JPH10324622A - Sheet-like patching material - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a sheet-like patching material which gives little pain when exfoliating and is suitable for removal of keratin plug. SOLUTION: This sheet-like patching material is prepared by forming a patching layer formed by formulating a local anesthetic ingredient such as lidocaine and dibucaine with a wetting adhesive composition containing a polyvinyl pyrrolidone or/and a vinyl pyrrolidone-vinyl acetate copolymer as A component, a liquid plasticizer compatible with the A component as B component and a filler as C component on a holding layer consisting of sheet-like substances such as nonwoven fabrics and porous films and further pasting an exfoliating layer on the patching layer.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a sheet-like patch. In particular, the present invention relates to a sheet-like patch suitable for removing a cork plug.

[0002]

2. Description of the Related Art In recent years, as a sheet-like patch suitable for removing keratotic plugs from the skin, a sheet-like patch having a sticky layer made of a wet adhesive composition formed on a sheet-like holding layer is known. In this sheet-shaped patch, the wet-adhesive composition forming the patch layer is made to be wet or wet by water or a hydrophilic medium such as ethyl alcohol or methyl alcohol, and exhibits adhesiveness. After being brought into a wet state or a wet state by being brought into contact with water or a hydrophilic medium before, it is adhered to a sticking part, or water or a hydrophilic medium is applied to the sticking part in advance, and then the paste is applied. Then, after the wet or wet adhesive layer is sufficiently dried, the adhesive layer together with the holding layer is peeled off from the application site and used.

[0003] At this time, the wet or wet state of the wet adhesive composition penetrates into the pores of the skin, and the penetrated wet adhesive composition is combined with the horn plug present in the pores.
Then, at the same time that the dried adhesive layer is peeled off, the plug is removed from the pores.

[0004] However, such an adhesive layer can be applied to the skin surface because it contains a suitable amount of water at the time of application and has an adhesive property. It is in close contact. For this reason, the adhesive layer was forcibly peeled off from the skin surface, resulting in considerable pain at the time of peeling. This pain is significantly different depending on the wet adhesive composition used, while maintaining the mechanical strength so that the adhesive residue is reduced when drying, while maintaining the appropriate adhesive strength when peeling. Obtaining the composition is very difficult. In addition, when it is dried too much, the pain at the time of peeling increases.

The present invention has been made in view of the above-mentioned drawbacks of the prior art, and has as its object to provide a sheet-like adhesive material which is less painful at the time of peeling and which is suitable for removing a plug. .

[0006] The inventors of the present invention have made intensive efforts and found that a pain at the time of peeling can be suppressed by blending a local anesthetic component into the wet adhesive composition, and have completed the present invention.

[0007]

According to the present invention, there is provided a sheet-like patch having a patch containing a wet adhesive composition, wherein the patch contains a local anesthetic component. And

[0008] The local anesthetic component used in the present invention may be any as long as it has a function of numbing the sensation (particularly pain sensation) on the surface of the site to which the sheet-like patch has been applied. There is no particular limitation as long as it can be used as. More specifically, dibucaine hydrochloride, lidocaine, and the like can be given, and one or more of these can be used.
Further, in the present invention, the sheet-like patch is peeled off after about 10 to 30 minutes have passed since the sticking,
It is desirable to have an anesthetic effect within this time or an anesthetic effect immediately after application and have a sustained effect within the time. Furthermore, since the sheet-like patch is used by being attached to the human skin surface, a material having good permeability from the skin is particularly preferable.

The amount of the local anesthetic component used depends on the type of the local anesthetic component and the wet adhesive composition used, but it may be sufficient if it is contained to such an extent that pain at the time of peeling can be reduced. Alternatively, an appropriate amount may be blended in a smaller amount. More specifically, 3 parts by weight to 40 parts by weight, preferably 3 parts by weight to 30 parts by weight, based on 100 parts by weight of the wet adhesive composition. If the amount is less than 3 parts by weight, the anesthetic effect cannot be sufficiently exerted.
When the amount is more than the weight part, not only the effect is too strong, but also waste is increased economically.

[0010] The wet adhesive composition to be used is not particularly limited either, but a peel-off type cosmetic, ie, an adhesive layer formed in a sheet shape is applied to an application site, and after drying for a certain period of time, No particular limitation is imposed on the composition on which the film is formed, as long as the composition has tackiness with a hydrophilic medium such as water, lotion, methyl alcohol or ethyl alcohol applied at the time of use. In particular, those suitable for removing keratotic plugs are preferable, for example,
Polyvinyl alcohol and other polymers and compositions comprising polyhydric alcohols, and compositions comprising sodium alginate and polyhydric alcohol, having compatibility with sodium polyacrylate such as sodium polyacrylate and glycerin, dissolved Various wet adhesive compositions containing polyacrylamide, carboxymethylcellulose, gum arabic, polymethylvinylether or the like as a main component can be used in addition to a mixture composed of a material exhibiting a plasticizing effect. It is particularly effective when the composition contains polyvinylpyrrolidone or / and vinylpyrrolidone / vinyl acetate copolymer as the component A, a liquid plasticizer compatible with the component A as the component B, and a filler as the component C.

