JPH1014561A - Automatically testing apparatus for microorganism test or the like - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an automatic testing apparatus capable of automatically carrying out a sterile testing operation, a microorganism limit testing operation, an insoluble particle measuring test, a divided injection testing operation such as chemical analysis, a chemical reaction testing operation, etc., freely dealing with a test even if a specimen or the shape of a test target container are changed for each sample and the order of a testing operation is changed for each sample, optionally supplying a self completion type automatic testing apparatus equipped with self digesting function and green booth function, eliminating possibility of artificial mistakes and contamination of an operation environment by person, improving the reliability of tested result and saving labor. SOLUTION: This apparatus uses a work base placing a set of various machine parts including specimens or test target containers requiring changes for each sample on the same work pallet as a basic unit, supplies each work base to the operation zone of a robot and prepares a sample by handling operation of the robot for each machine part on the work base.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[Industrial use classification] In order to determine the presence or absence of bacteria and fungi in a specimen consisting of a powder injection or liquid injection vial by a membrane filter method or the like, an operation of preparing a medium sample of the specimen is generally performed by a vial or the like. Is known as the sterility test of The present invention relates to a sterility test device such as a vial, or more precisely, a device capable of maximizing its effect as an operating device for a sterility test. However, the present invention is not limited to the sterility test apparatus, the same conditions as the environment and operation for the sterility test,
Some changes have been made as an automatic test device for general microbial tests that perform operations, and also as an automatic test device for insoluble fine particle tests.
The same can be applied simply by adding, and further, there are some tests that require a similar test environment and operation method, such as chemical analysis tests and automatic reaction devices for chemical reaction tests. It will be understood in the description. However, in the following, an example in which the apparatus of the present invention is configured and applied as an automatic test apparatus for a sterility test as a typical application object will be described.

That is, in the first basic invention, the operations necessary for the above-described tests and the like are performed completely even if the shape, size, operation method, and operation order of the object such as a specimen to be inspected are changed. The present invention relates to an automatic apparatus that automatically performs operations without human intervention, reduces complicated operations, and performs highly reliable operations without errors. Further, the second invention has a disinfection means in the apparatus itself, maintains a clean environment, automatically performs all necessary operations under the clean environment, and further manually operates the effect of the first invention. The present invention relates to an automatic and environmental sterilization test apparatus capable of producing a sample such as a specimen with high test accuracy and high reliability without any concern about recontamination.

[0003]

2. Description of the Related Art Conventionally, a sample for judging the presence or absence of bacteria by a membrane filter method has been disclosed in JP-A-63-23.
As shown in the drawing (FIG. 24) for explaining the conventional method of No. 0077, the vacuum suction filtration method using a syringe, a flask, a lottery, etc., was all performed manually. By the way, this vacuum suction filtration system is premised on manual operation in a clean room, so it is difficult to completely prevent contamination in the clean room by an operator. That is, in the vacuum suction filtration method, since there is a possibility that air in the surrounding environment may be sucked into the sample as it is, there is a possibility that a false positive problem may occur and there is a problem in reliability of test accuracy.

[0004] In order to solve this problem, a suction needle, 2
A pressurized filtration type steritest unit equipped with two tubes each communicating with one of the culture tubes was developed, and contamination of bacteria due to the working environment during the test operation was greatly improved. However, even when the steritest unit is used, when a series of operations are performed manually in a clean room, it is difficult to prevent environmental pollution by humans, and extinction of bacterial contamination cannot be expected. In addition, problems such as operation procedure errors, poor test efficiency, and high costs have been carried over.

As means for solving these problems, an automatic sterility test apparatus for vials described in the above-mentioned Japanese Patent Application Laid-Open No. 63-230077 has been developed, but this apparatus also has the following problems. However, the problems required for the sterility test operation have not been fundamentally solved. B) When the necessary equipment is set in the apparatus (when performing pre-setup), a person must enter the clean room and work. If a human enters the clean room, the clean room will be contaminated, and a sterility test will be performed in the contaminated environment, leaving concerns about false positives. B) When a plurality of samples of different lots are set in the apparatus, the injection needle for injecting the dissolving solution has a structure in which the same needle is used as it is even if the sample changes, so that the injection needle for the second and subsequent samples is used. There is a risk of contamination. C) The sample transport tray must be replaced every time one of the sample container shape, the number of samples per sample, the shape and quantity of each container other than the sample, the test order, etc. changes. Is extremely complicated, the number of trays is remarkably large, the storage space for the trays is considerably required, and the burden of managing them is large. D) Stock devices for various container cases are arranged in a plane,
In addition, since a stock device is required both before and after the test, increasing the number of processed samples per device increases
Since the occupied installation area of the apparatus increases, the number of samples that can be processed per set in the existing clean room cannot be increased. E) The work procedure is fixed, and each process starts simultaneously each time. Therefore, the integrated value of the process requiring the longest time becomes the required time as it is, and the total time required for the test Time becomes very long. F) When the operation procedure is fixed and the same operation is repeated, it is necessary to further add a device for performing the operation, the occupied area is further increased, and the investment cost is also increased. G) The device is exclusively for vials, and cannot be used for sample containers of other shapes (ampoules, infusion bags, ophthalmic solutions, etc.) nor for other purposes (such as making a sample for sterility test by a direct method). Separate equipment must be considered.

[0006]

SUMMARY OF THE INVENTION The present invention aims to solve the above-mentioned problems of the prior art. The first problem is that the sterility test operation using a steritest unit or the like is complicated. In order to eliminate operational errors due to this, it is intended to create and provide a device that can automatically perform all of the operations, and of course, the sample to be tested is not only used as a vial container and an ampule container, It is an object of the present invention to provide an automatic apparatus that can freely cope with infusion bags, eye drops, test tubes, syringes, bottles, cans, fresh, paper packs, and other irregular containers. In addition, the second problem is to simplify a device that does not require a clean room, has a clean booth function by itself, and can automatically perform operations on the above-described various samples without fear of contamination by humans. It is intended to provide a self-contained automatic test apparatus for microbial tests and the like, which can expect high-precision test results. Still another object of the present invention is to provide an automatic test apparatus for an insoluble fine particle test by adding or changing a part of the apparatus configuration so that an automatic test apparatus for an analysis test, a dispensing test, a chemical analysis test, a chemical reaction test, etc. An automatic test apparatus that can be used as a personal computer is not provided.

[0007]

SUMMARY OF THE INVENTION The present invention is based on the concept that a work base in which a set of equipment necessary for an operation for preparing a sample is placed on the same work pallet is used as a basic unit for each sample. Are sequentially supplied to the robot position, the common members common to the preparation of each sample sample are set in advance at the robot position, and the robot performs a handling operation on each supplied work base via the common member to create a sample sample. It is to do.

[0008] That is, a first invention of the present invention is an apparatus for handling operations required for a test using a robot, in which a set of equipment that needs to be replaced for each sample is placed on the same work base, The automatic test apparatus is configured to supply the operation range to the operation range, and to switch the operation range to the operation range for each work base every time the sample is changed. Further, the second invention provides a stocking apparatus for circulating and stocking the work base on which a set of equipment necessary for a sample making operation is mounted on the same work pallet, and a handling operation between the work base and the common equipment. The work base is reciprocated in both compartments or enters the robot operation section compartment from the compartment compartment with the disinfection, sterilization means and clean booth function. And an automatic test apparatus for a microorganism test or the like, which is configured to be taken out to the other side.

[0009]

According to the present invention, a sample base is installed in a clean room by using a set of equipment which needs to be replaced for each sample of the first invention on the same work pallet and used in a clean room. It is possible to avoid complicated operations for making, and also to reduce mistakes in the operation, to greatly reduce labor for preparing samples, and to make the shape and size of the test object Can be handled even if there are many types. Also, in the second invention, the work base is disinfected in the process in addition to the action of the first invention by installing and connecting the stock device and the robot device in a clean room capable of disinfecting and connecting them. Work-based preparation and handling operations can be made easier, and more reliable samples can be obtained in the preparation of specimen samples.

[0010]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail with reference to an embodiment of a sterility test apparatus shown in the drawings. However, as described above, the present invention is not limited to the apparatus of this embodiment, but includes the spirit of the present invention. The configuration and the application object thereof can be changed as appropriate within the scope of the invention.

In the embodiment shown in FIG. 1 (a plan view of the entire apparatus) and FIG. 2 (a view taken along the line MM in FIG. 1), a work attachment / detachment table (A), a work stocker (B), and a work operation table are shown. (C), a work operation auxiliary table (D), a work operation robot (E), and a work base (F).

As shown in FIG. 3 (work base configuration diagram), the work base (F) is equipment required for the work and needs to be replaced for each sample, that is, the container case F1.
And a solution filling pump unit F2 loaded with a tube unit for filling a solution or the like, a various solution filling pump unit F3 loaded with a steritest unit for filling various solutions, and these equipment. It is constituted by a work pallet F4. The container case F1 is detachable from the work pallet F4, and the solution filling pump unit F2 and various solution filling pump units F3 are fixed to the work pallet F4.

The container case F1 shown in FIG.
As shown in (Various container layout), the sample container F1-1 is a vial container, the number of samples per sample is 20 (20 containers), the pre-cleaning liquid container F1-2 is one container, and the cleaning liquid container F1-3. Are two containers, the solution container F1-4 is one container, the medium A container F1-5 is one container, and the medium B container F1-6.
Shows one container, one cap holder F1-7, and one empty space F1-8.

The solution filling pump unit F2 is shown in FIG.
As shown in the (solution solution filling pump unit plan view), the solution filling pump unit F2 includes a solution feeding pump F5, a solution suction needle fixing base F6, and a solution filling needle fixing base F7. Solution filling tube unit F
8 is set.

FIG. 6 shows a solution filling tube unit F8.
As shown in the (solution solution filling tube unit configuration diagram),
It is composed of a solution suction needle F8-1, a solution filling needle F8-2, and a connection tube F8-3. A filter (1) F8-4 is connected to the tube F8-
5 and a filter (2) F8-6 is connected to the solution filling needle F8-2 via a tube F8-7. Cap (1) is attached to the solution suction needle F8-1.
F8-8 is covered, and the solution filling needle F8-2 is covered with a cap (2) F8-9.

The solution suction needle F8-1 of the solution filling tube unit F8 is connected to the solution suction needle fixing table F6 as shown in FIGS. The liquid filling needle F8-2 is set on the solution filling needle fixing base F7, and the connection tube F8-3 is set on the solution feeding pump F5.

Various solution filling pump units F3 are shown in FIG.
(Various solution filling pump unit plan view)
Various solution feeding pump F9, various solution suction needle fixing base F1
0, pinch valve (1) F11, pinch valve (2) F
12 and a culture tube fixing stand F13, and a steritest unit F14 is set in the various solution filling pump unit F3.

