JPH10215815A - Propolis-containing cellulose - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the cellulose significant for the health of alimentary organs by the synergistic effects of the high pharmacological effects, such as sterilization effect and cell activity effect, of propolis and the physiological effect of cellulose by adding the propolis to the cellulose. SOLUTION: The desired propolis-contg. cellulose having the antimicrobial and sterilization effects, analgesic action, antiphlogistic effect, immune activation effect, cell activity, regeneration effect, hematopoietic effect, blood vessel reinforcing and blood circulation improving effects, cancericidal effect, effect of lessening the side effects of carcinostatics, effect of defending gene damage, etc., by adding 200g raw lump of the propolis to 1kg cellulose, thereby preparing the propolis-contg. cellulose.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cellulose containing propolis, which corrects dietary bias by adding propolis or a propolis extract having a medicinal effect such as a bactericidal action and a cell activating action to cellulose.

[0002]

2. Description of the Related Art Propolis, which has various pharmacological effects, has recently been greatly highlighted in the health food and medical fields. This propolis is obtained by mixing a resin component and pollen collected by bees from buds, buds and the like of a tree with a hormone called varinotin secreted from the pharyngeal line by the bees themselves to form a glue-like substance. This bead is used as an adhesive by which the honeycomb fills the gap between adjacent hexagonal cells when repairing the nest, and is applied to the inner wall surface of each cell to remove volatile components contained in the propolis into the nest. When mixed with air, it has a bactericidal effect in the nest, preventing bacteria or viruses from entering the nest. It is presumed that they are used to prevent water leakage into the nest.

[0003] The ingredients contained in propolis are described in "Hiroshi Hoshizaki" and "Kenji Fukushima" co-authored by "Health Research Institute of Kiel University" published by Health Institute, Inc. According to his findings on the components of propolis, he published: (1). Crabs, resin ... about 50-55
%, (2). Waxes: about 30%, (3). Essential oil (ether): about 8 to 10%, (4). Esters such as pollen ... about 5-18%, and other fine components are well-balanced with dozens of active ingredients such as protein, carbohydrate, mineral, vitamin, flavonoid etc. Is described in the above section "Medicinal effects of propolis". Experts speculate that this flavonoid is the source of the medical effects described below.

[0004] Propolis having such a component is in the form of a brown solid, and has been used in various forms in the past, for thousands of years, with the expectation of its medicinal properties for thousands of years. An example of an ancient use of propolis in the hope of its medicinal properties is, for example, a 1st-century ancient Roman general,
Used as a topical medicine in the Encyclopedia of Natural Sciences, an encyclopedia written by botanist Pliny (23-79), removes thorns and other substances stuck in muscles, causes swelling, induration (muscle hardening) ), Cures muscle pain and cures incurable wounds (Vol.22, fifty-six) published by Hyundai Shobayashi Co., Ltd., by Motohei Ogino, supervised by Takuya Saito, "Syakuyaku "Propolis".

[0005] Among the trace components contained in propolis, flavonoids have attracted particular pharmacological attention, and about 2,000 of flavonols, flavanones, anthocyanins, chalcones, etc., which are collectively referred to as flavonoids.
There are also types. The outline of the action of flavonoids on the human body can be summarized in the following five items listed in the following paragraphs (A) to (E) by reprinting the content of the above-mentioned book "" Super Drug "Propolis". (A). Strengthens cell membranes and activates cell functions. (B). Creates strong connective tissue that is less susceptible to cancer and various viruses. (C). It suppresses the synthesis and action of active oxygen and suppresses the production of carcinogens. (D). It has antiallergic, analgesic, hemostatic and anti-inflammatory effects. (E). Activates the immune function of ecology and increases resistance to bacteria.

[0006] With regard to the cell membrane strengthening and cell activation in the above item (A), when the flavonoid enters the body,
It is said to exhibit the action of vitamin P. Vitamin P prevents blood vessels from becoming fragile due to a lack of vitamin C, preventing proteins and vitamins in the blood from leaking out of the blood vessels and being mixed into urine, and improving blood circulation. It works well.

[0007] With regard to the anticancer and antivirus of section (B) and the anticancer and antiallergy of section (C), vitamin C is activated by flavonoids, and vitamin C is activated by its activating action. It suppresses the synthesis of carcinogenic substances and enhances collagen that has a cell-cell junction function, thereby suppressing the occurrence and growth of cancer.