In this case, as the component A, polyvinylpyrrolidone or vinylpyrrolidone / vinyl acetate copolymer or a mixture of both can be used. From the viewpoint of mechanical strength and peeling residue of the adhesive layer after application and drying, the weight is reduced. Those having an average molecular weight of 5,000 to 5,000,000, particularly those having an average molecular weight of 20,000 to 1.2,000,000 are preferred. Furthermore, from the viewpoint of shortening the drying time of the water or hydrophilic medium used at the time of application, and further reducing the pain at the time of peeling, a low molecular weight polymer, that is, a weight average molecular weight of less than 700,000, preferably 5,000 to 300,000 It is desirable to use a mixture of a polymer with a high molecular weight polymer, that is, a polymer having a weight average molecular weight of 700,000 or more, preferably 1,000,000 to 5,000,000. At this time, the mixing ratio of the two differs depending on the molecular weight of the polymer used, the purpose of use, and the like, but the ratio of the high molecular weight polymer to the low molecular weight polymer is approximately 5:95 to 95: 5 by weight ratio, preferably It can be used in a ratio of 20:80 to 70:30, and more preferably from the viewpoint of the removal efficiency of the keratotic plug and the pain at the time of peeling, it is preferable to mix the low-molecular-weight polymer so as to increase the blending ratio.

Further, as the component B, a material having compatibility with the component A and dissolving the component A to exhibit a plasticizing effect is used. For example, ethylene glycol, diethylene glycol, triethylene glycol, hexamethylene glycol, other polyethylene glycols, propylene glycol, dipropylene glycol, other polypropylene glycols, glycerin, diglycerin, other polyglycerins, 1,3-butylene Examples thereof include butylene glycols such as glycol and 1,4-butylene glycol, sugar alcohols such as sorbitol and mannitol, and glycerides such as lanolin, lecithin and olive oil. One or more of these can be used in combination as the B component.

As the C component, various inorganic or organic fillers that are hardly soluble or insoluble in the mixture of the A component and the B component are used. Examples of the inorganic filler include inorganic oxides or composite oxides such as silica, alumina, zinc oxide, titanium oxide, talc, clay, kaolin, and glass, barium sulfate, calcium carbonate, hydroxyapatite, ceramics, and carbon. And other inorganic compounds, metals such as metals and alloys of various metals, and the like. Examples of the inorganic filler include fiber-forming polymers such as cellulose, silk, polyester, and polyolefin, polyacrylates, polymethacrylates, polystyrene, and other organic polymers. These fillers are usually preferably used in a powder state, and the shape is not particularly limited, but is preferably spherical from the viewpoint of uniform dispersibility, and the average particle size is 0.01 to 50 μm. Especially 0.1
Those having a diameter of 10 to 10 μm are preferred. One or more of these can be used in combination as the C component.

As for the composition ratio, if the amount of the component B is too large relative to the amount of the component A, the mechanical strength of the adhesive layer obtained from the wet adhesive composition after being applied and dried is poor, On the other hand, if it is too small, the flexibility of the adhesive layer obtained from the wet adhesive composition is poor, and it is difficult for the adhesive layer to satisfactorily fit the application site. Therefore, the amount of the component B used is
The amount is preferably 1 to 75 parts by weight, more preferably 5 to 50 parts by weight, based on 100 parts by weight of the component A.

On the other hand, if the amount of the component C is too large relative to the amount of the component A, the flexibility of the adhesive layer obtained from the wet adhesive composition is poor, making it difficult for the adhesive layer to fit well on the adhesive site. If the amount is too small, the effect of improving the mechanical strength after attaching and drying the adhesive layer obtained from the wet adhesive composition is poor, and the time required for drying after application is long. For this reason, the use amount of the component C is 100
The amount is preferably from 10 to 200 parts by weight, more preferably from 25 to 100 parts by weight, based on parts by weight.

These wet adhesive compositions are coated with a hydrophilic medium such as ethyl alcohol, water and the like to form a coating solution.
It is applied and dried on a sheet-like material serving as a release layer or a sheet-like material serving as a holding layer, as described below, to produce a sheet-like sticking layer. In the coating solution, if necessary, cosmetics, fragrances, preservatives, coloring agents, alcohols, ultraviolet absorbers, and other drugs and additives usually used for patches can be added in usual amounts.