The steritest unit F14 is provided in FIG.
As shown in (Steritest unit configuration diagram), various solution suction needles F14-1, culture tubes (1) F14-2, culture tubes (2) F14-3, and connection tubes (1) F14-4,
The connecting tube (2) is composed of F14-5. Various solution suction needle caps F are attached to the various solution suction needles F14-1.
14-7 is covered, and the filter F14-6 is connected. Culture tube (1) F14-2 and culture tube (2) F14
The upper exhaust port (1) F14-12 and the upper exhaust port (2) F14-13 have an upper cap (1) F14-8.
And the upper cap (2) F14-9 is covered,
In addition, each lower drain port has a bottom cap (1) F14
-10 and bottom cap (2) F14-11 are attached.

As shown in FIGS. 8 and 10 (FIGS. 8M-M), the various solution suction needles F14-1 of the steritest unit F14 are connected to the various solution suction needle fixing bases F10 and the connection tubes (1). F14-4, connecting tube (2) F14
-5 is set in each solution sending pump F9,
Various solution suction needle fixing base F10 and various solution feeding pump F9
The connecting tube (1) F14-4 is set on the pinch valve (1) F11, the connecting tube (2) F14-5 is set on the pinch valve (2) F12, and the culture tube (1) F
14-2 and culture tube (2) F14-3 are a culture tube fixing table F
13 is set.

The container case F1 is detachable from the work pallet F4, and the solution filling pump unit F2 and the various solution filling pump units F3 are fixed to the work pallet F4. The attachment / detachment of the solution filling tube unit F8 to / from the liquid filling pump unit F2 and the attachment / detachment of the steritest unit F14 to / from the various solution filling pump units F3 are manually performed.

The work operation table (C) takes out the work base (F) from the work stocker (B) to a predetermined position of the work operation table (C) as shown in FIG. Or a work base removal / storage device C1 for storing the work base (F) from a predetermined position on the work operation table (C) into the work stocker (B), and a solution side operation for receiving the work base (F) on the solution side. Table C13, various solution side operation tables C14 for receiving the work base (F) on the various solution operation sides, and work base positioning adapted to fix the work base (F) on each dissolution side operation table C13. Device (1) C5, work base positioning for fixing the work base (F) with various melting side operation tables C14 Device (2) C12, lysis solution container holding / lifting device C2 installed above the lysis solution suction needle fixing stage F6, sample container installed below the lysis solution filling needle fixing stage F7 The gripper elevating device C3, the dissolving solution sending pump rotating device C4 installed below the setting position of the dissolving solution sending pump F5, and the various solution containers installed above the setting position of the solution suction needle fixing base F10. A gripping elevating device C6, an auxiliary device C7 for removing various solution suction needle caps (shown in FIG. 10), a pinch valve opening / closing device (1) C8 installed above the set position of the pinch valve (1) F11, a pinch valve (2) )
Pinch valve opening / closing device (2) C9 installed above the set position of F12, various solution feed pump rotating devices C10 installed below the set position of various solution feed pumps F9, and culture tube (1) F14-2 and culture tube (2)
The culture tube bottom cap attaching / detaching device C11 for attaching / detaching the bottom cap (1) F14-10 and the bottom cap (2) F14-11 of F14-3.

As shown in FIG. 13 (FIG. 12M-M), the work base take-out storage device C1
1. The cylinder C1-2 for horizontal movement, the support frame C1-3, the cylinder C1-4 for elevating and lowering, and the pin C1-5. When the cylinder C1-4 for elevating is lifted, the pin C1-5 works. The work base (F) gets into the gap between the handles provided on the pallet F4 and is taken out from the work stocker (B) toward the work operation table (C), or the work base (F) is moved from the work operation table (C) to the work stocker (B). Can be stored.

As shown in FIG. 7 (FIGS. 5M-M), the dissolving solution container gripping elevating device C2 includes an elevating cylinder C2-1 installed on the dissolving solution side operation table C13, a dissolving solution container supporting base. C2-2, a horizontal moving cylinder C2-3, and a gripper C2-4, and the solution container F1-4 is carried to the solution container gripping elevating device C2 by the work operation robot (E). The gripper C2-4 is closed by the operation of the horizontal movement cylinder C2-3, the cap portion of the solution container F1-4 is grasped, the lifting cylinder C2-1 is lowered, and the solution suction needle fixing base is moved. A solution suction needle F8-1 set in F6 is inserted into the cap.

As shown in FIG. 14 (FIG. 5N-N), the sample container holding / lifting device C3 is installed on the solution-side operation table C13, and includes a lifting / lowering cylinder C3-1 and a sample container support base. C3-2, horizontal movement cylinder C3-
3 and a gripper C3-4. When the sample container F1-4 is carried to the sample container gripper elevating device C3 by the work operation robot (E), the sample container F1-4 is gripped by the operation of the horizontal movement cylinder C3-3. The claws C3-4 are closed, the body of the sample container F1-1 is gripped, and the lifting cylinder C3 is lifted.
As a result, the solution filling needle F8-2 set on the solution filling needle fixing base F7 is inserted into the cap of the sample container F1-1.

The dissolving solution feed pump rotating device C4 is shown in FIG.
As shown in the figure, the lifting / lowering cylinder C4-1 and the rotating device support base C4 installed on the solution-side operation table C13.
-2, constituted by a rotating device C4-3 and a coupling C4-4, and the coupling C4-4 is connected to the rotating shaft of the dissolving solution sending pump F5 by raising the elevating cylinder C4-1. The pump F5 rotates.

The work base positioning device (1) C5
As shown in FIG. 15 (an arrow view in FIG. 12N), the elevating cylinder C5-
1, a cylinder fixing base C5-2 and a work base insertion pin C5-3.
As the 5-1 rises, the work base insertion pin C5-3 is inserted into a hole provided in the work pallet F4 in advance, and is operated simultaneously with a work base positioning device (2) C12 described later to position the work base. It is designed to be fixed.

FIG.
As shown in FIG. 8M-M arrow view, the cylinder C6-1 for raising and lowering installed on the various solution side operation table C14, the various bases C6-2 for the melter support, and the cylinder C6- for horizontal movement.
3 and gripping claws C6-4. When the various solution containers are carried to the various solution container gripping elevating and lowering device C2 by the work operation robot (E), they are gripped by the operation of the horizontal movement cylinder C6-3. The claws C6-4 are closed, the caps of the various solution containers are gripped, the lifting cylinder C2-1 is moved down, and the various solution suction needles F14-1 set on the various solution filling needle fixing base F10 are moved. It is designed to be inserted into caps of various solution containers.

As shown in FIG. 10, the various types of solution suction needle cap removal assisting devices C7 are attached to the support C7-1, the horizontal moving cylinder C7-2, and the tip of the rod, which are installed on the various solution side operation table C14. Claw C7
-3, which is an auxiliary device for facilitating removal of the suction needle cap F14-7 by the work operation robot (E). This is a device for loosening the fitting of the suction needle cap F14-7, which is put on the various solution suction needles F14-1 attached to the device before starting the operation. The various solution suction needle cap removal assisting device C7 is unnecessary if the removal operation of the suction needle cap F14-7 is easy.

The pinch valve opening / closing device (1) C8 is shown in FIG.
0 and various solution side operation tables C as shown in FIG.
14 and Cylinder C for lifting and lowering installed at 14
8-2 and a valve push rod C8-3, and the pinch valve (1)
F11 is opened and closed.

The pinch valve opening / closing device (2) C9 is also shown in FIG.
0 and various solution side operation tables C as shown in FIG.
14 and Cylinder C for lifting and lowering installed at 14
9-2 and a valve push rod C9-3, and the pinch valve (2) F
12 are opened and closed.

As shown in FIG. 16 (shown by arrows N-N in FIG. 8), the rotary pump C10 for various solutions is provided with a lifting cylinder C10-
1. Rotating device support base C10-2, rotating device C10-
3 and the coupling C10-4, and the coupling C10
-4 is connected to the rotating shaft of the various solution feed pumps F9 fixed to the work pallet F4, and the various solution feed pumps F
9 rotates.

The culture tube bottom cap attaching / detaching device C11 is shown in FIG.
As shown in FIG. 6 and FIG. 17 (viewed from the arrow P-P in FIG. 8), the support C1 installed on the various solution-side operation tables C14.
1-1, horizontal movement cylinder base C11-2, horizontal movement cylinder C11-3, lifting / lowering cylinder C11-4,
Base C11-5 for cap attaching / detaching device, culture tube bottom cap attaching / detaching device (1) C11-6, culture tube bottom cap attaching / detaching device (2) C11-7, drain pipe (1) C11-8, and drain pipe (2) C11. -9, the horizontal movement cylinder C11-3, the elevating cylinder C11-4, the culture tube bottom cap attaching / detaching device (1) C11-6, and the culture tube bottom cap attaching / detaching device (2) C11-7. The bottom cap of the culture tube (1) F14-2 (1)
The bottom cap (2) F14-11 of the F14-10 and the culture tube (2) F14-3 is detachably stored or attached. When the bottom cap (1) F14-10 and the bottom cap (2) F14-11 are detachably stored, the drainage port of the culture tube (1) F14-2 and the culture tube (2) F14-3.
The drain pipe (1) C11-8 and the drain pipe (2) C11-9 come under the drain port of the above to receive drainage.

Work base positioning device (2) C12
Has the same specifications as the work base positioning device (1) C5.
As shown in FIG. 12, the work base positioning device (1) is installed on the various solution side operation table C14.
5 and is simultaneously operated to position and fix the work base (F).

As shown in FIG. 1, the work operation auxiliary table (D) is provided at a position different from the work operation table (C) within the operable range of the work operation robot (E). The operation auxiliary table (D) is provided with common equipment and a container temporary storage place that can be used in common for each lot.

The common equipment and the container temporary storage place include a dissolution promoting vibration device D1, a container holding device D2, an ampule opening device D3, a preliminary cleaning liquid container temporary storage D4, a container holding position changing device D5, various solution suction needle cap temporary storage D6. , Culture tube upper cap (1) temporary storage site D7, culture tube upper cap (2) temporary storage site D8, ampoule filling auxiliary container upper cap temporary storage site D9, container shape confirmation sensor D10, lysis solution container temporary storage site D11, etc. It is composed of common equipment and temporary storage for containers.

The dissolution-promoting vibration device D1 (not shown) is a device for promoting the dissolution after filling the powder injection sample with the dissolving solution, and includes a vibration device main body and an air cylinder attached to the upper portion of the vibration device main body. It is constituted by a chuck operated by.

As shown in FIG. 18, the container holding device D2 is installed on the wall of the robot room and has a container receiving support shaft D2.
A container receiver D2-3 attached to the tip of a swing arm D2-2 swinging around a -1 as a fulcrum, and a container receiver storage cylinder D2-4 are provided. As shown in FIG. Or use when changing the container from lower grip to upper grip. If the robot is located within the normal robot operation range (H), it becomes an obstacle for the robot to perform other operations.
18 is stored outside the robot operation range (H) as indicated by a two-dot chain line in FIG. 18, and the container receiver D2-3 is set in the robot operation range (H) when necessary. It is supposed to be.

