JPH10128079A - Method for assembling plate and frame membrane separator - Google Patents

Abstract

PROBLEM TO BE SOLVED: To safely perform drug manufacturing and purification without bacterial contamination or the like by subjecting a matter prepared by laminating or integrating all membrane unit or several groups of plural membrane units in which all the membrane units are classified to sterilization or pyrogen removing treatment, and then arranging pressing frames at both the ends of the integrated matter, and tightening the membrane units between both the pressing frames. SOLUTION: In a plate frame membrane separator, a lot of membrane units 'u' are placed one upon another, pressing frame 6 are arranged at both the ends thereof, and the pressing frames 6, 6 are tightened by bolts 7. In this way, an original liquid main path 310, a concentrated liquid main path 320, and a permeated liquid main path 330 are respectively formed. When assembling the membrane separator, such membrane units 'u' are laminated, and are integrated by tightening bolts 71 inserted into the end parts of the support plates of the membrane units 'u', and the laminated and integrated matter E is subjected to sterilization and disinfection or pyrogen removal by steam treatment using an autoclave. After that, the laminated and integrated matter E is laminated by 'n' layers, and both the pressing frames 6, 6 are tightened by the bolts 7 to complete assembling.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for assembling a plate and frame type membrane separation apparatus, and relates to the treatment of pharmaceuticals and foods,
This is a useful method when replenishing a membrane unit of a plate and frame type membrane separation apparatus used for purification.

[0002]

2. Description of the Related Art In a plate and frame type membrane separation apparatus, a large number of membrane units are stacked, holding frames are arranged at both ends thereof, and these holding frames are fastened with bolts to make a membrane. This is a configuration in which the units are tightened. The membrane unit is
A concentrate main passage hole in which the concentrate main passage is formed by overlapping the units, a concentrate main passage hole in which the concentrate main passage is formed by the overlap, and a filtrate main passage is formed by the overlap. In the plate & frame type membrane separation apparatus, the raw liquid main passage is communicated with the raw liquid gap flow path between the membrane units, and the raw liquid gap between the membrane units is provided. The flow path is communicated with the concentrate main passage, and the filtrate chamber in the membrane unit is communicated with the filtrate main passage hole. Conventionally, in order to replace a membrane unit of a plate and frame type membrane separation apparatus, a holding frame at both ends is used.
And replace the membrane units one by one.
In the case of pharmaceutical and food processing and purification, the membrane units that have been sterilized or sterilized or depyrogenated are replaced one by one.

[0003]

However, in this repressing method, the membrane is exposed to the outside air for a long time, and is liable to be contaminated with bacteria and endotoxin. Therefore, in a plate and frame type membrane separation apparatus used for the treatment and purification of pharmaceuticals and foods, it is necessary to perform a disinfection / sterilization treatment or a depyrogen treatment again after the membrane unit is replaced. It is troublesome. An object of the present invention is to repress a plate and frame type membrane unit in a short time, and to treat pharmaceuticals and foods without performing sterilization / sterilization treatment or depyrogenation treatment again. And to enable the purification to be carried out safely without bacterial contamination.

[0004]

SUMMARY OF THE INVENTION A plate & plate according to the present invention is provided.
A method of assembling a frame type membrane separation apparatus is a membrane separation apparatus in which a large number of membrane units are stacked, holding frames are arranged at both ends thereof, and a large number of membrane units are fastened by these holding frames. Is a method of assembling, laminating and integrating all or a plurality of the above membrane units divided into several groups,
This laminated integrated product is subjected to sterilization or sterilization or depyrogen treatment, and both ends of the treated laminated integrated product or the laminated integrated product are stacked, and holding frames are arranged on both ends thereof,
The structure is characterized in that the two holding frames are fastened.

