JPH10165502A - Mixing atomizing device for usage time mixing-type medicine - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a device whereby a usage time mixing-type medicine is safely and also easily mixed and atomized without quality deterioration. SOLUTION: The device consists of a container mainbody, the container mainbody consists of a first medicine bottle containing chamber 4 and the second chemical bottle containing chamber 5 which are connected with an atomizing chamber 3, the first and the second containing chambers are opened outwards in an end at a side being far from the atomizing chamber and the first and the second containing chambers are communicated by a leading needle which is provided by penetrating the atomizing chamber. A communicating path communicating the first and the second containing chambers, an open path communicating the first containing chamber and an outside and the atomizing path communicating the second containing chamber and a liquid sucking communication port inside the atomizing chamber are provided inside the conductive needle, an atomizing device 11 having the liquid sucking communication port is incorporated in the atomizing chamber and the chamber is connected to the pump.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention is excellent in hygiene in that a powder formulation or a solution formulation sealed in a medicine bottle can be mixed and sprayed without opening the sealed state in order to maintain quality. The present invention relates to an apparatus for mixing and spraying a mixed-use medicine.
Further, the present invention relates to a compact and convenient mixing and spraying device in which the mixing mechanism and the spraying mechanism are integrated and which is easy to operate.

[0002]

2. Description of the Related Art Mixing and dispensing a powder formulation and a solution formulation in separate sealed containers to maintain quality at the time of use and spraying the obtained mixture are particularly popular in the medical field. Have been.

For example, influenza is caused by the influenza virus exploding on cells on the surface of the respiratory tract. Subcutaneous inoculation of influenza vaccines has been used to prevent infection or worsening the disease, and it will be used in the future.However, as a new vaccine inoculation method, the vaccine is sprayed into the nasal cavity and directly stimulates the mucous membrane in the nasal cavity. A new nasal spray vaccination vaccine has been developed that aims to confer mucosal immunity in addition to the effects of vaccination.

[0004] This new nasal spray inoculated vaccine is prepared by freeze-drying a vaccine preparation and a solution prepared by freeze-drying the vaccine virus in order to maintain the quality. It is a so-called mix-in-use drug that is sealed in a glass vial and mixed and dispensed at the time of use.

At present, in addition to such a nasal spray inoculated vaccine, a glass vial containing a lysate formulation is used for mixing and spraying a mix-in-use drug such as a combination of a powder formulation and a lysate formulation. Then, the dissolving solution is suctioned and collected using a syringe or the like, and the solution is poured into a glass vial in which a powdery formulation is sealed to prepare a mixed solution, or both caps are removed and either one or both are removed. After mixing and dispensing in a separate container, the mixture is sprayed in a separately provided spraying device. However, these methods involve many manual operations, and use a disposable syringe or the like as the operation, which may cause a needle stick accident, and also causes loss of medicine.

[0006] JP-A-58-169452 discloses that a syringe needle is inserted into a glass vial in which a powder preparation and a solution preparation are respectively sealed, and both preparations are once taken into a separately provided mixing device. Thus, an apparatus for mixing is described. However, this device sucks a substance, for example, sterile water, stored in an ampoule having a lid such as a rubber into a syringe or a pump by operating the valve direction, and then changes the valve direction to obtain the syringe. Alternatively, the liquid in the pump is transferred into an ampoule having a lid such as rubber in which the active ingredient such as influenza virus is stored, and the mixture is dispensed, and then the direction of the valve is changed and the mixture is collected. Steps such as the step of changing the valve direction and feeding the other parts to other parts, the multi-directional valve and the ampoule and the syringe or pump communicating with the valve are arranged on the plate, and the valve direction is changed for each step. This is a mixing device which is operated by changing operation, and is fundamentally different from the structure and operability of the device of the present invention.

[0007]

SUMMARY OF THE INVENTION The present invention makes it easy to carry by integrating and miniaturizing the apparatus itself including the spraying apparatus, and also minimizes the contact of the drug with the outside world. Accordingly, it is an object of the present invention to provide a mixing and spraying apparatus for a time-of-use mixing type medicine, which improves hygiene and facilitates and easily performs a mixing and spraying operation.