With respect to the antiallergic, analgesic, hemostatic and inflammatory actions of the above item (D), the synergistic action of the above-mentioned inhibition of the synthesis of carcinogenic substances by vitamin C and the action of enhancing collagen enhances these antiallergic, analgesic actions. It is thought to be effective for hemostasis and inflammation.

[0009] Further, regarding the activation of immune function and the antibacterial activity of the above item (E), the physical characteristics of flavonoids in propolis are that bees simply take in flavonoids collected from trees as they are to produce propolis. Instead of mixing bees themselves with the flavonoids collected from the tree, they break down polysaccharides to create a unique substance that activates immune function and reduces bacterial activity. It has been highly evaluated in the medical and pharmaceutical fields.

[0010] As described above, propolis contains a wide variety of components, and the components are greatly affected by the beekeeping area and the environment, and as a result, the action of propolis is also different. It is known that the sap of eucalyptus is the source of the highest quality propolis among the trees that bees make propolis.

[0011]

As described above, propolis is a very useful substance having various components and various medicinal effects. However, the component of propolis collected from different production areas is very useful. Due to differences and differences in the physical condition and constitution of the person who drinks, it is often the case that the medicinal effect does not appear for some people. There are three types of propolis products currently marketed in Japan: liquid, granular, and granular.To promote absorption into the body and enhance the medicinal effect, a propolis stock solution is obtained as the raw material. To extract the extract from the original propolis mass using alcohol or water as a solvent and serve directly for drinking,
Alternatively, a sugar is mixed with this extract, processed into a colloidal form, and served for drinking.

[0012] However, in view of the necessity of mixing the extract obtained by extracting the original propolis mass with alcohol with a saccharide to form a colloid, not only the variation in the medicinal effect among drinkers is not improved, but also In addition to difficult-to-handle aspects, such as reduced medicinal effects for some people, there is a problem that useful medicinal effects cannot be sufficiently obtained.

On the other hand, in order to maintain a healthy life, it is important to keep a balanced diet, and it is important to consume foods containing necessary amounts of proteins, carbohydrates, vitamins, and minerals. is there. Regarding diet and health,
In recent years, interest has been increasing, and erroneous eating habits and unbalanced eating may lead to various adult diseases and constipation induction. In particular, when there is a shortage of cellulose, constipation tends to occur,
At the same time as causing multiple outbreaks of bacteria in the digestive tract, at the same time there is a risk of being directly linked to intestinal cancer and colon cancer, and also reduces the effect of preventing the absorption of neutral fats, resulting in obesity, eventually causing arteriosclerosis,
It causes angina, myocardial infarction and the like.

The present invention has been made to solve the above-mentioned conventional problems, and it is not necessary to convert propolis extract into a colloid using saccharides or the like, the production process is simple, and it is difficult to directly use the original mass. Propolis, which enhances the usefulness of propolis and, combined with the effective physiological effects of cellulose, dramatically improves the medicinal effects of propolis in the gastrointestinal tract and can greatly contribute to digestive tract health It is intended to provide cellulose.

Further, in addition to the above objects, the present invention makes it possible to process into various forms such as granules, granules, capsules and the like without using various synthetic additives. It is an object of the present invention to provide a cellulose containing propolis that can appropriately change the duration of a target effect.

[0016]

Means for Solving the Problems To achieve the above object, the cellulose containing propolis of the present invention is characterized in that propolis is added to cellulose.

A cellulose containing propolis according to another aspect of the present invention is characterized in that a propolis extract is added to cellulose.

[0018]

DESCRIPTION OF THE PREFERRED EMBODIMENTS A first embodiment of the cellulose containing propolis of the present invention will be described below. In the first embodiment, cellulose is added with propolis. Specifically, it is prepared by crushing and adding 200 g of a propolis raw mass to 1 kg of cellulose.

Here, the medicinal effect of the original propolis mass used is such that the flavonoid, which is a component of the original propolis mass, retains the medicinal effects listed in the above items (A) to (E) on the human body. In addition to the physiological effect of cellulose, the pharmacological effects of both are synergized, and not only the sum of the medicinal effects of the propolis mass and the physiological effects of cellulose, but also the sum plus alpha (+ α) A medicinal effect is obtained.

Here, the medicinal effects listed in the above items (A) to (E) can be further subdivided and enumerated to be divided into the following ten items (a) to (j). (A). Antibacterial, bactericidal, and antibacterial effects of propolis are the oldest known and used, with a wide range of effects, and have been shown to be effective against many bacteria and bacterial groups. However, it has been reported that MRSA is effective in preventing and treating hospital-acquired MRSA infection caused by infection with S. aureus, which is difficult to get rid of. In addition, B-type and C-type infections caused by the virus have been reported. There are many talks about healing and improvement of hepatitis hepatitis.