[0005]

Embodiments of the present invention will be described below with reference to the drawings. FIG. 1 shows an example of a membrane unit used in the present invention. In FIG. 1, reference numeral 1 denotes a metal support plate, and reference numerals 2 and 2 denote membranes attached to both sides of the support plate 1. The support plate 1 is provided between the support plate 1 and the membrane 3 for holding a filtrate chamber a. Is provided with a hole 11 in the support plate 1 for communicating the filtrate chambers a on both sides. Reference numeral 31 denotes a hole for the undiluted liquid main passage provided in the support plate and the membrane, 3
2 is a hole for the concentrate main passage, and 33 is a hole for the filtrate main passage.

Reference numeral 41 denotes a stock solution main passage spacer mounted in the stock solution main passage hole, which is in close contact with the support plate and the membrane in a liquid-tight manner. And a stock solution communicating hole 411 for communicating with the liquid. Reference numeral 42 denotes a spacer for the concentrate main passage mounted in the hole for the concentrate main passage, which is in close contact with the support plate and the membrane in a liquid-tight manner. It has a concentrate communication hole 421 for communication. Reference numeral 43 denotes a filtrate main passage spacer mounted in the filtrate main passage hole, which is in liquid-tight contact with the support plate and the membrane, and has a filtrate chamber a in the membrane unit.
Has a filtrate communication hole 431 for communicating with the filtrate main passage. Reference numeral 5 denotes a packing attached to the outer periphery of one surface of the support plate. The locking projection 51 is engaged with the hole 12 of the support plate 1, and the outer periphery of the membrane 2 is supported on the support plate 1.

FIG. 2 shows a plate and frame type membrane separation apparatus assembled according to the present invention, in which a large number of membrane units u are stacked, and holding frames 6 are arranged at both ends thereof. By fastening the frames 6 and 6 with bolts 7, the raw liquid main passage holes of all the membrane units are liquid-tightly linked to form the raw liquid main passage 310, and the concentrated liquid main passage holes of all the membrane units are similarly formed. Liquid-tightly associated to form a concentrate main passage 320,
Similarly, the filtrate main passages 330 of all the membrane units are formed in a liquid-tight manner in association with the filtrate main passage holes.

In this plate and frame type membrane separation apparatus, the stock solution is supplied to a stock solution inlet 3 provided in one of the holding frames.
11 ⇒ stock solution main passage 310 ⇒ stock solution communication hole 411 of stock solution main passage spacer of each membrane unit ⇒ stock solution gap flow path b between membrane units ⇒ concentrate of concentrate solution main passage spacer of each membrane unit The communication hole 421 ⇒ the concentrated liquid main passage 320 ⇒ flows through the concentrated liquid outlet 321 provided in the other holding frame, and the solvent in the concentrated liquid flows while the concentrated liquid flows through the concentrated liquid gap flow path b between the membrane units. The solvent that has permeated the membrane, that is, the filtrate, passes through the filtrate chamber a in the membrane unit → the filtrate communication hole 431 of the filtrate main passage spacer → the filtrate main passage hole 330.
⇒ It is taken out from the filtrate outlet 331 provided in one of the holding frames.

In order to assemble the plate and frame type membrane separation apparatus according to the present invention, if the number of all the membrane units is a large number Y (16 in FIG. 2), the large number of the membrane units are n-glues. 2 (in FIG. 2, two groups).
In this case, eight membrane units are stacked, integrated by fastening bolts 71 inserted into the ends of the support plate of the membrane unit, and the laminated integrated product E is sterilized and sterilized by steam treatment using an autoclave. Alternatively, the membrane unit laminated integrated body subjected to the depyrogenation treatment and sterilized or sterilized or depyrogenated is stacked n times (two in FIG. 2), and holding frames 6 and 6 are arranged at both ends thereof. -6,6 bolt 7
To complete the assembly of the plate and frame type membrane separation apparatus.

[0010] It is desirable that the above-mentioned steam treatment is carried out by putting the laminated unit of the membrane unit in a bag, and after the steam treatment, the laminated unit is transported to the assembling work place in the bag. The above-mentioned pyrogen removal treatment is performed by immersion in an alkaline solution, and after the treatment, it is washed with water. The number of layers integrated with the membrane unit is as large as possible within a range that does not hinder the operation of sterilization / sterilization or depyrogenation treatment. For example, in the case of a membrane unit having a membrane area of about 0.17 m ² , 7 It is preferable to set the number of sheets to about nine.