[0008]

In order to solve the above-mentioned problems, the present invention relates to a container body 1 as shown in FIG.
And a pump 2, wherein a-a in FIG.
As shown in FIG. 2 which is a schematic diagram of a cross section taken along line a,
Comprises a first storage chamber 4 for drug bottles and a second storage chamber 5 connected via a spray chamber 3, and both the first storage chamber 4 and the second storage chamber 5 The end farther from the opening is open to the outside, and the first storage chamber 4 and the second storage chamber 5 are communicated by a conduction needle 6 provided through the spray chamber 3, and the conduction needle 6 The first accommodation room 4 and the second accommodation room 5
And an open path 8 for connecting the first storage chamber 4 to the outside, and a spray path 9 for connecting the second storage chamber 5 to the liquid suction communication port 10 in the spray chamber 3. I have. The spray chamber 3 is a spray device 1 having the liquid suction communication port 10.
1 and is connected to the pump 2 shown in FIG.

For example, as shown in FIG. 3, it is preferable that the first storage chamber 4 and the second storage chamber 5 have a shape into which medicine bottles 12 and 13 can be inserted from the outside.

The medicine in the medicine bottle 12 housed in the first housing chamber 4 is preferably in a liquid state.

Further, a glass vial in which a solution preparation is enclosed by blindly closing the medicine bottle 12 housed in the first housing chamber 4 with a lid stopper 14 made of a material through which a conducting needle can penetrate, is provided. And a medicine bottle 13 stored in the second storage chamber 5
Is preferably a glass vial in which the powder formulation is enclosed by blind plugging with a lid stopper 15 made of a material through which the conducting needle can penetrate.

Further, as shown in FIG. 4, which is a schematic view of a cross section taken along the line bb of the spray device 11 comprising the pump 2 and the spray tube 16 in FIG. 1, the spray device 11 has a spray tube 16, A discharge prevention valve 17 for preventing liquid from flowing back from the spray cylinder 16 to the liquid suction communication port 10, and a suction prevention valve 1 for preventing air from flowing back to the pump 2.
8 is preferred.

The pump is preferably in the form of a self-expanding figurine, as shown for example in FIG.

In the present invention, for example, as shown in FIG. 10, a first storage chamber 31 and a second storage chamber 32 for a medicine bottle are provided via a pump chamber 33, and the first storage chamber is provided. 3
Each of the first and second storage chambers 32 is open at the end farther from the pump chamber 33 to the outside, and the first storage chamber 31 is communicated with the pump chamber 33 by a first conduction needle 34, and the second storage chamber The chamber 32 is communicated with the pump chamber 33 by a second conduction needle 35, and the first conduction needle 34 has therein a first communication passage 36 that communicates the first storage chamber 31 with the pump chamber 33 and a first storage passage. There is an open passage 37 for communicating the chamber 31 with the outside, and the second conducting needle 35 has therein the second accommodation chamber 32 and the pump chamber 33.
And a spray passage 40 for communicating the second housing chamber 32 with the spray cylinder 39 protruding to the outside, and an end of the first conduction needle 34 on the pump chamber 33 side. The present invention relates to a mixing and spraying device for use-time mixing type medicine, in which a piston 41 provided in the air conditioner is slidably inserted into a pump chamber 33.

A plunger 43 is preferably provided between the piston 41 and the bottom plate 42 of the first storage chamber 31.

Further, as shown in FIG. 11, for example, it is preferable that the first storage chamber 31 and the second storage chamber 32 have a shape in which the medicine bottles 44 and 45 can be inserted from the outside.

It is preferable that the medicine in the medicine bottle 44 accommodated in the first accommodation chamber 31 is liquid.

The medicine bottle 44 accommodated in the first accommodating chamber 31 is made of a material such that the first conducting needle 34 can pass therethrough.
A lid 4 made of a glass vial in which the dissolving solution preparation is sealed by blind plugging, and in which the drug bottle 45 accommodated in the second accommodation chamber 32 can penetrate the second conduction needle 35.
Preferably, the vial is a glass vial in which the powder formulation is sealed by plugging at 7.