The ampoule opening device D3 is shown in FIGS.
As shown in FIG. 1, a frame D3-1-1, a rotary blade rotating motor D3-1-2, a revolving arm D3-1-3, a pulley (1) D3-1-4, a belt D3-1-5, a pulley (2) Ampoule cutting position scratching device D3-1 composed of D3-1-6, rotary blade D3-1-7, and spring D3-1-8, and a beard having a U-shaped groove shown in FIG. A cutting auxiliary jig D3-2, a gripping position setting bar D3-3 shown in FIG. 23H, a cutting beard guiding chute D3-4,
A collection box F1-7 constituted by a collection box receiver D3-5 and taken out of the container case F1 via the work operation robot (E) is set in the collection box receiver D3-5, and the cut beard guiding chute is set. The beard portion of the ampule cut through D3-4 is collected in a collection box F1-7, stored in the container case F1, and the waste generated in making the sample is collected together with the sample.

FIG. 2 shows a case where the sample container F1-1 is an ampoule.
As shown in FIG. 3, the relative position where the ampule is gripped by holding the ampoule by the robot hand E1 is corrected, and then the rotary blade is brought into contact with the rotary blade as shown in FIG.
The tip of the ampule is inserted into the U-shaped groove of No. 2 and the beard is cut by giving a twist with the robot hand E1. FIG.
3 (A) is a state where the sample container F1-1 is taken out by the robot hand E1, FIG. 23 (B) is a state where the sample container F1-1 is deposited in the container gripping position changing device hand D5-1 of the container gripping position changing device D5, and FIG. (C) is a container holding position changing device hand D
23 (D), the robot hand E1 is closed and the tip of the sample container F1-1 is pushed to facilitate grasping the lower part of the sample container F1-1 with the robot hand E1. FIG. 23E shows a state where the lower part of the sample container F1-1 is gripped by the robot hand E1, and FIG.
23 shows the state in which the container gripping position changing device hand D5-1 is opened, FIG. 23 (G) shows the operation of firmly grasping the entire sample container F1-1, and FIG. 23 (H) shows the position where the rotating blade damages the sample container F1-1. Position setting bar D3-3 for setting
In slightly lift the bottom of the specimen container F1-1, showing a state in which eliminate the effects of dimensional accuracy of bad beard unit L _2.

The pre-cleaning liquid container temporary storage space D4 (not shown) is a station for temporarily storing the same pre-cleaning liquid container F1-2 when sharing it with a plurality of samples. This device is unnecessary when the pre-cleaning solution is not shared for a plurality of samples.

Container holding position changing device D5 (not shown)
Is used as a temporary storage station when switching various containers from the upper grip to the torso or lower grip, when switching from the torso grip to the upper or lower grip, and when switching from the lower grip to the torso or upper grip,
It is intended for relatively small containers.

The various solution suction needle cap temporary storage site D6 (not shown) is a station where the various solution suction needle caps F14-7 are temporarily removed before starting the operation and returned to the original state after the operation is completed.

Culture tube upper cap (1) Temporary storage D7 (not shown) and culture tube upper cap (2) Temporary storage D8
(Not shown) is a station for temporarily placing a cap on the upper exhaust port of the steritest unit.

The ampoule filling auxiliary container upper cap temporary storage area D9 transfers the solution contained in the ampoule container to the culture tube of the Steritest unit, and uses the ampoule filling auxiliary container F15 (FIG. 35) used for pressure filtration. This is a station for removing the upper cap F15-3 (shown) before starting the operation and temporarily placing the upper cap F15-3 after returning to the original state after the operation is completed. The collection box F1-7 without returning the upper cap F15-3 to its original position.
You may leave. Place the upper cap F15-3 in the collection box F
In the case of putting into 1-7, the ampoule filling auxiliary container upper cap temporary storage space D9 is unnecessary.

Container shape confirmation sensor D10 (not shown)
Is a sensor for confirming whether the shape of the container held by the work operation robot (E) is a predetermined container at two positions in the width direction and the length direction, and holding the container over a preset position. To check. As shown in FIG. 24, R ₁ and R ₂ and H ₁ and H ₂ are set with respect to the reference dimensions R and H of the sample container F1-1 in consideration of an allowable dimensional error.
There vessel R _1, no vessel R _2, there container H _1, H
_{In step 2} , four points without a container are checked to check the shape of the container.

The dissolving solution container temporary storage place D11 (not shown)
This is a station where the same dissolving solution container F1-4 is temporarily placed when shared by a plurality of samples. Not required if not shared.

FIG. 1 shows the work operation auxiliary table (D).
As shown in (1), it may be divided into any number as long as it is within the operation range of the robot without being collected at one place.

In the above, the configuration of the apparatus of the present invention has been described assuming that the specimen to be tested is mainly a powder injection or liquid injection vial. However, the present invention can be applied to an irregular-shaped container such as an infusion bag, which will be described below.

When the target sample container F1-1 is a liquid injection ampule, the beard portion of the sample container F1-1 is cut, and the steritest unit F is directly connected to the cut opening of the sample container F1-1.
In the case where the solution suction needle F14-1 of No. 14 is inserted as it is and sucked up, the following measures are required. That is, (1) The various solution suction needles F14-1 can be set on the work base (F) with the downward direction. (2) An ampule container holding / lifting device similar to the sample container holding / lifting device C3 is separately required below the various solution suction needles F14-1. (3) The length of each solution suction needle F14-1 is
Match the size of 1-1 deepest container. And other operations are required. However, when these are performed as they are, the various solution suction needles F14-1 are attached to the work base.
Set two types of Steritest Unit F1
It is necessary to use four differently, to use various solution suction needle fixing base F10 more complicated, and to use very long various solution suction needle F14-1 depending on the size of the container. Various solution suction needles F
The operability, equipment cost, equipment reliability (in terms of centering accuracy with a long needle), stability of supply of applicable equipment, and specification change (specimen) There is a problem in terms of flexibility with respect to the change of the container size).

Therefore, as an alternative to the above countermeasures, in the present invention, the ampoule filling auxiliary container F shown in FIG.
15 to solve the above problem. That is, as shown in FIG. 25, the ampoule filling auxiliary container F15 is attached to the ampoule filling auxiliary container main body F15-1 and the lower part of the ampoule filling auxiliary container main body F15-1, and the various solution suction needles F14-1 are inserted therein. Filling auxiliary container lower cap F15-2 (cap having almost the same specification as the vial container) and an upper ampoule filling auxiliary container upper cap F15-3 for security protection, which is covered on the upper part, and Once the ampoule solution is poured into the filling auxiliary container F15, it can be handled in the same manner as the liquid injection vial.

When the target sample container F1-1 is an irregular-shaped container and has a large suction port, as shown in FIG. 26, an irregular-shaped container fixing container F16 in which the sample container F1-1 is directly inserted is prepared. Is what you do. The irregular-shaped container fixed container F16 includes an irregular-shaped container fixed container main body F16-1, an irregular-shaped container fixed container cap fixing portion F16-2, and an irregular-shaped container fixed container robot hand hanging portion F16-3. . That is, the fixed container F1
6 and put the sample container F1-1 in the container case F-1.
Once loaded into the vial, it can be handled in the same way as a liquid injection vial.

When the sample container F1-1 is indefinite, such as a plastic bag, the dissolving solution filling tube unit F-8 shown in FIG.

Therefore, in the present invention, as shown in FIG. 27, there is provided an irregular-shaped container suction needle F17-1 having one suction-side needle and not having a suction-side filter attached thereto. An irregular-shaped container filling tube unit F17 having the same specifications as the solution filling tube unit F8 is prepared. That is, the filling tube unit F17 for the irregular-shaped container is set in advance in the solution-filling pump unit F2, and the irregular-shaped container fixing the sample container F1-1 instead of the dissolving solution container F1-4 is fixed. The container 16 is set in the solution container holding / lifting device C2, an empty vial container is set in the sample container holding / lifting device C3, and the same operation as the solution injection operation is performed. Is once filled in the vial container, and then the container is set on the various solution container gripping elevating device C6 for operation.

As described above, the device of the present invention can be used for various shapes and sizes to be inspected, such as ampules, infusion bags, ophthalmic solution bottles, as well as vials.

The work stocker (B) is, as shown in FIG.
1. The work base (F) is stored in the work stocker (B), and when a circulation frame B2 (10 in the case of this figure) for circulating in the work stocker (B) circulates, the path is taken from the path. Circulation frame guide B to prevent it from coming off
3. A circulating frame lifting / lowering device B4 for raising / lowering the stored work base (F) together with the circulating frame B2, and a rising portion circulating frame supporting device B for always supporting the rising circulating frame B2.
5. The second lowermost circulation frame B2 of the circulation frame B2
2 for lowering the circulating frame lifting device B4 when the circulating frame raising / lowering device B4 is lowered, and upper circulating frame lateral movement for laterally moving the uppermost circulating frame B2 on the ascending side to the uppermost stage on the descending side. Device B7 and a lower circulating frame lateral moving device B for laterally moving the lowermost circulating frame B2 to the lowermost tier on the rising side.
8, the respective devices are operated to operate the circulation frame B
2 can be circulated.

As shown in FIGS. 29 (front view of the circulating frame raising device) and FIG. 30 (FIG. 29M-M arrow view), the circulating frame raising / lowering device B4 includes a raising / lowering device base B4-1 and a raising / lowering shaft B4-.
2. A lifting / lowering shaft synchronization device B4-6 for operating the lifting / lowering shaft bearing B4-3, the lifting / lowering arm B4-4, the lifting / lowering cylinder B4-5, and the four lifting / lowering shafts B4-2 in a synchronized manner.
The lifting device base B4-1 is raised and lowered by the operation of the lifting cylinder B4-5.

As shown in FIG. 31 (a front view of the ascending portion circulating frame support device), the ascending portion circulating frame supporting device B5 includes a ascending portion circulating frame supporting device mounting base B5-1, a rotating shaft B5-2,
The claw B5-3 and the spring B5-4,
When the lifting device base B4-1 rises, the lower circulation frame B2
-1 pushes up the circulation frame B2-2, and the claw B5
-3 is automatically disengaged, and when the supporting portion of the lower circulating frame B2-1 passes through the claw B5-3, the claw B5-3 is returned to its original position by the spring B5-4, and the elevating device base B4-1 is lowered Even so, the circulation frame B2-1 is supported by the claws B5-1,
The position of the circulation frame B2-2 is replaced.