When the number of membrane units of the plate & frame type membrane separation apparatus is small, for example, when the number of the membrane units is about 7 to 9 as described above, all of these membrane units are laminated and integrated. The compound can be sterilized or sterilized or depyrogenated, and holding frames can be disposed at both ends of the laminated integrated product, and the holding frames can be fastened.

[0012] In the lamination and integration of the membrane unit, the undiluted main passage is formed by association of the undiluted main passage holes of the membrane unit.
The concentrate main passage is formed by the association of the concentrate main passage holes of the membrane unit, and the membrane units are superimposed without displacement so as to form the filtrate main passage by the association of the filtrate main passage holes of the membrane unit, and The superimposed state is maintained during sterilization / sterilization or depyrogen treatment, during transportation to the assembly workplace, and during fastening of the holding frame. In addition to the above bolting, a clip system and a spring system are also used. it can.

[0013]

DESCRIPTION OF THE PREFERRED EMBODIMENTS A plate and frame type membrane separation apparatus has 16 membrane units, a polysulfone ultrafiltration membrane, and a total membrane area of 2.5 m ² . 2 of 8 membrane units
The two sets were stacked and integrated with bolts, and the two sets were depyrogenated with an alkaline solution, washed with water, and each set was placed in a steam sterilization bag.
Steam sterilization was performed at 20 ° C. for 20 minutes. The membrane unit of the plate & frame type membrane separation apparatus was replaced by using two sets of the laminated integrated unit of the membrane unit subjected to the depyrogenation treatment and the sterilization treatment. In this plate & frame type membrane separation device, raw water treated with reverse osmosis membrane is supplied at an inlet pressure of 1 kg / cm.
^{2. When} the membrane separation treatment was performed at a recovery rate of 50% and a temperature of 25 ° C., the viable cell count was 0 (cfu / m2) even 24 hours after the start of the membrane separation treatment.
l). The membrane unit was subjected to a depyrogenation treatment and a sterilization treatment. However, when the membrane units were replaced one by one, the viable cell count 24 hours after the start of the membrane separation treatment was 120 (cfu / ml).

[0014]

According to the method for assembling a plate and frame type membrane separation apparatus according to the present invention, the membrane unit obtained by sterilizing or sterilizing or depyrogenating the membrane unit is brought into contact with the environment and workers. As much as possible and can be replaced in a short time, eliminating bacterial contamination and endotoxin contamination during replacement.
Drying and deterioration of the membrane can be prevented, and highly reliable membrane separation can be performed even after the membrane unit is replaced.

[Brief description of the drawings]

FIG. 1 is a drawing showing an example of a membrane unit of a plate and frame type membrane separation apparatus assembled according to the present invention.

FIG. 2 is a drawing showing an example of a plate and frame type membrane separation apparatus assembled according to the present invention.

[Explanation of symbols]

 u Membrane unit E Laminated unit of membrane unit 6 Holding frame 7 Bolt 71 Bolt

Claims (2)

[Claims] 1. A method for assembling a membrane separation apparatus comprising a plurality of membrane units stacked one on another, holding frames disposed at both ends thereof, and fastening the large number of membrane units with these holding frames. All or a plurality of the membrane units divided into several groups are laminated and integrated, and both ends of the laminated integrated product or the laminated integrated product are stacked, and holding frames are disposed at both ends thereof. And a method for assembling a plate and frame type membrane separation apparatus. 2. A method of assembling a membrane separation apparatus comprising a plurality of membrane units stacked one on another, holding frames disposed at both ends thereof, and fastening the plurality of membrane units with these holding frames. All or a plurality of membrane units divided into several groups are laminated and integrated, and the laminated integrated product is subjected to sterilization or sterilization or depyrogenation treatment, and both ends of the laminated integrated product or the laminated integrated product subjected to this treatment. A plate and frame is disposed at both ends thereof, and the two frames are fastened to each other.