Further, as shown in FIG. 10, for example, a backflow prevention valve 48 for preventing backflow from the pump chamber 33 is provided in the first communication passage 36 of the first conduction needle 34, and a spray cylinder is provided. In order to prevent the liquid in 39 from flowing back into the medicine bottle 45 in the second storage chamber 32, a check valve 4 is provided in the spray cylinder 39.
9 are preferably provided.

A nasal drug, an oral drug or a transdermal drug is preferably applied to the above-mentioned device of the present invention, and a biological drug is preferable as the nasal drug.

[0021]

Embodiments of the present invention will be described below with reference to the drawings.

(Embodiment 1) Embodiment 1 is shown in FIGS.
9 will be described. FIG. 1 shows Embodiment 1 of the present invention.
Use-time mixing type spraying device (hereinafter, "mixing spraying device")
FIG. 2 is a schematic cross-sectional view taken along line aa of the mixing and spraying apparatus of FIG. 1, and FIG. 3 is a view of the mixing and spraying apparatus shown in FIG. FIG. 4 is a schematic longitudinal sectional view of a spraying device including a pump and a spray cylinder, and FIGS. 5 and 6 are schematic diagrams of a section taken along line pp and qq in FIG. 17 has the same cross section as the pp line cross section of the inhalation prevention valve 18), FIG. 7 is a schematic longitudinal sectional view of a part of the conduction needle 6 in FIG. And 9 are schematic illustrations for explaining the procedure of operation of the mixing and spraying apparatus shown in FIG.

The first embodiment basically comprises a container body 1 and a pump 2 as shown in FIG. 1. As shown in FIG. 2, the container body 1 comprises a first medicine bottle accommodating chamber 4 and a second medicine bottle. It comprises a bottle storage chamber 5 and a spray chamber 3, and the first storage chamber 4 and the second storage chamber 5 are connected so as to sandwich the spray chamber 3. The ends of the first storage chamber 4 and the second storage chamber farther from the spray chamber 3 are
It is open to the outside so that a medicine bottle (shown in FIG. 3) can be inserted. The container body 1 is made of a rigid material such as polyethylene, polypropylene, polycarbonate,
It is made of synthetic resin such as polyester, metal, or cardboard. A part or the whole may be made of a transparent material so that the inside of the medicine bottle can be seen.

The internal shape and size of the first storage chamber 4 and the second storage chamber 5 may be determined according to the outer shape of the medicine bottle to be inserted. For example, it may be a cylindrical or prismatic inner peripheral surface.

The first storage chamber 4 and the second storage chamber 5 are connected by a conducting needle 6 extending through the spray chamber 3. As shown in FIG. 7, both ends of the conduction needle 6 on both sides of the storage chambers 4 and 5 are pointed, and as shown in FIG. 3, the lids 14 and 15 of the medicine bottles 12 and 13 are easily pierced. is there. A communication path 7 for communicating the first storage chamber 4 and the second storage chamber 5 is provided in the conduction needle 6. In addition, an open path 8 is provided inside the conductive needle 6 on the first storage chamber 4 side, and communicates the first storage chamber 4 with the spray chamber 3. Since the spray chamber 3 is open to the outside, the end of the spray chamber 3 of the open path 8 is open to the outside air. On the other hand, the spray path 9 is
Is provided, and the second storage chamber 5 communicates with the liquid suction communication port 10 in the spray chamber 3.

A spray device 11 having a liquid suction communication port 10 is provided in the spray chamber 3, and the liquid suction communication port 10 is opened in a spray cylinder 16 (see FIG. 4). As shown in FIG. 2, the spray device 11 and the conducting needle 6 may be detachably fitted to the liquid suction communication port 10 of the spray device 11 and the end of the spray path 9 of the conducting needle 6. Of course, it may be fixed.

As shown in FIG.
6 and a liquid suction connection port 10 provided therein.
One end of the spray cylinder 16 forms a spray port, and the other end is connected to the pump 2. It is preferable to provide a discharge prevention valve 17 near the liquid suction port 10 so that the mixed liquid does not flow back to the spray path 9 of the conduction needle 6. Further, it is preferable that the spray cylinder 16 is provided with a suction prevention valve 18 so that the liquid does not flow back to the pump 2. When the suction prevention valve 18 is of a type in which a ball is sealed, the atomization of the liquid can be performed efficiently by selecting the diameter of the ball, and the liquid diameter can be appropriately selected.

The discharge prevention valve 17 and the suction prevention valve 18
As shown in FIG. 5 (a cross-sectional view taken along the line pp in FIG. 4), a portion into which the liquid formulation flows is formed by a slit 1 around the flow path 10a.
0b is provided so that the liquid preparation can flow through the slit 10b even if the flow path 10a is closed by, for example, a ball-shaped valve. The part where the liquid preparation flows out is formed so as to be completely closed by the valve as shown in FIG. 6 (a sectional view taken along the line qq in FIG. 4).

As shown in FIG. 7, the end of the conducting needle 6 protruding into each of the storage chambers 4 and 5 is pointed as shown in FIG.

The medicine bottle used in the first embodiment is shown in FIG.
As shown in the figure, a glass vial 1 containing a drug
2 and 13, which are rubber or synthetic rubber caps 14 and 1 through which the conducting needle 6 can penetrate relatively easily.
5 blind plugged. Drug bottle 12 to be put into first storage room 4
Preferably, a liquid preparation such as a solution preparation is enclosed. In the second storage room 5, a medicine bottle 1 in which a powder formulation or the like is sealed
Load 3 Of course, a liquid preparation may be used.

FIG. 1 is a schematic perspective view of the mixing and spraying apparatus according to the first embodiment. The embodiment shown in FIG. 1 is miniaturized so as to be convenient for carrying, and a finger hook 19 may be provided so that the pump 2 can be pressed with a palm or a thumb.

The operation at the time of using the mixing and spraying apparatus according to the first embodiment will be described with reference to FIGS.

The medicine bottle 12 containing the solution is pushed into the first storage chamber 4 of the apparatus shown in FIG. 2 and the lid 14 is pierced with the conduction needle 6. Similarly, the medicine bottle 13 containing the powder preparation is pushed into the second storage chamber 5 and the lid 15 is pierced with the conduction needle 6. FIG. 3 shows this state. At this time, the first storage chamber in which the drug bottle 12 containing the solution preparation is loaded faces upward. As a result, as shown in FIG.
Flows down to the medicine bottle 13 through the communication path 7 of the above. At that time, air enters the bottle 12 from outside through the open channel 8 in order to keep the internal pressure of the drug bottle 12 equal to the external pressure. In FIGS. 8 and 9, the flow of the liquid (including the mixed liquid) is indicated by solid arrows, and the flow of air is indicated by broken lines.

Finally, as shown in FIG. 8 (b), all the solution preparations enter the medicine bottle 13 and are mixed with the powder preparation to form a mixed solution. In this state, the first storage chamber 4 and the second storage chamber 5 are turned upside down. Then, as shown in FIG. 8 (c), the mixed liquid in the upper medicine bottle 13 passes through the spray passage 9, passes through the liquid suction port 10 of the spray device 11, and as shown in FIG. Go inside 2. At that time, the air is as shown in FIG.
Is supplied from the lower medicine bottle 12 as shown in FIG.
3. Make the pressure inside 3 the same as the outside air. Then, (e) of FIG.
As shown in (2), the mixed liquid accumulated in the pump 2 is sprayed from the spray port of the spray cylinder 16 by the pump 2.

According to the first embodiment, two kinds of medicines can be mixed without taking out the medicine in the medicine bottle to the outside, so that the sanitary and quality maintenance can be ensured. In addition, since the mixing function and the spraying function can be integrated, the number of parts can be reduced, miniaturization and portability can be easily achieved, and the device can be manufactured at low cost.

(Embodiment 2) Next, another embodiment of the present invention (hereinafter referred to as Embodiment 2) will be described with reference to FIG.
13 will be described.

FIG. 10 is a schematic longitudinal sectional view of an example of the mixing and spraying apparatus according to the second embodiment, FIG. 11 is a schematic longitudinal sectional view when a medicine bottle is mounted on the mixing and spraying apparatus, and FIGS. It is a schematic explanatory view for explaining the operation procedure of the mixing and spraying device according to the second embodiment.

An example of the mixing and spraying apparatus according to Embodiment 2 of the present invention will be described first with reference to FIG. The mixing and spraying apparatus according to this embodiment differs from the first embodiment in that a pump mechanism is provided inside and a pump chamber 33 is provided for the pump mechanism.

The mixing and spraying apparatus according to the second embodiment basically includes a first medicine bottle accommodation chamber 31 and a second medicine bottle accommodation chamber 32.
And a pump chamber 33. Both storage chambers 31 and 32 have their ends remote from the pump chamber 33 open to the outside so that a medicine bottle can be inserted.

The first storage chamber 31 is in communication with the pump chamber 33 via a first conduction needle 34. The first conducting needle 34 has therein an open passage 37 that communicates a first communication passage 36 that communicates with the pump chamber 33 and the outside (the outside world).

A second conduction needle 35 projects from the second storage chamber 32. The second conduction needle 35 communicates with the pump chamber 33 and the second storage chamber 32 through the second communication passage 38 and the second communication needle 38. There is a spray path 40 that connects the two storage chambers 32 and the spray cylinder 39. The spray cylinder 39 can be an extension of the spray path 40.

The first conduction needle 34 extends to the pump chamber 33 side, and its length is almost the same as or slightly longer than the height of the pump chamber 33. And at its end is a piston 41
Are fixedly provided. The piston 41 is in the pump chamber 3
3 is fitted in the pump chamber 33 in an airtight manner and slidably with the inner wall surface of the pump chamber 33. Preferably, a plunger 43 is provided between the bottom plate 42 of the first storage chamber 31 and the piston 41 in order to smoothly and stably move the piston 41 and the first storage chamber 31.

FIG. 11 shows the medicine bottles 44, 4 in the first and second storage chambers 31, 32 in the second embodiment shown in FIG.
FIG. 5 is a schematic longitudinal sectional view of a glass vial in which a solution preparation and a powder preparation are preferably enclosed, respectively.
And the second conducting needle 35 penetrates. At this time, piston 4
1 is located at the lowest point of the pump chamber 33.

As shown in FIG. 10, the piston 41 has
A backflow prevention valve 48 is provided to prevent the liquid from flowing back into the first storage chamber 31 when the fluid flows into the pump chamber 33 (described later). In the spray cylinder 39, the mixed liquid and air sent from the spray passage 40 are filled with the second storage chamber 32.
It is preferable to provide a check valve 49 so as not to flow back into the medicine bottle 45 inside. The prevention valve 49 is preferably of a type in which a ball is sealed, and the efficiency of atomization and the liquid diameter can be controlled by selecting the size of the ball. The cross-section of these check valves is the same as that of the discharge prevention valve 1 of the first embodiment.
Similarly to 7 and the inhalation prevention valve, the cross section on the side where the medicine flows in has the cross section shown in FIG. 5, and the cross section on the side where the medicine flows out has the cross section shown in FIG.

The operation when the second embodiment is used will be described with reference to FIGS.

First, as described with reference to FIG. 11, a glass vial in which a solution preparation is sealed is placed in the first storage chamber 31.
Then, a glass vial enclosing the powder formulation is inserted into the second storage chamber 32, and pressed firmly into each of the first vials.
The conduction needle 34 and the second conduction needle 35 are penetrated into the medicine bottle. This state is shown in FIG. The plunger 43 protects the first conducting needle 34 from being broken when being strongly pushed.

Next, as shown in FIG. 12B, the first storage chamber 31 is pulled up. Then, the check valve 49 closes and the pressure in the pump chamber 33 becomes negative, so that the solution in the medicine bottle 44 is opened through the first communication passage 36 of the first conduction needle 34 and the check valve 48 (open) of the piston 41. Through the pump room 33
Flows into. At this time, air enters the medicine bottle 44 through the open path 37.

When all of the solution preparation enters the pump chamber 33, as shown in FIG. 12C, the first storage chamber 31 is pushed down, and the solution preparation in the pump chamber 33 is transferred to the second storage chamber 32.
Into the drug bottle 45 loaded in the container and mixed with the powder formulation to form a mixed solution. At this time, the check valve 48 in the piston 41 is closed, and excess air in the medicine bottle 45 passes through the check valve 49 (open) to the outside.

Next, as shown in FIG. 13D, the first storage chamber 31 is raised to the highest point. At this time, piston 4
The first check valve 48 is opened, and the first
Air flows from the outside through the open path 37 of the conduction needle 34 and the first communication path 36.

In this state, the upper and lower sides are reversed (reversed). Next, as shown in FIG. 13E, when the second storage chamber 32 is pushed down or the first storage chamber 31 is pushed up, the piston 41 slides and the air in the pump chamber 33 passes through the second conduction needle 35. Through the second communication path 38 into the medicine bottle 45 containing the mixed solution. The mixture is pushed by this air and the second liquid
It is sprayed from the spray path 40 of the conduction needle 35 to the spray cylinder 39 and sprayed to the outside. At this time, the function of the backflow prevention valve 49 (open) allows the mixture to be atomized efficiently.

Thereafter, the operation of pushing up and down the first storage chamber 31 (the operation of reciprocating the piston) can be repeated to intermittently spray the mixed liquid.

According to the second embodiment, when the size of the vial is small, the size and weight of the vial can be reduced so that the vial can be operated with one hand. Furthermore, since there is no need to install a pump outside, it is convenient to store and carry.

The apparatus of the present invention is most suitable for mixing and spraying of the medicine of the mixing type at the time of use. Examples of the mix-type drug for use include a combination of a powder formulation and a solution formulation thereof, and a combination of a liquid formulation and a liquid formulation. Further, the device of the present invention can be suitably used when such a mixed-use drug is used as a nasal preparation or an oral preparation. Specific examples include, for example, the above-mentioned nasal spray-inoculated influenza vaccine and various live vaccines, such as hay fever treatment drugs, oral drug preparations, and transdermal drug preparations in which the main drug and auxiliary drugs are enclosed in separate containers. But not limited to these.

The spray cylinders 16 and 39 in the first and second embodiments can be used, for example, when spraying a vaccine or the like into the nasal cavity with the device of the present invention, even if the recipient is standing or sitting. It is preferable to have an angle of 0 to 45 ° upward with respect to the horizontal direction. In addition, ±
It may be movable at an angle within the range of 90 °.

[Brief description of the drawings]

FIG. 1 is a schematic perspective view showing Embodiment 1 of a mixing and spraying apparatus of the present invention.

FIG. 2 is a schematic view of a cross section taken along line aa of the mixing and spraying apparatus of FIG.

FIG. 3 is a schematic vertical sectional view when a medicine bottle is mounted in both storage chambers of the mixing and spraying apparatus of FIG. 2;

FIG. 4 is a schematic longitudinal sectional view of a spray device including a pump and a spray cylinder used in the mixing spray device of FIG. 1;

FIG. 5 is a schematic view showing a cross section taken along line pp in the mixing and spraying apparatus of FIG. 4;

6 is a schematic view showing a cross section taken along line qq in the mixing and spraying apparatus of FIG.

FIG. 7 is a schematic longitudinal sectional view of a part of a conduction needle used in the mixing and spraying apparatus of FIG. 1;

FIG. 8 is a schematic explanatory view for explaining an operation procedure of the mixing and spraying apparatus of FIG. 1;

FIG. 9 is a schematic explanatory view for explaining an operation procedure of the mixing and spraying apparatus of FIG. 1;

FIG. 10 is a schematic longitudinal sectional view showing Embodiment 2 of the mixing and spraying apparatus of the present invention.

FIG. 11 is a schematic vertical sectional view when a medicine bottle is mounted in a storage chamber of the mixing and spraying apparatus of FIG. 10;

FIG. 12 is a schematic explanatory view for explaining an operation procedure of the mixing and spraying apparatus of FIG. 10;

FIG. 13 is a schematic explanatory view for explaining an operation procedure of the mixing and spraying apparatus of FIG. 10;

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Container main body 2 Pump 3 Spray chamber 4 1st storage chamber 5 2nd storage chamber 6 Conducting needle 7 Communication path 8 Open path 9 Spray path 10 Liquid suction connection port 10a Channel 10b Slit 11 Spray device 12 Drug bottle 13 Drug bottle 14 Lid stopper 15 Lid stopper 16 Spray cylinder 17 Discharge prevention valve 18 Inhalation prevention valve 31 First storage chamber 32 Second storage chamber 33 Pump chamber 34 First conduction needle 35 Second conduction needle 36 First communication path 37 Open path 38 Second Communication path 39 Spray cylinder 40 Spray path 41 Piston 42 Bottom plate of first storage chamber 43 Plunger 44 Drug bottle 45 Drug bottle 46 Cap stopper 47 Cap stopper 48 Check valve 49 Check valve