As shown in FIG. 32 (a front view of the descending portion circulating frame supporting device), the descending portion circulating frame supporting device B6 includes a descending portion circulating frame supporting device mounting base B6-1, a rotating shaft B6-2,
The claw B6-3, the spring B6-4, and the claw releasing cylinder B6-5 are configured. When the lifting / lowering device base B4-1 is raised and the circulation frame B2-10 is lifted, the claw releasing cylinder B6-5 is moved. Actuating, the pawl B6-3 is released from the supporting position, and then the lifting / lowering device base B4-1 starts descending, and the supporting portion of the circulating frame B2-10 and the circulating frame B2-
The lower needle of the circulation frame B2-9 at the upper stage of the ten is the claw B6.
After passing through the third section, the claw releasing cylinder B6-5 is operated to support the circulation frame B2-9 with the claw B6-3, and the circulation frame B2-10 is cut off. It descends to the lifting device base B4-1.

As shown in FIG. 33 (a side view of the upper circulating frame lateral moving device), the upper circulating frame lateral moving device B7 includes an upper circulating frame lateral moving cylinder B7-1 mounted in the upper chamber of the frame body B1. The upper circulating frame lateral movement cylinder B7-1 is constituted by a pushing plate support B7-2 and a pushing plate B7-3, and the uppermost circulating frame B2-5 in the ascending row (the uppermost left side in this figure) is operated. Is moved laterally to the uppermost row of the descending row (the uppermost row on the right side in this figure).

As shown in FIG. 34 (a side view of the lower circulating frame lateral moving device), the lower circulating frame lateral moving device B8 includes a lower circulating frame lateral moving cylinder B8-1 attached to the elevating device base B4-1. The lower frame circulating frame B2-10 is constituted by a pressing plate support B8-2 and a pressing plate B8-3, and the lower circulating frame horizontal moving cylinder B8-1 is actuated to operate the lowermost row of the descending row (lower right side in this figure). Is moved laterally to the lowermost row of the ascending row (the lowermost row on the left side in this figure). In this figure, the lower circulation frame lateral movement cylinder B8-1 is attached to the elevating device base B4-1, but the lower circulation frame lateral movement cylinder B8-1 may be attached to the frame body B1. . Although the work stocker (B) has been described as a lifting / lowering system using a cylinder system, it may be a chain system as shown in FIG. 55 or an elevator system.

As shown in FIG. 35 (a front view of the stocker room), the work stocker (B) is entirely covered with covers (1).
It is surrounded by G1 and has a closed structure {hereinafter referred to as a stocker room (S)}, and a filter unit (1) G2
, An exhaust port G3 is provided on the lower side surface, a door G4 is provided on the work attachment / detachment table (A) side for taking in and out the work table (F), and an automatic door is provided on the work operation table (C) side. G5 is provided and has a clean booth function.

A spray nozzle (1) G6-1 is installed in the stocker room (S), and a work base (F)
And the inside of the stocker room (S) can be disinfected.

Further, as shown in FIG. 36 (front view of the robot room), the entire area around the work operation table (C), the work operation auxiliary table (D) and the work operation robot (E) is covered ( 2) It is surrounded by G7 and has a sealed structure (hereinafter referred to as the robot room (R)). A filter unit (2) G8 is mounted on the upper part, an exhaust port G9 is provided on the lower side, and a maintenance is provided on the front. Door G10
And has a clean booth function like the stocker room (S).

As in the case of the stocker room (S), a spray nozzle (not shown) is also installed in the robot room (R), so that each device installed in the robot room (R) can be disinfected. It has become.

FIG. 37 shows an external view of the entire apparatus. In the above description, the basic example in which the stocker room (S) is connected to one side of the robot room (R) has been described. As shown in (view), the stocker room (S) can be connected to both sides of the robot room (R) to increase the productivity for preparing a sample sample. Although the present apparatus has been described as an example of an automatic sterility test operation apparatus of a pressure filtration type such as a vial and an ampule, the present apparatus is designed to test the shape of a container whose work base (F) is to be tested and its operation. By following the configuration of the equipment necessary for the work, changing the part of the work operation auxiliary table device, adding it, and changing the program of the work operation robot, it is explained below without being restricted by the container shape and test procedure As
To be used as an automatic sterility test operating device by the suction filtration method, an automatic sterility test operating device by the direct method, an automatic test operating device for insoluble fine particles, and an automatic dispensing test operating device related to analysis and reaction. Can be.

That is, when the operation is performed by a suction filtration method using a membrane filter, a suction joint C15 (not shown) is provided at the center of the support of the various solution support bases C3-2, and the suction joint C15 is provided above the funnel. A lower exhaust port of a funnel unit F18 (not shown) having a cap and a valve below the filter is connected to the suction joint C15.
Connected to the funnel unit F18.
Has a suction filtration function. The funnel unit F18 is prepared in advance in various container cases F1, and the funnel unit F18 is set in the specimen container gripping elevating device C3 whenever necessary, and a sample similar to the pressure filtration method is filtered by suction filtration. Can be made.

Since the sample preparation by the direct method is only a combination of the operation of attaching and detaching the cap of the test tube, the dispensing operation of each solution, the dissolution promoting vibration operation, and the repetition operation, the solution filling pump unit F2 is also used in this case. Just use
We can make the required sample.

When a sample filter for measuring insoluble fine particles in a sample is prepared, the operation can be performed in substantially the same manner as in the suction filtration method. In this case, the medium injection operation is unnecessary.

The dispensing operation often performed in the analysis operation is also performed using only the solution filling pump unit F2 without using the various solution filling pump units F3.

Next, several examples of the operation of the automatic sterility test operation device of the above embodiment will be described. << I: When the target sample container F1-1 is a powder injection vial >> (1) [Preliminary setup operation] (1-1): A door that is also used manually as the work attachment / detachment table (A) of the work stocker (B). G4 is opened, the work base (F) is taken out, and the container case F1, the solution filling tube unit F8 and the steritest unit F14 which have been operated are removed. Container case F prepared in advance
1. Attach the solution filling tube unit F8 and the steritest unit F14, and Or registration NO. Is input to the control device. (1-2): The above operation (1-1) is repeated the required number of times (arbitrarily settable from 1 to 10 in this figure), and the door G4, which is also used as the work attaching / detaching table (A), is closed. (1-3): The work start switch is turned on. Hereinafter, all operations are automatically performed up to operation (15).

(2) [Disinfection operation in stocker room (S)] (2-1): The spray nozzle G6-1 is operated to spray the disinfectant for a predetermined cycle or a predetermined time. (2-2): After the spraying is completed, fumigation is performed for a predetermined cycle or a predetermined time. (2-3): After completion of fumigation, exhaust is performed for a predetermined cycle or for a predetermined time. (2-4): Further circulating the work stocker (B),
The first frame of the circulation frame B2 is brought to the position of the automatic door G5.

(3) [Work base (F) take-out operation] (3-1): The automatic door G5 of the work stocker (B) is opened. (3-2): Work base take-out and storage device C1 is operated to take out the work base (F) onto the work operation table (C), and the work base positioning device (1)
The work base (F) is fixed on the work operation table (C) by raising C5 and the work base positioning device (2) C12. (3-3): Close the automatic door G5.

(4) [Preparation operation of solution supply pump unit F2] (4-1): The solution supply pump rotating device C4 is raised and connected to the solution supply pump F5. (4-2): The cap (1) F8-8 of the solution suction needle F8-1 is removed by the work operation robot (E), and the cap F1-7 of the container case F1 is put into the cap case F1-7. (4-3): Remove the cap (2) F8-9 of the solution filling needle F8-2 with the work operation robot (E) and put it in the cap case F1-7 of the container case F1.

(5) [Various melting and filling pump unit F3
Preparation Operation] (5-1): The rotating device C10 of the various solution sending pumps is raised and connected to the various solution sending pumps F9. (5-2): Various solution suction needle caps are removed and various solution suction needles F14-1 and various solution suction needle caps F14 of the steritest unit F14 are operated by operating the auxiliary device C7.
Loosen the -7 fitting. (5-3): The various solution suction needle caps F14-7 are removed by the work operation robot (E) and are temporarily placed in the various solution suction cap temporary storage areas D6. (5-4): The culture tube bottom cap attaching / detaching device C11 is operated to remove the culture tube bottom cap (1) F14-10 and the culture tube bottom cap (2) F14-11. In addition, the culture tube bottom cap attaching / detaching device C11 is laterally moved, and the drainage pipes (1) C11-8 and the drainage pipe ( 2) C
Set 11-9. (5-5): The pinch valve opening / closing device (1) C8 and the pinch valve opening / closing device (2) C9 are operated to open the pinch valves (1) F11 and (2) F12.

(6) [Pre-cleaning liquid injection operation] (6-1): The pre-cleaning liquid container F1-2 is taken out of the container case F1 by the work operation robot (E), and the container is gripped by the container gripping position changing device D5. The position is changed, and the solution container gripping elevating device C6 is inverted. (6-2): The various solution container holding / lifting device C6 is lowered, and the various solution suction needles F14-1 attached to the various solution suction needle fixing bases F10 are inserted into the caps of the pre-cleaning liquid container F1-2. (6-3): The various solution feeding pumps F9 are rotated at a predetermined number of rotations, and a predetermined amount of the pre-cleaning solution is supplied to the culture tube (1) F14-.
2 and into culture tube (2) F14-3 and filtered under pressure. (6-4): When the operation of injecting the pre-cleaning liquid and filtering under pressure is completed, the various solution container holding / lifting device C6 is raised,
Withdraw the various solution suction needles F14-1. The pre-cleaning liquid container F1-2 is taken out from the various solution container holding / lifting device C6 by the work operation robot (E) and stored in a predetermined position of the container case F1 via the container holding position changing device D5.

(7) [Dissolving solution injection operation] (7-1): The dissolving solution container F is operated by the work operation robot (E).
1-4 is taken out of the container case F1, the holding position of the container is changed by the container holding position changing device D5, and the solution liquid container holding / lifting device C2 is set upside down. (7-2): Lower the solution container gripping elevating device C2,
A solution suction needle F8 is provided on the cap of the solution container F1-4.
Insert -1. (7-3): Sample container F1 by the work operation robot (E)
-1 is taken out of the container case F1, the container holding position is changed by the container holding position changing device D5, and set in the verification container holding / lifting device C3. (7-4): The sample container holding / lifting device C3 is raised, and the solution filling needle F8-2 is attached to the cap of the sample container F1-1.
Insert. (7-5): The solution supply pump F5 is rotated at a predetermined number of revolutions, and a predetermined amount of the solution is injected into the sample container F1-1.

(8) [Dissolution-Promoting Vibration Operation] (8-1): After the operation of dissolving solution injection is completed, the sample container gripping / lifting device C3 is lowered to move the sample container F1-1 to the dissolving solution filling needle F8-. 2, the sample container F1-1 is taken out of the sample container gripping / lifting device C3 by the work operation robot (E), and set on the dissolution promoting vibration device D1 installed on the work operation auxiliary table (D). Give time vibration.

(9) [Sample liquid injection operation] (9-1): After vibrating for a predetermined time, the dissolution promoting vibration device D1
, The sample container F1-1 is taken out by the work operation robot (E), and is inverted and set to the various solution container holding / lifting device C6 via the container holding position changing device D5. (In the case of a liquid injection sample, it is directly taken out of the container case and inverted and set in the various solution container holding / lifting device C6 via the container holding position changing device D5.) (9-2): Various solution container holding / lifting device C6 is lowered, and various solution suction needles F14-1 are inserted into the caps of the sample container F1-1. (9-3): The solution feeding pump F9 is rotated at a predetermined number of rotations, and the whole or predetermined amount of the sample container is placed in the culture tube (1) F.
Inject into 14-2 and culture tube (2) F14-3 and perform pressure filtration. (9-4): After completion of the operation of injecting / pressurizing and filtering the sample container, the various solution container holding / lifting device C6 is raised, and various solution suction needles F14-1 are withdrawn from the sample container F1-1. The sample container F1-1 is taken out of the various solution container holding / lifting device C6 by the work operation robot (E), and stored in a predetermined position of the container case F1 via the container holding position changing device D5. (9-5): If the number of samples is 20, for example, the above operations (7) to (9) are repeated 20 times.

(10) [Cleaning liquid injection operation] (10-1): After the operation of injecting the sample solution into the steritest unit is completed, the work operation robot (E) takes out the cleaning liquid container F1-3 from the container case F1. It is inverted to the various solution container gripping elevating device C6 via the container gripping position changing device D5. (10-2): The various solution container holding / lifting device C6 is lowered, and the various solution suction needles F14-1 are inserted into the caps of the cleaning solution containers F1-3. (10-3): Various solution container pumps F9 are rotated at a predetermined number of revolutions, and the entire amount or a predetermined amount of the washing solution is supplied to the culture tube (1) F1.
4-2 and the culture tube (2) are injected into F14-3 and filtered under pressure. (10-4): After completion of the above-described operations of injecting and pressure-filtering the cleaning liquid, raise and lower the various solution container gripping / lifting device C6, withdraw the various solution suction needles F14-1, and use the work operation robot (E) to clean the cleaning liquid. The container F1-3 is taken out from the various solution container holding / lifting device C6 and stored in a predetermined position of the container case F1 via the container holding position changing device D5. (10-5): When the number of cleaning liquid containers is two or more, the above operation is repeated as many times as necessary.

(11) [Preparation of Medium Injection] (11-1): After the operation of injecting the sample solution into the Steritest unit is completed, the culture tube bottom cap attaching / detaching device C11 is laterally moved to the culture tube (1). F14-2 and culture tube (2) The drainage tube (1) C11-8 and the drainage tube (2) C11-9 set at the lower part of the drainage port of F14-3 are moved to the side, and the culture tube bottom cap is moved. The detachable device C11 is moved to attach the culture tube bottom cap (1) F14-10 and the culture tube bottom cap (2) F14-11. (11-2): The culture tube upper cap (1) F14-8 and the culture tube upper cap (2) F14-9 are removed by the work operation robot (E), and the culture tube upper cap (1) the temporary storage place D7 and the culture tube The upper cap (2) is temporarily placed in the temporary storage place D8.

(12) [Media A Injection Operation] (12-1): The pinch valve opening and closing device (2) C9 is returned to the original position and the pinch valve (2) F12 is closed. (12-2): The medium A container F1-5 is taken out of the container case F1 by the work operation robot (E), and is inverted and set to the various solution container holding / lifting devices C6 via the container holding position changing device D5. (12-3): The various solution container holding / lifting device C6 is lowered, and the various solution suction needles F14-1 are inserted into the caps of the medium A container F1-5. (12-4): The various solution feed pumps F9 are rotated at a predetermined number of revolutions, and the whole or predetermined amount of the medium A is supplied to the culture tube (1) F.
Inject into 14-2. (12-5): After the above-described operation of injecting the culture medium A is completed, the various solution container holding / lifting device C6 is raised, and the various solution suction needles F
14-1 is taken out, the medium A container F1-5 is taken out from the various solution container holding / lifting device C6 by the work operation robot (E), and stored in a predetermined position of the container case F1 via the container holding position changing device D5.

(13) [Media B Injection Operation] (13-1): The pinch valve opening / closing device (1) C8 is returned to the original position, and the pinch valve (1) F11 is closed. (13-2): Return the pinch valve opening / closing device (2) C9 to the original position and open the pinch valve (2) F12. (13-3): The culture medium B container F1-6 is taken out of the container case F1 by the work operation robot (E), and is invertedly set to the various solution container holding / lifting device C6 via the container holding position changing device D5. (13-4): The various solution container holding / lifting device C6 is lowered, and the various solution suction needles F14-1 are inserted into the cap of the medium B container F1-6. (13-5): The solution feed pump F9 is rotated at a predetermined number of revolutions, and the whole or predetermined amount of the medium B is supplied to the culture tube (1) F.
Inject into 14-3. (13-6): After the operation of injecting the culture medium B is completed, the various solution container holding / lifting device C6 is raised, and the various solution suction needles F
14-1 is taken out, the medium B container F1-6 is taken out of the various solution container holding / lifting device C6 by the work operation robot (E), and stored in a predetermined position of the container case F1 via the container holding position changing device D5.

(14) [Work base (F) storing operation] (14-1): The pinch valve (2) F12 is closed by returning the pinch valve opening / closing device (2) C9 to the original position. (14-2): The upper cap (1) F14-8 for the culture tube exhaust port temporarily placed in the upper cap (1) temporary storage place D7 by the work operation robot (E) is replaced with the culture tube (1) F14-.
Attach to the 2 exhaust port. (14-3): An upper cap (2) F14-9 for the culture tube drain port temporarily placed in the upper cap (2) temporary storage place D8 by the work operation robot (E) is replaced with a culture tube (2) F14-.
Attach to the 2 exhaust port. (14-4): The various solution suction needle caps F14-7 temporarily installed in the various solution suction needle cap temporary storage areas D6 by the work operation robot (E) are taken out, and the various solution suction needles F
14-1. (14-5): The various solution feed pump rotating device C10 is lowered, and separated from the various solution feed pumps F9. (14-6): Lower the solution feed pump rotating device C4 to disconnect it from the solution feed pump F5. (14-7): Robot room (R) in stocker room (S)
The automatic door G5 on the side is opened. (14-8): Return the work base positioning device (1) C5 and the work base positioning device (2) C12 to the original position,
The work base (F) is released from being fixed to the work operation table, and the work base (F) is stored in the work stocker (B) by operating the work base take-out storage device C1. (14-9): Automatic door G after storage of work base (F) is completed
Close 5.

(15) [Work base take-out preparation operation] (15-1): The work stocker is circulated by one pitch. Hereinafter, when the target specimen is a powder injection vial and the number of samples is, for example, ten, the operation (3) [work base removal operation] to the operation (15) [work base removal preparation operation] are repeated a total of ten times.

Operation Example (Target Sample Container F1-1)
Is a powder injection vial) is shown in FIG.
Note that the reference numerals in front of each frame in the figure correspond to the reference numerals assigned to the respective operations in the above description of the operations. The same applies to the following flowchart.

<< II: When the target sample container F1-1 is a liquid injection vial >> The operations (1) to (6) are the same as the case of the powder injection vial, and the operations (7) and (8) Is usually unnecessary and jumps from (9) to (1)
Perform the operation of 5).

Operation Example (Target Sample Container F1-1)
Is a powder injection vial) is shown in FIG.

<< III: When the target sample container F1-1 is a liquid-injected ampoule >> As described above, the ampoule filling auxiliary container F15 is prepared, and the ampoule filling auxiliary container F15 is prepared in advance of the operation (1). Setup operation] at the time of container case F1
In an empty space. The operations (1) to (6) are the same as those for the powder injection vial, and the operations (7) and (8) are usually unnecessary. Instead of the operation (9), the following operations (16) and (8) Perform 17) and continue to operation (10).

(16) [Sample liquid injection preparation operation] (16-1): The work operation robot (E) removes the ampoule filling auxiliary container upper cap F15-3 of the ampoule filling auxiliary container F15 set in the container case F1. Remove and temporarily place the ampoule filling auxiliary container in the upper cap temporary storage area D9. (If there is room in the collection box F1-7, the collection box F
(16-2): Take out the ampoule filling auxiliary container main body F15-1 (ampoule filling auxiliary container lower cap F15-2) from the container case F1 with the work operation robot (E),
It is set in the various solution container gripping elevating device C6. (16-3): The various solution container holding / lifting device C6 is lowered, and the various solution suction needles F14-1 are attached to the ampule filling auxiliary container lower cap F15-2 of the ampoule filling auxiliary container F15.
Insert. (16-4): The collection box F1-7 is taken out of the container case F1 by the work operation robot (E) and set in a predetermined place of the ampule opening device D3.

(17) [Sample Liquid Injection Operation] (17-1): The sample container F1-1 is taken out of the container case F1 by the work operation robot (E), and the holding position is changed via the container holding position changing device D5. Then, the neck portion is cut and removed using the ampoule opening device D3. (The cut part of the sample container F1-1 falls naturally and the collection box F1-
7. (17-2): The sample container F1-1 whose neck has been cut is inverted and set in the ampoule filling auxiliary container F15 set in the various solution container holding / lifting device C6. ｛At this time, the sample container F1-1 whose neck has been cut is still held by the work operation robot (E). ｝ (17-3): Rotate various solution feeding pumps F9 at a predetermined number of revolutions, and transfer the whole or predetermined amount of the sample solution to the culture tube (1) F
Inject into 14-2 and culture tube (2) F14-3 and perform pressure filtration. (17-4): After the operation of injecting and filtering under pressure of the sample solution is completed, the sample container F1-1 is filled with the ampoule filling auxiliary container F1.
5 and put into the collection box F1-7. (17-5): When the number of samples is 20, for example, the above operations (17-1) to (17-4) are repeated a total of 20 times. (17-6): After completion of the operation of injecting and filtering under a predetermined number of sample solutions, the various solution container holding / lifting device C6 is raised, the ampoule filling auxiliary container F15 is taken out, and placed in a predetermined position of the container case F1. Store.

Sample solution injection operation of liquid injection ampule (17)
Is completed, the operations (10) to (15) for the powder injection vial are performed.

If the target sample is a liquid injection ampoule and the number of samples is equal to 10, the above (3) [work base removal operation] to (15) [work base removal preparation operation] are repeated 10 times. .

The above operation example (target sample container F1-1)
FIG. 42 shows the flow of the case where is a liquid injection ampule.

<< IV: When the target sample container FF1-1 is a powder ampule >> The operations (1) to (6) are the same as those for the powder injection vial, and then the operation (1)
6), and the following operations (18) and (19) are performed.