(B). Analgesic effect, propolis is also known as natural aspirin, which is thought to have an effect of suppressing the production of prostaglandin that causes headache in the body by propolis, resulting in an analgesic effect . In addition, since propolis is a natural substance, there is no tendency for side effects and habits to accompany it as in a chemically synthesized analgesic.

(C). Propolis is directly related to the suppression of inflammation-causing diseases that cause anti-inflammatory effects, hyperemia, swelling, fever, pain, etc. It is particularly effective because it is presumed to have the effect of eliminating the cause of inflammation.

(D). Individuals have different immune activating effects and resistance to pathogens such as viruses and bacteria.Therefore, when these pathogens enter the body, it is often observed that highly resistant individuals do not become infected or have mild illness. You. This is due to the action of leukocytes and macrophages to drive out pathogens, and to the immune response involving lymphocytes, one of the white blood cells. , Activates the action of propolis to produce BRM (Biological Response Modulator). This has the effect of increasing the body's resistance to pathogens.

(E). Cell activity, regenerative action, laparotomy and injuries initially produce granulocytes,
The wound is healed by replacing it with normal tissue cells over time. In this case, if the process of replacing the granulocytes with the tissue cells is not smooth, the wound often remains as a scar. However, many people have heard that drinking propolis after laparotomy or severe injuries closed the wound quickly and healed without leaving scars. This phenomenon is presumed that the component contained in propolis has a function of activating cell activity. Also,
Drinking propolis can cure alopecia areata,
The phenomenon that gray hair changes to black hair appears to be a result of the activation of metabolism of cells by propolis.

(F). Hematopoietic effects, diseases in which blood is abnormal include anemia, hemolytic anemia in which red blood cells are decomposed, pernicious anemia due to vitamin B16 deficiency,
There are aplastic anemia due to a decrease in hematopoietic ability, and among them, in the case of aplastic anemia, the number of red blood cells, white blood cells, and platelets decreases, making it more susceptible to infection and bleeding difficult to stop. Manifests symptoms of Further, the decrease in leukocytes occurs due to an allergic reaction to a drug, the effect of an anticancer drug, radiation exposure, and the like. Such abnormalities in the blood may induce abnormalities in the whole body or exacerbate the pre-existing symptoms.In such a case, drinking propolis causes the cell activating action of the propolis to spread to the cells of the bone marrow, and to cause the blood to circulate. It supplies trace elements required for production and normalizes and activates cells such as red blood cells, white blood cells, and lymphocytes.

(G). Vascular strengthening, blood circulation improvement, and recent medical research have shown that the root cause of arteriosclerosis is active oxygen, and low-density lipoprotein (LDL) denatured by this active oxygen
Has been found to be taken up by macrophages to form foam cells that accumulate on the inner walls of arteries and cause arteriosclerosis. It is presumed that propolis softens the blood vessel itself by this antioxidant action and strengthens the blood vessel, thereby extending the blood circulation improving action.

(H). It has been scientifically proved that a cancer killing action, a component contained in propolis, acts only when cancer cells divide and proliferate, and has a function of necrosis of cancer cells. This action selectively kills or damages only cancer cells that repeat active proliferation, but has a feature that the effect is minimal on normal cells. In addition, there is immunotherapy which is one of the treatment methods for cancer, including interferon, monoclonal antibody, TNF.
BRMs such as (tumor necrosis factor) have been produced in the pharmaceutical industry, and they are expected to work synergistically with immunotherapy and radiotherapy to administer these substances to cancer patients, thereby enhancing the cancer killing effect. I have. It is said that propolis inhibits the growth of cancer cells by enhancing BR
It is said that it works in the same way as M.

(I). Anti-cancer drug side effect reducing effect, Anti-cancer drug acts directly on cancer cells to damage cancer cells, and enhances body immunity to obtain indirect anti-cancer effects B
There are RMs, all of which are drugs showing a strong action, and have a drawback that they affect not only cancer cells but also normal cells. In addition, in chemotherapy using anticancer drugs, multidrug combinations are usually used, and the side effects caused by each anticancer drug are synergistic, and the QOL of patients
(Quality of life) has been severely affected. However, there are many experiences that drinking propolis in combination with anticancer drugs has a high cancer killing effect,
It is natural that the effect of reducing the side effects of propolis is that the analgesic action, cell activating action, hematopoietic action, etc. of the components contained in propolis work comprehensively to improve the general condition.

(J). Action to protect against genetic damage. Damaged genes produce cells and proteins that are different from their normal forms, causing malignant cancers and tumors. It has been found that the cause of this malignant cancer or tumor is to damage gene DNA in the nucleus of cells. Propolis suppresses the production of substances that adversely affect genes, such as active oxygen, and activates and strengthens cells.

As described above, cellulose to which propolis having various medicinal effects is added, absorbs water in the digestive tract and expands, thereby eliminating constipation and improving the function of the digestive tract. Prevent colorectal cancer. In addition, it combines with water-retaining intestinal ions and organic substances in the digestive tract to excrete bile acids with stool. As a result, bile acids are reduced, and the liver produces bile acids using cholesterol as a raw material, thereby reducing cholesterol. In addition, cellulose prevents the absorption of neutral fats and has an effect of preventing obesity.

If propolis is added to such a physiologically active cellulose for drinking, the shortage of cellulose due to uneven diet can be compensated for, and the medicinal effects of the above-mentioned propolis and the physiological effects of cellulose can be improved. Be compounded.
Therefore, only excretion of waste products in the digestive tract when passing through the digestive tract such as the small intestine due to drinking of cellulose alone is expected, whereas in the first embodiment, propolis has The various pharmaceutical effects, especially the synergistic effect of the pharmaceutical effect on the digestive tract and the physiological action of cellulose, promotes the absorption of propolis from the digestive tract and dramatically corrects the medicinal effect of propolis. It can make a great contribution to the digestive tract health. In addition, although the release time of propolis from cellulose varies depending on the person, propolis can be circulated in the body over a long period of time due to the physiological action of cellulose rather than taking propolis alone, which has a medicinal effect on cell activity. To make it last longer.

In the first embodiment,
Although the case where 200 g of propolis fine powder is added to 1 kg of cellulose has been described, it goes without saying that these values can be arbitrarily selected.

Next, a second embodiment of the present invention will be described. In the second embodiment, for example, as an example, an original propolis mass is immersed in alcohol to extract a propolis extract using alcohol as a medium. The alcohol used at this time is high-purity ethanol alcohol.
Eighty percent of the original propolis mass is wax or beeswax, so alcohol is the most effective in dissolving them, and furthermore, the active ingredient of propolis, the flavonoid, is poorly soluble in water and can be extracted by alcohol. Because.

The 16W (weight) thus extracted
/ V (volume)% propolis extract 1.2
By preparing a liter by adsorbing it on 1 kg of cellulose, 1.4 kg of powdered or granulated cellulose containing propolis can be obtained. Thus, as in the first embodiment of Doki, the medicinal effects of propolis itself,
The synergistic effect of the physiological action of cellulose makes a great contribution to the digestive tract health as compared to taking cellulose and propolis alone.

In the second embodiment,
Propolis-containing cellulose is in the form of powder or granules, so it can be processed into granules or capsules of any shape from these conditions, and it is used in the form of so-called soft capsules by adding oil to give fluidity. can do. Further, the amount of the propolis extract and the amount of the cellulose can be arbitrarily selected and freely processed. Also in the second embodiment, it is not necessary to use a saccharide or the like to form a colloid as in the related art, so that the manufacturing process can be simplified and the cost can be reduced.

[0036]

As described above, according to the cellulose containing propolis of the present invention, since the propolis is added to the cellulose, the labor for processing the propolis extract into a colloid using saccharides or the like can be omitted, and the production can be reduced. The process can be simplified, the availability of propolis, which is difficult to directly use in the original mass, can be increased, and cellulose helps the absorption of propolis into the body. The action can make a great contribution to the digestive tract health.

Further, according to the cellulose containing propolis of the present invention, since the propolis extract is added to the cellulose, it can be processed into various forms such as granules, granules, capsules, etc. in addition to the above effects. Therefore, the sustainability of propolis in the body can be prolonged, and the medicinal effect of propolis can be increased, depending on the processing form.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 31/715 ADN A61K 31/715 ADN 35/64 AAH 35/64 AAH ABD ABD ABE ABE ABW ABW ABY ABY ADT ADT AUD AUD AD UAD ADZ ADZ

Claims (2)

[Claims] 1. A cellulose containing propolis, wherein propolis is added to cellulose. 2. A cellulose containing propolis, wherein a propolis extract is added to cellulose.