Claims (14)

[Claims] 1. An apparatus comprising a container body and a pump, wherein the container body comprises a first medicine bottle accommodation chamber and a second medicine bottle accommodation chamber connected via a spray chamber. Both the first and second storage chambers are open at the ends farther from the spray chamber to the outside, and the first and second storage chambers are communicated by a conducting needle provided through the spray chamber. The conduction needle has a communication passage therein for communicating the first storage chamber and the second storage chamber, an open path for communication between the first storage chamber and the outside, and liquid suction in the second storage chamber and the spray chamber. A spraying device having a spraying passage communicating with a communication port, wherein the spraying chamber has a built-in spraying device having the liquid suction communication port and is connected to the pump; 2. The apparatus according to claim 1, wherein the first storage chamber and the second storage chamber are shaped so that a medicine bottle can be inserted from outside. 3. The apparatus according to claim 1, wherein the medicine in the medicine bottle accommodated in the first accommodation chamber is in a liquid state. 4. A glass vial in which a solution preparation is enclosed by blindly closing a medicine bottle accommodated in the first accommodation chamber with a lid stopper made of a material through which a conduction needle can penetrate, and The device according to any one of claims 1 to 3, wherein the drug bottle accommodated in the accommodation chamber is a glass vial in which a powder formulation is enclosed by being blind-plugged with a lid stopper made of a material through which a conduction needle can penetrate. . 5. The spray device has a spray tube, a discharge prevention valve for preventing the liquid from flowing back into the spray path, and a suction prevention valve for preventing air from flowing back to the pump. The device according to any one of claims 1 to 4, comprising: 6. The device according to claim 1, wherein the pump is a self-expanding rub. 7. A first medicine bottle accommodating chamber and a second medicine bottle accommodating chamber are provided via a pump chamber, and both the first accommodating chamber and the second accommodating chamber are located farther from the pump chamber. The end is open to the outside, the first storage chamber is communicated with the pump chamber via a first conduction needle, and the second storage chamber is communicated with the pump chamber via a second conduction needle. Has therein a first communication path for communicating the first storage chamber with the pump chamber and an open path for communicating the first storage chamber with the outside, and the second conduction needle has the second storage needle therein. A second communication passage communicating the chamber with the pump chamber, and a spray path communicating the second storage chamber with the spray cylinder protruding to the outside, and provided at an end of the first conduction needle on the pump chamber side. A mixing / spraying device for use-time mixing type medicine, wherein a piston provided is slidably inserted into a pump chamber in an airtight state. 8. The apparatus according to claim 7, wherein a plunger is disposed between the piston and a bottom plate of the first storage chamber. 9. The apparatus according to claim 7, wherein the first storage chamber and the second storage chamber are shaped so that a medicine bottle can be inserted from the outside. 10. The apparatus according to claim 7, wherein the medicine in the medicine bottle accommodated in the first accommodation chamber is in a liquid state. 11. A glass vial in which the drug solution is enclosed by capping the medicine bottle accommodated in the first accommodation chamber with a lid stopper made of a material through which the first conduction needle can penetrate, and 11. The glass vial in which the drug preparation is enclosed by blindly closing the medicine bottle accommodated in the second accommodation chamber with a lid stopper made of a material through which the second conduction needle can penetrate. An apparatus according to claim 1. 12. A backflow prevention valve for preventing backflow from a pump chamber is provided in a first communication path of the first conduction needle, and liquid in a spray cylinder flows back to a medicine bottle in a second storage chamber. The apparatus according to any one of claims 7 to 11, wherein a check valve is provided in the spray cylinder so as not to prevent it. 13. The device according to claim 1, wherein the drug is a nasal drug formulation, an oral drug formulation, or a transdermal drug formulation. 14. The device according to claim 13, wherein the nasal drug preparation is a biological preparation.