(18) [Solution Injection Operation] (18-1): The work operation robot (E) takes out the solution container F1-4 from the container case F1 and changes the gripping via the container gripping position changing device D5. Then, it is set upside down in the dissolution liquid container gripping elevating device C2. (18-2): The solution container holding / lifting device C2 is lowered, and the solution suction needle F8 is attached to the cap of the solution container F1-4.
Insert -1. (18-3): Sample container F by the work operation robot (E)
1-1 is taken out of the container case F1, and is gripped and changed via the container gripping position changing device D5, and the ampule opening device D3 is opened.
The neck is cut and removed by using. (18-4): The sample container F1-1 whose neck has been cut is set in the sample container holding / lifting device C3. (18-5): The sample container holding / lifting device C3 is raised, and the solution filling needle F8-2 is inserted into the open portion of the sample container F1-1. (18-6): The solution supply pump F5 is rotated a predetermined number of times, and a predetermined amount of the solution is injected into the sample container F1-1.

(19) [Dissolution-Promoting Vibration Operation] (19-1): After the operation of dissolving solution injection is completed, the sample container holding / lifting device C3 is lowered to release the holding of the sample container F1-1, and the sample container F1-1 is released. The container F1-1 is taken out of the sample container gripping elevating device C3 by the work operation robot (E), set on the dissolution promoting vibration device D1 installed on the work operation auxiliary table (D), and vibrated for a predetermined time.

(20) [Sample Solution Injection Operation] (20-1): After vibrating for a predetermined time, the dissolution promoting vibration device D1
, The sample container F1-1 is taken out by the work operation robot (E), and is inverted and set in the ampoule filling auxiliary container F15 set in the various solution container holding / lifting device C6.お く Keep it held by the work operation robot (E). ｝ (20-2): Rotate various solution feeding pumps F9 at a predetermined number of rotations, and transfer the entire amount or a predetermined amount of the sample solution to the culture tube (1) F
Inject into 14-2 and culture tube (2) F14-3 and perform pressure filtration. (20-3): After the operation of injecting and filtering under pressure of the sample solution is completed, the sample container F1-1 is replaced with the ampoule filling auxiliary container F1.
5 and put into a collection box F1-7. (20-4): When the number of samples is, for example, 20, the above steps (18-3) to (20-3) are repeated a total of 20 times. (20-5): After completion of the operation of injecting and filtering the predetermined number of sample solutions and pressurizing and filtering, the various solution container holding / lifting device C6 is raised, the ampoule filling auxiliary container F15 is removed, and the container is placed at a predetermined position in the container case F1. Store.

After the above operation is completed, operations (10) to (15) are performed as in the case of the powder injection vial. Hereinafter, when the target specimen is a powder injection vial and the number of samples is, for example, 10, the operation (3) [work base removal operation] to the operation (15) [work base removal preparation operation] are repeated a total of 10 times.

The above operation example (target sample container F1-1)
Is a powder injection ampule) is shown in FIG.

<< V: When the target sample container F1-1 is an irregular-shaped container and the suction port is large >> The irregular-shaped container fixing container F16 is used as described above. As the operation procedure, the sample container F1-1 targeted in (II) is a liquid injection vial (FIG. 4).
Since it is almost the same as 1), the description is omitted. ｛Sample container F1-1
If is an infusion bag, the operations (6) and (10) may be omitted. ｝

<< VI: The target sample container F1-1 is an irregular-shaped container and the suction port is small >> The irregular-shaped container filling tube unit F17 is previously set in the dissolving solution filling pump unit F2, and the dissolving solution container Instead of F1-4, an irregular-shaped container fixing container F16 containing a sample container F1-1 is set in the solution container holding / lifting device C2, and an empty vial container is set in the sample container holding / lifting device C3. The same operation as the solution injection operation of 7) is performed, and the solution of the sample container F1-1 is once filled into the vial container. Thereafter, the container is set in the various solution container gripping elevating device C6, and the operation (9) and subsequent steps are performed.も Also in this case, the operation (6) and the operation (10) may be omitted. ｝

The above operation example (target sample container F1-1)
FIG. 44 shows a flow in the case where is an irregular-shaped container and the suction port is small.

<< VII: When the sample container F1-1 is a powder injection vial and the liquid volume is small >> Each operation is performed according to the flow shown in FIG. 40, but once the operation (7) and the operation are performed using the sample container F1-1. (8) After performing the operation (9), the operation (8) is omitted, the operation (7) and the operation (9) are repeated as many times as necessary, and thereafter, the operation (10) and the subsequent steps are performed. By this operation, most of the solution in the sample container F1-1 can be sent to the culture tube.

<< VIII: When the sample container F1-1 has a small amount of liquid in the liquid injection vial >> Each operation is performed according to the flow shown in FIG. 41. After the operation (9) is once performed using the sample container, the washing liquid The container F1-3 is a solution container holding / lifting device C
2, the sample container F1-1 is set in the sample container gripping elevating device C3, and the same washing liquid injection operation as the operation (7) is performed, and the operation (9) is performed again. After repeating the washing liquid operation and the operation (9) as many times as necessary, the operation (10) and the subsequent steps are performed. By this operation, most of the solution in the sample container F1-1 can be sent to the culture tube as in (VII).

<IX: When the Sample Container F1-1 is a Liquid Injection Ampule and the Liquid Volume is Small> Each operation is performed according to the flow shown in FIG. 42.
After performing 7), the washing liquid container F1-3 is set in the dissolving solution container gripping elevating device C2, and the sample container F1-1 is set in the various solution container gripping elevating devices C6, and the dissolving solution in the operation (7) is injected. A cleaning liquid injection operation similar to the operation is performed, and the operation (17) is performed again. After repeating the operation (21) and the operation (17) a required number of times, the operation (10) and the subsequent steps are performed. By this operation, most of the solution in the sample container F1-1 can be sent to the culture tube as in (VII).

<X: When the sample container is a powder injection ampoule and the liquid volume is small> Each operation is performed according to the flow shown in FIG. 43, but once using the sample container F1-1, the operations (18), (19), After performing the operation (20), the operation (19) is omitted, and the operation (18) and the operation (20) are repeated a required number of times, and thereafter, the operation (10) and the subsequent steps are performed. By this operation, most of the solution in the sample container F1-1 can be sent to the culture tube as in (VII).

<< XI: Another method when the amount of liquid is small >> (V
When the liquid volume is small as in II) to (X), the sample container F1-1 is set as it is in the case of a vial in the solution container holding / lifting device C2, and in the case of an ampoule, the ampoule filling auxiliary container. F15 is set, and a large-capacity empty vial is set in the sample container holding / lifting device C3.
Once the entire amount is transferred to the vial, a lysis solution or a washing solution is injected into the vial container, and the total amount of the specimen is increased.
Operations (15) to (15) may be performed.

<< XII: In the case of suction method >> The operation of filling various solutions into the funnel unit F18 (not shown) is as follows.
Since this is performed using the solution filling pump unit F2,
The place where the funnel unit F18 is set is the sample container holding / lifting device C3, and the various solution filling pump units F3 are not used. The operation procedure is almost the same for both vials and ampules as in the cases (I) to (X) just by changing the operation position.

<< XIII: Direct Method >> In the direct method, since no filter is used, the operation of filling various solutions is a dispensing operation. When the dispensed amount and the dispensed amount are large, the solution filling pump unit F2 is used. The flow in this case is shown in FIG. In the case of this figure, the case where each container is one is illustrated, but if the number of containers increases,
Repeat the necessary operations for that number. The opening and closing operations are performed using the container gripping position changing device D5, but are omitted in the flow. When the dispensed amount and the dispensed amount are small, a dispensing operation is performed using a syringe instead of the solution filling pump unit F2. When performing this operation, one additional set of a container gripping assist device (not shown) having the same specifications as the container gripping position changing device D5 is required as a work operation assisting device.

Next, an operation example in the case where the container to be dispensed is a test tube will be described. As shown in FIG. 46, a test tube stand (1) F19-1 and a test tube stand (2) F19-2 storing a container case F1 and a test tube (not shown) are arranged on a work pallet F4. The sample solution in the case F1 is taken out by the robot hand E1, and a predetermined amount of the sample solution is injected into the test tube. The test tubes are adjacent and the test tube stand (1) F19-1 and the test stand (2) F19
If the test tube cannot be taken out with the robot hand E1 while the test tube is set at -2, the test tube stand F19 storing the test tube is taken out from the work pallet F4 to the work auxiliary table (D) by the robot hand E1. FIG.
7 is set to the state of F19-A. At this time, the test tube (1) is set so that a test tube push-up device D22 (not shown) provided on the work auxiliary table (D) is located directly below the test tube (1). The test tube push-up device D22 is operated to push up the test tube (1) so as to protrude from the surrounding test tubes. Even if the test tubes are adjacent to each other, the surrounding test tubes do not become an obstacle, and are aimed at. The test tube (1) can be easily taken out by the robot hand E1. When the necessary operation of the test tube (1) is completed, the test tube stand F19 is moved to the left by one pitch with the robot hand E1, so that the test tube (2) comes directly above the test tube push-up device D22. To
F19-A is sequentially moved from the state of FIG.
The state of 19-B, the state in which the test tube (9) is directly above the test tube push-up device D22 is the state of F19-C, and the test tube (16) is right above the test tube push-up device D22. Is the state of F19-D, and the state in which the test tube (17) is directly above the test tube push-up device D22 is F19-D.
In the state of E, the test tube (24) is the test tube push-up device D2.
The state just above 2 is the state of F19-F. F
When the operation of the test tube (24) is completed in the state of 19-F, the test tube stand F19 is returned to the original position (work pallet F4
To store).

Next, several examples of operations for preparing a sample for a microorganism limit test will be described. << XIV: In the case of preparing a sample by a membrane filter sticking method >> In substantially the same manner as in the direct method (XIII), the culture bacterial solution is dispensed and diluted into a container containing a diluent, and the funnel unit F18 described above is used. After performing a filtration operation by a suction filtration method, and after a filtration operation as necessary after filtration, the funnel unit F18 is moved to a station (not shown) for removing a lottery part, and the lottery part is removed (disassembled). The container case F1 previously stores a filter suction jig unit F20 for taking out a sample filter attached to the funnel unit F18 as one of the necessary base materials and attaching the sample filter to the surface of the agar medium. FIG. 48 shows the filter suction jig unit F20. The filter suction jig unit F20 has a suction jig body F20-1 having a circumferential suction disk F20-6.
And an exhaust port cap F20-2, an exhaust port F20-3,
It is constituted by a suction port storage case F20-4. The sample filter is removed by using the suction jig body F20-1, and the sample filter is attached to the surface of the agar medium of the agar medium container whose lid has been removed in advance by using the robot hand E1, and the agar medium container is covered. Storing each used device in a predetermined location of the container case F1 is the same as in the automatic sterility test device.

FIG. 49 shows an arrangement example of a container case by a membrane filter attaching method, in which the sample is a beer bottle. Here, (1) to (4) correspond to the sample container F1-
1 (beer bottle), (5) to (8) are funnel units F18, (9) to (12) are medium containers (agar medium), (13) is a crown opening jig, and (14) is a filter suction jig. Unit F20, (15) is a collection box, (16)
Indicates a spare space.