In addition, a holding layer is generally formed on the adhesive layer. The holding layer is not particularly limited as long as it can contribute to improvement in mechanical strength without impairing the drying speed of the adhesive layer after application and the flexibility before and after application, for example. Various structures made of materials can be used. At this time, it is preferable to use a material having moisture permeability from the viewpoint of the drying speed of the adhesive layer. Regarding the structure, woven fabric, non-woven fabric, knitted fabric,
Examples include sheet aggregates such as aggregates of fibers such as paper and films such as porous films and air-permeable films. Among these, those having an appropriate elasticity that is easily adaptable to the curved surface of the attachment site are particularly preferable. Examples of the material include synthetic or natural organic polymers such as nylon, polyester, polyethylene, polypropylene, polyurethane, and cellulose.

Further, in the sheet-like patch of the present invention, the release layer is further provided on the patch because the patch can be stored in a hygienic manner and the patches can be stacked or stored in a roll. Are preferably laminated. Examples of the release layer include polyester, polyethylene, polypropylene, paper whose surface is polymer-treated, and other films and sheets.

[0019]

EXAMPLES Next, sheet-like adhesive materials of various examples according to the present invention and sheet-like adhesive materials of comparative examples were produced, and the effects of the present invention were confirmed. In the following, "parts" refers to parts by weight,
"%" Shall mean weight%.

Example 1 A liquid material to be a coating liquid was obtained by stirring and mixing 50 parts of polyvinylpyrrolidone having a weight average molecular weight of 1.2 million, 15 parts of glycerin, 35 parts of silicic anhydride, 15 parts of lidocaine and an appropriate amount of ethanol. . This liquid material has a thickness of 5 whose surface (contact surface with the adhesive layer) has been subjected to a release treatment.
It was uniformly applied on a 0 μm polyethylene film, and a polyester nonwoven fabric having a basis weight of 40 g / m ² was laminated thereon. This was dried to obtain a sheet-like patch of Example 1 having a three-layer structure. The thickness of the sticking layer of this sheet-like sticking material is 3
The water content was 00 μm, and the water content was 22% (calculated from the change in weight after drying at 75 ° C. for 30 minutes; the same applies hereinafter).

Comparative Example 1 Example 1 except for lidocaine
In the same manner as the sheet-shaped patch of Comparative Example 1, a sheet-shaped patch of Comparative Example 1 was obtained. The thickness of the sticking layer of this sheet-like sticking material is 30.
0 μm and the water content was 22%.

Next, ten panelists actually used the sheet-like adhesive materials of these Examples and Comparative Examples, and evaluated the keratotic plug removability, the pain at the time of peeling, and the skin irritation.

[Evaluation Test] Each of the sheet-like adhesive materials of the examples and comparative examples was cut into a suitable size, attached to the nose of each of the panelists wetted with water, and allowed to dry for 10 minutes. Then, the sheet-like patch was peeled off. At that time, the following evaluation criteria were used to evaluate the pain at the time of peeling, keratotic plug removal properties, and skin irritation, and the average score was calculated for each sheet-like patch. The test was performed at three-day intervals.

[Evaluation Criteria] (Pain at the time of peeling)-Not painful: 3 points-Slightly painful: 2 points-Painful: 1 point (removability of keratotic plugs)-Well removed: 3 points-Removed: 2 points-Did not remove: 1 point (skin irritation)-Redness: 3 points-Slightly reddish: 2 points-No redness: 1 point

[Evaluation Results] The evaluation results were as shown in Table 1. As can be seen from Table 1, in the sheet-like patch of the example, the pain at the time of peeling could be drastically reduced as compared with the sheet-like patch of the comparative example to which no local anesthetic component was added. On the other hand, the addition of the local anesthetic component did not significantly affect the keratotic plug removability and did not cause irritation to the skin. In addition, although not shown in Table 1, glue residue at the time of peeling did not worsen as compared with the comparative example.

[0026]

[Table 1]

[0027]

According to the present invention, since the local anesthetic component is contained in the adhesive layer having the wet adhesive composition, the pain at the time of peeling can be drastically reduced, and the removal of the keratotic plug with a good feeling of use can be achieved. Can provide a sheet-like patch material suitable for the above.

Claims (2)

[Claims] 1. A sheet-like patch having a patch layer containing a wet adhesive composition, wherein the patch layer contains a local anesthetic component. 2. The wet-adhesive composition comprises polyvinylpyrrolidone or / and vinylpyrrolidone / vinyl acetate copolymer as component A, a liquid plasticizer compatible with component A as component B, and a filler as component C. The sheet-like patch according to claim 1, further comprising: