET, and then pressure-bonded the liner to obtain a patch. The composition of this product after coating and drying is also shown. When this patch was applied to three patients with tinea unguium for one month, two of them were significantly improved. 50% polyvinyl acetate ethanol solution 3 parts by weight 4% ethyl cellulose ethanol solution 5 parts by weight 0.1 M potassium hydroxide ethanol solution 0.5 parts by weight Isostearyl alcohol 0.3 parts by weight Butenafine 0.2 parts by weight (after coating and drying) Component composition of polyvinyl acetate 68.1 parts by weight Ethyl cellulose 9.1 parts by weight Potassium hydroxide 0.1 part by weight Isostearyl alcohol 13.6 parts by weight Butenafine 9.1 parts by weight

Example 5 A patch matrix solution was prepared according to the following recipe. That is, the prescription components were mixed well, and the patch matrix solution was applied to a nonwoven sheet having a thickness of 25 μm and having a wet film thickness of 150 μm, as shown in FIG.
m, and dried at 60 ° C. for 1 hour to fix the matrix of the present invention on the nonwoven fabric. Then, the liner was pressed to obtain a patch. The composition of this product after coating and drying is also shown. When this patch was applied to five people with severely damaged nails for one month, the condition of all nails was significantly improved. 50% polyvinyl acetate ethanol solution 3 parts by weight 4% ethyl cellulose ethanol solution 5 parts by weight 0.1 M potassium hydroxide ethanol solution 0.5 parts by weight Isostearyl alcohol 0.3 parts by weight Triethyl citrate 0.1 parts by weight Sulfated trehalose Sodium 0.1 part by weight (component composition after coating and drying) Polyvinyl acetate 68.1 parts by weight Ethyl cellulose 9.1 parts by weight Potassium hydroxide 0.1 part by weight Isostearyl alcohol 13.6 parts by weight Triethyl citrate 4. 6 parts by weight Sulfated trehalose sodium 4.5 parts by weight

Example 6 A patch matrix solution was prepared according to the following formulation. That is, the prescription components were mixed well, and the patch matrix solution was coated on a PET sheet having a thickness of 25 μm and having a wet film thickness of 150 μm as shown in FIG.
m, dried at 60 ° C. for 1 hour to fix the matrix of the present invention on PET, and then pressure-bonded the liner to obtain a patch. The composition of this product after coating and drying is also shown. When this patch was applied to three patients with tinea unguium for one month, all the symptoms including the properties of the nails were remarkably improved. 50% polyvinyl acetate ethanol solution 3 parts by weight 4% ethyl cellulose ethanol solution 5 parts by weight 0.1 M potassium hydroxide ethanol solution 0.5 parts by weight Isostearyl alcohol 0.3 parts by weight Terbinafine 0.1 parts by weight Irei extract 0. 1 part by weight (Ingredient composition after coating and drying) Polyvinyl acetate 68.1 parts by weight Ethyl cellulose 9.1 parts by weight Potassium hydroxide 0.1 part by weight Isostearyl alcohol 13.6 parts by weight Terbinanafine 4.6 parts by weight Chorei Extract 4.5 parts by weight

[0021]

According to the present invention, it is possible to provide means for improving health through nails, and means for maintaining or improving the health of nails.

[Brief description of the drawings]

FIG. 1 is a view showing one example of a support for a patch.

FIG. 2 is a view showing an example of a support for a patch.

Claims (6)

[Claims] 1. A patch matrix for nails containing an adhesive and a medicinal ingredient. 2. The patch matrix according to claim 1, wherein the medicinal component is one or more selected from a cooling component, a warming component, an antibacterial component, a moisturizing component, and a keratin growth promoting component. 3. The cooling component is one or more selected from menthol, thymol, camphor, methyl salicylate and cyclodextrin clathrate thereof, and the warming component is glycerin, capsicum extract, capsaicin and One or two or more selected from these cyclodextrin clathrates, and the antibacterial component is one or two or more selected from clotrimazole, miconazole nitrate, econazole nitrate, bifonazole, butenafine, and terbinafine. The moisturizing component is one or more selected from sodium hyaluronate, trehalose sodium and sodium sulfated trehalose, and the keratin growth-promoting component is borei extract, hawthorn extract, ecdysteroid, polyporsterone and 9,10
One or two selected from dihydroxystearic acid
The patch matrix according to claim 1, wherein the patch matrix is at least one species. 4. Menthol, thymol, camphor, methyl salicylate, their cyclodextrin inclusions, glycerin, capsicum extract, capsaicin, their cyclodextrin inclusions, clotrimazole, miconazole nitrate, econazole nitrate, bifonazole, One or more selected from butenafine, terbinafine, sodium hyaluronate, trehalose sodium, sulfated trehalose sodium, borei extract, hawthorn extract, ecdysteroid, polyporsterone and 9,10-dihydroxystearic acid And a patch matrix containing a pressure-sensitive adhesive. 5. A patch for nails comprising a support coated with the patch matrix according to any one of claims 1 to 5. 6. The nail patch according to claim 5, wherein the support is a nonwoven fabric.