<XV: In the case of preparing a sample by the agar plate pour method> The culture solution is dispensed and diluted into a container containing a diluent by the same operation as in the direct method (XIII), and the solution is transferred via a syringe. Put in a fixed amount Petri dish, put agar medium, cover, set on dissolution promoting vibrator D1, mix the medium and diluted culture solution, and when predetermined operation is completed, put the Petri dish in container case F1 At a predetermined location.

<< XVI: Other Samples for Microbial Limit Test >> Manipulation methods such as agar plate surface smearing method, specific microbial test, or potency preservation test are also used directly (XII
I), which is almost the same as the membrane filter attaching method (XIV) or the agar plate pour method (XIV), or a combination of the partial operations of the operations described so far, so that the description is omitted.

<XVII: In the case of preparing a sample for an insoluble fine particle measurement test> FIG. 50 shows an example of an apparatus for an insoluble fine particle measurement test, and FIG. 51 and FIG.
2 and FIG. 53, and FIG. 54 shows an example flow of the operation example. The operation number of this apparatus is attached to the right side outside the frame. It is. As in (XIII) above, opening and closing operations are omitted. 51, 52, and 53, (1) to (5)
Represents a sample container F1-1, (6) to (10) represent empty containers, and (1)
1) to (15) are funnel units F18, (16)
FIG. 51 shows an example of an arrangement for performing a blank test. FIG. 52 shows a sample container F1-1 having a large capacity, and FIG. 52 shows a sample container F1-.
1 is an example of the arrangement in the case where the capacity of the first element is small. The case of FIG. 53 is an example of a case where the operation is once performed by transferring to a container having a large capacity. In FIG. 50, D12 is a solution injection / filtration facility, D13 is a container washing / drying facility, D14 is a solution injection counter facility, D15 is a shaking machine, D16 is a sample filter drying facility, and D17 is a solution injection counter. The body is D
18 is a suction device for drying, D19 is a solution injection device,
D20f denotes a washing water pressurizing device, and D21 denotes a suction device for filtration.

<< XVIII: When used as a dispensing test device for chemical analysis and the like and a chemical reaction test device >> Operation example << I >> to << XVII >> itself is a dispensing operation, and the chemical reaction test operation is also a dispensing operation. Therefore, the description is omitted because it does not require new explanation.

<XVI: When Sample Container F1-1 Changes from Lot to Lot> A set of equipment necessary for the sample preparation is set at a predetermined location on one work base, and a program required for the operation is called. They can be set and the operation can be switched on a sample basis according to the order. Therefore, even if the types of the specimen and the container and the test order are changed for each sample, it can be handled without any problem.

As is clear from the above description, the automatic test apparatus according to the present invention is not limited to the use of vials and ampoules in plastic containers, plastic bottles, ophthalmic solution bottles, blood bag syringes, test tubes, and the like. , Fresh, paper packs, spray cans, regular bottles / cans, and other various shapes.Sterility tests by membrane filter pressurization, suction, direct methods, etc. Not only can it be operated automatically without occurrence, but also in membrane filter sticking method, agar plate pour method, agar plate smearing method, other microbial limit test, etc. It is equally applicable to chemical reaction tests.

[0119]

As is apparent from the above description, according to the automatic sterility test operating device such as a vial according to the present invention,
Except for the preparatory work, after setting in the device, the sterility test can be performed automatically without manual intervention until the medium is added to the culture tube and even if the sample type changes. In addition, by installing an automation device consisting of this work base and a robot in a clean booth, highly reliable automatic operation capable of highly eliminating human recontamination can be performed. These problems have been solved as follows. B) If necessary, the device itself has a clean booth function, and since the device itself can have a cleaning / sterilizing function, there is no need to worry about recontamination by humans. Is provided. B) Since the system for replacing the needle for injecting the solution for each sample is replaced, there is no need to worry about contamination of other samples by the solution injection needle. C) Even if the sample type, quantity, or work procedure changes for each sample, it can be flexibly dealt with only by setting the program. Manual work (preparation work) can also be performed by replacing the container case, solution filling tube unit, and steritest unit. Only,
In addition, the work can be easily performed at the same place, and the manual setup work has been significantly simplified. D) Since the container case for the specimen and the like, the solution filling pump unit and the various solution filling pump units are mounted on the same base, and the stocking device is made three-dimensional, the stock space is not required even if the number of samples increases. It has become possible to provide a device having an extremely small occupation area. E) Even in the case where it takes time to dissolve, after applying to the vibrating device, it can be temporarily removed from the line and other operations can be performed in parallel, so that the processing capacity per unit time is greatly improved. F) Even when the same operation is repeated between other operations, it can be dealt with only by changing the program without adding equipment. G) It can be used for almost all sample containers simply by replacing the necessary equipment in the container case, and it can be used not only as an automatic sterility test operation device but also for other uses. That is, 1. With a self-sterilizing function, no human involvement in the operation at all, eliminating the possibility of human error and contamination of the work environment.In addition, since the necessary equipment is replaced for each lot, there is no problem of contamination between lots. It can be expected that the test accuracy will be greatly improved. 2. This equipment can be installed outside the clean room and does not require an expensive clean room. Therefore, there is no work in the clean room, and the worker is free from work under a special work environment. 3. All operations other than setup (removal of work) are automated, so significant labor savings can be expected, of course, and there is no need for workers to work in a clean room, greatly reducing the burden of training, training and management of workers. It is reduced. 4. Since a multi-joint robot is used, one device can handle almost all pharmaceutical containers (vials, ampules, ophthalmic solutions, infusions, etc.) and containers other than pharmaceuticals. Can respond flexibly. 5. Since the stocking device is three-dimensional and the stocking location for the work before operation and the stocking location for the work after the operation are the same, the processing capacity is 10 lots and the processing equipment is 1/4 to 1/5 of the conventional equipment. Space. 6. When it is desired to increase the processing amount per unit of the present apparatus, as shown in FIGS. 38 and 39, the work attachment / detachment table (A), the work stocker unit (B) and the work operation table (C) are replaced with a work operation auxiliary table. (D) and the right side of the work operation robot (E) can easily double the capacity. And so on.

[Brief description of the drawings]

FIG. 1 is an overall plan view of an example of the apparatus of the present invention.

FIG. 2 is a view taken along the line MM in FIG. 1 (1).

FIG. 3 is a configuration diagram of a work base according to the present invention.

FIG. 4 is a layout view of various containers in the present invention.

FIG. 5 is a plan view of a solution filling pump unit according to the present invention.

FIG. 6 is a configuration diagram of a solution-filled tube unit according to the present invention.

FIG. 7 is a view taken along the line MM in FIG. 5;

FIG. 8 is a plan view of various solution filling pump units according to the present invention.

FIG. 9 is a configuration diagram of a steritest unit.

FIG. 10 is a view taken along the line MM in FIG. 8;

FIG. 11 is a side view of a pinch valve.

FIG. 12 is a plan view of a work operation table according to the present invention.

FIG. 13 is a view taken along the line MM in FIG. 11;

FIG. 14 is a view taken in the direction of arrows NN in FIG. 5;

FIG. 15 is a sectional view taken along line NN of FIG. 11;

FIG. 16 is a view taken along the line NN of FIG. 8;

FIG. 17 is a view taken in the direction of arrows PP in FIG. 8;

FIG. 18 is a plan view of a container holding device according to the present invention.

19 is a view taken in the direction of arrows MM in FIG. 40.

FIG. 20 is a plan view of an ampule opening device.

FIG. 21 is a view taken along the line MM in FIG. 42;

FIG. 22 is a front view of an ampule-cut beard collecting device according to the present invention.

FIG. 23 is an explanatory diagram of a method of correcting an ampule gripping position according to the present invention.

FIG. 24 is an explanatory view of a method for confirming a container shape according to the present invention.

FIG. 25 is a configuration diagram of an ampoule filling auxiliary container according to the present invention.

FIG. 26 is a configuration diagram of an infusion bag fixed container according to the present invention.

FIG. 27 is a configuration diagram of an irregular-shaped container filling tube unit.

FIG. 28 is a front view of a work stocker according to the present invention.

FIG. 29 is a front view of the circulating frame elevating device according to the present invention.

FIG. 30 is a view taken along the line MM in FIG. 29;

FIG. 31 is a front view of an ascending portion circulation frame supporting device according to the present invention.

FIG. 32 is a front view of a descending portion circulating frame support device according to the present invention.

FIG. 33 is a side view of the upper circulation frame lateral moving device according to the present invention.

FIG. 34 is a side view of the lower circulation frame lateral moving device according to the present invention.

FIG. 35 is a front view of a stocker room according to the present invention.

FIG. 36 is a front view of a robot room according to the present invention.

FIG. 37 is an external view of the entire device of the present invention.

FIG. 38 is a plan view of an enlarged example of the system.

FIG. 39 is a view taken along the line AA in FIG. 38;

FIG. 40: Operation example flow for a powder injection vial

FIG. 41: Operation example flow in the case of a liquid injection vial

FIG. 42: Operation example flow for a liquid injection ampule

FIG. 43: Operation example flow for powder injection ampule

FIG. 44 is a flowchart of an operation example in the case of a small-diameter irregular type.

FIG. 45 is an operation example flow in the case of the direct method

FIG. 46: Example of container case arrangement when the target container is a test tube and fresh by the direct method

FIG. 47: Test tube moving method in the present invention

FIG. 48 shows a filter suction jig unit according to the present invention.

FIG. 49: Example of container case arrangement for membrane filter attachment method

FIG. 50 is a plan view of an example of an apparatus for testing insoluble fine particles according to the present invention.

FIG. 51 shows an example of container case arrangement of an insoluble particle testing apparatus (1).

FIG. 52 shows a container case arrangement example (2) of the insoluble particle testing apparatus.

FIG. 53 shows an example of container case arrangement of an insoluble particle testing apparatus (3).

FIG. 54: Operation example flow of insoluble particle test

[Explanation of symbols]

(A) Work attachment / detachment table (B) Work stocker B1 Frame body B2 Circulating frame B2-1-10 Circulating frame B3 Circulating frame guide B4 Circulating frame elevating device B4-1 Elevating device base B4-2 Elevating shaft B4-3 For elevating shaft Bearing B4-4 Elevating arm B4-5 Elevating cylinder B4-6 Elevating shaft synchronizing device B5 Elevating portion circulating frame support device B5-1 Ascent portion circulating frame supporting device mounting base B5-2 Rotating shaft B5-3 Claw B5-4 Spring B6 Descending portion circulation frame support device B6-1 Descending portion circulation frame support device mounting base B6-2 Rotary shaft B6-3 Claw B6-4 Spring B6-5 Claw releasing cylinder B7 Upper circulation frame lateral moving device B7-1 Upper circulation Frame horizontal movement cylinder B7-2 Push plate support B7-3 Push plate B8 Lower circulation frame horizontal movement device B8-1 Lower circulation frame horizontal movement Cylinder B8-2 Support for push plate B8-3 Push plate (C) Work operation table C1 Work base removal and storage device C1-1 Mount C1-2 Horizontal movement cylinder C1-3 Support frame C1-4 Lifting cylinder C1-5 Pin C2 Dissolution liquid container gripping elevating device C2-1 Elevating cylinder C2-2 Dissolution liquid container supporting base C2-3 Horizontal moving cylinder C2-4 Grip claw C3 Sample container gripping elevating device C3-1 Elevating cylinder C3-2 Sample Container support base C3-3 Horizontal movement cylinder C3-4 Gripping claw C4 Dissolving solution feed pump rotation device C4-1 Elevating cylinder C4-2 Rotation device support base C4-3 Rotation device C4-4 Coupling C5 Work base positioning device (1) C5-1 Elevating cylinder C5-2 Cylinder fixed base C5-3 Work base Insertion pin C6 Various solution container gripping elevating device C6-1 Elevating cylinder C6-2 Various container support base C6-3 Horizontal moving cylinder C6-4 Gripping claw C7 Various solution suction needle cap removal assist device C7-1 Support C7- 2 Cylinder for horizontal movement C7-3 Claw C8 Pinch valve opening / closing device (1) C8-1 Support C8-2 Elevating cylinder C8-3 Valve push rod C9 Pinch valve opening / closing device (2) C9-1 Support C9-2 Elevating Cylinder C9-3 Valve push rod C10 Various solution feeding pump rotating device C10-1 Lifting cylinder C10-2 Rotating device support base C10-3 Rotating device C10-4 Coupling C11 Culture tube bottom cap attaching / detaching device C11-1 Support C11 -2 Horizontal movement cylinder base C11-3 Horizontal movement cylinder C11-4 Cylinder for lifting and lowering C11-5 Base for cap attaching / detaching device C11-6 Culture tube bottom cap attaching / detaching device (1) C11-7 Culture tube bottom cap attaching / detaching device (2) C11-8 Drainage pipe (1) C11-9 Drainage Pipe (2) C12 Work base positioning device (2) C13 Dissolution side operation table C14 Various solution side operation tables C15 Suction joint (not shown) (D) Work operation auxiliary table D1 Dissolution accelerating vibration device D2 Container holding device D2- DESCRIPTION OF SYMBOLS 1 Container support shaft D2-2 Swing arm D2-3 Container receiver D2-4 Container receiver storage cylinder D3 Ampoule opening device D3-1 Ampule cutting position and scratching device D3-1-1 Frame D3-1-2 For rotating blade rotation Motor D3-1-3 Revolving arm D3-1-4 Pulley (1) D3-1-5 Belt D3- -6 Pulley (2) D3-1-7 Rotating blade D3-1-8 Spring D3-2 A mustache part cutting auxiliary jig D3-3 Gripping position setting bar D3-4 Cutting mustache guiding chute D3-5 Collection box receiver D4 Preliminary washing liquid container temporary storage area D5 Container gripping position changing device D5-1 Container gripping position changing device hand D6 Various solution suction needle cap temporary storage area D7 Culture tube upper cap (1) Temporary storage area D8 Culture tube upper cap (2) Temporary storage area D9 Temporary storage area for upper cap of ampoule filling auxiliary container D10 Container shape confirmation sensor D11 Temporary storage area for solution container D12 Solution injection / filtration equipment D13 Container washing / drying equipment D14 Liquid injection counter equipment D15 Shaker D16 Sample filter drying equipment D17 Liquid injection counter Main unit D18 Drying suction device D19 Solvent injection device D20 Wash water pressurizing device D2 Filtration suction device D22 Test tube push-up device (E) Work operation robot E1 Robot hand E2 Robot room frame (F) Work base F1 Container case F1-1 Sample container F1-2 Pre-cleaning container F1-3 Washing liquid container F1-4 Dissolution Liquid container F1-5 Medium A container F1-6 Medium B container F1-7 Collection box F1-8 Empty space F1-9 Empty container F2 Solution filling pump unit F3 Various solution filling pump units F4 Work pallet F5 Solution sending pump F6 Dissolvent suction needle fixing stand F7 Dissolvent fill needle fixing stand F8 Dissolvent fill tube unit F8-1 Dissolvent suction needle F8-2 Dissolvent fill needle F8-3 Connection tube F8-4 Filter (1) F8-5 tube (1) F8-6 filter (2) F8-7 tube (2) F8-8 cap 1) F8-9 Cap (2) F9 Various solution feeding pumps F10 Various solution suction needle fixing base F11 Pinch valve (1) F12 Pinch valve (2) F13 Culture tube fixing base F14 Steritest unit F14-1 Various solution suction needles F14-2 Culture tube (1) F14-3 Culture tube (2) F14-4 Connection tube (1) F14-5 Connection tube (2) F14-6 Filter F14-7 Suction needle cap F14-8 Upper cap (1) F14-9 Upper cap (2) F14-10 Bottom cap (1) F14-11 Bottom cap (2) F14-12 Upper exhaust port (1) F14-13 Upper exhaust port (2) F15 Ampoule filling auxiliary container F15-1 Main body F15-2 Lower cap F15-3 Upper cap F16 Irregular container fixed container F16-1 Irregular container fixed Container body part F16-2 Irregular container fixed container cap fixing unit F16-3 Irregular container fixed container robot handle hanging part F17 Irregular container filling tube unit F17-1 Irregular container suction needle F18 Funnel unit F19 Test tube stand F20 Filter suction jig unit F20-1 Suction jig body F20-2 Exhaust port cap F20-3 Exhaust port F20-4 Suction port storage case F20-5 Suction port fixed base F20-6 Suction port (G) Environmental equipment G1 Covers (1) G2 filter unit (1) G3 exhaust port G4 door G5 automatic door G6-1 spray nozzle G7 covers (2) G8 filter unit (2) G9 exhaust port G10 maintenance door G12 damper device (R) Robot room ( S) Stocker room

Claims (18)

[Claims] 1. An apparatus in which a robot is used as a handling means for an operation required for a microbial test or the like, wherein a set of equipment that needs to be replaced for each sample is placed on the same work base and supplied to the operation range of the robot. An automatic test apparatus such as a microbial test, wherein the work range can be changed to the operation range every time the sample is changed. 2. The apparatus according to claim 1, wherein the robot operation unit includes a work operation table on which the work base, on which a set of equipment is mounted, is placed on a work pallet and supplied to the operation unit. The work operation table has a lifting means for raising and lowering a pin, and the raised pin is fitted into a hole of the mounted work pallet to fix a position of the mounted work pallet. An automatic testing device for a microorganism test or the like, comprising a positioning means. 3. The apparatus according to claim 1, further comprising a container gripping elevating device provided at a predetermined position of the robot operation unit, wherein the various containers gripped by the gripping elevating device are fixed on a work pallet of each work base. An automatic testing device for a microbial test or the like, wherein the automatic testing device is configured to be guided to or retracted from a suction needle and a filling needle. 4. The apparatus according to claim 1, wherein the robot operation unit includes a work unit mounted on the work operation table, and a pump unit mounted on the pallet, which is provided with a lifting function at each lower position thereof. An automatic test apparatus such as a microbial test, comprising: a driving unit having: a pump unit connected to a shaft of the driving unit by raising the driving unit to drive a pump of the pump unit. 5. The apparatus according to claim 1, wherein the robot operation unit is provided with a sharable device and a temporary storage space that do not need to be replaced for each sample at a position different from the work operation table. Automatic test equipment for microbial tests and the like characterized by the following. 6. The apparatus according to claim 1, wherein the robot operation section has a compartment that encloses and seals a handling operation range of the robot, and includes a sealable entrance / exit section for entrance / exit of each work base. An automatic test apparatus for testing microorganisms or the like, wherein a filter unit is provided in the upper part of the compartment, and an exhaust port is provided in the lower part or the side part, so that the robot is operated in a room having a clean booth function. . 7. A work base stock device is provided at a stage preceding the robot operation unit compartment according to claim 6, and each work base is supplied from the stock device to the robot operation unit compartment. Automatic test equipment for microbial tests and the like characterized by the following. 8. The apparatus according to claim 7, wherein the work-based stocking device has a compartment that encloses and seals the stocking device, and includes a sealable inlet / outlet for entering and exiting each work base. An automatic testing apparatus for testing microorganisms or the like, characterized in that an exhaust port is provided at a lower or side portion and a stock device is operated in a room equipped with a clean booth function. 9. A section between the robot operation section compartment described in claim 6 and the stock apparatus compartment described in claim 8 is provided.
An automatic testing device for a microorganism test or the like, wherein a work base is configured to be able to reciprocate in both compartments. 10. The automatic testing apparatus for microbial tests and the like according to claim 8, further comprising a disinfecting means for spraying a disinfecting solution into the robot operating section compartment and the stock apparatus compartment. 11. An ampule opening device, which is one of the devices according to claim 5, wherein the ampule is gripped by a robot hand and is applied to a rotating tooth for ampule cutting, thereby damaging the ampule and forming a U-shape. An automatic testing apparatus for testing microorganisms or the like, characterized in that an ampoule mustache portion is inserted into a groove or a hollow cylinder of (1) and the ampule is opened. 12. The ampule opening device according to claim 11, wherein the relative position between the ampule and the robot hand is set by applying the bottom of the ampule to a gripping position setting bar while holding the ampule with the robot hand. Automatic testing equipment such as microbial test. 13. A container holding device as one of the devices according to claim 5, wherein a container receiver for temporarily depositing when a container held by the robot is changed is stored outside the operation range of the robot. An automatic testing device for a microorganism test or the like, characterized in that it is configured as described above. 14. The apparatus according to claim 5, wherein a sensor for confirming an outer diameter and a length of the sample container is provided on the work auxiliary table, and the container held by the robot hand is a predetermined container. An automatic testing device for testing microorganisms and the like, characterized in that the device is configured to check whether the test is performed. 15. An automatic testing apparatus for a microorganism test or the like, wherein an automatic testing apparatus for a microbial test or the like is configured such that, when the container to be handled is an irregular type, the container is placed in an irregular-shaped container fixed container. 16. In an automatic testing apparatus such as a microbial test, when the shape of a container to be handled is different, a corresponding adapter having an outer shape of the container fitted to a plurality of set holes in the container case at a predetermined position of the container case is also used. An automatic test apparatus for testing microorganisms and the like, characterized in that the apparatus is configured to perform the test. 17. The apparatus according to claim 1, wherein, when the sample containers are adjacent to each other, the container case is taken out to a predetermined position on the work auxiliary table, and the container case is lifted by a container push-up device provided below the work auxiliary table. An automatic testing device for a microorganism test or the like, characterized in that it is configured to lift only a container. 18. The apparatus according to claim 1, wherein the sample filter is detached from the filter holder by using a suction jig provided with a suction port on the circumference, and is attached to the agar medium. Automatic testing equipment for microbial tests.